LOCUS       NM_001402033            2743 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus methyltransferase 16, RNA N6-adenosine (Mettl16),
            mRNA.
ACCESSION   NM_001402033 XR_085968
VERSION     NM_001402033.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2743)
  AUTHORS   Zhang,X., Meng,W., Feng,J., Gao,X., Qin,C., Feng,P., Huang,Y. and
            Gao,S.J.
  TITLE     METTL16 controls Kaposi's sarcoma-associated herpesvirus
            replication by regulating S-adenosylmethionine cycle
  JOURNAL   Cell Death Dis 14 (9), 591 (2023)
   PUBMED   37673880
  REMARK    GeneRIF: METTL16 controls Kaposi's sarcoma-associated herpesvirus
            replication by regulating S-adenosylmethionine cycle.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2743)
  AUTHORS   Mendel,M., Chen,K.M., Homolka,D., Gos,P., Pandey,R.R.,
            McCarthy,A.A. and Pillai,R.S.
  TITLE     Methylation of Structured RNA by the m6A Writer METTL16 Is
            Essential for Mouse Embryonic Development
  JOURNAL   Mol Cell 71 (6), 986-1000 (2018)
   PUBMED   30197299
REFERENCE   3  (bases 1 to 2743)
  AUTHORS   Doxtader,K.A., Wang,P., Scarborough,A.M., Seo,D., Conrad,N.K. and
            Nam,Y.
  TITLE     Structural Basis for Regulation of METTL16, an S-Adenosylmethionine
            Homeostasis Factor
  JOURNAL   Mol Cell 71 (6), 1001-1011 (2018)
   PUBMED   30197297
REFERENCE   4  (bases 1 to 2743)
  AUTHORS   Shima,H., Matsumoto,M., Ishigami,Y., Ebina,M., Muto,A., Sato,Y.,
            Kumagai,S., Ochiai,K., Suzuki,T. and Igarashi,K.
  TITLE     S-Adenosylmethionine Synthesis Is Regulated by Selective
            N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and
            YTHDC1
  JOURNAL   Cell Rep 21 (12), 3354-3363 (2017)
   PUBMED   29262316
REFERENCE   5  (bases 1 to 2743)
  AUTHORS   Warda,A.S., Kretschmer,J., Hackert,P., Lenz,C., Urlaub,H.,
            Hobartner,C., Sloan,K.E. and Bohnsack,M.T.
  TITLE     Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that
            targets pre-mRNAs and various non-coding RNAs
  JOURNAL   EMBO Rep 18 (11), 2004-2014 (2017)
   PUBMED   29051200
REFERENCE   6  (bases 1 to 2743)
  AUTHORS   Pendleton,K.E., Chen,B., Liu,K., Hunter,O.V., Xie,Y., Tu,B.P. and
            Conrad,N.K.
  TITLE     The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase
            Intron Retention
  JOURNAL   Cell 169 (5), 824-835 (2017)
   PUBMED   28525753
REFERENCE   7  (bases 1 to 2743)
  AUTHORS   Brown,J.A., Kinzig,C.G., DeGregorio,S.J. and Steitz,J.A.
