LOCUS       NM_001105872            4201 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus melanotransferrin (Meltf), mRNA.
ACCESSION   NM_001105872 XM_001073388 XM_237839
VERSION     NM_001105872.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4201)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   2  (bases 1 to 4201)
  AUTHORS   Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and
            Yates JR.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 4201)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 4201)
  AUTHORS   Sekyere EO, Dunn LL, Suryo Rahmanto Y and Richardson DR.
  TITLE     Role of melanotransferrin in iron metabolism: studies using
            targeted gene disruption in vivo
  JOURNAL   Blood 107 (7), 2599-2601 (2006)
   PUBMED   16291590
REFERENCE   5  (bases 1 to 4201)
  AUTHORS   Rolland Y, Demeule M and Beliveau R.
  TITLE     Melanotransferrin stimulates t-PA-dependent activation of
            plasminogen in endothelial cells leading to cell detachment
  JOURNAL   Biochim Biophys Acta 1763 (4), 393-401 (2006)
   PUBMED   16713448
REFERENCE   6  (bases 1 to 4201)
  AUTHORS   Richardson DR and Morgan EH.
  TITLE     The transferrin homologue, melanotransferrin (p97), is rapidly
            catabolized by the liver of the rat and does not effectively donate
            iron to the brain
  JOURNAL   Biochim Biophys Acta 1690 (2), 124-133 (2004)
   PUBMED   15469901
  REMARK    GeneRIF: compared to transferrin, soluble melanotransferrin
            (Magea1) plays little or no role in Fe supply to the brain and
            erythropoietic tissue.
REFERENCE   7  (bases 1 to 4201)
  AUTHORS   Kennard ML, Richardson DR, Gabathuler R, Ponka P and Jefferies WA.
  TITLE     A novel iron uptake mechanism mediated by GPI-anchored human p97
  JOURNAL   EMBO J 14 (17), 4178-4186 (1995)
   PUBMED   7556058
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000222.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by
            NM_001105872.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001105872.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132263
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JACYVU010000222.1  48215908-48216074   c
            168-322             JACYVU010000222.1  48214537-48214691   c
            323-422             JACYVU010000222.1  48212508-48212607   c
            423-605             JACYVU010000222.1  48210582-48210764   c
            606-762             JACYVU010000222.1  48209452-48209608   c
            763-830             JACYVU010000222.1  48208266-48208333   c
            831-1018            JACYVU010000222.1  48205579-48205766   c
            1019-1199           JACYVU010000222.1  48204824-48205004   c
            1200-1351           JACYVU010000222.1  48204094-48204245   c
            1352-1448           JACYVU010000222.1  48202475-48202571   c
            1449-1643           JACYVU010000222.1  48201481-48201675   c
            1644-1800           JACYVU010000222.1  48200632-48200788   c
            1801-1868           JACYVU010000222.1  48200468-48200535   c
            1869-2056           JACYVU010000222.1  48198588-48198775   c
            2057-2255           JACYVU010000222.1  48196710-48196908   c
            2256-4201           JACYVU010000222.1  48194220-48196165   c
FEATURES             Location/Qualifiers
     source          1..4201
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4201
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /note="melanotransferrin"
                     /db_xref="GeneID:288038"
                     /db_xref="RGD:1308155"
     exon            1..167
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..2335
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /note="melanoma antigen, family A, 1; antigen p97
