LOCUS       NM_001398933            1650 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus methyltransferase 1, tRNA methylguanosine
            (Mettl1), transcript variant 1, mRNA.
ACCESSION   NM_001398933 XM_003750329
VERSION     NM_001398933.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Cartlidge,R.A., Knebel,A., Peggie,M., Alexandrov,A., Phizicky,E.M.
            and Cohen,P.
  TITLE     The tRNA methylase METTL1 is phosphorylated and inactivated by PKB
            and RSK in vitro and in cells
  JOURNAL   EMBO J 24 (9), 1696-1705 (2005)
   PUBMED   15861136
REFERENCE   2  (bases 1 to 1650)
  AUTHORS   Alexandrov,A., Martzen,M.R. and Phizicky,E.M.
  TITLE     Two proteins that form a complex are required for 7-methylguanosine
            modification of yeast tRNA
  JOURNAL   RNA 8 (10), 1253-1266 (2002)
   PUBMED   12403464
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 28, 2021 this sequence version replaced XM_003750329.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.30198.1,
                                           SRR26360190.3065095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               JAXUCZ010000007.1  64750189-64750303
            116-279             JAXUCZ010000007.1  64751339-64751502
            280-464             JAXUCZ010000007.1  64752758-64752942
            465-578             JAXUCZ010000007.1  64753039-64753152
            579-680             JAXUCZ010000007.1  64753296-64753397
            681-1650            JAXUCZ010000007.1  64753562-64754531
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1650
                     /gene="Mettl1"
                     /note="methyltransferase 1, tRNA methylguanosine"
                     /db_xref="GeneID:679091"
                     /db_xref="RGD:1593036"
     exon            1..115
                     /gene="Mettl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..830
                     /gene="Mettl1"
                     /EC_number="2.1.1.33"
                     /note="isoform 1 is encoded by transcript variant 1; tRNA
                     (guanine-N(7)-)-methyltransferase; methyltransferase like
                     1"
                     /codon_start=1
                     /product="tRNA (guanine-N(7)-)-methyltransferase isoform
                     1"
                     /protein_id="NP_001385862.1"
                     /db_xref="GeneID:679091"
                     /db_xref="RGD:1593036"
                     /translation="MAGAEAPQPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYP
                     EFFAPPNQNKSHDDPKDEKEKHSGAQVEFADIGCGYGGLLVALSPLFPDTLILGLEIR
                     VKVSDYVQDRIRALRATPGGGFQNIACLRSNAMKHLPNFFRKGQLAKMFFLFPDPHFK
                     RTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLELHEWMCTHFEEHPLFEHVPLEEL
                     SEDPVVEHLGTSTEEGKKVLRNNGKNFPAIFRRIQDPLLQAVTPNPTLP"
     exon            116..279
                     /gene="Mettl1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..464
                     /gene="Mettl1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..578
                     /gene="Mettl1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..680
                     /gene="Mettl1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..1650
                     /gene="Mettl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctctccacg tgtactgtgt ggcatcatgg cgggagccga ggccccccag ccgcagaagc
       61 gctactaccg gcagcgcgcc cactccaacc ctatggcgga ccacacactg cgctaccctg
      121 tgaagccaga ggagatggac tggtctgagc tttacccaga gttctttgct ccacctaatc
      181 aaaacaagag ccatgatgat ccaaaggatg agaaagaaaa gcactctggg gcccaagtgg
      241 agtttgcaga cataggctgt ggctatggtg gcttgttagt ggcactgtca ccgctcttcc
      301 cagataccct gattctgggt ctggaaattc gggtgaaggt gtccgactat gtgcaagaca
      361 ggattcgggc cctccgtgca actcccggag gtggattcca gaacatcgcc tgtctccgca
      421 gtaacgccat gaagcacctt cctaacttct tccgcaaggg ccagctggca aagatgttct
      481 tcctctttcc cgacccacac tttaagcgaa cgaagcataa atggcgaatc atcagcccca
      541 cacttctggc agagtatgcc tacgtgctga gagtcggggg cctggtatac accatcaccg
      601 atgtcctgga actgcacgaa tggatgtgca cccattttga agagcaccca ctatttgagc
      661 atgtgcctct ggaagagcta agtgaagacc ccgttgtgga acatctaggc acttcaactg
      721 aggaaggaaa gaaagttcta cgcaacaatg gaaagaattt cccagccatc ttccgaagaa
      781 tacaggatcc cctcctccag gcagtgaccc ccaatcccac cctaccttag ccggaccccc
      841 tcttctagtg actggaaaaa gatgagctcg ccgttccagg ccttcccagt ctggtggaac
      901 tgtgaggcca tgacctctcc aagaagtcag ggtgcagtct atcagtggtc tttcctatca
      961 ttcttactgc ctttctgttc ctccactgtc aggagaaagc agatgaagtg gactgagatc
     1021 aaaggacctt agacgagagg gggtatttgg gagactgtgg gtattttgtt ctccttgagc
     1081 acccccgccc cccggcttct ctagctgggg tgaagagtgc agtgctccac tgtcttaggc
     1141 cagatgtttg gctcaggttg ccctcagctg tgtttacttt gtagtcctgg ggatgatggg
     1201 tgtgtgcaca catacccaca tgtatgtgcc taagttcccg tgtgtgtgcg tgtgtgcgtg
     1261 tgtgtgtgcg tgcgtgtgtg tgtgtgtgtg tgtgtgtgtg tgcctgcacg cgcactcgtg
     1321 cctatgcctg agtgcccatg tatatgtgtc tgtgtgtgtc tgtgtgtgcc actgtttccc
     1381 aagaatggct ggacaatgta tcaagtgcct cctcccaact tctccctgct tacagtctga
     1441 cccaggcagt ctctgctgcc tttactgttg ctatctctgt ggagtctctg gaggtcaaga
     1501 gggtagagcg ccttccttgt ctttaccatg ttgaacttta atttcagaat ttcagacctg
     1561 actgacttgc atagtaagta gtacctcatg gggaaggcgg aggaacaggg aaataagctg
     1621 gaaaacattt aaagatttat ttttattgta
//
