LOCUS       NM_031517               4187 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus MET proto-oncogene, receptor tyrosine kinase
            (Met), mRNA.
ACCESSION   NM_031517 XM_346692 XM_347367
VERSION     NM_031517.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4187)
  AUTHORS   Xu,Z., Hu,J., Cao,H., Pilo,M.G., Cigliano,A., Shao,Z., Xu,M.,
            Ribback,S., Dombrowski,F., Calvisi,D.F. and Chen,X.
  TITLE     Loss of Pten synergizes with c-Met to promote hepatocellular
            carcinoma development via mTORC2 pathway
  JOURNAL   Exp Mol Med 50 (1), e417 (2018)
   PUBMED   29303510
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4187)
  AUTHORS   Wang,K., Li,Y., Zhu,T., Zhang,Y., Li,W., Lin,W., Li,J. and Zhu,C.
  TITLE     Overexpression of c-Met in bone marrow mesenchymal stem cells
            improves their effectiveness in homing and repair of acute liver
            failure
  JOURNAL   Stem Cell Res Ther 8 (1), 162 (2017)
   PUBMED   28679425
  REMARK    GeneRIF: transplantation of c-Met-bone marrow-derived mesenchymal
            stem cells (BMSCs) ameliorated liver injury with reduced hepatic
            activity index (HAI) scores, and that the effects of c-Met-BMSCs
            were more profound than those of control BMSCs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4187)
  AUTHORS   Kato,T., Oka,K., Nakamura,T. and Ito,A.
  TITLE     Decreased expression of Met during differentiation in rat lung
  JOURNAL   Eur J Histochem 60 (1), 2575 (2016)
   PUBMED   26972715
  REMARK    GeneRIF: Met was strongly expressed in BASCs, which expressed an
            AT2 cell marker, pro-SP-C, and a club cell marker, CCSP.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4187)
  AUTHORS   Wu,Y., Cheng,M., Shi,Z., Feng,Z. and Guan,X.
  TITLE     Dynamic expression and localization of c-MET isoforms in the
            developing rat pancreas
  JOURNAL   Int J Clin Exp Pathol 7 (12), 8563-8572 (2014)
   PUBMED   25674220
  REMARK    GeneRIF: The dynamic expression and localization of different c-MET
            isoforms in the rat pancreas during different developmental stages
            indicates that distinct c-MET isoform might be involved in
            different aspects of pancreatic development
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4187)
  AUTHORS   Gregorini,M., Bosio,F., Rocca,C., Corradetti,V., Valsania,T.,
            Pattonieri,E.F., Esposito,P., Bedino,G., Collesi,C., Libetta,C.,
            Frassoni,F., Dal Canton,A. and Rampino,T.
  TITLE     Mesenchymal stromal cells reset the scatter factor system and
            cytokine network in experimental kidney transplantation
  JOURNAL   BMC Immunol 15, 44 (2014)
   PUBMED   25277788
  REMARK    GeneRIF: Mesenchymal stromal cells increased serum and tissue HGF
            levels, Met tubular expression and prevented the suppression of
            tubular MSP/RON expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4187)
  AUTHORS   Komada,M. and Kitamura,N.
  TITLE     Growth factor-induced tyrosine phosphorylation of Hrs, a novel
            115-kilodalton protein with a structurally conserved putative zinc
            finger domain
  JOURNAL   Mol Cell Biol 15 (11), 6213-6221 (1995)
   PUBMED   7565774
REFERENCE   7  (bases 1 to 4187)
  AUTHORS   Humphrey,P.A., Zhu,X., Zarnegar,R., Swanson,P.E., Ratliff,T.L.,
            Vollmer,R.T. and Day,M.L.
  TITLE     Hepatocyte growth factor and its receptor (c-MET) in prostatic
            carcinoma
  JOURNAL   Am J Pathol 147 (2), 386-396 (1995)
   PUBMED   7639332
REFERENCE   8  (bases 1 to 4187)
  AUTHORS   Horimoto,M., Hayashi,N., Sasaki,Y., Ito,T., Ito,Y., Wada,S.,
            Tanaka,Y., Kaneko,A., Fusamoto,H., Tohyama,M. et al.
