LOCUS       NM_013183               2289 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus meprin A subunit beta (Mep1b), mRNA.
ACCESSION   NM_013183
VERSION     NM_013183.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2289)
  AUTHORS   Schmidt,F., Muller,M., Prox,J., Arnold,P., Schonherr,C., Tredup,C.,
            Minder,P., Ebsen,H., Janssen,O., Annaert,W., Pietrzik,C.,
            Schmidt-Arras,D., Sterchi,E.E. and Becker-Pauly,C.
  TITLE     Tetraspanin 8 is an interactor of the metalloprotease meprin beta
            within tetraspanin-enriched microdomains
  JOURNAL   Biol Chem 397 (9), 857-869 (2016)
   PUBMED   27180358
REFERENCE   2  (bases 1 to 2289)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   3  (bases 1 to 2289)
  AUTHORS   Arolas,J.L., Broder,C., Jefferson,T., Guevara,T., Sterchi,E.E.,
            Bode,W., Stocker,W., Becker-Pauly,C. and Gomis-Ruth,F.X.
  TITLE     Structural basis for the sheddase function of human meprin beta
            metalloproteinase at the plasma membrane
  JOURNAL   Proc Natl Acad Sci U S A 109 (40), 16131-16136 (2012)
   PUBMED   22988105
REFERENCE   4  (bases 1 to 2289)
  AUTHORS   Banerjee,S. and Bond,J.S.
  TITLE     Prointerleukin-18 is activated by meprin beta in vitro and in vivo
            in intestinal inflammation
  JOURNAL   J Biol Chem 283 (46), 31371-31377 (2008)
   PUBMED   18786924
  REMARK    GeneRIF: identifies proIL-18 as a biologically important substrate
            for meprin beta and implicates meprins in the modulation of
            inflammation
REFERENCE   5  (bases 1 to 2289)
  AUTHORS   Oneda,B., Lods,N., Lottaz,D., Becker-Pauly,C., Stocker,W.,
            Pippin,J., Huguenin,M., Ambort,D., Marti,H.P. and Sterchi,E.E.
  TITLE     Metalloprotease meprin beta in rat kidney: glomerular localization
            and differential expression in glomerulonephritis
  JOURNAL   PLoS One 3 (5), e2278 (2008)
   PUBMED   18509531
  REMARK    GeneRIF: In anti-Thy 1.1 glomerulonephritis we observed striking
            redistribution of meprin beta in tubular epithelial cells from the
            apical to the basolateral side and the cytosol. This might point to
            an involvement of meprin beta in this form of glomerulonephritis
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2289)
  AUTHORS   Eldering,J.A., Grunberg,J., Hahn,D., Croes,H.J., Fransen,J.A. and
            Sterchi,E.E.
  TITLE     Polarised expression of human intestinal
            N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin)
            alpha and beta subunits in Madin-Darby canine kidney cells
  JOURNAL   Eur J Biochem 247 (3), 920-932 (1997)
   PUBMED   9288916
REFERENCE   7  (bases 1 to 2289)
  AUTHORS   Chestukhin,A., Muradov,K., Litovchick,L. and Shaltiel,S.
  TITLE     The cleavage of protein kinase A by the kinase-splitting membranal
            proteinase is reproduced by meprin beta
  JOURNAL   J Biol Chem 271 (47), 30272-30280 (1996)
   PUBMED   8939981
REFERENCE   8  (bases 1 to 2289)
  AUTHORS   Chevallier,S., Ahn,J., Boileau,G. and Crine,P.
  TITLE     Identification of the cysteine residues implicated in the formation
            of alpha 2 and alpha/beta dimers of rat meprin
  JOURNAL   Biochem J 317 (Pt 3) (Pt 3), 731-738 (1996)
   PUBMED   8760356
REFERENCE   9  (bases 1 to 2289)
  AUTHORS   Gorbea,C.M., Marchand,P., Jiang,W., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Bond,J.S.
