LOCUS       NM_022539               2338 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus methionyl aminopeptidase 2 (Metap2), mRNA.
ACCESSION   NM_022539 XM_001077355 XM_001077368 XM_001077392 XM_039079852
VERSION     NM_022539.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2338)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 2338)
  AUTHORS   Majumdar,A., Ghosh,A., Datta,S., Prudner,B.C. and Datta,B.
  TITLE     p67/MetAP2 suppresses K-RasV12-mediated transformation of NIH3T3
            mouse fibroblasts in culture and in athymic mice
  JOURNAL   Biochemistry 49 (47), 10146-10157 (2010)
   PUBMED   21033716
  REMARK    GeneRIF: ectopic expression of rat p67/MetAP2 in transformed cells
            can inhibit the tumorigenic phenotype by inhibiting the activation
            and activity of ERK1/2 MAP kinases and, thus, that p67/MetAP2 has
            tumor suppression activity.
REFERENCE   3  (bases 1 to 2338)
  AUTHORS   Kass,D., Bridges,R.S., Borczuk,A. and Greenberg,S.
  TITLE     Methionine aminopeptidase-2 as a selective target of myofibroblasts
            in pulmonary fibrosis
  JOURNAL   Am J Respir Cell Mol Biol 37 (2), 193-201 (2007)
   PUBMED   17446530
  REMARK    GeneRIF: Data suggest that methionine aminopeptidase 2 plays a role
            in the proliferation of fibroblasts and myofibroblasts in fibrotic
            lung diseases and may serve as a novel pharmacologic target in
            idiopathic pulmonary fibrosis.
REFERENCE   4  (bases 1 to 2338)
  AUTHORS   Selvakumar,P., Lakshmikuttyamma,A., Kanthan,R., Kanthan,S.C.,
            Dimmock,J.R. and Sharma,R.K.
  TITLE     High expression of methionine aminopeptidase 2 in human colorectal
            adenocarcinomas
  JOURNAL   Clin Cancer Res 10 (8), 2771-2775 (2004)
   PUBMED   15102683
REFERENCE   5  (bases 1 to 2338)
  AUTHORS   Datta,R., Tammali,R. and Datta,B.
  TITLE     Negative regulation of the protection of eIF2alpha phosphorylation
            activity by a unique acidic domain present at the N-terminus of p67
  JOURNAL   Exp Cell Res 283 (2), 237-246 (2003)
   PUBMED   12581743
REFERENCE   6  (bases 1 to 2338)
  AUTHORS   Li,X. and Chang,Y.H.
  TITLE     Evidence that the human homologue of a rat initiation factor-2
            associated protein (p67) is a methionine aminopeptidase
  JOURNAL   Biochem Biophys Res Commun 227 (1), 152-159 (1996)
   PUBMED   8858118
REFERENCE   7  (bases 1 to 2338)
  AUTHORS   Arfin,S.M., Kendall,R.L., Hall,L., Weaver,L.H., Stewart,A.E.,
            Matthews,B.W. and Bradshaw,R.A.
  TITLE     Eukaryotic methionyl aminopeptidases: two classes of
            cobalt-dependent enzymes
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7714-7718 (1995)
   PUBMED   7644482
REFERENCE   8  (bases 1 to 2338)
  AUTHORS   Wu,S., Gupta,S., Chatterjee,N., Hileman,R.E., Kinzy,T.G.,
            Denslow,N.D., Merrick,W.C., Chakrabarti,D., Osterman,J.C. and
            Gupta,N.K.
  TITLE     Cloning and characterization of complementary DNA encoding the
            eukaryotic initiation factor 2-associated 67-kDa protein (p67)
  JOURNAL   J Biol Chem 268 (15), 10796-10801 (1993)
   PUBMED   8496145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Mar 2, 2021 this sequence version replaced
            XM_039079852.1, NM_022539.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091150.1, L10652.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               JAXUCZ010000007.1  30327172-30327448   c
            278-385             JAXUCZ010000007.1  30325217-30325324   c
            386-451             JAXUCZ010000007.1  30318801-30318866   c
            452-554             JAXUCZ010000007.1  30318297-30318399   c
            555-716             JAXUCZ010000007.1  30310493-30310654   c
            717-898             JAXUCZ010000007.1  30309112-30309293   c
            899-993             JAXUCZ010000007.1  30308002-30308096   c
            994-1090            JAXUCZ010000007.1  30303938-30304034   c
            1091-1194           JAXUCZ010000007.1  30301599-30301702   c
            1195-1310           JAXUCZ010000007.1  30301009-30301124   c
            1311-2338           JAXUCZ010000007.1  30299433-30300460   c
FEATURES             Location/Qualifiers
     source          1..2338
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2338
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /note="methionyl aminopeptidase 2"
                     /db_xref="GeneID:64370"
                     /db_xref="RGD:70995"
     exon            1..277
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1563
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /EC_number="3.4.11.18"
                     /note="MAP 2; metAP 2; p67eIF2; peptidase M 2; initiation
                     factor 2-associated 67 kDa glycoprotein; initiation factor
