LOCUS       NP_071984                478 aa            linear   ROD 31-MAR-2024
DEFINITION  methionine aminopeptidase 2 [Rattus norvegicus].
ACCESSION   NP_071984 XP_001077355 XP_001077368 XP_001077392 XP_038935780
VERSION     NP_071984.2
DBSOURCE    REFSEQ: accession NM_022539.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 478)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (residues 1 to 478)
  AUTHORS   Majumdar,A., Ghosh,A., Datta,S., Prudner,B.C. and Datta,B.
  TITLE     p67/MetAP2 suppresses K-RasV12-mediated transformation of NIH3T3
            mouse fibroblasts in culture and in athymic mice
  JOURNAL   Biochemistry 49 (47), 10146-10157 (2010)
   PUBMED   21033716
  REMARK    GeneRIF: ectopic expression of rat p67/MetAP2 in transformed cells
            can inhibit the tumorigenic phenotype by inhibiting the activation
            and activity of ERK1/2 MAP kinases and, thus, that p67/MetAP2 has
            tumor suppression activity.
REFERENCE   3  (residues 1 to 478)
  AUTHORS   Kass,D., Bridges,R.S., Borczuk,A. and Greenberg,S.
  TITLE     Methionine aminopeptidase-2 as a selective target of myofibroblasts
            in pulmonary fibrosis
  JOURNAL   Am J Respir Cell Mol Biol 37 (2), 193-201 (2007)
   PUBMED   17446530
  REMARK    GeneRIF: Data suggest that methionine aminopeptidase 2 plays a role
            in the proliferation of fibroblasts and myofibroblasts in fibrotic
            lung diseases and may serve as a novel pharmacologic target in
            idiopathic pulmonary fibrosis.
REFERENCE   4  (residues 1 to 478)
  AUTHORS   Selvakumar,P., Lakshmikuttyamma,A., Kanthan,R., Kanthan,S.C.,
            Dimmock,J.R. and Sharma,R.K.
  TITLE     High expression of methionine aminopeptidase 2 in human colorectal
            adenocarcinomas
  JOURNAL   Clin Cancer Res 10 (8), 2771-2775 (2004)
   PUBMED   15102683
REFERENCE   5  (residues 1 to 478)
  AUTHORS   Datta,R., Tammali,R. and Datta,B.
  TITLE     Negative regulation of the protection of eIF2alpha phosphorylation
            activity by a unique acidic domain present at the N-terminus of p67
  JOURNAL   Exp Cell Res 283 (2), 237-246 (2003)
   PUBMED   12581743
REFERENCE   6  (residues 1 to 478)
  AUTHORS   Li,X. and Chang,Y.H.
  TITLE     Evidence that the human homologue of a rat initiation factor-2
            associated protein (p67) is a methionine aminopeptidase
  JOURNAL   Biochem Biophys Res Commun 227 (1), 152-159 (1996)
   PUBMED   8858118
REFERENCE   7  (residues 1 to 478)
  AUTHORS   Arfin,S.M., Kendall,R.L., Hall,L., Weaver,L.H., Stewart,A.E.,
            Matthews,B.W. and Bradshaw,R.A.
  TITLE     Eukaryotic methionyl aminopeptidases: two classes of
            cobalt-dependent enzymes
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7714-7718 (1995)
   PUBMED   7644482
REFERENCE   8  (residues 1 to 478)
  AUTHORS   Wu,S., Gupta,S., Chatterjee,N., Hileman,R.E., Kinzy,T.G.,
            Denslow,N.D., Merrick,W.C., Chakrabarti,D., Osterman,J.C. and
            Gupta,N.K.
  TITLE     Cloning and characterization of complementary DNA encoding the
            eukaryotic initiation factor 2-associated 67-kDa protein (p67)
  JOURNAL   J Biol Chem 268 (15), 10796-10801 (1993)
   PUBMED   8496145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Mar 2, 2021 this sequence version replaced
            XP_038935780.1, NP_071984.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091150.1, L10652.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     Protein         1..478
                     /product="methionine aminopeptidase 2"
                     /EC_number="3.4.11.18"
                     /note="MAP 2; metAP 2; p67eIF2; peptidase M 2; initiation
                     factor 2-associated 67 kDa glycoprotein; initiation factor
                     2 associated 67 kDa protein"
                     /calculated_mol_wt=52822
     Region          1..123
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P38062.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P50579; propagated from
                     UniProtKB/Swiss-Prot (P38062.2)"
     Site            60
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine, alternate.
                     /evidence=ECO:0000305|PubMed:12731887; propagated from
                     UniProtKB/Swiss-Prot (P38062.2)"
     Site            60
                     /site_type="phosphorylation"
                     /note="Phosphoserine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P50579; propagated from
                     UniProtKB/Swiss-Prot (P38062.2)"
     Site            63
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine, alternate.
                     /evidence=ECO:0000305|PubMed:12731887; propagated from
                     UniProtKB/Swiss-Prot (P38062.2)"
     Site            63
                     /site_type="phosphorylation"
                     /note="Phosphoserine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P50579; propagated from
                     UniProtKB/Swiss-Prot (P38062.2)"
     Region          <107..478
                     /region_name="PTZ00053"
                     /note="methionine aminopeptidase 2; Provisional"
                     /db_xref="CDD:240246"
     CDS             1..478
                     /gene="Metap2"
                     /gene_synonym="Amp2; Mnpep; p67"
                     /coded_by="NM_022539.2:127..1563"
                     /db_xref="GeneID:64370"
                     /db_xref="RGD:70995"
ORIGIN      
        1 magveeassf gghlngdldp ddreegtsst aeeaakkkrr kkkkgkgavs agqqeldkes
       61 gtsvdevakq lerqaleeke kddddedgdg dgdgaagkkk kkkkkkrgpr vqtdppsvpi
      121 cdlypngvfp kgqeceyppt qdgrtaawrt tseekkaldq aseeiwndfr eaaeahrqvr
      181 kyvmswikpg mtmieicekl edcsrklike nglnaglafp tgcslnncaa hytpnagdtt
      241 vlqyddicki dfgthisgri idcaftvtfn pkydillkav kdatntgikc agidvrlcdv
      301 geaiqevmes yeveidgkty qvkpirnlng hsigpyriha gktvpivkgg eatrmeegev
      361 yaietfgstg kgvvhddmec shymknfdvg hvpirlprtk hllnvinenf gtlafcrrwl
      421 drlgeskylm alknlcdlgi vdpypplcdi kgsytaqfeh tillrptcke vvsrgddy
//
