LOCUS       NM_024142               1655 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus matrix extracellular phosphoglycoprotein (Mepe),
            mRNA.
ACCESSION   NM_024142 XM_346456
VERSION     NM_024142.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1655)
  AUTHORS   Zakhary,I., Alotibi,F., Lewis,J., ElSalanty,M., Wenger,K.,
            Sharawy,M. and Messer,R.L.
  TITLE     Inherent physical characteristics and gene expression differences
            between alveolar and basal bones
  JOURNAL   Oral Surg Oral Med Oral Pathol Oral Radiol 122 (1), 35-42 (2016)
   PUBMED   27039006
  REMARK    GeneRIF: Four genes are expressed significantly higher in basal
            bone than in alveolar bone: SOST, E-11, DMP-1, and MEPE. Three of
            the proteins (SOST, MEPE, and DMP-1) are associated with mature
            osteocytes, indicating that basal bone has more mature osteocyte
            phenotypes because the immature osteocyte converts to a mature
            osteocyte as a result of bone mineralization.
REFERENCE   2  (bases 1 to 1655)
  AUTHORS   Reijnders,C.M., van Essen,H.W., van Rens,B.T., van Beek,J.H.,
            Ylstra,B., Blankenstein,M.A., Lips,P. and Bravenboer,N.
  TITLE     Increased expression of matrix extracellular phosphoglycoprotein
            (MEPE) in cortical bone of the rat tibia after mechanical loading:
            identification by oligonucleotide microarray
  JOURNAL   PLoS One 8 (11), e79672 (2013)
   PUBMED   24255709
  REMARK    GeneRIF: expression of matrix extracellular phosphoglycoprotein
            (MEPE) in cortical bone of the rat tibia after mechanical loading
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1655)
  AUTHORS   Staines,K.A., Mackenzie,N.C., Clarkin,C.E., Zelenchuk,L.,
            Rowe,P.S., MacRae,V.E. and Farquharson,C.
  TITLE     MEPE is a novel regulator of growth plate cartilage mineralization
  JOURNAL   Bone 51 (3), 418-430 (2012)
   PUBMED   22766095
REFERENCE   4  (bases 1 to 1655)
  AUTHORS   Cho,Y.D., Yoon,W.J., Woo,K.M., Baek,J.H., Lee,G., Cho,J.Y. and
            Ryoo,H.M.
  TITLE     Molecular regulation of matrix extracellular phosphoglycoprotein
            expression by bone morphogenetic protein-2
  JOURNAL   J Biol Chem 284 (37), 25230-25240 (2009)
   PUBMED   19617624
  REMARK    GeneRIF: MEPE expression is bone cell-specific and induced by the
            BMP-2 signaling pathway
REFERENCE   5  (bases 1 to 1655)
  AUTHORS   Marks,J., Churchill,L.J., Debnam,E.S. and Unwin,R.J.
  TITLE     Matrix extracellular phosphoglycoprotein inhibits phosphate
            transport
  JOURNAL   J Am Soc Nephrol 19 (12), 2313-2320 (2008)
   PUBMED   19005008
  REMARK    GeneRIF: MEPE is a candidate phosphatonin involved in phosphate
            homeostasis, acting in both the kidney and the gastrointestinal
            tract
REFERENCE   6  (bases 1 to 1655)
  AUTHORS   Liu,S., Brown,T.A., Zhou,J., Xiao,Z.S., Awad,H., Guilak,F. and
            Quarles,L.D.
  TITLE     Role of matrix extracellular phosphoglycoprotein in the
            pathogenesis of X-linked hypophosphatemia
  JOURNAL   J Am Soc Nephrol 16 (6), 1645-1653 (2005)
   PUBMED   15843468
REFERENCE   7  (bases 1 to 1655)
  AUTHORS   Gowen,L.C., Petersen,D.N., Mansolf,A.L., Qi,H., Stock,J.L.,
            Tkalcevic,G.T., Simmons,H.A., Crawford,D.T., Chidsey-Frink,K.L.,
            Ke,H.Z., McNeish,J.D. and Brown,T.A.
  TITLE     Targeted disruption of the osteoblast/osteocyte factor 45 gene
            (OF45) results in increased bone formation and bone mass
  JOURNAL   J Biol Chem 278 (3), 1998-2007 (2003)
   PUBMED   12421822
REFERENCE   8  (bases 1 to 1655)
  AUTHORS   Petersen,D.N., Tkalcevic,G.T., Mansolf,A.L., Rivera-Gonzalez,R. and
            Brown,T.A.
  TITLE     Identification of osteoblast/osteocyte factor 45 (OF45), a
            bone-specific cDNA encoding an RGD-containing protein that is
            highly expressed in osteoblasts and osteocytes
  JOURNAL   J Biol Chem 275 (46), 36172-36180 (2000)
   PUBMED   10967096
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF260922.1.