                     2 associated 67 kDa protein"
                     /codon_start=1
                     /product="methionine aminopeptidase 2"
                     /protein_id="NP_071984.2"
                     /db_xref="GeneID:64370"
                     /db_xref="RGD:70995"
                     /translation="MAGVEEASSFGGHLNGDLDPDDREEGTSSTAEEAAKKKRRKKKK
                     GKGAVSAGQQELDKESGTSVDEVAKQLERQALEEKEKDDDDEDGDGDGDGAAGKKKKK
                     KKKKRGPRVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQ
                     ASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLA
                     FPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDIL
                     LKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIG
                     PYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHV
                     PIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDI
                     KGSYTAQFEHTILLRPTCKEVVSRGDDY"
     exon            278..385
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /inference="alignment:Splign:2.1.0"
     exon            386..451
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /inference="alignment:Splign:2.1.0"
     exon            452..554
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /inference="alignment:Splign:2.1.0"
     exon            555..716
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /inference="alignment:Splign:2.1.0"
     exon            717..898
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /inference="alignment:Splign:2.1.0"
     exon            899..993
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1090
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1194
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1310
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..2338
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaccatcga gcgcggcttc cggcgtcgct ggtggaggtg ggtgaagaag gagcgggccc
       61 tcgccgctcg ttctcgctcc ctctttctct ctctcttctt ctctctctct ttccctctcg
      121 ggcaacatgg cgggcgtgga agaggcatcg tctttcgggg gccacctgaa tggcgacctg
      181 gatccagacg acagggaaga gggaacctcc agcacggccg aggaagccgc caagaagaaa
      241 agacggaaga agaagaaggg caaaggggct gtgtcagcag ggcaacaaga acttgataaa
      301 gaatcgggaa cctcagtgga cgaagtagca aaacagttgg agagacaagc actggaggag
      361 aaagagaaag atgatgacga tgaagatgga gatggtgatg gtgatggtgc agctgggaag
      421 aagaagaaaa agaagaagaa gaagagagga ccaagagttc aaacagaccc tccctcagtt
      481 ccaatatgtg acctgtatcc taatggtgta tttcccaaag gacaagagtg tgaataccca
      541 cccacccaag atgggcggac agctgcttgg agaaccacaa gtgaagagaa aaaggcgcta
      601 gaccaggcta gtgaggagat ttggaacgac ttccgagaag ctgccgaagc acaccggcaa
      661 gttaggaaat acgtcatgag ctggatcaag cctgggatga caatgataga aatatgtgag
      721 aagttggaag actgttcccg aaagctcata aaggagaatg ggttaaatgc aggcctggcc
      781 tttcccactg ggtgttctct caacaactgt gctgcacatt acactcccaa tgctggtgac
      841 acgacagtct tacagtacga cgacatctgt aagatcgact ttggaacgca tataagtggt
      901 agaataattg attgtgcttt tactgttact tttaatccca aatatgacat attattaaaa
      961 gctgtaaaag atgccaccaa tactggaata aagtgtgcgg ggattgacgt ccgtctctgt
     1021 gatgtcggcg aggccattca agaagttatg gagtcctatg aagtggaaat agatgggaag
     1081 acctaccaag tgaaacccat acgtaactta aatggacatt caattgggcc atatagaatt
     1141 catgctggaa aaacagtgcc cattgtgaaa ggaggggaag ctacaaggat ggaggaagga
     1201 gaggtgtatg ccattgagac ctttggtagc acagggaagg gcgtggttca tgacgatatg
     1261 gaatgttcac actacatgaa aaattttgat gtgggacacg tgccaataag gcttccaaga
     1321 acaaaacact tgttgaatgt catcaatgaa aactttggta cccttgcctt ctgccgaagg
     1381 tggctggatc gcttgggaga aagtaaatac ttaatggctc tgaagaacct gtgtgacttg
     1441 ggcattgtag atccatatcc accactctgt gacattaaag gatcatacac agcacagttt
     1501 gaacatacca tactgctgcg cccaacctgt aaagaagttg tcagcagagg agatgactat
     1561 taaaacttag tccaaagcca actcaacgtc tttattttct aagctttgtt ggaacacatt
     1621 ataccacaag taatttgcaa catgtctgtt ttaacagtgg acctgtgtaa tgccgttatc
     1681 catgtttaaa ggagtttgat caaagccaaa ctgtctacat gtaattaacc aaggaaaagg
     1741 ctttcaagac tttactgtta actgtttctc ccgtctagga aatgctgtac tgctcactag
     1801 ttaggaatta cttaaacgtt ttgttttgaa gacctaagag atgctttttg gatatttata
     1861 ttgccatatt cttacttgga tgctttgaat gactacatac atccagttct gcacctatgc
     1921 cctctggtat tgctttttaa ccttcctgga atccattttc taaaaaataa agacattttc
     1981 agatctgaga gccacatttt aatgtctacg attgtaattc taaacagaaa gctgcttgag
     2041 tgtggatggt gttatctgac tgtgcataca gcagataccg cagattctct tcaggcatgg
     2101 tggctacaag gtcttcatgt gtatgaagca ggcaggaatg agtgcagttg aggaatgtgt
     2161 tttgtagaag catatttaaa atgtctcccc cacctctcat aggaagatgt actgatttaa
     2221 gcatcgtggg aggaaacatt gtgccaactg gaaaaccttg atgtagtaaa tatcccttaa
     2281 cccatatatg tattccacat tagaaaacca aatcaacatt aaagccacaa gcaaaata
//
