LOCUS       NM_001130555            4018 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus meiotic double-stranded break formation protein 1
            (Mei1), mRNA.
ACCESSION   NM_001130555 XM_001077460 XM_235509
VERSION     NM_001130555.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4018)
  AUTHORS   Nguyen NMP, Ge ZJ, Reddy R, Fahiminiya S, Sauthier P, Bagga R,
            Sahin FI, Mahadevan S, Osmond M, Breguet M, Rahimi K, Lapensee L,
            Hovanes K, Srinivasan R, Van den Veyver IB, Sahoo T, Ao A, Majewski
            J, Taketo T and Slim R.
  TITLE     Causative Mutations and Mechanism of Androgenetic Hydatidiform
            Moles
  JOURNAL   Am J Hum Genet 103 (5), 740-751 (2018)
   PUBMED   30388401
REFERENCE   2  (bases 1 to 4018)
  AUTHORS   Li XC and Schimenti JC.
  TITLE     Mouse pachytene checkpoint 2 (trip13) is required for completing
            meiotic recombination but not synapsis
  JOURNAL   PLoS Genet 3 (8), e130 (2007)
   PUBMED   17696610
  REMARK    Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to
            Li, Xin Chenglin]]
REFERENCE   3  (bases 1 to 4018)
  AUTHORS   Liebe B, Petukhova G, Barchi M, Bellani M, Braselmann H, Nakano T,
            Pandita TK, Jasin M, Fornace A, Meistrich ML, Baarends WM,
            Schimenti J, de Lange T, Keeney S, Camerini-Otero RD and Scherthan
            H.
  TITLE     Mutations that affect meiosis in male mice influence the dynamics
            of the mid-preleptotene and bouquet stages
  JOURNAL   Exp Cell Res 312 (19), 3768-3781 (2006)
   PUBMED   17010969
REFERENCE   4  (bases 1 to 4018)
  AUTHORS   Reinholdt LG and Schimenti JC.
  TITLE     Mei1 is epistatic to Dmc1 during mouse meiosis
  JOURNAL   Chromosoma 114 (2), 127-134 (2005)
   PUBMED   15928951
REFERENCE   5  (bases 1 to 4018)
  AUTHORS   Munroe RJ, Bergstrom RA, Zheng QY, Libby B, Smith R, John SW,
            Schimenti KJ, Browning VL and Schimenti JC.
  TITLE     Mouse mutants from chemically mutagenized embryonic stem cells
  JOURNAL   Nat Genet 24 (3), 318-321 (2000)
   PUBMED   10700192
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_235509.4, XM_001077460.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4018
                     /gene="Mei1"
                     /note="meiotic double-stranded break formation protein 1"
                     /db_xref="GeneID:315162"
                     /db_xref="RGD:1307210"
     exon            1..218
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..3869
                     /gene="Mei1"
                     /note="meiosis defective 1; meiosis inhibitor 1"
                     /codon_start=1
                     /product="meiosis inhibitor protein 1"
                     /protein_id="NP_001124027.1"
                     /db_xref="GeneID:315162"
                     /db_xref="RGD:1307210"
                     /translation="MKAADHSAFGRDEEAVLLLERTHHRHDPRWLLPVSPHVCLACAL
                     ELLPEPGVSLVRKKHVLFCFQDALVRHTSLVTQLVAQDPRVCIHFVRVLFGLLSSVED
                     GSVADLCIEVLIQLTTQPNMEQTIQCLLNECHRELCNLPSMGGSLATTTLLGKLVNAI
                     PDLAEDLVMEYGNLMEHLLRGLVYPNEGVQASICYLYGKLYSSPTAAEMLSGHFREKL
                     CALFLSTLDNAQTRDLQINCLGLLRQLLKYDLFVSVIMSKSVPVEGAESVEQPSRETS
                     LPLVLKKFLLSRDEVLQVASSHCITAVLVHSPAKHAVAFIYADIPEFLFEHLSSSSEI
                     LVWSSYNCLILLAEEPLFFSKCHTVYGIEAVVRSLQGSLQMTNTELHKQGLLLFAEIL
                     TRQPEEIRLFTSSAMCRDASRALQEAVSSPVLAVAAEALRAISAFLRKDHQSSLPVQY
                     RALRALLEAMLSRCMEFSQTPLNRRSLGHACSRNLEKATLRKGKFLLSTLEGFRNACR
                     LAVEFQGEPSAQENPFTAPSAEKEDTLEAFSEFLLSACDSLCIPMMMRYSEETTHPNL
                     MEVFLSILHSLFVIVPHMKVKFSRKLADASFIRLTLELKARFCSGQSHSSLNQVCSSF
                     LYYMCLNLLFAPEKTESLSQEELPAVSEFLQHGLPHISSRTPESLAFLSDRQHVEVAA
                     RQRQYCILLLFYLAHIHDDRFVPDAELCVAVQSFLLSLQDQGECPPPVVCKAAIYLLA
