LOCUS       NM_001100657            4054 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus multiple EGF-like domains 10 (Megf10), mRNA.
ACCESSION   NM_001100657 XM_001059780 XM_238019
VERSION     NM_001100657.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4054)
  AUTHORS   Saha,M., Mitsuhashi,S., Jones,M.D., Manko,K., Reddy,H.M.,
            Bruels,C.C., Cho,K.A., Pacak,C.A., Draper,I. and Kang,P.B.
  TITLE     Consequences of MEGF10 deficiency on myoblast function and Notch1
            interactions
  JOURNAL   Hum Mol Genet 26 (15), 2984-3000 (2017)
   PUBMED   28498977
REFERENCE   2  (bases 1 to 4054)
  AUTHORS   Iram,T., Ramirez-Ortiz,Z., Byrne,M.H., Coleman,U.A., Kingery,N.D.,
            Means,T.K., Frenkel,D. and El Khoury,J.
  TITLE     Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic
            Cells by Astrocytes
  JOURNAL   J Neurosci 36 (19), 5185-5192 (2016)
   PUBMED   27170117
REFERENCE   3  (bases 1 to 4054)
  AUTHORS   Kay,J.N., Chu,M.W. and Sanes,J.R.
  TITLE     MEGF10 and MEGF11 mediate homotypic interactions required for
            mosaic spacing of retinal neurons
  JOURNAL   Nature 483 (7390), 465-469 (2012)
   PUBMED   22407321
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4054)
  AUTHORS   Logan,C.V., Lucke,B., Pottinger,C., Abdelhamed,Z.A., Parry,D.A.,
            Szymanska,K., Diggle,C.P., van Riesen,A., Morgan,J.E., Markham,G.,
            Ellis,I., Manzur,A.Y., Markham,A.F., Shires,M., Helliwell,T.,
            Scoto,M., Hubner,C., Bonthron,D.T., Taylor,G.R., Sheridan,E.,
            Muntoni,F., Carr,I.M., Schuelke,M. and Johnson,C.A.
  TITLE     Mutations in MEGF10, a regulator of satellite cell myogenesis,
            cause early onset myopathy, areflexia, respiratory distress and
            dysphagia (EMARDD)
  JOURNAL   Nat Genet 43 (12), 1189-1192 (2011)
   PUBMED   22101682
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4054)
  AUTHORS   Wu,H.H., Bellmunt,E., Scheib,J.L., Venegas,V., Burkert,C.,
            Reichardt,L.F., Zhou,Z., Farinas,I. and Carter,B.D.
  TITLE     Glial precursors clear sensory neuron corpses during development
            via Jedi-1, an engulfment receptor
  JOURNAL   Nat Neurosci 12 (12), 1534-1541 (2009)
   PUBMED   19915564
REFERENCE   6  (bases 1 to 4054)
  AUTHORS   Holterman,C.E., Le Grand,F., Kuang,S., Seale,P. and Rudnicki,M.A.
  TITLE     Megf10 regulates the progression of the satellite cell myogenic
            program
  JOURNAL   J Cell Biol 179 (5), 911-922 (2007)
   PUBMED   18056409
REFERENCE   7  (bases 1 to 4054)
  AUTHORS   Suzuki,E. and Nakayama,M.
  TITLE     MEGF10 is a mammalian ortholog of CED-1 that interacts with
            clathrin assembly protein complex 2 medium chain and induces large
            vacuole formation
  JOURNAL   Exp Cell Res 313 (17), 3729-3742 (2007)
   PUBMED   17643423
REFERENCE   8  (bases 1 to 4054)
  AUTHORS   Hamon,Y., Trompier,D., Ma,Z., Venegas,V., Pophillat,M.,
            Mignotte,V., Zhou,Z. and Chimini,G.
  TITLE     Cooperation between engulfment receptors: the case of ABCA1 and
            MEGF10
  JOURNAL   PLoS One 1 (1), e120 (2006)
   PUBMED   17205124
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4054)
  AUTHORS   Asakura,K., Pogulis,R.J., Pease,L.R. and Rodriguez,M.
