LOCUS       NM_017149               2247 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus mesenchyme homeobox 2 (Meox2), mRNA.
ACCESSION   NM_017149
VERSION     NM_017149.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2247)
  AUTHORS   Shi,H., Duan,L., Lan,Y., He,Q., Pu,P. and Tang,H.
  TITLE     RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate
            Pirarubicin-Induced Cardiomyocyte Apoptosis
  JOURNAL   Oxid Med Cell Longev 2023, 7872193 (2023)
   PUBMED   36713029
  REMARK    GeneRIF: RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate
            Pirarubicin-Induced Cardiomyocyte Apoptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2247)
  AUTHORS   Liu,P., Feng,J., Kong,F., Lu,Q., Xu,H., Meng,J. and Jiang,Y.
  TITLE     Gax inhibits perivascular preadipocyte biofunction mediated by
            IGF-1 induced FAK/Pyk2 and ERK2 cooperative pathways
  JOURNAL   Cell Signal 26 (12), 3036-3045 (2014)
   PUBMED   25280940
  REMARK    GeneRIF: The present study was designed to investigate whether
            FAK/Pyk2 and ERK1/2 MAPK signaling pathways participate in
            Perivascular adipocyte functions, which is activated by
            insulin-like growth factor 1(IGF-1) and inhibited by Gax.
REFERENCE   3  (bases 1 to 2247)
  AUTHORS   Cunnington,R.H., Northcott,J.M., Ghavami,S., Filomeno,K.L.,
            Jahan,F., Kavosh,M.S., Davies,J.J., Wigle,J.T. and Dixon,I.M.
  TITLE     The Ski-Zeb2-Meox2 pathway provides a novel mechanism for
            regulation of the cardiac myofibroblast phenotype
  JOURNAL   J Cell Sci 127 (Pt 1), 40-49 (2014)
   PUBMED   24155330
  REMARK    GeneRIF: Ski modulates the cardiac myofibroblast phenotype and
            function through suppression of Zeb2 by upregulating the expression
            of Meox2.
REFERENCE   4  (bases 1 to 2247)
  AUTHORS   Rovelet-Lecrux,A., Legallic,S., Wallon,D., Flaman,J.M.,
            Martinaud,O., Bombois,S., Rollin-Sillaire,A., Michon,A., Le Ber,I.,
            Pariente,J., Puel,M., Paquet,C., Croisile,B., Thomas-Anterion,C.,
            Vercelletto,M., Levy,R., Frebourg,T., Hannequin,D. and Campion,D.
  CONSRTM   Investigators of the GMAJ project
  TITLE     A genome-wide study reveals rare CNVs exclusive to extreme
            phenotypes of Alzheimer disease
  JOURNAL   Eur J Hum Genet 20 (6), 613-617 (2012)
   PUBMED   22166940
REFERENCE   5  (bases 1 to 2247)
  AUTHORS   Douville,J.M., Cheung,D.Y., Herbert,K.L., Moffatt,T. and Wigle,J.T.
  TITLE     Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent
            kinase inhibitors p21 and p16 in vascular endothelial cells
  JOURNAL   PLoS One 6 (12), e29099 (2011)
   PUBMED   22206000
REFERENCE   6  (bases 1 to 2247)
  AUTHORS   Saito,T., Itoh,H., Yamashita,J., Doi,K., Chun,T.H., Tanaka,T.,
            Inoue,M., Masatsugu,K., Fukunaga,Y., Sawada,N., Sakaguchi,S.,
            Arai,H., Tojo,K., Tajima,N., Hosoya,T. and Nakao,K.
  TITLE     Angiotensin II suppresses growth arrest specific homeobox (Gax)
            expression via redox-sensitive mitogen-activated protein kinase
            (MAPK)
  JOURNAL   Regul Pept 127 (1-3), 159-167 (2005)
   PUBMED   15680482
  REMARK    GeneRIF: demonstrated that Ang II down-regulated Gax expression via
            redox-sensitive ERK1/2 activation in vascular smooth muscle cells
            [Gax]
REFERENCE   7  (bases 1 to 2247)
  AUTHORS   Mankoo,B.S., Skuntz,S., Harrigan,I., Grigorieva,E., Candia,A.,
            Wright,C.V., Arnheiter,H. and Pachnis,V.
  TITLE     The concerted action of Meox homeobox genes is required upstream of
            genetic pathways essential for the formation, patterning and
            differentiation of somites
  JOURNAL   Development 130 (19), 4655-4664 (2003)
   PUBMED   12925591
REFERENCE   8  (bases 1 to 2247)
  AUTHORS   Mankoo,B.S., Collins,N.S., Ashby,P., Grigorieva,E., Pevny,L.H.,
            Candia,A., Wright,C.V., Rigby,P.W. and Pachnis,V.
  TITLE     Mox2 is a component of the genetic hierarchy controlling limb
            muscle development
  JOURNAL   Nature 400 (6739), 69-73 (1999)
   PUBMED   10403250
REFERENCE   9  (bases 1 to 2247)
  AUTHORS   Quinn,L.M., Johnson,B.V., Nicholl,J., Sutherland,G.R. and
            Kalionis,B.
  TITLE     Isolation and identification of homeobox genes from the human
            placenta including a novel member of the Distal-less family, DLX4
  JOURNAL   Gene 187 (1), 55-61 (1997)
   PUBMED   9073066
REFERENCE   10 (bases 1 to 2247)
  AUTHORS   Gorski,D.H., LePage,D.F., Patel,C.V., Copeland,N.G., Jenkins,N.A.
            and Walsh,K.