  TITLE     Methyltransferase-like protein 16 binds the 3'-terminal triple
            helix of MALAT1 long noncoding RNA
  JOURNAL   Proc Natl Acad Sci U S A 113 (49), 14013-14018 (2016)
   PUBMED   27872311
REFERENCE   8  (bases 1 to 2743)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   9  (bases 1 to 2743)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 3, 2022 this sequence version replaced XR_085968.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.738097.1,
                                           SRR26643429.37579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000010.1  60139317-60139452
            137-264             JAXUCZ010000010.1  60141920-60142047
            265-464             JAXUCZ010000010.1  60152632-60152831
            465-605             JAXUCZ010000010.1  60155856-60155996
            606-721             JAXUCZ010000010.1  60161297-60161412
            722-864             JAXUCZ010000010.1  60164409-60164551
            865-934             JAXUCZ010000010.1  60171496-60171565
            935-1024            JAXUCZ010000010.1  60172631-60172720
            1025-1198           JAXUCZ010000010.1  60183581-60183754
            1199-2743           JAXUCZ010000010.1  60183894-60185438
FEATURES             Location/Qualifiers
     source          1..2743
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2743
                     /gene="Mettl16"
                     /gene_synonym="Mett10d"
                     /note="methyltransferase 16, RNA N6-adenosine"
                     /db_xref="GeneID:360568"
                     /db_xref="RGD:1593242"
     exon            1..136
                     /gene="Mettl16"
                     /gene_synonym="Mett10d"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1798
                     /gene="Mettl16"
                     /gene_synonym="Mett10d"
                     /note="methyltransferase 10 domain containing;
                     methyltransferase like 16; methyltransferase 16,
                     N6-methyladenosine"
                     /codon_start=1
                     /product="RNA N6-adenosine-methyltransferase METTL16"
                     /protein_id="NP_001388962.1"
                     /db_xref="GeneID:360568"
                     /db_xref="RGD:1593242"
                     /translation="MALSKSMHARNRYKDKPPDFAYLASKYPDFKQHIQINLNGRVSL
                     NFKDPEAVRALTCTLLREDFGLSIDIPLERLIPTVPLRLNYIHWVEDLIGHQDSDKTT
                     LRRGIDIGTGASCIYPLLGATLNGWYFLATEVDDMCFNYAKKNVEQNNLSDLIKVVKV
                     PQKTLLMDALKEESEIVYDFCMCNPPFFANQLEAKGVNSRNSRRPPPSSVNTGGITEI
                     MAEGGELEFVKRIIHDSLQLKKRLRWYSCMLGKKCSLAPLKEELRIQGVPKVTFTEFC
                     QGRTMRWALAWSFYDDVTVPSPPSKRRKLEKPRKPITFVVLGSVMKELSLKASSLGSE
                     TVEGIVVVTTWIEKILTDLKVQHKRIPCGREEVSLFLTAIENSWIHLRRKRRERVRQL
                     REVPRAPEDVILALEERKSTPKELSSGQDMTHCLQESALCGLDVPEGESAAVGGHCFS
                     QKLLCQEETPEAMEDERDEERGGMEAMESCKGSSNGAQDGEASEKGDHLDGAAGHYLF
                     KCLMNIKKEADDAVVEMHWVEGQNRDLMNQLCTYIRNQILRLVAS"
     exon            137..264
                     /gene="Mettl16"
                     /gene_synonym="Mett10d"
                     /inference="alignment:Splign:2.1.0"
     exon            265..464
                     /gene="Mettl16"
                     /gene_synonym="Mett10d"
                     /inference="alignment:Splign:2.1.0"
     exon            465..605
                     /gene="Mettl16"
                     /gene_synonym="Mett10d"
                     /inference="alignment:Splign:2.1.0"
     exon            606..721
                     /gene="Mettl16"
                     /gene_synonym="Mett10d"
                     /inference="alignment:Splign:2.1.0"
     exon            722..864
                     /gene="Mettl16"
                     /gene_synonym="Mett10d"
                     /inference="alignment:Splign:2.1.0"
     exon            865..934
                     /gene="Mettl16"
