LOCUS       NM_022943               3024 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Rattus norvegicus MER proto-oncogene, tyrosine kinase (Mertk),
            mRNA.
ACCESSION   NM_022943
VERSION     NM_022943.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3024)
  AUTHORS   Su,X., Chen,W., Fu,Y., Wu,B., Mao,F., Zhao,Y., Yang,Q. and Lan,D.
  TITLE     Protective Role of MerTK in Diabetic Peripheral Neuropathy via
            Inhibition of the NF-kappaB Signaling Pathway
  JOURNAL   Exp Clin Endocrinol Diabetes 132 (7), 396-406 (2024)
   PUBMED   38588709
  REMARK    GeneRIF: Protective Role of MerTK in Diabetic Peripheral Neuropathy
            via Inhibition of the NF-kappaB Signaling Pathway.
REFERENCE   2  (bases 1 to 3024)
  AUTHORS   Edvinsson,J.C.A., Ran,C., Olofsgard,F.J., Steinberg,A.,
            Edvinsson,L. and Belin,A.C.
  TITLE     MERTK in the rat trigeminal system: a potential novel target for
            cluster headache?
  JOURNAL   J Headache Pain 25 (1), 85 (2024)
   PUBMED   38783191
  REMARK    GeneRIF: MERTK in the rat trigeminal system: a potential novel
            target for cluster headache?
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3024)
  AUTHORS   Pele,T., Giraud,S., Joffrion,S., Ameteau,V., Delwail,A.,
            Goujon,J.M., Macchi,L., Hauet,T., Dkhissi,F. and Benzakour,O.
  TITLE     Study of the Role of the Tyrosine Kinase Receptor MerTK in the
            Development of Kidney Ischemia-Reperfusion Injury in RCS Rats
  JOURNAL   Int J Mol Sci 22 (22), 12103 (2021)
   PUBMED   34829984
  REMARK    GeneRIF: Study of the Role of the Tyrosine Kinase Receptor MerTK in
            the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3024)
  AUTHORS   Mao,Y. and Finnemann,S.C.
  TITLE     Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore
            Phagocytic Capacity to Retinal Pigment Epithelium Lacking the
            Engulfment Receptor MerTK
  JOURNAL   Cells 10 (8), 1927 (2021)
   PUBMED   34440696
  REMARK    GeneRIF: Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore
            Phagocytic Capacity to Retinal Pigment Epithelium Lacking the
            Engulfment Receptor MerTK.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3024)
  AUTHORS   Lorach,H., Kang,S., Dalal,R., Bhuckory,M.B., Quan,Y. and
            Palanker,D.
  TITLE     Long-term Rescue of Photoreceptors in a Rodent Model of Retinitis
            Pigmentosa Associated with MERTK Mutation
  JOURNAL   Sci Rep 8 (1), 11312 (2018)
   PUBMED   30054542
  REMARK    GeneRIF: The long-term preservation of photoreceptors we observed
            indicates that MERTK-related form of inherited retinal
            degeneration, which has currently no cure, could be amenable to
            laser therapy or subretinal surgery, to extend the visual function,
            potentially for life.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3024)
  AUTHORS   Vollrath,D., Feng,W., Duncan,J.L., Yasumura,D., D'Cruz,P.M.,
            Chappelow,A., Matthes,M.T., Kay,M.A. and LaVail,M.M.
  TITLE     Correction of the retinal dystrophy phenotype of the RCS rat by
            viral gene transfer of Mertk
  JOURNAL   Proc Natl Acad Sci U S A 98 (22), 12584-12589 (2001)
   PUBMED   11592982
REFERENCE   7  (bases 1 to 3024)
  AUTHORS   Lu,Q. and Lemke,G.
  TITLE     Homeostatic regulation of the immune system by receptor tyrosine
            kinases of the Tyro 3 family
  JOURNAL   Science 293 (5528), 306-311 (2001)
   PUBMED   11452127
REFERENCE   8  (bases 1 to 3024)
  AUTHORS   D'Cruz,P.M., Yasumura,D., Weir,J., Matthes,M.T., Abderrahim,H.,
            LaVail,M.M. and Vollrath,D.
  TITLE     Mutation of the receptor tyrosine kinase gene Mertk in the retinal
            dystrophic RCS rat
  JOURNAL   Hum Mol Genet 9 (4), 645-651 (2000)
   PUBMED   10699188
REFERENCE   9  (bases 1 to 3024)
  AUTHORS   Lu,Q., Gore,M., Zhang,Q., Camenisch,T., Boast,S., Casagranda,F.,
            Lai,C., Skinner,M.K., Klein,R., Matsushima,G.K., Earp,H.S.,
            Goff,S.P. and Lemke,G.
