LOCUS       NP_001386178             456 aa            linear   ROD 13-OCT-2024
DEFINITION  N6-adenosine-methyltransferase non-catalytic subunit [Rattus
            norvegicus].
ACCESSION   NP_001386178 XP_006233328
VERSION     NP_001386178.1
DBSOURCE    REFSEQ: accession NM_001399249.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 456)
  AUTHORS   Liu,D., Ren,L. and Liu,J.
  TITLE     METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A
            modification of GPX4
  JOURNAL   Int J Rheum Dis 27 (8), e15297 (2024)
   PUBMED   39175261
  REMARK    GeneRIF: METTL14 promotes chondrocyte ferroptosis in osteoarthritis
            via m6A modification of GPX4.
REFERENCE   2  (residues 1 to 456)
  AUTHORS   Li,Y., Li,J., Yu,Q., Ji,L. and Peng,B.
  TITLE     METTL14 regulates microglia/macrophage polarization and NLRP3
            inflammasome activation after ischemic stroke by the KAT3B-STING
            axis
  JOURNAL   Neurobiol Dis 185, 106253 (2023)
   PUBMED   37541353
  REMARK    GeneRIF: METTL14 regulates microglia/macrophage polarization and
            NLRP3 inflammasome activation after ischemic stroke by the
            KAT3B-STING axis.
REFERENCE   3  (residues 1 to 456)
  AUTHORS   Wang,C., Zhu,X., Chen,R., Zhang,X. and Lian,N.
  TITLE     Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy
            in Spinal Cord Injury
  JOURNAL   eNeuro 10 (6) (2023)
   PUBMED   37094938
  REMARK    GeneRIF: Upregulation of UBR1 m6A Methylation by METTL14 Inhibits
            Autophagy in Spinal Cord Injury.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 456)
  AUTHORS   Li,X., Xu,X., Zhang,Q., Ling,M., Li,X. and Tan,X.
  TITLE     METTL14 promotes fibroblast-like synoviocytes activation via the
            LASP1/SRC/AKT axis in rheumatoid arthritis
  JOURNAL   Am J Physiol Cell Physiol 324 (5), C1089-C1100 (2023)
   PUBMED   36878846
  REMARK    GeneRIF: METTL14 promotes fibroblast-like synoviocytes activation
            via the LASP1/SRC/AKT axis in rheumatoid arthritis.
REFERENCE   5  (residues 1 to 456)
  AUTHORS   Meng,L., Lin,H., Huang,X., Weng,J., Peng,F. and Wu,S.
  TITLE     METTL14 suppresses pyroptosis and diabetic cardiomyopathy by
            downregulating TINCR lncRNA
  JOURNAL   Cell Death Dis 13 (1), 38 (2022)
   PUBMED   35013106
  REMARK    GeneRIF: METTL14 suppresses pyroptosis and diabetic cardiomyopathy
            by downregulating TINCR lncRNA.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 456)
  AUTHORS   Zhou,J., Wan,J., Gao,X., Zhang,X., Jaffrey,S.R. and Qian,S.B.
  TITLE     Dynamic m(6)A mRNA methylation directs translational control of
            heat shock response
  JOURNAL   Nature 526 (7574), 591-594 (2015)
   PUBMED   26458103
REFERENCE   7  (residues 1 to 456)
  AUTHORS   Liu,N., Dai,Q., Zheng,G., He,C., Parisien,M. and Pan,T.
  TITLE     N(6)-methyladenosine-dependent RNA structural switches regulate
            RNA-protein interactions
  JOURNAL   Nature 518 (7540), 560-564 (2015)
   PUBMED   25719671
REFERENCE   8  (residues 1 to 456)
  AUTHORS   Schwartz,S., Mumbach,M.R., Jovanovic,M., Wang,T., Maciag,K.,
            Bushkin,G.G., Mertins,P., Ter-Ovanesyan,D., Habib,N.,
            Cacchiarelli,D., Sanjana,N.E., Freinkman,E., Pacold,M.E.,
            Satija,R., Mikkelsen,T.S., Hacohen,N., Zhang,F., Carr,S.A.,
            Lander,E.S. and Regev,A.
  TITLE     Perturbation of m6A writers reveals two distinct classes of mRNA
            methylation at internal and 5' sites
  JOURNAL   Cell Rep 8 (1), 284-296 (2014)
   PUBMED   24981863
REFERENCE   9  (residues 1 to 456)
  AUTHORS   Wang,Y., Li,Y., Toth,J.I., Petroski,M.D., Zhang,Z. and Zhao,J.C.
  TITLE     N6-methyladenosine modification destabilizes developmental
            regulators in embryonic stem cells
  JOURNAL   Nat Cell Biol 16 (2), 191-198 (2014)
   PUBMED   24394384
REFERENCE   10 (residues 1 to 456)
  AUTHORS   Liu,J., Yue,Y., Han,D., Wang,X., Fu,Y., Zhang,L., Jia,G., Yu,M.,
            Lu,Z., Deng,X., Dai,Q., Chen,W. and He,C.
  TITLE     A METTL3-METTL14 complex mediates mammalian nuclear RNA
            N6-adenosine methylation
  JOURNAL   Nat Chem Biol 10 (2), 93-95 (2014)
   PUBMED   24316715
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 5, 2022 this sequence version replaced XP_006233328.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166789.1, SRR26360172.1186009.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     Protein         1..456
                     /product="N6-adenosine-methyltransferase non-catalytic
                     subunit"
                     /EC_number="2.1.1.62"
                     /note="methyltransferase-like protein 14;
                     N6-adenosine-methyltransferase subunit METTL14;
                     methyltransferase like 14; methyltransferase 14,
                     N6-adenosine-methyltransferase subunit"
                     /calculated_mol_wt=51961
     Region          186..363
                     /region_name="MT-A70"
                     /note="pfam05063"
                     /db_xref="CDD:368270"
     CDS             1..456
                     /gene="Mettl14"
                     /gene_synonym="RGD1304822"
                     /coded_by="NM_001399249.1:152..1522"
                     /db_xref="GeneID:295428"
                     /db_xref="RGD:1304822"
ORIGIN      
        1 mdsrlqeire rqklrrqlla qqlgaesads igavlnskde qreiaetret crasydtsap
       61 nskrkcldeg etdedkveey kdelemqqee enlpyeeeiy kdsstflkgt qslnphndyc
      121 qhfvdtghrp qnfirdvgla drfeeypklr elirlkdeli aksntppmyl qadieafdir
      181 eltpkfdvil leppleeyyr etgiaanekc wtwddimkle ideiaaprsf iflwcgsgeg
      241 ldlgrvclrk wgyrrcedic wiktnknnpg ktktldpkav fqrtkehclm gikgtvkrst
      301 dgdfihanvd idliiteepe igniekpvei fhiiehfclg rrrlhlfgrd stirpgwltv
      361 gptltnsnyn aetyasyfsa pnsyltgcte eierlrpksp ppksksdrgg gaprgggrgg
      421 tsagrgrern rsnfrgergg frggrggthr ggftpr
//