                     /gene_synonym="Mett10d"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1024
                     /gene="Mettl16"
                     /gene_synonym="Mett10d"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1198
                     /gene="Mettl16"
                     /gene_synonym="Mett10d"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..2743
                     /gene="Mettl16"
                     /gene_synonym="Mett10d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgcgcaa gatggcggcg cgcttggagc gtagcatctg cgtctttagg agcttggctg
       61 tgtgagtggg ttgggattct tgggcttttg caggcccagc cacacactct gtccagctac
      121 tacattggcc tacgagatgg cgctaagcaa atcaatgcat gcaagaaata gatacaagga
      181 caaaccacct gacttcgcgt atctggcgtc taaatatcca gactttaagc agcacattca
      241 gataaatctg aatgggagag taagtcttaa tttcaaagac cctgaagcag tcagagctct
      301 gacttgtact ctcctgagag aggactttgg actttctatt gatattcctt tggagagact
      361 aattcccaca gtccccttga gacttaacta tattcactgg gtagaagatc tgattggtca
      421 ccaggattct gacaaaacta ctctccgaag aggaattgac ataggtactg gggcgtcctg
      481 catctatccc ttacttggag caaccttaaa tggctggtat ttcctggcca cagaagtgga
      541 cgacatgtgc ttcaattatg ccaagaaaaa tgtagagcag aataacctgt ctgatctcat
      601 caaagtggtg aaagtgccgc agaagacact tctgatggac gcgcttaagg aagagtctga
      661 gatagtctat gacttctgta tgtgcaaccc tccctttttt gccaaccaat tggaagccaa
      721 gggtgtaaac tctcggaatt ctcgaagacc tccacctagt tctgtaaata caggaggcat
      781 cacagagatc atggcagagg gaggtgaact agaatttgtc aaaaggatca tccatgacag
      841 tttacaactt aaaaaaagat taaggtggta cagctgtatg ctgggaaaga agtgcagtct
      901 ggctccactg aaggaagagc ttagaatcca aggggttcct aaagtcacct tcacggagtt
      961 ttgtcagggt cggacgatga gatgggcctt agcttggagt ttttatgatg atgtcacagt
     1021 accatcacct ccaagtaaac gaagaaaatt ggaaaagcca aggaaaccca ttacttttgt
     1081 agtgttgggg tctgtgatga aagagttatc cctcaaagcc tcatctttgg gctccgagac
     1141 agtggaaggc atagtggttg taacaacatg gatagaaaaa atcctcactg atctgaaggt
     1201 gcaacataag cggattccct gtggaagaga agaagttagc cttttcctga cagccataga
     1261 aaactcgtgg attcatttaa ggcggaagag aagagagcga gtgaggcagc tgcgggaggt
     1321 gcctcgggct cctgaggatg tcatcttagc cttggaagag agaaagtcca ctcccaaaga
     1381 gctgagtagt ggccaagaca tgacccattg cctccaagag agtgccttgt gtggacttga
     1441 tgtgccggaa ggcgagtctg ctgctgttgg tggccattgc ttcagccaga agttactgtg
     1501 ccaggaggaa acaccggaag ctatggagga tgaaagggat gaggaaaggg gagggatgga
     1561 ggccatggaa agttgtaaag gctccagcaa tggagcccag gacggagagg cttctgagaa
     1621 gggggatcac ctggatggag cagctggaca ttacctgttt aagtgtttga tgaacattaa
     1681 gaaggaggca gacgatgctg ttgttgaaat gcactgggtt gagggccaga atagggattt
     1741 gatgaaccag ctttgcacct acatacggaa ccaaattttg aggcttgttg ctagttaatt
     1801 cttagtttct tcgacagtta gaaaagtgtc tgtctggggc tagggatatg gtgcaatggc
     1861 cttatgtgct tagtatccag aagttaccct gtgttgagtc ccttacatct aacatcaata
     1921 caaggaaaaa aaaatctata aaatagcttg ctttggaggt agaacctatt gggaagtcag
     1981 aagactttca ccccgtcctt tagtgacccc acgtggagtc atcttacaaa gcacacgttt
     2041 agttggatgt gctctgtgac acttgtaatc ccactacttg gaggctgagg caggaagact
     2101 gctatgggtg taaggtcagt ctacgctaca gagaaagcca cctgtctaaa taaaaagaaa
     2161 agaggaaaac aaatgaatcc atttttaatc actccgctct taaaagttat ctggagttat
     2221 ataaatagca caggaggaat tacgattatt gcaacagtag ataaacctag caggtcatct
     2281 cagccaaagg ccagaggggc tcgggtggca tctggtgtgg gtcagtgctg cctagaacat
     2341 gtctgtcact gagggttgct tggtgaagag ggtagccgtg ttctccagtg aaagcaacac
     2401 agcagagcag aggcccagga atgctcattg ttgcctttaa gacacctgct ttctcaagga
     2461 acctggctag cctggtaata ggtggtcagt gtgtcaggga gggcatctta gaccaagccc
     2521 ggggaacaca caggaagctg cacgttcacc gctcactgct cttctgacac tgcctattgc
     2581 agaagcagaa ttgagtgagc aaaactctga gatgtagctg cggcacagca cagtgcgccc
     2641 gtcagcccac cggcagcatc gttttgtaac agttgtactg ctttttttaa atgtgaaatg
     2701 gaatgttttg ttttttaata taagacttaa gaattgaaaa tta
//
