LOCUS       NM_001108837            1871 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mesenchyme homeobox 1 (Meox1), mRNA.
ACCESSION   NM_001108837 XM_001081499 XM_343970
VERSION     NM_001108837.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Wu,Y., Li,Y.J., Shi,L.L., Liu,Y., Wang,Y., Bao,X., Xu,W., Yao,L.Y.,
            Mbadhi,M.N., Chen,L., Li,S., Li,X.Y., Zhang,Z.F., Zhao,S.,
            Zhang,R.N., Chen,S.Y., Zhang,J.X. and Jun-mingTang.
  TITLE     Spatio-temporal model of Meox1 expression control involvement of
            Sca-1-positive stem cells in neointima formation through the
            synergistic effect of Rho/CDC42 and SDF-1alpha/CXCR4
  JOURNAL   Stem Cell Res Ther 12 (1), 387 (2021)
   PUBMED   34233723
  REMARK    GeneRIF: Spatio-temporal model of Meox1 expression control
            involvement of Sca-1-positive stem cells in neointima formation
            through the synergistic effect of Rho/CDC42 and SDF-1alpha/CXCR4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Wu,B., Zhang,L., Zhu,Y.H., Zhang,Y.E., Zheng,F., Yang,J.Y.,
            Guo,L.Y., Li,X.Y., Wang,L., Tang,J.M., Chen,S.Y. and Wang,J.N.
  TITLE     Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle
            cell phenotypic modulation and vascular remodeling
  JOURNAL   Int J Cardiol 251, 82-89 (2018)
   PUBMED   29113690
  REMARK    GeneRIF: Meox1 promotes vascular smooth muscle cell phenotypic
            modulation.
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Douville,J.M., Cheung,D.Y., Herbert,K.L., Moffatt,T. and Wigle,J.T.
  TITLE     Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent
            kinase inhibitors p21 and p16 in vascular endothelial cells
  JOURNAL   PLoS One 6 (12), e29099 (2011)
   PUBMED   22206000
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Skuntz,S., Mankoo,B., Nguyen,M.T., Hustert,E., Nakayama,A.,
            Tournier-Lasserve,E., Wright,C.V., Pachnis,V., Bharti,K. and
            Arnheiter,H.
  TITLE     Lack of the mesodermal homeodomain protein MEOX1 disrupts
            sclerotome polarity and leads to a remodeling of the
            cranio-cervical joints of the axial skeleton
  JOURNAL   Dev Biol 332 (2), 383-395 (2009)
   PUBMED   19520072
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   Wissmuller,S., Kosian,T., Wolf,M., Finzsch,M. and Wegner,M.
  TITLE     The high-mobility-group domain of Sox proteins interacts with
            DNA-binding domains of many transcription factors
  JOURNAL   Nucleic Acids Res 34 (6), 1735-1744 (2006)
   PUBMED   16582099
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1871)
  AUTHORS   Rodrigo,I., Bovolenta,P., Mankoo,B.S. and Imai,K.
  TITLE     Meox homeodomain proteins are required for Bapx1 expression in the
            sclerotome and activate its transcription by direct binding to its
            promoter
  JOURNAL   Mol Cell Biol 24 (7), 2757-2766 (2004)
   PUBMED   15024065
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   Mankoo,B.S., Skuntz,S., Harrigan,I., Grigorieva,E., Candia,A.,
            Wright,C.V., Arnheiter,H. and Pachnis,V.