  TITLE     Expression and phosphorylation of rat c-met/hepatocyte growth
            factor receptor during rat liver regeneration
  JOURNAL   J Hepatol 23 (2), 174-183 (1995)
   PUBMED   7499789
REFERENCE   9  (bases 1 to 4187)
  AUTHORS   Pepper,M.S., Soriano,J.V., Menoud,P.A., Sappino,A.P., Orci,L. and
            Montesano,R.
  TITLE     Modulation of hepatocyte growth factor and c-met in the rat mammary
            gland during pregnancy, lactation, and involution
  JOURNAL   Exp Cell Res 219 (1), 204-210 (1995)
   PUBMED   7628535
REFERENCE   10 (bases 1 to 4187)
  AUTHORS   de Juan,C., Sanchez,A., Nakamura,T., Fabregat,I. and Benito,M.
  TITLE     Hepatocyte growth factor up-regulates met expression in rat fetal
            hepatocytes in primary culture
  JOURNAL   Biochem Biophys Res Commun 204 (3), 1364-1370 (1994)
   PUBMED   7526865
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U65007.1.
            
            [WARNING] On Aug 22, 2024 this sequence was replaced by
            NM_031517.3.
            
            On Feb 21, 2013 this sequence version replaced NM_031517.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U65007.1, X96786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4187              U65007.1           1-4187
FEATURES             Location/Qualifiers
     source          1..4187
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..4187
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /note="MET proto-oncogene, receptor tyrosine kinase"
                     /db_xref="GeneID:24553"
                     /db_xref="RGD:3082"
     CDS             1..4149
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /EC_number="2.7.10.1"
                     /note="c-Met; SF receptor; HGF receptor; HGF/SF receptor;
                     scatter factor receptor; met proto-oncogene tyrosine
                     kinase; proto-oncogene c-Met; tyrosine-protein kinase Met;
                     hepatocyte growth factor receptor"
                     /codon_start=1
                     /product="hepatocyte growth factor receptor precursor"
                     /protein_id="NP_113705.1"
                     /db_xref="GeneID:24553"
                     /db_xref="RGD:3082"
                     /translation="MKAPTALAPGILLLLLTLAQRSHGECKEALVKSEMNVNMKYQLP
                     NFTAETPIQNVVLHGHHIYLGATNYIYVLNDKDLQKVSEFKTGPVVEHPDCFPCQDCS
                     SKANVSGGVWKDNVNMALLVDTYYDDQLISCGSVNRGTCQRHVLPPDNAADIQSEVHC
                     MFSPLAEEESGQCPDCVVSALGAKVLLSEKDRFINFFVGNTINSSYPPDYSLHSISVR
                     RLKETQDGFKFLTDQSYIDVLGEFRDSYPIKYIHAFESNHFIYFLTVQKETLDAQTFH
                     TRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGANLAKQI
                     GASPYDDILYGVFAQSKPDSAEPMNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYG
                     PNHEHCFNRTLLRNSSGCEVRSDEYRTEFTTALQAVDLFMGRLNHVLLTSISTFIKGD
                     LTIANLGTSEGRFMQVVLSRTAHFTPHVNFLLDSHPVSPEVIVEHPSNQNGYTLVVTG
                     KKITKIPLNGLGCGHFQSCSQCLSAPYFIQCGWCHNRCVHSNECPSGTWTQEICLPAV
                     YKVFPTSAPLEGGTMLTICGWDFGFKKNNKFDLRKTKVLLGNESCTLTLSESTTNTLK
                     CTVGPAMSEHFNVSVIVSNSRETTQYSAFSYVDPVITSISPRYGPHAGGTLLTLTGKY
                     LNSGNSRHISIGGKTCTLKSVSDSILECYTPGHTVSAEFPVKLKIDLADRVTSSFSYG
                     EDPFVSEIHPTKSFISGGSTITGIGKNLNSVSTPKLVIEVHDVGVNYTVACQHRSSSE
                     IICCTTPSLQQLDLQLPLKTKAFFLLDGILSKHFDLTYVHDPMFKPFEKPVMISMGNE
                     NVVEIKGDDIDPEAVKGEVLKVGNKSCENLHWHSEALLCTVPSDLLKLNGGELNIEWK
                     QAVSSTVLGKVIVQPDQNFAGLIIGAVSISVVVLLVSGLFLWLRKRKHKDLGSELVRY