  TITLE     Tyro-3 family receptors are essential regulators of mammalian
            spermatogenesis
  JOURNAL   Nature 398 (6729), 723-728 (1999)
   PUBMED   10227296
REFERENCE   10 (bases 1 to 3024)
  AUTHORS   Fernando,C.C. and Fraser,H.H.
  TITLE     Technical report: fallopian tube recanalization facilitated by a
            hydrophillic glide wire
  JOURNAL   Australas Radiol 36 (4), 323 (1992)
   PUBMED   1299193
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF208235.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF208235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3024
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="RCS-rdy+"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..3024
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="MER proto-oncogene, tyrosine kinase"
                     /db_xref="GeneID:65037"
                     /db_xref="RGD:69283"
     exon            1..97
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..3024
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /EC_number="2.7.10.1"
                     /note="proto-oncogene tyrosine-protein kinase MER;
                     tyrosine-protein kinase Mer; retinal dystrophy; receptor
                     tyrosine kinase MerTK; proto-oncogene c-Mer; Receptor
                     tyrosine tinase gene probably the gene for Rdy; c-mer
                     proto-oncogene tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase Mer precursor"
                     /protein_id="NP_075232.1"
                     /db_xref="GeneID:65037"
                     /db_xref="RGD:69283"
                     /translation="MVLAPLLLGLLLLSALWNGGTAEKEEEIKPDQPFSGPLPGSLPA
                     DHRPFFAPHSSGDQLSPSQTGRSHPAHTATPQMTSAASNLLPPVAFKNTIGRIVLSEH
                     KSVKFNCSINIPNVYQETAGISWWKDGKELLGAHHSITQFYPDEEGVSIIALFSITSV
                     QRSDNGSYICKMKVNDREVVSDPIYVEVQGLPYFTKQPESVNVTRNTAFNLTCQAVGP
                     PEPVNIFWVQNSSRVNENPERSPSVLTVAGLTETAVFSCEAHNDKGLTVSKGVQINIK
                     VIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEADQLSNGSVMVFNTSA
                     SPHLYEVQQLQALANYSVTVSCRNEIGWSAVSPWILASTTEGAPAVAPLNITVFLNES
                     SNNLEIRWTKPPIKRQDGELVGYRISHVWESAGTSKELSEEVSQNGSWAQVPVQMHNA
                     TCTVRIAVITKGGIGPFSEPVDVAIPEHSRVDYAPSSTPAPGNTESMLIILGCFCGFV
                     LMGLILYLSLAIKRRVQETKFGGAFSEEDSQLVVNYRAKKSFCRRAIELTLQSLGVSE
                     ELQNKLEDVVVDRNLLILGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSLR
                     EIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYSR
                     IESVPKSIPLQTLLKFMVDIAQGMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLS
                     KKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG
                     VQNHEMYDYLLHGHRLKQPEDCLDDLYEIMYSCWSADPLDRPTFSVLRLQLEKLSESL
                     PDAQDKESIIYINTQLLESCEGLANRSSLAGLDMNIDPDSIIASCTAGAAVSVVMAEV
                     HENNLHEERYILNGGNEEWEDVASTPFATVTAGKDGVLPEDRLTKNGISWSHHSTLPL
                     GSPSPDELLFADDSSGDSEVLM"
     exon            98..506
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            507..607
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            608..781
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            782..868
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            869..984
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1168
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1320
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1474
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1628
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1714
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1810
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1891
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1984
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2103
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2213
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2373
