LOCUS       NM_001134702            2506 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus Meis homeobox 1 (Meis1), mRNA.
ACCESSION   NM_001134702 XM_001054791 XM_001054850 XM_001054906 XM_001054960
            XM_001055028 XM_001070142 XM_001070196 XM_001070244 XM_001070286
            XM_001070326
VERSION     NM_001134702.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2506)
  AUTHORS   Yao,M.Z., Ge,X.Y., Liu,T., Huang,N., Liu,H., Chen,Y., Zhang,Z. and
            Hu,C.P.
  TITLE     MEIS1 regulated proliferation and migration of pulmonary artery
            smooth muscle cells in hypoxia-induced pulmonary hypertension
  JOURNAL   Life Sci 255, 117822 (2020)
   PUBMED   32450174
  REMARK    GeneRIF: MEIS1 regulated the proliferation and migration of
            pulmonary artery smooth muscle cells during hypoxia-induced
            pulmonary hypertension
REFERENCE   2  (bases 1 to 2506)
  AUTHORS   Zhang,Y., Si,Y. and Ma,N.
  TITLE     Meis1 promotes poly (rC)-binding protein 2 expression and inhibits
            angiotensin II-induced cardiomyocyte hypertrophy
  JOURNAL   IUBMB Life 68 (1), 13-22 (2016)
   PUBMED   26597775
REFERENCE   3  (bases 1 to 2506)
  AUTHORS   Pandey,R., Yang,Y., Jackson,L. and Ahmed,R.P.
  TITLE     MicroRNAs regulating meis1 expression and inducing cardiomyocyte
            proliferation
  JOURNAL   Cardiovasc Regen Med 3 (2016)
   PUBMED   28111633
REFERENCE   4  (bases 1 to 2506)
  AUTHORS   Jolma,A., Yin,Y., Nitta,K.R., Dave,K., Popov,A., Taipale,M.,
            Enge,M., Kivioja,T., Morgunova,E. and Taipale,J.
  TITLE     DNA-dependent formation of transcription factor pairs alters their
            binding specificity
  JOURNAL   Nature 527 (7578), 384-388 (2015)
   PUBMED   26550823
REFERENCE   5  (bases 1 to 2506)
  AUTHORS   Spieler,D., Kaffe,M., Knauf,F., Bessa,J., Tena,J.J., Giesert,F.,
            Schormair,B., Tilch,E., Lee,H., Horsch,M., Czamara,D., Karbalai,N.,
            von Toerne,C., Waldenberger,M., Gieger,C., Lichtner,P.,
            Claussnitzer,M., Naumann,R., Muller-Myhsok,B., Torres,M.,
            Garrett,L., Rozman,J., Klingenspor,M., Gailus-Durner,V., Fuchs,H.,
            Hrabe de Angelis,M., Beckers,J., Holter,S.M., Meitinger,T.,
            Hauck,S.M., Laumen,H., Wurst,W., Casares,F., Gomez-Skarmeta,J.L.
            and Winkelmann,J.
  TITLE     Restless legs syndrome-associated intronic common variant in Meis1
            alters enhancer function in the developing telencephalon
  JOURNAL   Genome Res 24 (4), 592-603 (2014)
   PUBMED   24642863
REFERENCE   6  (bases 1 to 2506)
  AUTHORS   Toresson,H., Parmar,M. and Campbell,K.
  TITLE     Expression of Meis and Pbx genes and their protein products in the
            developing telencephalon: implications for regional differentiation
  JOURNAL   Mech Dev 94 (1-2), 183-187 (2000)
   PUBMED   10842069
REFERENCE   7  (bases 1 to 2506)
  AUTHORS   Jacobs,Y., Schnabel,C.A. and Cleary,M.L.
  TITLE     Trimeric association of Hox and TALE homeodomain proteins mediates
            Hoxb2 hindbrain enhancer activity
  JOURNAL   Mol Cell Biol 19 (7), 5134-5142 (1999)
   PUBMED   10373562
REFERENCE   8  (bases 1 to 2506)
  AUTHORS   Knoepfler,P.S., Calvo,K.R., Chen,H., Antonarakis,S.E. and
            Kamps,M.P.
  TITLE     Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an
            interaction surface disrupted in oncoprotein E2a-Pbx1
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14553-14558 (1997)
   PUBMED   9405651
REFERENCE   9  (bases 1 to 2506)
  AUTHORS   Shen,W.F., Montgomery,J.C., Rozenfeld,S., Moskow,J.J.,
            Lawrence,H.J., Buchberg,A.M. and Largman,C.
  TITLE     AbdB-like Hox proteins stabilize DNA binding by the Meis1
            homeodomain proteins
  JOURNAL   Mol Cell Biol 17 (11), 6448-6458 (1997)
   PUBMED   9343407
REFERENCE   10 (bases 1 to 2506)
  AUTHORS   Chang,C.P., Jacobs,Y., Nakamura,T., Jenkins,N.A., Copeland,N.G. and
            Cleary,M.L.
  TITLE     Meis proteins are major in vivo DNA binding partners for wild-type
            but not chimeric Pbx proteins
  JOURNAL   Mol Cell Biol 17 (10), 5679-5687 (1997)
   PUBMED   9315626
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161984.1.
