LOCUS       NM_019208               2996 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus menin 1 (Men1), mRNA.
ACCESSION   NM_019208
VERSION     NM_019208.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2996)
  AUTHORS   Jiang,Z., Wan,S. and Xing,B.
  TITLE     Wild-type menin is rapidly degraded via the ubiquitin-proteasome
            pathway in a rat insulinoma cell line
  JOURNAL   Biosci Rep 39 (10) (2019)
   PUBMED   31652443
  REMARK    GeneRIF: Wild-type menin is rapidly degraded via the
            ubiquitin-proteasome pathway in a rat insulinoma cell line.
REFERENCE   2  (bases 1 to 2996)
  AUTHORS   Xing,B., Ma,J., Jiang,Z., Feng,Z., Ling,S., Szigety,K., Su,W.,
            Zhang,L., Jia,R., Sun,Y., Zhang,L., Kong,X., Ma,X. and Hua,X.
  TITLE     GLP-1 signaling suppresses menin's transcriptional block by
            phosphorylation in beta cells
  JOURNAL   J Cell Biol 218 (3), 855-870 (2019)
   PUBMED   30792230
  REMARK    GeneRIF: results have uncovered a previously unappreciated
            physiological link in which GLP-1 signaling suppresses menin
            function through phosphorylation-triggered and actin/myosin
            cytoskeletal protein-mediated derepression of gene transcription.
REFERENCE   3  (bases 1 to 2996)
  AUTHORS   Gillam,M.P., Nimbalkar,D., Sun,L., Christov,K., Ray,D., Kaldis,P.,
            Liu,X. and Kiyokawa,H.
  TITLE     MEN1 tumorigenesis in the pituitary and pancreatic islet requires
            Cdk4 but not Cdk2
  JOURNAL   Oncogene 34 (7), 932-938 (2015)
   PUBMED   24531709
  REMARK    GeneRIF: CDK4 is a critical downstream target of MEN1-dependent
            tumor suppression and is required for tumorigenic proliferation in
            the pituitary and pancreatic islet, whereas CDK2 is dispensable for
            tumorigenesis in these neuroendocrine cell types.
REFERENCE   4  (bases 1 to 2996)
  AUTHORS   Ouyang,M., Su,W., Xiao,L., Rao,J.N., Jiang,L., Li,Y., Turner,D.J.,
            Gorospe,M. and Wang,J.Y.
  TITLE     Modulation by miR-29b of intestinal epithelium homoeostasis through
            the repression of menin translation
  JOURNAL   Biochem J 465 (2), 315-323 (2015)
   PUBMED   25317587
  REMARK    GeneRIF: These findings indicate that miR-29b represses translation
            of Men1 mRNA, in turn affecting intestinal epithelial homoeostasis
            by altering IEC apoptosis.
REFERENCE   5  (bases 1 to 2996)
  AUTHORS   Vijayaraghavan,J., Maggi,E.C. and Crabtree,J.S.
  TITLE     miR-24 regulates menin in the endocrine pancreas
  JOURNAL   Am J Physiol Endocrinol Metab 307 (1), E84-E92 (2014)
   PUBMED   24824656
REFERENCE   6  (bases 1 to 2996)
  AUTHORS   Karges,W., Maier,S., Wissmann,A., Dralle,H., Dosch,H.M. and
            Boehm,B.O.
  TITLE     Primary structure, gene expression and chromosomal mapping of
            rodent homologs of the MEN1 tumor suppressor gene
  JOURNAL   Biochim Biophys Acta 1446 (3), 286-294 (1999)
   PUBMED   10524203
REFERENCE   7  (bases 1 to 2996)
  AUTHORS   Agarwal,S.K., Guru,S.C., Heppner,C., Erdos,M.R., Collins,R.M.,
            Park,S.Y., Saggar,S., Chandrasekharappa,S.C., Collins,F.S.,
            Spiegel,A.M., Marx,S.J. and Burns,A.L.
  TITLE     Menin interacts with the AP1 transcription factor JunD and
            represses JunD-activated transcription
  JOURNAL   Cell 96 (1), 143-152 (1999)
   PUBMED   9989505
REFERENCE   8  (bases 1 to 2996)
  AUTHORS   Stewart,C., Parente,F., Piehl,F., Farnebo,F., Quincey,D.,
            Silins,G., Bergman,L., Carle,G.F., Lemmens,I., Grimmond,S.,
            Xian,C.Z., Khodei,S., Teh,B.T., Lagercrantz,J., Siggers,P.,
            Calender,A., Van de Vem,V., Kas,K., Weber,G., Hayward,N.,
            Gaudray,P. and Larsson,C.
