LOCUS       NP_001019965             580 aa            linear   ROD 24-OCT-2024
DEFINITION  N6-adenosine-methyltransferase catalytic subunit [Rattus
            norvegicus].
ACCESSION   NP_001019965 XP_341311
VERSION     NP_001019965.1
DBSOURCE    REFSEQ: accession NM_001024794.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 580)
  AUTHORS   Wu,L., Ning,P., Liang,Y., Wang,T., Chen,L., Lu,D. and Tang,H.
  TITLE     Methyltransferase METTL3 regulates neuropathic pain through m6A
            methylation modification of SOCS1
  JOURNAL   Neuropharmacology 261, 110176 (2024)
   PUBMED   39357736
  REMARK    GeneRIF: Methyltransferase METTL3 regulates neuropathic pain
            through m6A methylation modification of SOCS1.
REFERENCE   2  (residues 1 to 580)
  AUTHORS   Bao,T., Liao,T., Cai,X., Lu,B., Dai,G., Pei,S., Zhang,Y., Li,Y. and
            Xu,B.
  TITLE     METTL3 mediated ferroptosis in chondrocytes and promoted pain in
            KOA via HMGB1 m6A modification
  JOURNAL   Cell Biol Int 48 (11), 1755-1765 (2024)
   PUBMED   39129231
  REMARK    GeneRIF: METTL3 mediated ferroptosis in chondrocytes and promoted
            pain in KOA via HMGB1 m6A modification.
REFERENCE   3  (residues 1 to 580)
  AUTHORS   Yu,Z., Xia,Y., Li,J., Jiang,J., Li,Y., Li,Y. and Wang,L.
  TITLE     METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10
            expression and improve brain ischemia/reperfusion injury through
            YTHDC1
  JOURNAL   Biol Direct 19 (1), 92 (2024)
   PUBMED   39407279
  REMARK    GeneRIF: METTL3 mediates m6A modification of lncRNA CRNDE to
            promote ATG10 expression and improve brain ischemia/reperfusion
            injury through YTHDC1.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 580)
  AUTHORS   Xiao,B., Zhu,Y., Liu,M., Chen,M., Huang,C., Xu,D., Wang,F., Sun,S.,
            Huang,J., Sun,N. and Yang,F.
  TITLE     miR-340-3p-modified bone marrow mesenchymal stem cell-derived
            exosomes inhibit ferroptosis through METTL3-mediated m6A
            modification of HMOX1 to promote recovery of injured rat uterus
  JOURNAL   Stem Cell Res Ther 15 (1), 224 (2024)
   PUBMED   39075530
  REMARK    GeneRIF: miR-340-3p-modified bone marrow mesenchymal stem
            cell-derived exosomes inhibit ferroptosis through METTL3-mediated
            m[6]A modification of HMOX1 to promote recovery of injured rat
            uterus.
            Erratum:[Stem Cell Res Ther. 2024 Oct 10;15(1):357. doi:
            10.1186/s13287-024-03985-w. PMID: 39390524]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 580)
  AUTHORS   Wang,Y., Zhang,G., Gao,Y., Zhang,X. and Qi,H.
  TITLE     METTL3 promotes trophoblast ferroptosis in preeclampsia by
            stabilizing the ACSL4 m6A modification
  JOURNAL   Exp Cell Res 437 (1), 113990 (2024)
   PUBMED   38462207
  REMARK    GeneRIF: METTL3 promotes trophoblast ferroptosis in preeclampsia by
            stabilizing the ACSL4 m[6]A modification.
REFERENCE   6  (residues 1 to 580)
  AUTHORS   Liu,J., Yue,Y., Han,D., Wang,X., Fu,Y., Zhang,L., Jia,G., Yu,M.,
            Lu,Z., Deng,X., Dai,Q., Chen,W. and He,C.