                     (melanoma associated) identified by monoclonal antibodies
                     133.2 and 96.5"
                     /codon_start=1
                     /product="melanotransferrin precursor"
                     /protein_id="NP_001099342.1"
                     /db_xref="GeneID:288038"
                     /db_xref="RGD:1308155"
                     /translation="MRLLSVTFWLLLSLRTVLCVMEMQWCTISDPEQQKCKDMSKAFQ
                     GAGIQPSLLCVQGTSTDHCVQLIKDQKADAITLDGGAIYQAGKEYGLKPVVGEVYDQD
                     IGTSYYAVAVVRRNSNVTINTLKGVKSCHTGINRTVGWNVPVGYLVETGHLSVMGCDV
                     LKAVGDYFGGSCVPGAGETSHSESLCRLCRGDSSGHNVCDKSPLERYYDYSGAFRCLA
                     EGAGDVAFVKHSTVLENTDGKTLPSWGKALMSQDFQLLCRDGSRADITEWRRCHLAKV
                     PAHAVVVRDDMDGGLIFRLLNEGQLLFSHEDSSFQMFSSKAYGQKNLLFKDSTLELVP
                     IATQNYESWLGQEYLHAMKGLLCDPNRLPHYLRWCVLSVPEIQKCGDMAVAFSRQSLK
                     PEIQCVSAESPEHCMQQIQAGHIDAVTLRGEDIYRAGKAYGLVPAAGELYAEEDRSNS
                     YFVVAVVRRDSSYSFTLDELRSKRSCHPGLGSPAGWEVPIGSLIQRGFIRPKDCDVLT
                     AVSEFFNASCVPVNNPKNYPSSLCALCVGDEKGRNKCVGSSQERYYGYSGAFRCLVEN
                     AGDVAFLKHTTVFENTNGHNPEPWASHLRWQDYELLCPNGARAEVDQFQACNLAQMPS
                     HAVMVHPDTNIFTVYGLLDKAQDLFGDDHNKNGFQMFDSSKYHSQDLLFKDATVRAVP
                     VREKTTYLDWLGPDYVVALEGMLSQQCSGAGAAVHRVPPPALLLLALAAGLLPRVL"
     exon            168..322
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..422
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..605
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            606..762
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..830
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1018
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1199
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1351
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1448
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1643
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1800
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1868
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2056
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2255
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..4201
                     /gene="Meltf"
                     /gene_synonym="Magea1; Mfi2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgtgttga ggggcgtgga ctcttccagg actgcgctta aatagtgaag ggccaaagag
       61 accagggagg aggaagccag gacggacccg ccagcacccc agccaaccca acgttgccat
      121 gaggctcctg agcgtgactt tttggctact cctgtccctg cgcactgtcc tctgtgtgat
      181 ggagatgcag tggtgtacca tctcagaccc ggaacagcag aaatgcaagg acatgagcaa
      241 ggctttccag ggagctggaa ttcagccctc cctcctctgc gtccagggca cctccactga
      301 ccactgcgtc cagctcatca aggaccaaaa agcggatgcc atcaccctgg atggaggagc
      361 catctatcag gctggcaagg agtatggcct gaagccagtg gtgggtgaag tctatgacca
      421 agacattggg acttcctatt atgcggtggc tgtggtcagg aggaattcca atgtgaccat
      481 caacaccctg aagggcgtca agtcctgcca cactggcatt aaccggactg tgggctggaa
      541 tgtgcctgtc ggctacctcg tagagactgg ccatctgtca gtgatgggct gcgatgtgct
      601 caaagccgtt ggcgattatt ttgggggcag ctgtgtccct ggagcgggag aaaccagcca
      661 ttccgagtcc ctctgtcgcc tctgccgtgg tgactcttct gggcacaatg tgtgtgacaa
      721 gagtccccta gagagatact atgactacag cggagccttc cggtgcctgg cggaaggagc
      781 cggtgatgtg gccttcgtga agcacagcac agtgttggag aacactgatg ggaaaaccct
      841 gccttcctgg ggcaaggccc tgatgtcaca ggacttccag ctactctgca gggacggcag
      901 ccgggctgac attactgagt ggagacgatg ccacttggcc aaggtgcctg ctcatgctgt
      961 ggtggtcagg gatgacatgg acggaggcct catattccgg ctgctcaacg aaggccagct
     1021 tctgttcagc catgaagaca gcagcttcca gatgttcagc tccaaagcct acggccagaa
     1081 gaacttgctg ttcaaagact ccaccctaga gctcgtgccc attgccacac agaactatga
     1141 gtcctggctg ggccaggaat acctgcatgc catgaagggg ctgctctgtg atcccaaccg