  TITLE     Cloning, expression, and chromosomal localization of the mouse
            meprin beta subunit
  JOURNAL   J Biol Chem 268 (28), 21035-21043 (1993)
   PUBMED   8407940
REFERENCE   10 (bases 1 to 2289)
  AUTHORS   Johnson,G.D. and Hersh,L.B.
  TITLE     Cloning a rat meprin cDNA reveals the enzyme is a heterodimer
  JOURNAL   J Biol Chem 267 (19), 13505-13512 (1992)
   PUBMED   1377685
  REMARK    Erratum:[J Biol Chem 1993 Aug 15;268(23):17647]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M88601.1.
            
            [WARNING] On Aug 14, 2024 this sequence was replaced by
            NM_013183.3.
            
            On Aug 31, 2012 this sequence version replaced NM_013183.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M88601.1, BC081833.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2289              M88601.1           2-2290
FEATURES             Location/Qualifiers
     source          1..2289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2289
                     /gene="Mep1b"
                     /note="meprin A subunit beta"
                     /db_xref="GeneID:25727"
                     /db_xref="RGD:3081"
     exon            1..88
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2140
                     /gene="Mep1b"
                     /EC_number="3.4.24.63"
                     /note="meprin A beta; endopeptidase-2; meprin B; meprin 1
                     beta"
                     /codon_start=1
                     /product="meprin A subunit beta precursor"
                     /protein_id="NP_037315.1"
                     /db_xref="GeneID:25727"
                     /db_xref="RGD:3081"
                     /translation="MDARHWPWFLVFATFLLVSGLPAPEKFVKDIDGGIDQDIFDINE
                     DLGLDLFEGDIKLEASGRNSIIGDNYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLK
                     TCIDFKPWSGEENYISVFKGSGCWSSVGNIHAGKQELSIGTNCDRIATVQHEFLHALG
                     FWHEQSRADRDDYITIVWDRILSGKEHNFNIYNDSVSDSLNVPYDYTSVMHYSKTAFQ
                     NGTESTIITKISDFEDVIGQRMDFSDYDLLKLNQLYSCTSSLSFMDSCDFELENICGM
                     IQSSQDSADWQRLSQVLSGPENDHSNMGQCKDSGFFMHFNTSTGNGGITAMLESRVLY
                     PKRGFQCVEFYLYNSGSGNGQLNVYTREYTAGHQDGVLTLQREIRDIPTGSWQLYYVT
                     LQVTEKFRVVFEGVGGPGASSGGLSIDDINLSETRCPHHIWHIQNFTQLLGGQTTVYS
                     PPFYSSKGYAFQINLDLTSPTNVGLYFHLISGANDDQLQWPCPWQQATMTLLDQNPDI
                     RQRMSNQRSITTDPKMTDDNGSYLWDRPSKVGVEAFFPNGTQFSRGRGYGTSVFITQE
                     RLKSREFLKGDDVYILLTVEDISHLNSTAAVPGPVPTTSTVHNACSEVECQNGGICTL
                     QEGRAECKCPAGEDWWYMGKRCEKRGSTKDTIVIAVSSTVTVFAVMLIITLISVYCTR
                     RKYRKKASAKTAAMNLENQHAF"
     exon            89..107
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     exon            108..158
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     exon            159..199
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     exon            200..278
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     exon            279..396
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     exon            397..575
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     exon            576..794
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     exon            795..947
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1163
