LOCUS       NM_001399249            2649 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus methyltransferase 14,
            N6-adenosine-methyltransferase non-catalytic subunit (Mettl14),
            mRNA.
ACCESSION   NM_001399249 XM_006233266
VERSION     NM_001399249.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2649)
  AUTHORS   Liu,D., Ren,L. and Liu,J.
  TITLE     METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A
            modification of GPX4
  JOURNAL   Int J Rheum Dis 27 (8), e15297 (2024)
   PUBMED   39175261
  REMARK    GeneRIF: METTL14 promotes chondrocyte ferroptosis in osteoarthritis
            via m6A modification of GPX4.
REFERENCE   2  (bases 1 to 2649)
  AUTHORS   Li,Y., Li,J., Yu,Q., Ji,L. and Peng,B.
  TITLE     METTL14 regulates microglia/macrophage polarization and NLRP3
            inflammasome activation after ischemic stroke by the KAT3B-STING
            axis
  JOURNAL   Neurobiol Dis 185, 106253 (2023)
   PUBMED   37541353
  REMARK    GeneRIF: METTL14 regulates microglia/macrophage polarization and
            NLRP3 inflammasome activation after ischemic stroke by the
            KAT3B-STING axis.
REFERENCE   3  (bases 1 to 2649)
  AUTHORS   Wang,C., Zhu,X., Chen,R., Zhang,X. and Lian,N.
  TITLE     Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy
            in Spinal Cord Injury
  JOURNAL   eNeuro 10 (6) (2023)
   PUBMED   37094938
  REMARK    GeneRIF: Upregulation of UBR1 m6A Methylation by METTL14 Inhibits
            Autophagy in Spinal Cord Injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2649)
  AUTHORS   Li,X., Xu,X., Zhang,Q., Ling,M., Li,X. and Tan,X.
  TITLE     METTL14 promotes fibroblast-like synoviocytes activation via the
            LASP1/SRC/AKT axis in rheumatoid arthritis
  JOURNAL   Am J Physiol Cell Physiol 324 (5), C1089-C1100 (2023)
   PUBMED   36878846
  REMARK    GeneRIF: METTL14 promotes fibroblast-like synoviocytes activation
            via the LASP1/SRC/AKT axis in rheumatoid arthritis.
REFERENCE   5  (bases 1 to 2649)
  AUTHORS   Meng,L., Lin,H., Huang,X., Weng,J., Peng,F. and Wu,S.
  TITLE     METTL14 suppresses pyroptosis and diabetic cardiomyopathy by
            downregulating TINCR lncRNA
  JOURNAL   Cell Death Dis 13 (1), 38 (2022)
   PUBMED   35013106
  REMARK    GeneRIF: METTL14 suppresses pyroptosis and diabetic cardiomyopathy
            by downregulating TINCR lncRNA.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2649)
  AUTHORS   Zhou,J., Wan,J., Gao,X., Zhang,X., Jaffrey,S.R. and Qian,S.B.
  TITLE     Dynamic m(6)A mRNA methylation directs translational control of
            heat shock response
  JOURNAL   Nature 526 (7574), 591-594 (2015)
   PUBMED   26458103
REFERENCE   7  (bases 1 to 2649)
  AUTHORS   Liu,N., Dai,Q., Zheng,G., He,C., Parisien,M. and Pan,T.
  TITLE     N(6)-methyladenosine-dependent RNA structural switches regulate
            RNA-protein interactions
  JOURNAL   Nature 518 (7540), 560-564 (2015)
   PUBMED   25719671
REFERENCE   8  (bases 1 to 2649)
  AUTHORS   Schwartz,S., Mumbach,M.R., Jovanovic,M., Wang,T., Maciag,K.,
            Bushkin,G.G., Mertins,P., Ter-Ovanesyan,D., Habib,N.,
            Cacchiarelli,D., Sanjana,N.E., Freinkman,E., Pacold,M.E.,
            Satija,R., Mikkelsen,T.S., Hacohen,N., Zhang,F., Carr,S.A.,
            Lander,E.S. and Regev,A.
