LOCUS       NM_001107531            1275 bp    mRNA    linear   ROD 05-APR-2023
DEFINITION  Rattus norvegicus mesoderm posterior bHLH transcription factor 1
            (Mesp1), mRNA.
ACCESSION   NM_001107531 XM_001065593 XM_218826
VERSION     NM_001107531.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1275)
  AUTHORS   Han L, Chen C, Lu X, Song Y, Zhang Z, Zeng C, Chiu R, Li L, Xu M,
            He C, Zhang W and Duan S.
  TITLE     Alterations of 5-hydroxymethylcytosines in circulating cell-free
            DNA reflect retinopathy in type 2 diabetes
  JOURNAL   Genomics 113 (1 Pt 1), 79-87 (2021)
   PUBMED   33221518
REFERENCE   2  (bases 1 to 1275)
  AUTHORS   Wang L, Zhang F, Duan F, Huang R, Chen X, Ming J and Na J.
  TITLE     Homozygous MESP1 knock-in reporter hESCs facilitated cardiovascular
            cell differentiation and myocardial infarction repair
  JOURNAL   Theranostics 10 (15), 6898-6914 (2020)
   PUBMED   32550911
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1275)
  AUTHORS   Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA,
            Steinhauser ML, Ding H, Butty VL, Torrey L, Haas S, Abo R,
            Tabebordbar M, Lee RT, Burge CB and Boyer LA.
  TITLE     Braveheart, a long noncoding RNA required for cardiovascular
            lineage commitment
  JOURNAL   Cell 152 (3), 570-583 (2013)
   PUBMED   23352431
REFERENCE   4  (bases 1 to 1275)
  AUTHORS   Bondue A, Lapouge G, Paulissen C, Semeraro C, Iacovino M, Kyba M
            and Blanpain C.
  TITLE     Mesp1 acts as a master regulator of multipotent cardiovascular
            progenitor specification
  JOURNAL   Cell Stem Cell 3 (1), 69-84 (2008)
   PUBMED   18593560
REFERENCE   5  (bases 1 to 1275)
  AUTHORS   Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez
            G, Kyba M, Lin S, Janknecht R, Lim DS and Choi K.
  TITLE     ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and
            vessel progenitor specification
  JOURNAL   Cell Stem Cell 2 (5), 497-507 (2008)
   PUBMED   18462699
REFERENCE   6  (bases 1 to 1275)
  AUTHORS   David R, Brenner C, Stieber J, Schwarz F, Brunner S, Vollmer M,
            Mentele E, Muller-Hocker J, Kitajima S, Lickert H, Rupp R and Franz
            WM.
  TITLE     MesP1 drives vertebrate cardiovascular differentiation through
            Dkk-1-mediated blockade of Wnt-signalling
  JOURNAL   Nat Cell Biol 10 (3), 338-345 (2008)
   PUBMED   18297060
REFERENCE   7  (bases 1 to 1275)
  AUTHORS   Saga Y, Miyagawa-Tomita S, Takagi A, Kitajima S, Miyazaki Ji and
            Inoue T.
  TITLE     MesP1 is expressed in the heart precursor cells and required for
            the formation of a single heart tube
  JOURNAL   Development 126 (15), 3437-3447 (1999)
   PUBMED   10393122
REFERENCE   8  (bases 1 to 1275)
  AUTHORS   Saga Y, Hata N, Kobayashi S, Magnuson T, Seldin MF and Taketo MM.
  TITLE     MesP1: a novel basic helix-loop-helix protein expressed in the
            nascent mesodermal cells during mouse gastrulation
  JOURNAL   Development 122 (9), 2769-2778 (1996)
   PUBMED   8787751
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218826.3, XM_001065593.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1275
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..1275
                     /gene="Mesp1"
                     /note="mesoderm posterior bHLH transcription factor 1"
                     /db_xref="GeneID:308766"
                     /db_xref="RGD:1311751"
     exon            1..927
                     /gene="Mesp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..993
                     /gene="Mesp1"
                     /note="mesoderm posterior 1 homolog; mesoderm posterior
                     basic helix-loop-helix transcription factor 1"
                     /codon_start=1
                     /product="mesoderm posterior protein 1"
                     /protein_id="NP_001101001.1"
                     /db_xref="GeneID:308766"
                     /db_xref="RGD:1311751"
                     /translation="MAQPLCAPLSKSWIPSPARPQPSMPSDGDSFCSPAWSSDSWDGA
                     QASSPALPCARPARRAGTPGRRGTHGSRLGSGQRQSASEREKLRMRTLARALHELRRF
                     LPPSVAPIGQNLTKIETLRLAIRYIGHLSAVLGLSEDSLRQQRHAVSPRGCPLCPDSG
                     LAQAQSLGPHLSPVACSGVSWGSSPAYPRPRVAAESWDPSFLYTETASLERQEMEPSP
                     SSPLFSSDMLALLETWTPQEWPPA"
     exon            928..1275
                     /gene="Mesp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttgcaggg ctggcttaac accctggaca ccgcaggctt taggtgcctg tcttactgat
       61 gccccatcta tggcctaggt ggagcaaact ggaccaaggg gtcctgcacc taagagcccc
      121 tgctcttggt tcaaagggtt caagccctgc ccccctccag gctcgagccg gctttgatgt
      181 gctgatgagt tctggaaggg gccgcttcac acctagggct ccggataaag ctgcagcgga
      241 cccaatggtc aggcctccgc tgccatggcc cagcccctgt gcgcgccact ctccaagtcc
      301 tggatcccga gtcccgctcg tccgcagcca tcgatgcctt ccgatgggga cagcttctgc
      361 tccccagcct ggtcctcgga ctcgtgggac ggtgcccagg ccagcagccc tgcactaccc
      421 tgtgcccgcc cggcccggcg tgctgggacc cccggtaggc gcgggacgca tggcagccgc
      481 ctgggtagcg gacagcggca gagcgccagc gaacgcgaga agcttcgtat gcgcacgctc
      541 gcccgcgcgc tgcacgagct gcgccgcttc ttgcctcctt cagtggcacc aatcggccag
      601 aacctgacca agatcgagac gctgcgcctg gccatccgct acatcggcca cctgtcggct
      661 gtgctgggcc tcagcgagga cagcctccgg caacagcgac acgcggtgtc acctcgaggc
      721 tgcccgctgt gccccgacag cggcctggcg caggcgcagt ctctcggtcc ccatttaagc
      781 ccggttgcct gcagcggggt gtcctggggt tcttcgcccg cctaccctag accccgggtc
      841 gccgcagaat cgtgggaccc atcattcctg tacaccgaaa cagcatccct ggaaaggcag
      901 gagatggagc ccagcccctc gtctccgctc ttcagcagcg acatgctggc tctgctagaa
      961 acctggacac ctcaggagtg gccgccagcc tgaagagttg aagggacaat gcagtggatg
     1021 actggcatcc tgtctgagca cagacacttt tccttttgcc ttggcacctt cgaagggggt
     1081 atttcctgga agaggcacca gtgataccaa catgggcgtc cccgaggtgg gagctggtcc
     1141 ccatctagac tgtacctttc caatcctcct tggaaggagg gacccaatgg ggtacacgct
     1201 ctaaagctga agcgggcaca agttctgcct ggtgtgtatt tatttatttg tgaataaacc
     1261 gtttgtgcta gtgtc
//