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1604
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1784
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1920
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2125
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2289
                     /gene="Mep1b"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2289
                     /gene="Mep1b"
ORIGIN      
        1 agcttgcaac tttgaaagcc acagtatgga tgcccggcat tggccctggt ttctggtttt
       61 tgccacattt ctcctggttt ctggcttgcc agctccagaa aagtttgtca aagacataga
      121 tgggggaatc gatcaagaca tattcgatat caatgaagat ttaggactgg accttttcga
      181 gggagacatc aaactggagg caagtgggag gaattccatc attggagaca actacagatg
      241 gccacatacc attccatatg ttctagaaga cagcttggaa atgaatgcta aaggagtaat
      301 cctcaatgcg ttcgagcgct atcgccttaa aacgtgcatt gacttcaagc cctggtctgg
      361 agaagagaac tatatatcag tgttcaaggg cagtgggtgc tggtcttcag tgggaaacat
      421 tcacgctggg aagcaagagt tgtccatcgg gacaaactgt gacagaatag caacagttca
      481 acatgagttc ctccacgccc tgggattctg gcacgagcag tcgcgtgctg accgagatga
      541 ttacatcact atagtttggg acaggatctt gtccggcaag gaacacaatt tcaacatcta
      601 caacgacagt gtgtctgatt ccctgaatgt cccatacgac tacacctcgg taatgcacta
      661 cagcaaaacc gctttccaga atgggacaga gtctaccatc attacgaaaa tctcagactt
      721 tgaggatgtg attggccaac gaatggactt cagtgactat gaccttctga agctgaacca
      781 gctgtacagc tgcacttctt ccttgagttt tatggactcc tgcgattttg agctggagaa
      841 tatctgtggc atgatccaaa gttcacaaga tagcgctgac tggcagcggc tttcacaggt
      901 tctcagtggt ccggagaatg accactccaa catgggccag tgcaaagact ctggcttctt
      961 tatgcacttc aacactagca ctgggaatgg ggggatcaca gcgatgctgg agagcagagt
     1021 gctgtacccc aagagagggt ttcagtgcgt ggagttttat ctgtataaca gtggaagtgg
     1081 aaatggccaa ctgaacgtct acacccggga gtacactgca ggccaccagg atggcgtttt
     1141 gacccttcag agagaaataa gagacatacc cactgggagc tggcagcttt actatgtaac
     1201 actgcaagtg actgaaaaat tccgagtggt gtttgaaggc gtcggaggcc ctggcgcatc
     1261 atcgggtggt ctgtctatcg atgacatcaa tctctcggaa acaaggtgtc cccaccacat
     1321 ctggcacata cagaatttca ctcagcttct tggaggccag accactgtat acagtcctcc
     1381 attttattcc tctaaaggtt acgcttttca gattaacctg gatctaacat ccccgaccaa
     1441 tgtagggctt tatttccacc tgatctccgg ggccaatgac gatcaattac agtggccgtg
     1501 tccttggcag caagccacaa tgacactctt ggatcagaat cctgacatcc ggcagcgtat
     1561 gtccaaccag cggagtataa ccacagaccc aaagatgacc gatgataatg gaagctatct
     1621 ttgggacagg ccttccaagg tgggagtgga ggcttttttc cctaatggaa ctcagtttag
     1681 cagaggcaga ggctatggaa ccagtgtctt cataacccaa gagaggctga agagcagaga
     1741 gttcttaaaa ggagatgacg tttacatctt actgacggtt gaagatatat ctcacctcaa
     1801 ttctacagcg gctgtcccag ggccagtccc caccacctcg actgtccata atgcctgctc
     1861 tgaggtcgaa tgtcagaacg gcggcatctg cactctccaa gaaggcagag ctgagtgcaa
     1921 gtgtcctgca ggagaagact ggtggtacat gggcaaaagg tgtgagaaga gagggtccac
     1981 caaggacacg attgtcattg ctgtgtcttc cacggtcacc gtgtttgccg tgatgctgat
     2041 catcaccctt atcagcgtct actgcacccg gaggaaatat cgtaagaagg ctagtgcaaa
     2101 gacagcagcc atgaatctag aaaaccaaca tgcgttttga atattaactc gtgccagcag
     2161 gtgaaacaaa aagaaacctt ctgtcgtcgt agaagaatat ttcgcccagg ctgtgcgacg
     2221 acattcacag catttcaaac cagaccatct ctgtaaatag ctgagtgcct aataaaccat
     2281 tattttggt
//