                     DARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGACRQVQYPLT
                     DLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRG
                     HFGCVYHGTLLDSDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGI
                     CLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHR
                     DLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFT
                     TKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKC
                     WHPKAEMRPSFSELVSRISSIFSTFIGEHYVHVNATYVNVKCVAPYPSLLPSQDNIDG
                     EANT"
     exon            1..1203
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1395
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1530
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1704
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1865
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1968
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2105
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2267
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2367
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2586
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2736
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2890
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3031
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3262
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3343
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3525
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            3526..3635
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3801
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            3802..3938
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
     exon            3939..4187
                     /gene="Met"
                     /gene_synonym="Hgfr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaggctc ccaccgcgct ggcacctggc attctgctgc tgctgctgac cttggcgcag
       61 aggagccatg gggagtgcaa ggaggcccta gtgaagtctg agatgaacgt gaacatgaag
      121 taccagcttc ccaacttcac cgcagaaacc cccatccaga atgtcgtcct ccatgggcac
      181 catatttatc tcggagccac aaactacatt tatgttttaa atgacaaaga ccttcagaag
      241 gtatctgagt tcaagaccgg gcccgtggtg gaacacccag attgttttcc ttgtcaggac
      301 tgcagcagca aagccaatgt gtcaggaggt gtttggaaag acaacgtcaa catggcgctg
      361 cttgttgaca cttactatga cgaccagctc atcagctgtg gcagcgtcaa cagagggacc
      421 tgccaaaggc atgtccttcc tcctgacaat gctgccgaca ttcagtccga ggttcactgc
      481 atgttctccc cacttgcgga ggaagagtca ggccagtgtc ccgactgtgt agtgagtgcc
      541 ctgggagcca aagtcctcct gtctgaaaag gaccggttca tcaatttctt cgtggggaat
      601 acgataaact cttcctaccc tcccgattat tcattgcatt caatatcggt gaggcggctg
      661 aaggaaaccc aggacggttt taagtttttg acagaccagt cctacattga tgtcctggga
      721 gaattccgag attcctaccc catcaagtac atacatgcct tcgaaagcaa ccattttatc
      781 tactttctga ctgtccagaa ggaaacccta gatgctcaga ctttccatac aagaataatc
      841 aggttctgtt ctgtagactc tgggttgcac tcctacatgg aaatgcctct ggagtgcatt
      901 ctgacggaaa aaagaagaaa gagatccaca agggaagaag tgtttaatat cctccaagcc
      961 gcgtatgtca gtaaaccagg ggccaatctt gctaagcaaa taggggccag cccgtatgat
     1021 gacattctct acggggtgtt tgcacaaagc aagccagatt ctgctgagcc catgaaccga
     1081 tcagcggtct gtgcattccc catcaaatat gtcaatgact tcttcaacaa gattgtcaac
     1141 aaaaacaacg tacggtgtct ccagcatttt tatggaccca accacgagca ctgtttcaat
     1201 aggaccctgc tgagaaattc atcgggctgc gaagtgcgca gtgacgagta ccggacggag
     1261 tttaccacag cgctgcaggc tgtggattta ttcatgggcc ggctcaacca tgtactcttg