            
            On or before Sep 5, 2008 this sequence version replaced
            XM_001054960.1, XM_001055028.1, XM_001054850.1, XM_001054791.1,
            XM_001054906.1, XM_001070286.1, XM_001070326.1, XM_001070196.1,
            XM_001070244.1, XM_001070142.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161984.1, SRR8487227.99997.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2506
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..2506
                     /gene="Meis1"
                     /note="Meis homeobox 1"
                     /db_xref="GeneID:686117"
                     /db_xref="RGD:1585482"
     exon            1..68
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1229
                     /gene="Meis1"
                     /note="Meis1, myeloid ecotropic viral integration site 1
                     homolog"
                     /codon_start=1
                     /product="homeobox protein Meis1"
                     /protein_id="NP_001128174.1"
                     /db_xref="GeneID:686117"
                     /db_xref="RGD:1585482"
                     /translation="MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPP
                     LHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPR
                     EPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELE
                     KVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDVTRAANLTDQPSWNRDHD
                     DTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKR
                     GIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPM
                     IDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGPMSGMGMNMGMEGQWHYM"
     exon            69..295
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..437
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            438..488
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..539
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..686
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..798
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            799..944
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1021
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1080
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1170
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1265
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..2480
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggccttaa agaggatata ttagaagttg aagaaggaag ggaggcagag aggccgatgg
       61 cgcaaaggta cgacgatcta ccccattatg ggggcatgga tggagtaggc atcccctcca
      121 cgatgtatgg ggacccgcat gcagccaggt ctatgcagcc ggtccaccac ctgaaccacg
      181 ggcctcctct gcactctcat cagtacccgc acacagctca taccaacgcc atggccccca
      241 gcatgggctc ctcagtcaat gacgctttaa agagagataa agatgccatt tatggacacc
      301 ccctcttccc tctcttagca ctgatttttg agaaatgtga attagctact tgtacccccc
      361 gcgagccggg ggtggcgggc ggggacgtct gctcgtcaga gtcattcaat gaagatatag
      421 cggtgttcgc caaacagatt cgtgcagaaa aacctctatt ctcttctaat ccagaactgg
      481 ataacttgat gatccaagcc atacaagtat taaggtttca tctgttggaa ttagagaagg
      541 tacacgaatt atgtgacaat ttctgccacc ggtatattag ctgtttgaaa gggaaaatgc
      601 ctatcgattt ggtgatagat gatagagaag gcggatcaaa atcagacagt gaagatgtaa
      661 caagagcagc aaatctaact gaccagccct cttggaatag agaccatgat gacacggcat
      721 ccactcgttc aggaggaacc ccgggccctt ccagcggtgg ccacacttca cacagtgggg
      781 ataacagcag tgagcaaggt gatggcttgg acaacagtgt agcttccccc agcacaggtg
      841 acgatgatga ccctgataag gacaaaaagc gtcacaaaaa gcgtggcatc tttcccaaag
      901 tagccaccaa tatcatgagg gcgtggctgt tccagcatct aacacaccct tacccttctg
      961 aagagcagaa aaagcagttg gcacaagata cgggactcac catccttcaa gtgaacaatt
     1021 ggtttattaa tgcgcggaga agaatagtgc agcccatgat agatcagtcc aaccgagcag
     1081 tcagccaagg gacaccttat aaccccgatg gacagccaat gggaggtttt gtaatggacg
     1141 gtcagcagca catgggcatc agagcgccag gacctatgag tggaatgggc atgaatatgg
     1201 gcatggaggg gcagtggcac tacatgtaac gttcatctag ttaaccaatc gaaagccagg
     1261 gggaaggctg caaagtatgc caggggagta tgtagcccgg ggtggtccaa tgggtgtgag
     1321 tatgggacag ccgagttata cccaagccca gatgcccccc catcctgctc agctgcgtca
     1381 tgggcccccc atgcatacgt acattcctgg acatcctcac caccccgcag tgatgatgca
     1441 tggaggacag ccccaccctg gaatgccaat gtcagcgtca agcccctcgg ttcttaatac
     1501 aggagacccg acaatgagtg gacaagtcat gaacattcac gctcagtagc ttaagggaat
     1561 atgcattgtc tgcaatggtg actgatctcg aatcatgtct ttttctgcaa tgactatgga
     1621 gttccattct tgacatctac tttggaccaa ggagcatccc taattcttca tagggactct
     1681 taaaaatgca ggaaaaccaa ccgaagtcaa tttgggggac atgcaaaaat aactatataa
     1741 gacattaaaa gaacaaagag tgaaatattg taaatgctat tatactgtta tccatattac
     1801 gttgtttctt atagattttt taaaaaaaat gtgaaatttt tccacactat gtgtgttgtt
     1861 tccatagctc ttcacttcct ccagaagcct ccttacatta aaaagcctta cagtcatcct
     1921 gcaagggaca ggaaggtctg atttgcagga tttttagagc attaaaataa ctatcaggca
     1981 gaagaatctt tcttctcgcc taggatttca gccatgtgcg cgctctctct ctctctcctc
     2041 tctctctctt ctcctctctc tccctctctc tagcctgggg cttgaatttg catgtctaat
     2101 tcatttactc accatatttg aattggcctg aacagatgta aatcgggaag gatgggaaaa
     2161 actgcagtca cccaacaatg attaatcagc tgttgcaggc agtgtcttaa ggagactggt
     2221 agaaggagcc atggaaaccc aaaggccgtg tgtttagaag cctaactgtc acgtcaagcg
     2281 tcatcgtccc catgcgacaa caaccatcac cttatacatc acttcctgtt ttatgcagct
     2341 caaaaaaaca tagactgaag atttattttt aatatgttga ctttgtttct cagcaaagca
     2401 ttggtcatgt gtgtattttt ccatagtccc accttggagc atttatgtag acattgtaaa
     2461 taaattttgt gcaaaaagga aaaaaaaaaa aaaaaaaaaa aaaaaa
//