  TITLE     A METTL3-METTL14 complex mediates mammalian nuclear RNA
            N6-adenosine methylation
  JOURNAL   Nat Chem Biol 10 (2), 93-95 (2014)
   PUBMED   24316715
REFERENCE   7  (residues 1 to 580)
  AUTHORS   Wang,X., Lu,Z., Gomez,A., Hon,G.C., Yue,Y., Han,D., Fu,Y.,
            Parisien,M., Dai,Q., Jia,G., Ren,B., Pan,T. and He,C.
  TITLE     N6-methyladenosine-dependent regulation of messenger RNA stability
  JOURNAL   Nature 505 (7481), 117-120 (2014)
   PUBMED   24284625
REFERENCE   8  (residues 1 to 580)
  AUTHORS   Fustin,J.M., Doi,M., Yamaguchi,Y., Hida,H., Nishimura,S.,
            Yoshida,M., Isagawa,T., Morioka,M.S., Kakeya,H., Manabe,I. and
            Okamura,H.
  TITLE     RNA-methylation-dependent RNA processing controls the speed of the
            circadian clock
  JOURNAL   Cell 155 (4), 793-806 (2013)
   PUBMED   24209618
REFERENCE   9  (residues 1 to 580)
  AUTHORS   Dominissini,D., Moshitch-Moshkovitz,S., Schwartz,S.,
            Salmon-Divon,M., Ungar,L., Osenberg,S., Cesarkas,K.,
            Jacob-Hirsch,J., Amariglio,N., Kupiec,M., Sorek,R. and Rechavi,G.
  TITLE     Topology of the human and mouse m6A RNA methylomes revealed by
            m6A-seq
  JOURNAL   Nature 485 (7397), 201-206 (2012)
   PUBMED   22575960
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 580)
  AUTHORS   Bokar,J.A., Shambaugh,M.E., Polayes,D., Matera,A.G. and
            Rottman,F.M.
  TITLE     Purification and cDNA cloning of the AdoMet-binding subunit of the
            human mRNA (N6-adenosine)-methyltransferase
  JOURNAL   RNA 3 (11), 1233-1247 (1997)
   PUBMED   9409616
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097400.1.
            
            On Jun 10, 2005 this sequence version replaced XP_341311.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097400.1, SRR8487226.213014.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     Protein         1..580
                     /product="N6-adenosine-methyltransferase catalytic
                     subunit"
                     /EC_number="2.1.1.62"
                     /note="N6-adenosine-methyltransferase 70 kDa subunit;
                     methyltransferase-like 3"
                     /calculated_mol_wt=64554
     Region          389..550
                     /region_name="MT-A70"
                     /note="pfam05063"
                     /db_xref="CDD:368270"
     CDS             1..580
                     /gene="Mettl3"
                     /coded_by="NM_001024794.1:67..1809"
                     /db_xref="GeneID:361035"
                     /db_xref="RGD:1311750"
ORIGIN      
        1 msdtwssiqa hkkqldslre rlqrrrkqds ghldlrnpea alsptfrsds pvptaptssg
       61 pkpsttsivp elatdpelek kllhhlsdla ltlptdavsi rlaistpdap atqdgvesll
      121 qkfaaqelie vkrgllqdda hptlvtyadh sklsammgav aekkglgeaa gtitgqkrra
      181 eqdlttvatf tsslasglgs stsepakepa kksrkhaasd vdleieslln qqstkeqqsk
      241 kvsqeilell ntttakeqsi vekfrsrgra qvqefcdygt keecmkasda drpcrklhfr
      301 riinkhtdes lgdcsflntc fhmdtckyvh yeidacvdse spgskehmps qelaltqsvg
      361 gdssadrlfp pqwiccdiry ldvsilgkfa vvmadppwdi hmelpygtlt ddemrrlnip
      421 vlqddgflfl wvtgramelg reclnlwgye rvdeiiwvkt nqlqriirtg rtghwlnhgk
      481 ehclvgvkgn pqgfnqgldc dvivaevrst shkpdeiygm ierlspgtrk ielfgrphnv
      541 qpnwitlgnq ldgihlldpd vvarfkhryp dgviskpknl
//