  TITLE     Molecular cloning of a diverged homeobox gene that is rapidly
            down-regulated during the G0/G1 transition in vascular smooth
            muscle cells
  JOURNAL   Mol Cell Biol 13 (6), 3722-3733 (1993)
   PUBMED   8098844
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017149.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z17223.1, SRR26643292.25900.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-706               JAXUCZ010000006.1  59584025-59584730
            707-879             JAXUCZ010000006.1  59633682-59633854
            880-2247            JAXUCZ010000006.1  59643355-59644722
FEATURES             Location/Qualifiers
     source          1..2247
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q21"
     gene            1..2247
                     /gene="Meox2"
                     /note="mesenchyme homeobox 2"
                     /db_xref="GeneID:29279"
                     /db_xref="RGD:3079"
     exon            1..706
                     /gene="Meox2"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1104
                     /gene="Meox2"
                     /note="growth arrest-specific homeobox; mesenchyme homeo
                     box 2 (growth arrest-specific homeo box)"
                     /codon_start=1
                     /product="homeobox protein MOX-2"
                     /protein_id="NP_058845.2"
                     /db_xref="GeneID:29279"
                     /db_xref="RGD:3079"
                     /translation="MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTS
                     SSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHQQQQHQALQSNWHLPQMSSPPSA
                     ARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEVEK
                     RSGSKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYE
                     IAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGA
                     ATLQQTGDSLANDDSRDSDHSSEHAHL"
     exon            707..879
                     /gene="Meox2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..2247
                     /gene="Meox2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtttata cgtgcaggag actggccgct cggctcagga ctgggattag cgggctctgc
       61 tcaaacccgc gcggctttta cattaggagt gagtggggga gagtcctagg atttctagtg
      121 aaaagtgaca gcgcttggtg gactttggga ccttcgtgaa gtcttctgct tggaagctga
      181 gacttgcatg ccatggaaca ccccctcttt ggctgcctgc gcagccccca cgccacagcg
      241 caaggcttgc accccttctc gcagtcttct ctggccctcc atggaagatc tgaccacatg
      301 tcctaccccg aactctccac atcttcctcg tcttgcataa tcgcgggata ccccaatgag
      361 gagggcatgt ttgccagcca gcatcacagg gggcaccacc accaccacca ccaccaccat
      421 caccaccacc agcagcagca gcaccaggct ctgcaaagca actggcacct cccgcagatg
      481 tcctccccgc caagcgcggc ccggcacagc ctttgcctgc agcctgattc cggagggccc
      541 ccggagctgg ggagcagccc tccggtcctg tgctccaact cttctagcct gggctccagc
      601 accccgaccg gagccgcgtg cgcaccaggg gattatggcc gtcaagcgct gtcacccgca
      661 gaagtggaga agagaagtgg cagcaaaaga aaaagcgaca gttcagattc ccaggaagga
      721 aattacaagt cagaagtgaa cagcaaacct aggaaggaaa gaacagcttt caccaaagag
      781 caaatcagag aacttgaggc agagttcgcc catcataact atctgaccag actgagaaga
      841 tatgagatag cggtgaacct agacctcact gaaagacagg tgaaagtgtg gttccagaac
      901 aggagaatga agtggaagcg ggtcaagggg ggacaacaag gagctgcagc ccgagaaaag
      961 gaactggtga atgtgaaaaa gggaacactt cttccatcag agctgtcagg aattggtgca
     1021 gccaccctcc agcagacagg ggactcacta gcaaatgacg acagtcgcga tagtgaccac
     1081 agctctgagc acgcacactt atgatacata cagagaccag ctccgttctc aggaaagcac
     1141 cattgtgatg gcaaatctca cccaaacatc gtttacatgg cagatgactg tggcagtgtt
     1201 gcttaatata attaaacgca ggcatctcaa gtctgtttct catgattgat agaaggttta
     1261 cactaagtgc ctcttattga agatgcttcc acagtgaaat tggagaaagt gaacatattc
     1321 taaatatact tgttccttta tatgacagag agggagatga atgtttgctt tggcttgcac
     1381 tgaaaattaa attgctacca agagcaaact cggtaagaca ttttgactca agttgtctcc
     1441 agagtgaaga tgttatagaa atgctttgaa cattccagtt gtaccaggtc atgtgtgtga
     1501 cactgggcag gtatttgctt ttgcttgcac tgaaacttaa actgctatca agttaaccca
     1561 tgaaatagtt tatcttgaac agccacagtg cctgaaatca ccaagtggat ataaaatgaa
     1621 ctgaaattct gtatatatta ctcctaagtc attttcctgt cttcactaat tttagcaaat
     1681 gcattcatat tagctgatga aaataggctt tcccgtggac aaatgcagcc agcttcttgt
     1741 atttttatac atttttttgt cagtcagaga caatcagtat gtgcttactt gtgttcaagt
     1801 agaggaaatg cagtagagtc tgataggaca tattcttgta ccacagacaa aacaaatctt
     1861 ctgttgcatt gactatcaac tgctgcagat acattagaga acacacctag cccccctcca
     1921 gcctccctct gttatagctc gaagaacatt aggatcatag gcaagtaggt taccttgcca
     1981 aatgagtctt gtgtggcaga tgtctgattt tgtatcttta aactgttaat gtgtatgggt
     2041 ctgcttcagt ttaacaggga aaaagatttc ttcctcattg tttatgatac aaaacccaag
     2101 tgccaaacaa agctagttct tcaagggaat agatgagaaa ctgaatgtct gacaagtaga
     2161 ctcagcgaaa atacattatt tttcagaggc tgtgtattca tgcagtacaa gtccttgtat
     2221 tttgtaaaaa aaaaagttaa ataaatg
//