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2510
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..3024
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catctgtccg gagagaactg ccagatccgc ggccccgcga tggttctggc cccactactg
       61 ctggggctgc tgctgctatc cgcactctgg aatggaggca ctgctgaaaa ggaggaagaa
      121 atcaagccag atcagccatt ttcagggcct ttaccaggga gcctaccagc tgaccacagg
      181 ccattcttcg cccctcactc cagtggggac cagctgtcac catcccagac tggaagatca
      241 catccagcac acacagccac tccccagatg acctctgcag catcaaacct cctgcctcct
      301 gttgcattta aaaacacaat tggacgcata gtactttcgg aacataaaag tgtcaaattt
      361 aattgctcga tcaacattcc taacgtgtat caagaaacag ctggcatttc gtggtggaaa
      421 gatggaaagg aactgcttgg ggcacatcat tcaatcacac agttttatcc tgatgaggaa
      481 ggggtatcaa taattgcatt gttcagcata accagtgtgc agcgctcaga caatgggtcg
      541 tacatctgta agatgaaggt gaacgataga gaggttgtgt ctgatcccat atacgtggaa
      601 gtccaaggac tcccttactt tactaagcag cctgagagcg tgaatgtcac cagaaacaca
      661 gccttcaacc tcacctgcca ggctgtggga ccccctgagc ccgtcaacat cttctgggtt
      721 caaaatagca gccgtgttaa tgaaaatcca gaaaggtccc cgtctgtcct aactgtcgct
      781 ggtctgacag agaccgcagt cttcagctgt gaggcccaca acgacaaagg actgacggtg
      841 tccaagggtg tacagatcaa catcaaagtc atcccttccc cacccactga agtccatatc
      901 ctcaacagca cagcgcacag catcctggtc tcctgggtcc cagggtttga tggctactcc
      961 ccacttcaga actgcagcat tcaggtcaag gaagctgacc agctgagtaa tggctcagtc
     1021 atggttttta atacctctgc ttcgccacat ctgtatgaag tccagcagct gcaagccctg
     1081 gctaattaca gcgtcactgt gtcctgtcgg aatgagattg gctggtctgc agtgagccct
     1141 tggatcctgg ccagcactac agaaggagct ccagcagtgg cgcctctaaa catcactgtg
     1201 tttctgaacg aatccagcaa caacctggaa atcagatgga cgaagcctcc aattaagcgg
     1261 caggatgggg aactggtggg ctaccggata tctcacgtgt gggagagtgc ggggacttcc
     1321 aaagagcttt ctgaagaagt cagccagaat ggcagctggg ctcaggttcc tgtccaaatg
     1381 cacaatgcca cctgcacagt gagaatcgcc gtcatcacta aagggggcat tgggcccttc
     1441 agtgagccag tggacgtagc cattccggag cacagtaggg tagattacgc accctcatca
     1501 accccagccc ctggcaacac cgagtctatg ctcatcatcc tgggctgctt ctgcgggttt
     1561 gttctcatgg ggttgattct gtatctttct ctggccatca aaaggagagt ccaggaaaca
     1621 aagtttgggg gtgcattctc cgaggaggac tcccaattag ttgtaaatta cagagcaaag
     1681 aagtccttct gtcggcgagc catcgagctt accttgcaaa gcctgggggt gagcgaggag
     1741 ctgcaaaaca agctagaaga tgttgtggtt gacagaaatc ttctaattct tgggaaagtt
     1801 ctgggcgaag gagagtttgg gtctgtaatg gaaggaaatc tgaagcagga agatgggact
     1861 tctcagaagg tggcagtgaa gaccatgaag ttggacaact tttctctacg ggagatcgag
     1921 gagtttctca gcgaagcagc gtgcatgaaa gacttcaatc acccaaacgt catccggctt
     1981 ctaggcgtgt gtatagaact gagctctcaa ggcatcccga agcccatggt gattttaccc
     2041 ttcatgaaat acggagacct ccacaccttc ctgctatatt cccggataga atcagtaccg
     2101 aagtccatcc ccctgcagac actgctgaag ttcatggtgg acattgccca gggaatggag
     2161 tacctgagca gcaggaattt tctccacagg gatttagctg ctcggaattg catgttgcgg
     2221 gatgacatga ctgtctgcgt ggcagacttt ggcctctcta agaagattta cagtggtgat
     2281 tattaccgcc aaggccgcat tgccaaaatg cctgtgaagt ggatcgccat agagagcctg
     2341 gcggaccgag tctacacaag caagagtgac gtgtgggctt ttggcgtgac catgtgggaa
     2401 atagcaacac ggggaatgac tccctatcct ggagtccaga accatgagat gtacgattac
     2461 cttctccacg gccacaggct gaagcagccc gaggactgcc tggatgatct gtatgaaatc
     2521 atgtactctt gctggagtgc tgatcccctg gaccgaccca ccttctcagt gctgaggctg
     2581 cagctggaaa agctctccga gagtttgcct gatgcccagg acaaagaatc catcatctac
     2641 atcaatacac agttactaga gagctgcgag ggcctagcca acaggtcctc cctcgcaggg
     2701 ctagacatga acattgatcc tgactccatc attgcctctt gcacagcagg tgctgctgtc
     2761 agcgtggtca tggcggaagt tcacgagaac aaccttcatg aggaaagata catcttaaat
     2821 gggggcaacg aggaatggga agatgtggcc tccactccat ttgctacagt cacagctgga
     2881 aaagatggtg tgttaccaga ggacagactc accaaaaatg gcatctcctg gtctcaccat
     2941 agtacgctac ccttggggag cccatcacca gatgaacttc tgtttgcaga cgactcctcg
     3001 ggagactctg aagttctgat gtga
//