            
            On Jan 12, 2005 this sequence version replaced XM_346456.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF260922.1, AF530558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1655
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1655
                     /gene="Mepe"
                     /gene_synonym="OF45"
                     /note="matrix extracellular phosphoglycoprotein"
                     /db_xref="GeneID:79110"
                     /db_xref="RGD:71036"
     exon            1..47
                     /gene="Mepe"
                     /gene_synonym="OF45"
                     /inference="alignment:Splign:2.1.0"
     exon            48..115
                     /gene="Mepe"
                     /gene_synonym="OF45"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1369
                     /gene="Mepe"
                     /gene_synonym="OF45"
                     /note="osteoregulin; matrix extracellular
                     phosphoglycoprotein with ASARM motif (bone);
                     osteoblast/osteocyte factor 45"
                     /codon_start=1
                     /product="matrix extracellular phosphoglycoprotein
                     precursor"
                     /protein_id="NP_077056.1"
                     /db_xref="GeneID:79110"
                     /db_xref="RGD:71036"
                     /translation="MQAVSVGLFLFSMTWAAPKLNEDGSSGGNQGNIHLASVKPEPMV
                     GKGTEGGRDAPLHLLDQNRQGATLLRNITQPVKSLVTGTEVQSDRNKEKKPQSVLSVI
                     PTDVHNTNDYSEDTENQQRDLLLQNSPGQSKHTPRARRSTHYLTHLPQIRKILSDFED
                     SASPDLLVRGDNDVPPFSGDGQHFMHTPDRGGAVGSDPESSAGHPVSGSSNVEIVDPH
                     TNGLGSNEIPGREGHIGGAYATRGKTAQGAGSADVSLVEGSNEITGSTKFRELPGKEG
                     NRVDASSQNAHQGKVEFHYPQAPSKEKVKGGSREHTGKAGYNEIPKSSKGGASKDAEE
                     SKGNQVTLTESQRFPGKGKGQSSHSLGNEVKSEEDSSNSLSREGIAIAHRRTSHPTRN
                     RGMSQRRGSWASRRPHPHRRVSTRQRDSSESSSSGSSSESSGD"
     exon            116..1655
                     /gene="Mepe"
                     /gene_synonym="OF45"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctaaaccc gaagaagcca agcttccctg aaggtgaacg acaccagaga gccgtgtgac
       61 gatgcaggct gtgtctgttg gactgttcct cttcagtatg acctgggcgg caccaaagct
      121 gaatgaagat ggcagcagcg gcggtaacca aggcaacatc cacttagcat ctgtgaagcc
      181 tgagcccatg gtgggtaaag gaacagaggg tgggcgagat gctccccttc acctgcttga
      241 ccagaacagg cagggtgcca ccctcctcag aaatatcact cagcctgtaa agagtctggt
      301 gacggggact gaagtacaga gcgacagaaa caaagagaag aaacctcaga gtgttctaag
      361 cgtaattcca acagatgtcc acaatactaa cgactactca gaagatacag agaaccaaca
      421 gagggatcta ctactccaga acagcccagg acaaagcaaa cacacccctc gggcccgacg
      481 aagcacgcac tacctaacac atctccccca aatcagaaag attctcagtg acttcgagga
      541 cagtgcttcc ccagaccttc tagtgagggg ggataatgat gtccctcctt tcagtggaga
      601 tggacaacat tttatgcaca ctcccgacag aggaggtgct gttggatctg atcctgaaag
      661 ctcagctggt caccctgtgt caggctccag caatgtcgag attgttgacc cacacacgaa
      721 tggactgggc tctaatgaga tcccagggag agaaggtcac ataggcggtg cctatgcaac
      781 cagaggaaaa actgcgcagg gggcaggttc cgcggatgtg agccttgtgg agggcagcaa
      841 tgaaatcacg ggcagtacca aatttaggga gctccctgga aaagaaggaa acagagtcga
      901 tgccagcagc caaaatgctc atcaaggaaa agtagaattt cactacccac aagcgccctc
      961 aaaagagaag gtaaaagggg gcagcaggga gcacacaggg aaagccggtt acaatgaaat
     1021 ccccaagagc agcaagggcg gcgctagcaa ggatgcggaa gaatctaaag ggaaccaagt
     1081 aaccttgact gaaagccaaa ggttcccagg caaaggcaaa ggccagtctt ctcacagtct
     1141 tggtaatgag gttaaaagtg aagaagactc ttctaatagt ctcagtagag aggggattgc
     1201 aatagcacac aggagaacaa gccaccctac acggaatagg gggatgtcac agcggagagg
     1261 ctcctgggcc tcgagaagac cccatcccca ccggcgcgta agcacccgcc aaagagacag
     1321 tagtgagtca tcatccagtg ggagttctag cgagagcagt ggtgactaga ccccggggtt
     1381 gaaccagttc ccagctctgg tcctggagaa agagaggacg cagcagggac tgagcaaggt
     1441 accagacttg gtcacctcca ggacactgtg ctgttttagt ggttgtaata agaatcccta
     1501 ctcaaagttc taatgctttc tgaataaaaa ctttcgtaag aatttatata ataggtaata
     1561 tttgactagg cggcccatta aaatagtctg tggatgtcac aggtgccttg atatgtgatt
     1621 tgctcttcag acatgaaaat aaagaggctt tctct
//
