LOCUS       NM_001009962             924 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus meteorin, glial cell differentiation regulator
            (Metrn), mRNA.
ACCESSION   NM_001009962 XM_213261
VERSION     NM_001009962.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 924)
  AUTHORS   Wang,Z., Andrade,N., Torp,M., Wattananit,S., Arvidsson,A.,
            Kokaia,Z., Jorgensen,J.R. and Lindvall,O.
  TITLE     Meteorin is a chemokinetic factor in neuroblast migration and
            promotes stroke-induced striatal neurogenesis
  JOURNAL   J Cereb Blood Flow Metab 32 (2), 387-398 (2012)
   PUBMED   22044868
  REMARK    GeneRIF: Metrn promotes migration of neuroblasts from
            subventricular zone explants of postnatal rats and stroke-subjected
            adult rats via a chemokinetic mechanism.
REFERENCE   2  (bases 1 to 924)
  AUTHORS   Jorgensen,J.R., Emerich,D.F., Thanos,C., Thompson,L.H., Torp,M.,
            Bintz,B., Fjord-Larsen,L., Johansen,T.E. and Wahlberg,L.U.
  TITLE     Lentiviral delivery of meteorin protects striatal neurons against
            excitotoxicity and reverses motor deficits in the quinolinic acid
            rat model
  JOURNAL   Neurobiol Dis 41 (1), 160-168 (2011)
   PUBMED   20840868
  REMARK    GeneRIF: Cellular protection afforded by meteorin is associated
            with normalization of neurological performance on spontaneous
            forelimb placing and cylinder behavioral tests.
REFERENCE   3  (bases 1 to 924)
  AUTHORS   Jorgensen,J.R., Thompson,L., Fjord-Larsen,L., Krabbe,C., Torp,M.,
            Kalkkinen,N., Hansen,C. and Wahlberg,L.
  TITLE     Characterization of Meteorin--an evolutionary conserved
            neurotrophic factor
  JOURNAL   J Mol Neurosci 39 (1-2), 104-116 (2009)
   PUBMED   19259827
  REMARK    GeneRIF: Data show that Meteorin is expressed in the central
            nervous system both during development and in adult mice.
REFERENCE   4  (bases 1 to 924)
  AUTHORS   Nishino,J., Yamashita,K., Hashiguchi,H., Fujii,H., Shimazaki,T. and
            Hamada,H.
  TITLE     Meteorin: a secreted protein that regulates glial cell
            differentiation and promotes axonal extension
  JOURNAL   EMBO J 23 (9), 1998-2008 (2004)
   PUBMED   15085178
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY800384.1.
            
            On Jan 22, 2005 this sequence version replaced XM_213261.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY800384.1, CB580649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..924
                     /gene="Metrn"
                     /gene_synonym="Hyrac; RGD1306222"
                     /note="meteorin, glial cell differentiation regulator"
                     /db_xref="GeneID:287151"
                     /db_xref="RGD:1306222"
     exon            1..107
                     /gene="Metrn"
                     /gene_synonym="Hyrac; RGD1306222"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..885
                     /gene="Metrn"
                     /gene_synonym="Hyrac; RGD1306222"
                     /note="hypoxia/reoxygenation regulatory factor"
                     /codon_start=1
                     /product="meteorin precursor"
                     /protein_id="NP_001009962.1"
                     /db_xref="GeneID:287151"
                     /db_xref="RGD:1306222"
                     /translation="MLVAALLCALCCGLLAASARAGYSEDRCSWRGSGLTQEPGSVGQ
                     LTLDCTEGAIEWLYPAGALRLTLGGSDPGTRPSIVCLRPTRPFAGAQVFAERMAGNLE
                     LLLAEGQGLAGGRCMRWGPRERRALFLQATPHRDISRRVAAFQFELHEDQRAEMSPQA
                     QGFGVDGACRPCSDAELLLTACTSDFVIHGTIHGVVHDMELQESVITVVATRVIRQTL
                     PLFQEGSSEGRGQASVRTLLRCGVRPGPGSFLFMGWSRFGEAWLGCAPRFQEFSRVYS
                     AALAAHLNPCEVALD"
     exon            108..508
                     /gene="Metrn"
                     /gene_synonym="Hyrac; RGD1306222"
                     /inference="alignment:Splign:2.1.0"
     exon            509..568
                     /gene="Metrn"
                     /gene_synonym="Hyrac; RGD1306222"
                     /inference="alignment:Splign:2.1.0"
     exon            569..924
                     /gene="Metrn"
                     /gene_synonym="Hyrac; RGD1306222"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccctaacca tgctggtagc ggcgcttctc tgcgcgctgt gctgcggcct cttggctgcg
       61 tccgctcgag ctggctactc cgaggaccgc tgcagctgga ggggcagcgg tttgacccag
      121 gaacctggca gcgtggggca gctgaccctg gattgtactg agggtgctat cgagtggctg
      181 tatccagctg gggcgctgcg cctgactcta ggcggctctg atccgggcac gcggcccagc
      241 atcgtctgtc tgcgcccaac acggcccttc gctggtgccc aggtcttcgc tgaacggatg
      301 gccggcaacc tagagttgct actggccgaa ggccaaggcc tggctggggg ccgctgcatg
      361 cgctggggtc ctcgcgagcg ccgagccctt ttcctgcagg ccacgccaca ccgggacatc
      421 agccgcagag ttgctgcctt ccaatttgaa ctgcacgagg accaacgtgc agaaatgtct
      481 ccccaggccc aaggttttgg tgtggatggt gcctgcaggc cctgcagtga tgccgagctc
      541 cttctgactg catgcaccag tgactttgtg atccatggga ccatccatgg ggtcgtccat
      601 gacatggagc tgcaagaatc agtcatcact gtggtggcca ctcgtgtcat ccgccagaca
      661 ctgccactgt tccaggaagg gagctcggag ggccggggcc aggcctccgt tcgtaccttg
      721 ttgcgctgtg gtgtgcgtcc tggcccaggc tccttcctct tcatgggctg gagccgattt
      781 ggcgaagctt ggctgggctg cgctccccgc ttccaagagt tcagccgtgt ctattcagct
      841 gctctcgcgg cccacctcaa cccatgtgag gtggcactgg actgagagac ctgggagcaa
      901 gccctggatg gatcttcctc tggg
//