  TITLE     Perturbation of m6A writers reveals two distinct classes of mRNA
            methylation at internal and 5' sites
  JOURNAL   Cell Rep 8 (1), 284-296 (2014)
   PUBMED   24981863
REFERENCE   9  (bases 1 to 2649)
  AUTHORS   Wang,Y., Li,Y., Toth,J.I., Petroski,M.D., Zhang,Z. and Zhao,J.C.
  TITLE     N6-methyladenosine modification destabilizes developmental
            regulators in embryonic stem cells
  JOURNAL   Nat Cell Biol 16 (2), 191-198 (2014)
   PUBMED   24394384
REFERENCE   10 (bases 1 to 2649)
  AUTHORS   Liu,J., Yue,Y., Han,D., Wang,X., Fu,Y., Zhang,L., Jia,G., Yu,M.,
            Lu,Z., Deng,X., Dai,Q., Chen,W. and He,C.
  TITLE     A METTL3-METTL14 complex mediates mammalian nuclear RNA
            N6-adenosine methylation
  JOURNAL   Nat Chem Biol 10 (2), 93-95 (2014)
   PUBMED   24316715
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 5, 2022 this sequence version replaced XM_006233266.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166789.1, SRR26360172.1186009.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               JAXUCZ010000002.1  214231196-214231412 c
            218-306             JAXUCZ010000002.1  214228933-214229021 c
            307-394             JAXUCZ010000002.1  214228074-214228161 c
            395-475             JAXUCZ010000002.1  214226586-214226666 c
            476-563             JAXUCZ010000002.1  214226142-214226229 c
            564-654             JAXUCZ010000002.1  214222128-214222218 c
            655-796             JAXUCZ010000002.1  214220753-214220894 c
            797-889             JAXUCZ010000002.1  214219989-214220081 c
            890-1006            JAXUCZ010000002.1  214219505-214219621 c
            1007-1217           JAXUCZ010000002.1  214218169-214218379 c
            1218-2649           JAXUCZ010000002.1  214215165-214216596 c
FEATURES             Location/Qualifiers
     source          1..2649
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..2649
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /note="methyltransferase 14,
                     N6-adenosine-methyltransferase non-catalytic subunit"
                     /db_xref="GeneID:295428"
                     /db_xref="RGD:1304822"
     exon            1..217
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1522
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /EC_number="2.1.1.62"
                     /note="methyltransferase-like protein 14;
                     N6-adenosine-methyltransferase subunit METTL14;
                     methyltransferase like 14; methyltransferase 14,
                     N6-adenosine-methyltransferase subunit"
                     /codon_start=1
                     /product="N6-adenosine-methyltransferase non-catalytic
                     subunit"
                     /protein_id="NP_001386178.1"
                     /db_xref="GeneID:295428"
                     /db_xref="RGD:1304822"
                     /translation="MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREI
                     AETRETCRASYDTSAPNSKRKCLDEGETDEDKVEEYKDELEMQQEEENLPYEEEIYKD
                     SSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELI
                     AKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGIAANEKCWTWDDIMK
                     LEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLD
                     PKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHII
                     EHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEI
                     ERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGTHR
                     GGFTPR"
     exon            218..306
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /inference="alignment:Splign:2.1.0"
     exon            307..394
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /inference="alignment:Splign:2.1.0"
     exon            395..475
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /inference="alignment:Splign:2.1.0"