     1321 acgtctatct ctaccttcat caaaggtgac ctcaccattg ctaatctagg gacatcagaa
     1381 ggtcgcttca tgcaggtggt gctctctcgc acagcacatt tcacccccca tgtgaatttc
     1441 ctcctggatt cccatcctgt gtctccggaa gttattgtcg aacatccatc aaatcaaaat
     1501 ggctataccc tggtggtcac agggaagaag atcaccaaga ttccactgaa tggcctaggc
     1561 tgtgggcatt tccagtcctg cagtcagtgt ctctctgccc cctactttat acagtgtggc
     1621 tggtgccaca atcggtgtgt gcattccaat gaatgcccca gcggtacatg gactcaagag
     1681 atctgtctgc cagcagttta taaggttttc cccactagtg cacccctcga aggaggaaca
     1741 atgctgacca tatgtggctg ggactttgga ttcaagaaga ataataaatt tgatttaagg
     1801 aaaaccaaag ttctgcttgg caacgagagc tgtaccttga ccttaagcga gagcacgaca
     1861 aatacgttga aatgcacagt tggccccgcg atgagtgagc acttcaatgt gtctgtgatc
     1921 gtctcaaaca gtcgagagac aacacagtac agtgcgtttt cctatgtgga tcctgtaata
     1981 acaagtattt ctccaaggta tggtcctcat gccggaggca ccttactcac tttgactgga
     2041 aaatacctca acagcggcaa ttctagacac atttcaatcg gagggaaaac atgtacttta
     2101 aaaagtgtat cagatagcat tctcgaatgc tacaccccag gccacaccgt ctctgccgag
     2161 tttcccgtga aattgaaaat cgacctggct gaccgagtga caagcagctt cagttacggg
     2221 gaagacccgt ttgtctctga aatccacccg accaaatctt ttatcagtgg tggaagcaca
     2281 ataacgggga ttggaaagaa cctgaattca gttagcaccc caaagctggt aatagaagtg
     2341 catgacgtgg gcgtgaacta caccgtggcg tgccaacatc gctcgagttc agagatcatc
     2401 tgctgcacca ctccttccct gcaacagctg gacctgcaac tccccctgaa gaccaaagcc
     2461 ttcttcctgc tggacgggat cctttccaaa cactttgatc tcacttatgt acatgatcct
     2521 atgtttaagc cttttgaaaa gccagtaatg atctccatgg gcaatgagaa tgtagtggaa
     2581 attaagggag acgatattga ccctgaagca gttaaaggtg aagtgttaaa agtcgggaat
     2641 aagagctgtg agaatctcca ctggcattct gaagctttgt tgtgtacggt ccccagtgac
     2701 ctgctgaagc tgaacggcgg cgagctaaat atagagtgga agcaagcagt ctcttcaact
     2761 gtccttggaa aagtgatcgt tcaaccggat cagaattttg caggattgat cattggtgcg
     2821 gtctcaatat cagtggtagt tttgttagta tccgggctct tcctgtggct gagaaagaga
     2881 aagcataaag atctgggcag tgaattagtt cgctatgacg caagagtaca cactcctcat
     2941 ttggataggc ttgtaagtgc ccgaagtgta agcccaacta cagagatggt ctcaaatgag
     3001 tctgtagact acagagctac ttttccagaa gaccagtttc ccaactcctc tcagaatgga
     3061 gcctgcagac aagtgcagta tccactgaca gatctgtccc ccatcctgac gagtggagac
     3121 tctgatatat ccagcccatt actacaaaac actgttcaca ttgacctcag cgctctaaat
     3181 ccagagctgg tccaagcggt gcagcacgta gtgattggac ccagtagcct gattgtgcat
     3241 ttcaatgaag tcataggaag agggcatttt ggctgtgtct atcatgggac tttgttggac
     3301 agtgacggaa agaaaattca ctgtgctgtg aaatccttga atagaatcac agatatagaa
     3361 gaagtctccc agtttctgac tgagggaatc atcatgaaag atttcagcca ccccaatgtt
     3421 ctctcactct tgggaatctg cctgcggagt gaagggtccc ctctggtggt tctgccctat
     3481 atgaagcacg gagatcttcg caatttcatt cgaaacgaga ctcataaccc aactgtgaaa
     3541 gatcttatag gattcggtct tcaagtagcc aagggcatga aatatcttgc cagcaaaaag
     3601 tttgtccaca gagacttagc tgcaagaaac tgcatgttgg atgaaaaatt cactgtcaag
     3661 gttgctgatt tcggtcttgc cagagacatg tacgacaaag agtattatag cgtccacaac
     3721 aaaacgggtg cgaaactacc ggtgaagtgg atggctttag agagtctgca gacgcaaaag
     3781 ttcaccacca agtcagacgt gtggtccttc ggtgtgcttc tctgggagct catgacgaga
     3841 ggagcccctc cttatcctga cgtgaacaca tttgatatca ctatatacct gttgcaaggc
     3901 agaagactct tgcaaccaga gtactgtcca gacgccttgt atgaagtgat gctaaaatgc
     3961 tggcacccca aagcagaaat gcgcccatcg ttttctgaac tggtctccag aatatcctca
     4021 atcttctcca ctttcattgg cgagcactat gtccatgtga acgctactta tgtgaatgta
     4081 aaatgtgttg ctccatatcc ttctctgttg ccatcccaag acaacattga cggcgaagcg
     4141 aacacatgac ggataagagg cccgccagcc cacttccaag aaacagt
//
