LOCUS       NM_001008345            2037 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus mesoderm development LRP chaperone (Mesd), mRNA.
ACCESSION   NM_001008345 XM_218854
VERSION     NM_001008345.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2037)
  AUTHORS   Moosa,S., Yamamoto,G.L., Garbes,L., Keupp,K., Beleza-Meireles,A.,
            Moreno,C.A., Valadares,E.R., de Sousa,S.B., Maia,S., Saraiva,J.,
            Honjo,R.S., Kim,C.A., Cabral de Menezes,H., Lausch,E., Lorini,P.V.,
            Lamounier,A. Jr., Carniero,T.C.B., Giunta,C., Rohrbach,M.,
            Janner,M., Semler,O., Beleggia,F., Li,Y., Yigit,G., Reintjes,N.,
            Altmuller,J., Nurnberg,P., Cavalcanti,D.P., Zabel,B., Warman,M.L.,
            Bertola,D.R., Wollnik,B. and Netzer,C.
  TITLE     Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta
  JOURNAL   Am J Hum Genet 105 (4), 836-843 (2019)
   PUBMED   31564437
REFERENCE   2  (bases 1 to 2037)
  AUTHORS   Chen,X., Guo,F., LeBlanc,M.E., Ding,Y., Zhang,C., Shakya,A. and
            Li,W.
  TITLE     Mesd extrinsically promotes phagocytosis by retinal pigment
            epithelial cells
  JOURNAL   Cell Biol Toxicol 32 (4), 347-358 (2016)
   PUBMED   27184668
REFERENCE   3  (bases 1 to 2037)
  AUTHORS   Hoshi,T., Tezuka,T., Yokoyama,K., Iemura,S., Natsume,T. and
            Yamanashi,Y.
  TITLE     Mesdc2 plays a key role in cell-surface expression of Lrp4 and
            postsynaptic specialization in myotubes
  JOURNAL   FEBS Lett 587 (23), 3749-3754 (2013)
   PUBMED   24140340
REFERENCE   4  (bases 1 to 2037)
  AUTHORS   Alapati,D., Rong,M., Chen,S., Lin,C., Li,Y. and Wu,S.
  TITLE     Inhibition of LRP5/6-mediated Wnt/beta-catenin signaling by Mesd
            attenuates hyperoxia-induced pulmonary hypertension in neonatal
            rats
  JOURNAL   Pediatr Res 73 (6), 719-725 (2013)
   PUBMED   23481549
  REMARK    GeneRIF: Mesd also significantly attenuated hyperoxia-induced
            pulmonary hypertension (PH) and pulmonary vascular remodeling
REFERENCE   5  (bases 1 to 2037)
  AUTHORS   Collins,M.N. and Hendrickson,W.A.
  TITLE     Structural characterization of the Boca/Mesd maturation factors for
            LDL-receptor-type beta propeller domains
  JOURNAL   Structure 19 (3), 324-336 (2011)
   PUBMED   21397184
REFERENCE   6  (bases 1 to 2037)
  AUTHORS   Chen,J., Liu,C.C., Li,Q., Nowak,C., Bu,G. and Wang,J.
  TITLE     Two structural and functional domains of MESD required for proper
            folding and trafficking of LRP5/6
  JOURNAL   Structure 19 (3), 313-323 (2011)
   PUBMED   21397183
REFERENCE   7  (bases 1 to 2037)
  AUTHORS   Kubota,T., Michigami,T., Sakaguchi,N., Kokubu,C., Suzuki,A.,
            Namba,N., Sakai,N., Nakajima,S., Imai,K. and Ozono,K.
  TITLE     Lrp6 hypomorphic mutation affects bone mass through bone resorption
            in mice and impairs interaction with Mesd
  JOURNAL   J Bone Miner Res 23 (10), 1661-1671 (2008)
   PUBMED   18505367
REFERENCE   8  (bases 1 to 2037)
  AUTHORS   Li,Y., Chen,J., Lu,W., McCormick,L.M., Wang,J. and Bu,G.
  TITLE     Mesd binds to mature LDL-receptor-related protein-6 and antagonizes
            ligand binding
  JOURNAL   J Cell Sci 118 (Pt 22), 5305-5314 (2005)
   PUBMED   16263759
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085892.1.