     exon            476..563
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /inference="alignment:Splign:2.1.0"
     exon            564..654
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /inference="alignment:Splign:2.1.0"
     exon            655..796
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /inference="alignment:Splign:2.1.0"
     exon            797..889
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1006
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1217
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..2649
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgtctcg ggcgcgccgg aaatccctcc tgagggacgt gaaagtctcc gggtcagaat
       61 ctcggtggga cgctgtttcc tggtttggga ggagggtttg cgttttggcg ggcgcggtgt
      121 ctgtcgggtg gtgagaagca ggacctgggg catggacagc cgcctgcagg agatccggga
      181 acggcagaag ttacggcggc agctcctagc tcagcagttg ggagctgaga gtgcagatag
      241 cattggtgct gtgttaaaca gcaaagatga acagagggag atcgctgaaa caagagaaac
      301 ttgcagggct tcctatgata cttctgctcc aaattcaaaa cggaagtgtc tggatgaagg
      361 agagacggat gaagataaag tagaagaata taaggatgaa ctagaaatgc aacaggaaga
      421 agaaaatttg ccatatgaag aagagattta caaagattcc agtaccttcc ttaagggaac
      481 gcagagctta aatccccata atgattactg ccagcatttt gtagacactg gacatagacc
      541 tcagaatttc atcagggatg taggcctagc cgacagattt gaagaatacc ctaaacttag
      601 ggagctcatc agactgaagg atgagctgat agctaagtca aatactcctc ccatgtactt
      661 acaggcagac atagaagcct ttgacatcag agaattgaca cccaagtttg atgtgattct
      721 tctggagcct cctctggaag aatactacag agagaccggc atcgctgcaa acgagaagtg
      781 ctggacgtgg gacgatatca tgaagttaga aatcgatgag atcgcagcac ctcggtcatt
      841 tatatttctc tggtgcggct ctggggaagg attggacctt gggagagtat gtttgcgaaa
      901 gtggggttac agaagatgtg aagatatttg ttggattaaa accaataaga acaatcctgg
      961 aaagacaaag accctagatc caaaggccgt tttccagagg acaaaggagc actgccttat
     1021 ggggatcaaa ggaaccgtga agcgaagcac agatggggac ttcattcatg ctaatgttga
     1081 cattgactta attatcacag aggaacctga gattggcaac atagaaaagc ccgtggagat
     1141 ttttcacata atagagcact tttgtctcgg tagaagacgc cttcatctct tcgggaggga
     1201 cagcactatc aggccaggct ggctcacagt tggaccaacg cttacaaata gtaactacaa
     1261 tgcagaaacc tacgcgtcct acttcagtgc ccccaattca tacttgactg gatgtaccga
     1321 ggaaattgag aggcttagac cgaagtcacc tcctcccaaa tccaagtctg accgtggtgg
     1381 tggagctccc agaggtggag ggagaggggg aacatctgct ggccgtggtc gtgaacgaaa
     1441 tcgatccaat ttccgaggag aaagaggtgg ctttaggggg ggtcgtggag ggacacacag
     1501 aggtggcttt acacctcggt agctgttaca aacgcttaac agtgtcccct ctgatctttt
     1561 ttgtgaagac ttgcttcaga actcactccc agcttgcact ttgctttagt ttctcatgct
     1621 gccagaaaga ccttagccac ccacccccac ccctaggtcc ttgcagttgt cacagactgt
     1681 ggttctgctc agggtaagtc acatgtgtgc aacactcagt catgggcttg actgatttca
     1741 ctcaaggctt tggcttcttg gaaataggag cgcagtggag cacctctcag aggaggatgg
     1801 caggaatggt gctctttcct tgtcgtggct gccgcagccg cagtaggaga ctgggaacct
     1861 gggcagagca gaactgagag aggcggtcac cctttttggg gcctttaatg ttttcttgtt
     1921 aaaacactaa aaagatgtag ttcccccccc cccttttaaa ttctaaaaaa taacatgaag
     1981 tatcatttga gtactgaaga ctcagagatg aaatgaagtc actttcttcc agatctgaat
     2041 ctgacggggc tggagccctc agggaaggta atggaagagg cagagcttcc tagatttaaa
     2101 acaaaagcaa aacaaaaacc aaagttatca taatgtaaat aacagctgca gatgacatat
     2161 aatcatgctt cttaagaagc aagaggaggc aggcacgtgt caggtcggag ggctgtgtgt
     2221 gatcttgaac ttggactgac cttctaagac aattcatatt tcttagcaaa ggtaaaaaca
     2281 gatttgctgg ggggagggat ggttcaaaca atctagaaaa taaacgcttg atgatgagga
     2341 aatgacatac atctttaaag ttgttattga acaaaattta ggtaaaagca attatagaaa
     2401 ccctaaggat acagcttgag agatggggtt gcagttgcct ttgattagag ctgtgtggtg
     2461 cagatgtctc tgcagggctg atgttcggat ctcttggctg tggaaagctt catactgttg
     2521 tttttctaca ccttaagtca tgtttgaatg gatttggcta tgccagatga gataatatca
     2581 ttattgttca tggtaactcc tttttttatt ttgctatact tttctaataa aaagtttaaa
     2641 cctttgaaa
//