  TITLE     The concerted action of Meox homeobox genes is required upstream of
            genetic pathways essential for the formation, patterning and
            differentiation of somites
  JOURNAL   Development 130 (19), 4655-4664 (2003)
   PUBMED   12925591
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_343970.3, XM_001081499.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1871
                     /gene="Meox1"
                     /note="mesenchyme homeobox 1"
                     /db_xref="GeneID:363684"
                     /db_xref="RGD:1308911"
     CDS             1..762
                     /gene="Meox1"
                     /codon_start=1
                     /product="homeobox protein MOX-1"
                     /protein_id="NP_001102307.1"
                     /db_xref="GeneID:363684"
                     /db_xref="RGD:1308911"
                     /translation="MDPVVNSCVRNPQPPAPVWGCLRNPHSEGSSASGLPHYPPTPFS
                     FHQKSDFPATAAYPDFSTSCLAATPHSLPRAERIFNEQHPAFPQTPDWHFPISEAGQR
                     LNLGPAGSAREMGAGSPGLVDGTGGLGEDCMVLGTIAHETEKKLSRRKKERSDNPENG
                     GGKPEGSSKARKERTAFTKEQLRELEAEFAHHNYLTRLRRYEIAVNLDLSERQVKVWF
                     QNRRMKWKRVKGGQPVSPQEQDPEDGDSAASPSSE"
     exon            1..463
                     /gene="Meox1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..639
                     /gene="Meox1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..1871
                     /gene="Meox1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggatccgg tggtcaacag ctgcgtgagg aacccccagc ccccagctcc cgtctggggc
       61 tgccttcgaa acccccactc ggaaggcagc agcgcctcag ggctgcccca ttacccacca
      121 accccgtttt ccttccacca aaagtccgat ttcccagcga cagcagcata ccccgacttc
      181 tctacttcct gcctggcagc caccccacac agcctgcccc gcgctgagcg aatcttcaat
      241 gagcagcatc ctgccttccc acagacccct gactggcatt tccccatctc tgaagcgggg
      301 caaaggctca acctaggccc agctgggagc gccagagaga tgggggctgg cagccccggc
      361 ctggtggacg gcacaggagg attgggtgag gactgcatgg tgcttgggac catcgcccat
      421 gagacggaga agaaattatc cagaaggaaa aaggagaggt cagacaaccc agagaatgga
      481 ggaggaaagc cagaaggcag cagcaaggcc cggaaggaaa ggacagcttt caccaaggag
      541 cagctacggg agctagaggc tgagttcgcc caccataact acctgaccag gctccgtaga
      601 tacgagattg cagtcaacct ggacctttca gagcggcagg tcaaagtgtg gttccagaac
      661 cggagaatga agtggaagcg tgtgaagggg ggtcagcccg tgtccccaca ggagcaggac
      721 ccagaggatg gagactctgc agcttctccg agttcagagt gagatgctcc aaagaccaaa
      781 accaagaaag actgaacgaa cgccctttcc aactcccacc acccactccc accctcacat
      841 cttctggacc cacccaggca gcctgcgcac actcgtacgt agatgtgaag ttgcccagtg
      901 tgggagcctt gaatttccca gaaggtttag cccagcatcg ccccagtctc agcagcccct
      961 tccccagggc ttcaattttc cacactctct tgaactccac aggacccagc ggactgggaa
     1021 actctagaaa cagaacctgg gacactcttt tctgggtctc ttggctgcta cccacaccta
     1081 ccatccccct cttacatcaa gtctcctctg ggtctggccc catatggcct gtgcagaatc
     1141 cattccttgg taccagctgg tgacttgtaa aagcaaaacc ctctccagat gttcacacca
     1201 ttgcattgag tggaaggcta gaaagtggct cctgtctcta aggacggaga gactagcaca
     1261 agagctgatg gatgatgacc tagacacatg gacctcaggc tacagcatcc tgtgtgctct
     1321 aaggactctg actgcaaatg aagacaggaa aacagtccat cttcctccat gggatgcatc
     1381 tggacctgtc ctgcatgttc cccaaagcta ttttgtggga agaactccca ggttcacaca
     1441 catgggcagc tcaaatctca gacccaactt ctaagaatgc cgctgtgagg actggtgggc
     1501 agacagcctc gggcagcagt atccttggag gagaccccgt atgcctcagt attagatggt
     1561 ggctctcgca ggtcctgctg ttgttgcaga aggaggtcag caagtgtttg gatttcttgc
     1621 atgtagattt gattgccagt gtttaaaaat aaccccggtt ccccacccca ccccatcaag
     1681 acagaagctg tggaaaatga ttgtcaaatg agatggcaag ttaaagcatg tatcagtttc
     1741 cccctaaagc atacttcata tggttttttt ttctaagatt atgtcaaaaa attgtgcaag
     1801 gtcaattcac tttgtaagaa aactctcgga gaaataaatc aaccaaaaaa aaaaaaaaaa
     1861 aaagcagttt c
//