            
            On Dec 16, 2004 this sequence version replaced XM_218854.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085892.1, EX493203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2037
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2037
                     /gene="Mesd"
                     /gene_synonym="Mesdc2"
                     /note="mesoderm development LRP chaperone"
                     /db_xref="GeneID:308796"
                     /db_xref="RGD:1310344"
     exon            1..434
                     /gene="Mesd"
                     /gene_synonym="Mesdc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..923
                     /gene="Mesd"
                     /gene_synonym="Mesdc2"
                     /note="LDLR chaperone MESD; mesoderm development protein;
                     mesoderm development candiate 2; mesoderm development
                     candidate 2; LRP chaperone MESD"
                     /codon_start=1
                     /product="LRP chaperone MESD precursor"
                     /protein_id="NP_001008346.1"
                     /db_xref="GeneID:308796"
                     /db_xref="RGD:1310344"
                     /translation="MAASSWLRAVLLFLCASDLLLLSPPEAYATDTPGEAITPPRKKK
                     DIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPIDFSKLDPGKPESILKMTKKG
                     KTLMMFVTISGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWE
                     IKDFLVNQDRCAEVTLEGQMYPGKGGGSKEKNKTKPEKGKKKEGDPKPRASKEDNRAG
                     SRREDL"
     exon            435..667
                     /gene="Mesd"
                     /gene_synonym="Mesdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            668..1992
                     /gene="Mesd"
                     /gene_synonym="Mesdc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatgaggtc cggactggag gaaacagaac ggcggggtgc ggtaggctag gacgcttagg
       61 aggaggagcc attggacctg tgtccgcgag agtggggcag ggtcgagtac tggctttagt
      121 tctgctcaga gcgagcgagg gactggattg gaggaccggg ggtggggtgg gggcgaggct
      181 ccggcgccga gactccgcac gctgtttgcg caggctcagt gtgtagcccg ttacactggg
      241 cagctaacat ggcggcctcc agctggctgc gcgcggttct cctgtttcta tgtgcctcgg
      301 accttctgtt gctctctcct cctgaagcct acgcgaccga tactcccggc gaggccatca
      361 cacctccacg gaaaaagaag gacatccgcg attacaacga tgccgacatg gcgcgacttc
      421 tggagcagtg ggagaaagat gatgacatag aagaaggaga ccttccggaa cacaagagac
      481 catcggcacc tatcgacttt tcaaagctag acccaggcaa acctgagagc atcttgaaaa
      541 tgacaaagaa agggaagact ctgatgatgt ttgtcaccat ctcagggaac cccactgaga
      601 aggagacaga ggaaatcacc agcctgtggc agggtagcct gttcaatgcc aactatgatg
      661 ttcagaggtt catcgtggga tcagaccgtg ctattttcat gctccgggat gggagctatg
      721 cctgggagat caaggacttt ttggtcaatc aagacaggtg tgctgaagtc actctagagg
      781 gacagatgta ccctggcaaa ggaggaggaa gcaaggagaa aaataaaaca aagccagaga
      841 agggtaaaaa gaaggaggga gatcccaagc cacgggcttc caaggaagac aaccgagctg
      901 ggagcagaag agaagacctc tagcgggtgg caggtttccc gccgggtagg caggaccaga
      961 tagcctcttg cagactggtg gggcaggtag gtgcaggaaa ctgcagagca gatggcattc
     1021 tcacgtcctc tagcaagggt ctgtgtgcga ccatctggcc aatatcacag ttactgtata
     1081 aaaggcttca catgtaaagg cagggtttgt gattcacagt ggactggcag gtcctgctta
     1141 ttgtggcatc acctgacttg gaaacttgat agatgtcttg tacgttttac atctcatgag
     1201 ttcttgacaa cccaagtatc actccctctt cactgcacct gctgtggccc aagggcctgt
     1261 tgtttctgtg tgttgcaagc tcaagtcaga caagccttga gaacctttgg cttgacaggc
     1321 gtaggcattg atcattgagg ggtgaagata actgtgctgt atgtgccgtg ctggacaccc
     1381 aggatctgga cagctgactc actgtgtaga atgtgcagat tcacaagaca gtgccatcca
     1441 gacggccaag gagtcatttc acgtggcttg cgttctcatc agttcagggg atcctgtctc
     1501 ccagtcttcc tgtggttgta gagggaatgc tgttgtgcct cacttgagga aagaagggtg
     1561 agcagctgag ggctcctgct ctgcatagcc ccacaactac aaagctggag gagggaccag
     1621 cagaatcttc cagaggagcg gacctcatct acggtatttc taagtggttt tctttgataa
     1681 agtgcctaaa cttgtgcttc tgtatggtac tctcatggtg ggctactgtt catactgttt
     1741 ttgctgttca gaggttgaag cttatctaag agaacatttc tatgaggatg ccatttttaa
     1801 gaacttacat ttttttaaaa cctcaattgt ggttttaaat tcaaaatagt acgtgtacac
     1861 atacccggct agaaagtgtc actgttagaa tgtcacagtg tgaagaattg ccctaccctg
     1921 ctgcccgtac tttgtcccag tgaagctact gttgattgtt ggtttttcaa aaataaaata
     1981 tgtttactgg ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