  TITLE     Characterization of the mouse Men1 gene and its expression during
            development
  JOURNAL   Oncogene 17 (19), 2485-2493 (1998)
   PUBMED   9824159
REFERENCE   9  (bases 1 to 2996)
  AUTHORS   Guru,S.C., Goldsmith,P.K., Burns,A.L., Marx,S.J., Spiegel,A.M.,
            Collins,F.S. and Chandrasekharappa,S.C.
  TITLE     Menin, the product of the MEN1 gene, is a nuclear protein
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1630-1634 (1998)
   PUBMED   9465067
REFERENCE   10 (bases 1 to 2996)
  AUTHORS   Lemmens,I., Van de Ven,W.J., Kas,K., Zhang,C.X., Giraud,S.,
            Wautot,V., Buisson,N., De Witte,K., Salandre,J., Lenoir,G.,
            Pugeat,M., Calender,A., Parente,F., Quincey,D., Gaudray,P., De
            Wit,M.J., Lips,C.J., Hoppener,J.W., Khodaei,S., Grant,A.L.,
            Weber,G., Kytola,S., Teh,B.T., Farnebo,F., Thakker,R.V. et al.
  TITLE     Identification of the multiple endocrine neoplasia type 1 (MEN1)
            gene. The European Consortium on MEN1
  JOURNAL   Hum Mol Genet 6 (7), 1177-1183 (1997)
   PUBMED   9215690
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB773186.1, CB814296.1, AF130370.1, CV079282.1 and BQ193347.1.
            
            On Apr 13, 2007 this sequence version replaced NM_019208.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023400.1, AF130369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               CB773186.1         1-364
            365-384             CB814296.1         311-330
            385-2072            AF130370.1         5-1692
            2073-2378           CV079282.1         252-557
            2379-2996           BQ193347.1         1-618               c
FEATURES             Location/Qualifiers
     source          1..2996
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2996
                     /gene="Men1"
                     /gene_synonym="menin"
                     /note="menin 1"
                     /db_xref="GeneID:29417"
                     /db_xref="RGD:3078"
     exon            1..847
                     /gene="Men1"
                     /gene_synonym="menin"
                     /inference="alignment:Splign:2.1.0"
     CDS             403..2235
                     /gene="Men1"
                     /gene_synonym="menin"
                     /note="multiple endocrine neoplasia 1; multiple endocrine
                     neoplasia I; multiple endocrine neoplasia type I"
                     /codon_start=1
                     /product="menin"
                     /protein_id="NP_062081.1"
                     /db_xref="GeneID:29417"
                     /db_xref="RGD:3078"
                     /translation="MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFV
                     EHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVD
                     LSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFA
                     VVGACQALGLRDVHLALSEDHAWVVFGSNGEQTAEVTWHGKGNEDRRGQTVNAGVAER
                     SWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERY
                     PMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYQDEHIYPYMYLAGYHCRNRNV
                     REALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGE
                     QAQGTQGQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQ
                     VRQKVHIVSREAEAAEAEEPWGDEAREGRRRGPRRESKPEEPPPPKKPALDKGPGSGQ
                     SAGSGPPRKTSGTVSGTARGTEVSSAAQAPAPAASPPPEGPVLTFQSEKMKGMKELLV
                     ATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL"
     exon            848..1056
                     /gene="Men1"
                     /gene_synonym="menin"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1185
                     /gene="Men1"
                     /gene_synonym="menin"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1226
                     /gene="Men1"
                     /gene_synonym="menin"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1314
                     /gene="Men1"
                     /gene_synonym="menin"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1451
                     /gene="Men1"
                     /gene_synonym="menin"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1587