                     VCQDKDCALGEAVVSAIRKCLEGTSDLRLVYTHHPLLLRLFLVCPGLMGRFGHRVLEL
                     WFSWEESGYENLDDDSSPGRTVFPANFAALFQMLRSMPSVLLILLDLVYSSPVDTAHK
                     VLIVLRAFLRENEDIEVGGLIRGHFLLILQRLLVEYGASPSGASGNLPLLLNLLSSLQ
                     LRTESEQELDSMAMKLLHQVSKLCGKCSPADVDILQPSFNFLYWSLHRTTPSSQKRAA
                     AVLLSNTALIELLEKMLALTWTEADSSPRTALLCSAWLLTASFSAQQNSGNLQVHQTL
                     SVELNQVLKALSFPKKSALLSAAILRFLRTALQQSFSSAFVAWVPSGGQPLSAPEDDV
                     LAPLGTSQVLSLLIGLQNLLVQKDPLLSQACIGCLEALLDYLHARSPDVALHVASQPW
                     NRFLLFTLLDSGENAFLRPEILRLMTLFVQYRSSGILSREEVALILQGAALADLSTLS
                     KDTLQALHGFLLQVQRIGLLNDNNMTQTLQASLEGLCSRTFPAQPVFQDMLCLGGVSV
                     SLSHIRD"
     exon            219..342
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..393
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..467
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..573
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..777
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..908
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1023
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1140
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1240
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1375
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1490
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1582
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1724
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1836
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1897
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..1995
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2164
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2312
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2588
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2754
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2859
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..2970
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            2971..3134
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3213
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3389
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3471
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            3472..3578
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3710
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            3711..3823
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..4018
                     /gene="Mei1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcggcgc gggaaaactt gcgctacaga gctgaagcga ggaggtggca gtggggcaga
       61 tgaaggctgc tgaccattct gcgttcggga gagatgaaga agccgtgctg ctcctggaga
      121 ggactcatca ccggcacgat ccgcgctggt tgctgccggt gtcccctcac gtctgcctgg
      181 cctgcgcatt ggagctgctg ccggagcccg gcgtgtcgct ggtgcgcaag aagcacgtgc
      241 tgttctgctt ccaagatgcc ctggtgaggc acacctcctt ggtcacccag ctggtagctc
      301 aggaccccag agtctgcatc cattttgtac gcgtgctttt cggactgtta agcagtgtgg
      361 aagacgggag tgtggcagac ctctgtattg aagtccttat ccagctcact actcagccca
      421 atatggagca gaccatccag tgcctactga atgagtgtca cagagagctg tgtaacctgc
      481 cctccatggg tggcagcctg gccaccacga ctcttcttgg caagctggtg aatgccattc
      541 ctgatttggc agaagatctt gtcatggagt acggcaactt gatggagcat ctgttgagag
      601 gcttggttta ccccaatgag ggggtgcagg cttccatctg ttacctctac gggaagctct
      661 actcctcgcc cacggctgct gagatgcttt ccggccattt ccgggagaag ctgtgtgccc
      721 tcttcctttc cactctggac aacgcccaga caagggacct acagatcaac tgcttgggtt
      781 tgctaaggca gctactgaag tacgatctct ttgtgtccgt gatcatgagc aagtctgtgc
      841 cggtggaggg tgccgagagt gttgagcagc catcgagaga gacctcacta ccattggtgc
      901 tcaaaaagtt tctcctgtcc agagatgagg tcctgcaggt ggccagctcc cactgtataa