     1201 gctgccccac tacctgcgct ggtgtgtgtt gtcggtgccc gagatccaga agtgtggcga
     1261 tatggctgtg gccttcagcc gccagagtct gaagccagag atccagtgtg tgtcagccga
     1321 gtcccctgag cactgcatgc agcagatcca ggctgggcac atcgatgctg tgactctgag
     1381 gggcgaagac atttacaggg caggaaaggc atatggcctg gttccggcgg ctggggagct
     1441 gtatgctgag gaggacagga gtaattccta ctttgtggtg gctgtggtga ggcgggacag
     1501 ctcctactcc ttcaccctgg atgagcttcg cagcaagcgt tcctgccacc caggcttggg
     1561 cagccctgcg ggctgggagg tgcccatagg ctccctcatc cagcggggct tcatccggcc
     1621 caaggactgt gatgtgctca cagcggtgag cgagttcttc aatgccagct gtgtgcctgt
     1681 aaacaaccct aagaactacc cctcctcact gtgcgcgctc tgcgtgggag atgagaaggg
     1741 ccgcaacaag tgtgtgggca gcagccagga gagatactac ggctacagtg gggccttcag
     1801 gtgccttgtg gagaatgcag gggacgttgc cttcctcaag cacacaactg tctttgagaa
     1861 cacaaatggt cacaatcctg agccctgggc ttctcacctc aggtggcaag actatgaact
     1921 actgtgcccc aatggggcac gggctgaggt agaccagttc caagcttgca acctggcaca
     1981 aatgccatcc catgctgtca tggttcatcc agacaccaac atcttcactg tgtacggact
     2041 tctggacaag gcccaggacc tatttggaga cgaccacaac aagaacggtt tccaaatgtt
     2101 tgactcctcc aaataccaca gccaagatct gcttttcaaa gatgctacgg tccgagcagt
     2161 gcccgtccgg gagaaaacca cgtatctgga ctggctgggt cctgactacg tggttgctct
     2221 ggaggggatg ctatctcagc agtgctcggg tgcaggggcc gcggtgcacc gagtcccccc
     2281 accggccctg ctcctgctgg ccctggctgc aggcctcctc ccgcgagttc tctgaaggtg
     2341 gctgcttcag gccacgccct gcccaggaaa agctacagaa tccaacccaa gaaaccagga
     2401 aatcagctaa ccctgcagga gagcgcgaga tgcgatgcga gaggcaaggt gagaattcac
     2461 acgcacaacc ctccgatgtg cgattctaac ccaaagagaa atttctagaa tcaggatgat
     2521 tgttaacgcc aagtcttccc acctgccgga gccctcagta cctgaggcga ctggcgagca
     2581 gcccagtcac tcctcccaca ctggtggcgc ctgcagcgaa cctgtgcctc cctcccacct
     2641 ggaacctccc ggctggctgg gggattgggg gaggggagag agagagagag agagagagag
     2701 agagagagag agagagagag agagagagag agagagagag agagagagag aaggctggtt
     2761 gccatggcaa ccgtggagct gcttccagcc tctgaactgg tcacgtggtt gggggagtgc
     2821 caaggaagga gcgcaacacc aacctccttg accagccagc agcccctgct cttgctgccc
     2881 caccccacgc actctcctgt ggacacttgc tcaccaaggc tcgggccacg ccctcggaag
     2941 agcagggttg ccgagcacat cagcttttgt cattgtcttc tgtgacacta accaaggacc
     3001 ccagcccact ggacaacaga ttttgccaga ctgggatggg aggaaagcca gagctgtact
     3061 gagggggtga agtctccaaa aatcctcaga ggacggaagt gcccctccta gtaagaatgt
     3121 taatgggtga ggaacttgat gcagggagag aactatcctg cttaacagct cctgcctcaa
     3181 acaggacttg ccctgccctg cctggacctc actgcacaat gaaactgtcg cctagaatct
     3241 accgttcgct ctcctgatct caatctcaac attacctttc tctctgcttc atatacccct
     3301 tcccacaatc aacacacatg cacaggcaca tgcacgcgcg cacgcgcaca tgcacgcaca
     3361 catgcacgca catggacaca cgtcccttat ctctgtgtga gcatatctgc ttgtctgaag
     3421 aagcatgagt taacccaaaa taagagcctt tcatgaactg ggctttagga cacaccacgg
     3481 agccaaggga ttgggaagaa ccctgtcttc ccctgacctt gcgtgttgac cggttgtatc
     3541 tttggagagg gtccctggtt cccaagagct gtaagagcca aggcctaggg aagagcctct
     3601 tctccaccat tttgccattg ttctctcgag aaccagaaaa agttttccaa agctaccaac
     3661 tcttactcca aatcgtgttc ctttaaaact aataaataaa acggggagga aataggatca
     3721 agcagccctc gtcagcacac tggaagcagc gtgggcctgg agttattttc gtcttggtct
     3781 gtgtgggggg cctcaggatg ctgatgacag gccaggttcc cagtggctcg cccccacctg
     3841 tgggtgccgg gacagatccg tacatggctc accagtgtcc cagccagagt cacacagtcc
     3901 tgaggaatct ccggtcacca tgctgcttcg gagagcaagc ccctcctctc agtacacagc
     3961 catccattct tccctgagct gagggctttc acagtgagaa gtgtactgtg tgtgggcgac
     4021 cgtgctgccc aaagtgtgat gtctgcaccg tgtgctttcc aggtgtgatt tttccagagc
     4081 gctctgtaaa tgacgtctga ttgccatggg ccactgccgt gttagtgcta aagaaagaca
     4141 ttggtttctt tttaaataaa gccaaatatc cctgcatacg cagaggcttg gatcctggta
     4201 g
//
