LOCUS       NM_001106908            1104 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus methyltransferase 21C, AARS1 lysine (Mettl21c),
            mRNA.
ACCESSION   NM_001106908 XM_001059953 XM_217389
VERSION     NM_001106908.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1104)
  AUTHORS   Huang,J., Hsu,Y.H., Mo,C., Abreu,E., Kiel,D.P., Bonewald,L.F.,
            Brotto,M. and Karasik,D.
  TITLE     METTL21C is a potential pleiotropic gene for osteoporosis and
            sarcopenia acting through the modulation of the NF-kappaB signaling
            pathway
  JOURNAL   J Bone Miner Res 29 (7), 1531-1540 (2014)
   PUBMED   24677265
REFERENCE   2  (bases 1 to 1104)
  AUTHORS   Cloutier,P., Lavallee-Adam,M., Faubert,D., Blanchette,M. and
            Coulombe,B.
  TITLE     A newly uncovered group of distantly related lysine
            methyltransferases preferentially interact with molecular
            chaperones to regulate their activity
  JOURNAL   PLoS Genet 9 (1), e1003210 (2013)
   PUBMED   23349634
REFERENCE   3  (bases 1 to 1104)
  AUTHORS   Kernstock,S., Davydova,E., Jakobsson,M., Moen,A., Pettersen,S.,
            Maelandsmo,G.M., Egge-Jacobsen,W. and Falnes,P.O.
  TITLE     Lysine methylation of VCP by a member of a novel human protein
            methyltransferase family
  JOURNAL   Nat Commun 3, 1038 (2012)
   PUBMED   22948820
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473965.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217389.3, XM_001059953.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1104
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..1104
                     /gene="Mettl21c"
                     /gene_synonym="RGD1561425"
                     /note="methyltransferase 21C, AARS1 lysine"
                     /db_xref="GeneID:301378"
                     /db_xref="RGD:1561425"
     exon            1..101
                     /gene="Mettl21c"
                     /gene_synonym="RGD1561425"
                     /inference="alignment:Splign:2.1.0"
     exon            102..192
                     /gene="Mettl21c"
                     /gene_synonym="RGD1561425"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..857
                     /gene="Mettl21c"
                     /gene_synonym="RGD1561425"
                     /note="methyltransferase-like protein 21C;
                     methyltransferase like 21C"
                     /codon_start=1
                     /product="protein-lysine methyltransferase METTL21C"
                     /protein_id="NP_001100378.1"
                     /db_xref="GeneID:301378"
                     /db_xref="RGD:1561425"
                     /translation="MDQHLHTAQQPLRLGTPQEDVFAGPSVESDMIESSLHSIQKFVP
                     TDYASYTQEHYHFAGKKIIIQESIENYGTVVWPGATALCQYLEDHTEELNLEDAKILE
                     IGAGPGLVSIVSSLLGAQVTATDLPDVLGNLQYNISKNTLECTAHLPEVKELVWGEDL
                     DQKFPKSSFYYDYVLASDVVYHHYFLDKLLATMVYLSQPGTVVLWANKFRFSTDYEFL
                     DKFKQAFDTTLLAEHSESSVKLFKGILKWD"
     exon            193..344
                     /gene="Mettl21c"
                     /gene_synonym="RGD1561425"
                     /inference="alignment:Splign:2.1.0"
     exon            345..462
                     /gene="Mettl21c"
                     /gene_synonym="RGD1561425"
                     /inference="alignment:Splign:2.1.0"
     exon            463..1104
                     /gene="Mettl21c"
                     /gene_synonym="RGD1561425"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcttttg gtcataaaga gcttatcatt tcaagtgcag acctatataa aaaaacactg
       61 gggacttgag gctacacaaa cttcgatctc tgcttcataa ggctctagct atggatcagc
      121 atctccacac ggcccagcag cccctacgct tggggactcc acaggaggat gtttttgcag
      181 gaccctcagt agagtctgac atgatagaat catctcttca tagcatccag aaatttgttc
      241 ctacagacta tgccagctac acacaagagc attatcactt cgcaggcaag aagatcatca
      301 ttcaagaatc cattgagaac tatggcacag tggtgtggcc aggggctaca gctttgtgcc
      361 aatatttaga agaccataca gaagaattaa atctcgaaga tgctaaaata cttgaaattg
      421 gtgctggacc aggccttgtt tccattgtgt ccagtctttt aggagctcaa gtcacagcaa
      481 cagacctgcc tgatgttcta ggaaatcttc aatacaatat ttcaaaaaac acactagaat
      541 gcacagccca tctacctgaa gtgaaagaac tggtatgggg ggaagacctg gaccagaaat
      601 tccctaagtc atccttttat tatgactatg tcctggcttc tgatgttgtc taccaccact
      661 acttcctgga taagctgctt gctaccatgg tgtacctttc ccagccaggc actgtggtgc
      721 tttgggcaaa caaattcaga tttagtactg attatgaatt tttagataag ttcaagcaag
      781 cttttgatac cactctcttg gctgaacatt cagagtcatc agtcaagctc tttaaaggaa
      841 tattaaaatg ggactgaaat gtaaagagcc tctcaaacca tcagtgtctt gtgaagctgt
      901 taaaaggtat actataccat actggtaagg ctagaataaa tgcattcaat atacaacttt
      961 ctaagatggt aagaatatgt ggtcaaccta agtatctaaa gaaaggaaac agacacatga
     1021 aagtagactt gctgagttcc cagtgtatta aatgtattaa ataagagctt acacaaagaa
     1081 gtaaatgaac aagtgggttc ctgt
//