                     /gene="Men1"
                     /gene_synonym="menin"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1752
                     /gene="Men1"
                     /gene_synonym="menin"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..2990
                     /gene="Men1"
                     /gene_synonym="menin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtgcctt gtgtgggatg taagcgcgga ggtgggctcg ggggaccgaa gccaggactc
       61 tccttgggac ttgcgggagg ctgctttagg ttcgcctttt ggacaggctc cagagggcta
      121 ggtagagatt gcagggaccg ggaggagtgg cctttgaggg tccccaagag gtctttggga
      181 cgcagcctca tcggggctgg gggtcccggg attgtaggga actagaaggc ccttggttga
      241 aaggtctcag aaaccgagcc gccgcccgtg tgcgcaggac gaagcggctg gcgaagcaga
      301 attgtggcgg agggtagagc cgtagccgag cctgggaggg ggctctctcg ccgagcccga
      361 ccctcccttc ctcggcttgc ccgcaggcca ccgcccgccg ccatggggct gaaggccgcc
      421 cagaagacgc tgttccctct gcgctctatc gacgacgtgg tgcgcctgtt cgctgcggag
      481 ctgggccgag aggagcctga cctggtgctc ctctccttgg ttctgggctt cgtagagcat
      541 ttcctggctg tcaaccgtgt catccccacc aacgtgccgg agctcacctt ccagcccagc
      601 ccggcacccg accctcctgg tggcctcacc tacttcccag tggccgacct atccatcatt
      661 gctgccctct atgcccgatt caccgctcag atccgcggtg ctgtggacct ctccctctat
      721 cctcgagagg ggggcgtttc cagtcgcgaa ctggtaaaaa aggtctcgga tgtcatatgg
      781 aacagcctca gccgctccta cttcaaggac cgggcccaca tccagtctct cttcagcttc
      841 atcacaggca ctaaactgga cagttcgggc gtggcctttg cagtggtagg ggcctgccag
      901 gctctaggtc tcagagatgt ccatctggcc ctgtccgagg atcatgcctg ggtggtgttc
      961 gggtccaatg gggaacagac ggctgaggtg acctggcatg gcaaaggcaa cgaggaccgc
     1021 agaggccaga cagtcaacgc tggtgtggct gagcggagct ggctgtacct gaaaggatcg
     1081 tacatgcgct gtgaccgcaa gatggaggtg gcgttcatgg tgtgtgccat caacccttcc
     1141 attgatcttc acactgactc tttggaactg ttgcaactac agcagaagct gctctggctg
     1201 ctgtatgacc taggacatct ggaaaggtac cccatggcgc tagggaactt ggcagacctg
     1261 gaggagctgg aacccacccc tggtcggcca gacccgctca ccctctatca caaggggatt
     1321 gcctcagcta agacctacta ccaggatgaa cacatctacc cctacatgta cctggctgga
     1381 taccattgtc gcaaccgcaa tgtgcgtgaa gccctgcagg cctgggccga cactgccact
     1441 gttatccaag actacaacta ctgtcgggag gatgaagaga tctacaagga attctttgaa
     1501 gtggccaatg acgtcatccc caacctgctg aaggaggcag ccagcctgct agaagcaggc
     1561 gaggagcggc caggagagca agcccagggc acccaaggcc aaggttctgc cctccaggac
     1621 ccagagtgct ttgcccacct gctgcgattc tatgatggca tctgcaaatg ggaggagggt
     1681 agccccacac cagtactgca cgtgggctgg gcaactttcc ttgtgcagtc cctaggacgc
     1741 tttgagggac aggtgcggca gaaggtgcac atagttagcc gggaagccga ggcagcagag
     1801 gcggaagaac catgggggga cgaagcccga gaaggtcgtc ggcgcggtcc ccgccgagag
     1861 tccaagcctg aggagccacc accacccaag aagcctgcgt tggacaaggg cccaggctca
     1921 gggcaaagtg cagggtcggg acctcctagg aaaacgtcag ggactgtctc aggtactgcc
     1981 cgtggcacag aagtcagcag tgctgctcag gctccagcac ctgcagcatc gccaccccca
     2041 gagggcccag tgctcacttt ccagagtgag aagatgaaag gaatgaagga gctactggtg
     2101 gccaccaaga tcaactctag tgccatcaag ctgcaactca cggcacagtc ccaagtgcag
     2161 atgaagaaac agaaggtgtc cacacccagc gactacacac tctctttcct aaagcggcag
     2221 cgcaagggcc tctgaactct tcgggattct gtgacaaggc ccccggcctg cccacactcc
     2281 catcaggctt cactctagtc ctctaactca agcctagact ctgcctacag tcctaggtgg
     2341 cccagaactg cccagcagtg actgggagcc ttcatttagc cccttttcgg gccccagagc
     2401 cctggctcgg ttcttagaat ttaggtttca tctcccacca gccagccaat tggaacattg
     2461 taggtccatg caaccggtct ttacaggtcc aaccccgtcc cccgaaattc agtggaccat
     2521 gacgggttcc ctagtcgagc ctgaacagtc cggcattcct cccacttggg gactagattg
     2581 accttagccc acaagcacag ttgctacctg gaaacccagg aaccaaggac cattcagtcc
     2641 ctaggggtag atttccgcac tttatagttg catcctttgg caatccaagt cccctacccc
     2701 aaagaaatta acatattgtt gcctgaatct ggaaatcttc ctcatctccc tagccccgga
     2761 gtccagggca tgaaggtcgg actcttatct gtgaatactg agcctcgccc ccttcctgac
     2821 caaactggcc ggagaacaga gcaggacctc ttccagccct ctgggaacct ccttgaggtc
     2881 ccaggaggaa atctgcacgg ggtgggggag ggccagtctt ttcctgtttt gtacatagat
     2941 ttatttttca gttccaagga agataaatac attttgttaa gaaaaaaaaa aaaaaa
//