      961 ctgcagtgct ggtccattcc cctgcaaagc atgctgtggc cttcatttat gctgacatcc
     1021 cagagttcct ctttgagcat ctttcatctt ccagcgaaat ccttgtctgg tccagctaca
     1081 actgcctgat actcctggca gaagagccac tcttcttttc aaagtgtcac acggtgtatg
     1141 ggatcgaggc cgtggtcagg agccttcagg gaagcctgca gatgaccaac acagaactgc
     1201 acaagcaggg cctgctgctc ttcgcagaaa tcctgactcg gcagcctgag gagatcaggc
     1261 tgttcacaag ctccgccatg tgcagagatg ccagccgtgc cctgcaggag gccgtgagca
     1321 gccctgtgtt agcggtggct gctgaagcac tgagggccat ttcagctttt ctgaggaagg
     1381 accaccagag ctctctgccc gtgcaataca gagcccttcg tgccttgctt gaagccatgc
     1441 tgagccgatg tatggaattt tcccagaccc ctctgaacag gaggtccctg ggccacgctt
     1501 gcagtagaaa cttagagaag gccactcttc gaaaggggaa gttccttctg agcaccctgg
     1561 aggggtttag aaacgcctgc aggttggctg tggaattcca aggtgagcct tctgcccagg
     1621 agaatccctt cacagctccc agcgcagaga aggaagacac cttggaggcc ttctcagagt
     1681 ttcttcttag tgcctgtgac tccctgtgta tccccatgat gatgaggtac tcggaggaga
     1741 ccacgcatcc aaacctgatg gaggttttcc tgtcaattct acacagcctc tttgtcatcg
     1801 ttccccacat gaaggtgaag ttctccagga agcttgctga tgcatcgttc atacgactga
     1861 ccctggagct gaaggccagg ttctgcagtg gccagagtca ctcgtcccta aatcaggtgt
     1921 gctccagctt cctctactac atgtgcctca atctcctctt tgctccagag aagacggaat
     1981 cactttccca agaagaactc cctgcagtgt ctgagttcct acaacatgga ctgccccaca
     2041 taagcagcag gaccccagaa agtctggcct tcctgtcaga tcggcagcat gtggaggtgg
     2101 ccgcgcgcca gagacagtac tgcatcctgc tcctcttcta ccttgctcac atccatgatg
     2161 acaggtttgt ccctgatgca gagctctgtg tggctgtgca gagcttcctt ttgtctctgc
     2221 aggaccaggg tgagtgccct ccaccagtgg tctgcaaagc tgccatctat ctgttggcgg
     2281 tgtgccaaga caaggactgt gcactgggtg aggccgtggt cagtgcaatc agaaaatgcc
     2341 tagagggcac ctcagacctg cgcctggtct acactcacca cccgctcctg ctcaggctct
     2401 tcctggtgtg cccagggctg atgggtaggt ttgggcaccg cgtcctggag ctttggttct
     2461 cttgggaaga gagcggctat gagaacctgg atgatgactc gtctccgggg cgaaccgtct
     2521 ttcccgccaa cttcgcagcc ctgttccaga tgctcaggag catgcccagc gtcctgctca
     2581 ttctgctgga cctcgtctat tccagtcctg tggacacagc ccacaaggtt ctgattgtcc
     2641 tgagggcctt ccttcgggag aatgaagaca ttgaagtggg cggtctcatc cgaggccact
     2701 tcctgctcat cctgcagcgc ctcttggtgg agtacggagc ctccccctca ggagcctctg
     2761 ggaacctgcc gctgctgctg aacctcctct cctcgctgca gctgaggact gagtcggaac
     2821 aggaactgga cagcatggcc atgaagctgc ttcaccaagt gagcaagctg tgtgggaagt
     2881 gcagccctgc agatgtggac atcctgcagc cctccttcaa cttcttgtac tggagtcttc
     2941 atcggaccac acccagtagt cagaaaagag ctgctgctgt cctgctgagc aacacagcct
     3001 tgattgagct tctggagaag atgctggccc tcacctggac agaggcagac tcctctccca
     3061 ggacggcact gctctgctct gcctggctgc tcactgcctc tttctccgcc cagcagaaca
     3121 gtggcaattt gcaggtccat cagacattat ctgtggaact gaaccaagta ttgaaggctc
     3181 tcagctttcc aaaaaagtcg gcattgctgt cagctgccat cctacgattc ctgcggacgg
     3241 ccttgcaaca aagcttttcc tctgcctttg tggcctgggt accctcaggg ggtcaaccac
     3301 tgtcagctcc tgaagatgat gtcctagctc cactgggaac atcacaagtg ctatccctgt
     3361 tgattgggct ccagaacctc ctggtacaga aagaccctct gttatctcaa gcttgtattg
     3421 gctgtctgga agccttgctc gattacctgc acgccaggag cccagacgtc gcactccatg
     3481 tggcctccca gccctggaat cggtttttgc tgttcaccct cttggattct ggagagaatg
     3541 ccttcctcag acctgaaata ctgagactta tgaccttgtt cgtgcagtac cggagcagtg
     3601 gcatcctctc tcgtgaagag gtggctctca ttttgcaagg tgcagctttg gctgacctgt
     3661 caactctctc aaaagataca ctccaggctc tgcatggctt cctcctgcag gtacagcgca
     3721 tcggtctcct aaatgacaac aacatgaccc agaccttgca agcctccttg gagggccttt
     3781 gctcccgcac cttcccagcc cagccagtct ttcaagacat gctttgcctt ggaggtgtgt
     3841 ctgtttccct gtctcacatc agagactgag acataaaggc ccagaaacag cagaaaaaat
     3901 gagacctgca gattcaggac acaattgtta aggggcaaac gacacgatca cgccttcctc
     3961 tggagctatt ttactccacc gtggaaatgg aatcaggaaa taaaataata cattatcg
//