  TITLE     A monoclonal autoantibody which promotes central nervous system
            remyelination is highly polyreactive to multiple known and novel
            antigens
  JOURNAL   J Neuroimmunol 65 (1), 11-19 (1996)
   PUBMED   8642059
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XM_001059780.1, XM_238019.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.74108.1,
                                           SRR26360176.2055538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000018.1  52847781-52847913
            134-235             JAXUCZ010000018.1  52855141-52855242
            236-336             JAXUCZ010000018.1  52856743-52856843
            337-429             JAXUCZ010000018.1  52876175-52876267
            430-676             JAXUCZ010000018.1  52892746-52892992
            677-797             JAXUCZ010000018.1  52894736-52894856
            798-934             JAXUCZ010000018.1  52898398-52898534
            935-1147            JAXUCZ010000018.1  52903838-52904050
            1148-1322           JAXUCZ010000018.1  52912540-52912714
            1323-1443           JAXUCZ010000018.1  52913967-52914087
            1444-1607           JAXUCZ010000018.1  52914842-52915005
            1608-1710           JAXUCZ010000018.1  52917343-52917445
            1711-1857           JAXUCZ010000018.1  52928120-52928266
            1858-1992           JAXUCZ010000018.1  52929401-52929535
            1993-2121           JAXUCZ010000018.1  52930004-52930132
            2122-2250           JAXUCZ010000018.1  52933985-52934113
            2251-2379           JAXUCZ010000018.1  52936303-52936431
            2380-2508           JAXUCZ010000018.1  52938424-52938552
            2509-2745           JAXUCZ010000018.1  52940613-52940849
            2746-2873           JAXUCZ010000018.1  52942066-52942193
            2874-2997           JAXUCZ010000018.1  52943162-52943285
            2998-3042           JAXUCZ010000018.1  52947903-52947947
            3043-3249           JAXUCZ010000018.1  52948644-52948850
            3250-4054           JAXUCZ010000018.1  52949871-52950675
FEATURES             Location/Qualifiers
     source          1..4054
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..4054
                     /gene="Megf10"
                     /note="multiple EGF-like domains 10"
                     /db_xref="GeneID:291445"
                     /db_xref="RGD:735084"
     exon            1..133
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..3455
                     /gene="Megf10"
                     /note="multiple epidermal growth factor-like domains
                     protein 10"
                     /codon_start=1
                     /product="multiple epidermal growth factor-like domains
                     protein 10 precursor"
                     /protein_id="NP_001094127.1"
                     /db_xref="GeneID:291445"
                     /db_xref="RGD:735084"
                     /translation="MAISSSSCLGLICSLLCHWLRAASSLNLEDPNVCSHWESYSVTV
                     QESYPHPFDQIYYTSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESR
                     DVCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCSSRCQCKNRALC
                     NPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHITGECRCSPGYTG
                     AFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKN
                     CSQECQCHNGGACDAATGQCHCSPGYTGERCQDECPVGTYGVRCAETCRCVNGGKCYH
                     VSGTCLCEAGFSGEFCEARLCPEGLYGIKCDKRCPCHLDNTHSCHPMSGECGCKPGWS
                     GLYCNETCSPGFYGEACQQICSCQNGADCDSVSGRCACAPGFKGTDCSTPCPLGRYGI
                     NCSSRCGCKNDAVCSPVDGSCICKAGWHGVDCSISCPSGTWGFGCNLTCQCLNGGACN
                     TLDGTCTCAPGWRGEKCEFPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGV
                     HCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRC
                     SQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGVCTCTNNGTCN
                     PIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGL
                     YCTQRCPLGFYGKDCALVCQCQNGADCDHISGQCTCRTGFMGRHCEQKCPAGTYGYGC
                     RQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSYQI
                     GAIAGIVVLLLVVLFLLALFVIYRHKQKRKESSMPAVTYTPAMRVINADYTIAETLPH
                     SNGGNANSHYFTNPSYHTLSQCAASPHVNNRDRMTIAKSKNNQLFVNLKNVNPGKRGA
                     LVDCTGTLPADWKQGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSTCSLSSSENPY
                     ATIKDPPALLPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPTVSVVQGVF
                     SNNGHVTQDPYDLPKNSHIPCHYDLLPVRDSSSSPKREDGGGSSSSTTTSNSSNSSE"
     exon            134..235
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            236..336
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            337..429
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            430..676
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            677..797
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            798..934
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1147
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1322
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1443
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1607
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1710
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1857
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1992
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2121
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2250
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2379
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2508
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2745
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2873
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..2997
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3042
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3249
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..4054
                     /gene="Megf10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgttcttc aaagaaaatg gctatttctt caagctcctg cctgggcctc atctgctcac
       61 tgctgtgcca ctggctgagg gcagcatcct cactgaacct ggaagacccc aatgtatgca
      121 gccactggga aagctactca gtgactgtgc aggagtctta cccacatccc ttcgatcaga
      181 tttactacac aagctgcact gacatactga actggtttaa atgcactcgg cacagagtga
      241 gctaccggac agcctaccgc catggggaga aaaccatgta cagacgcaaa tcccagtgtt
      301 gccccggatt ttatgaaagt cgagacgtgt gtgtccctca ctgcgctgat aaatgcgtcc
      361 acggtcgctg catcgctcca aacacctgtc agtgtgagcc tggctggggt gggaccaact
      421 gtagcagtgc ttgtgacggt gatcactggg gacctcactg cagcagccgg tgtcagtgca
      481 aaaacagagc tttgtgtaac cccatcaccg gagcttgtca ctgcgccgcg ggctaccggg
      541 gatggcgctg tgaggaccgt tgtgaacagg gcacctacgg taacgactgt catcaaaggt
      601 gccagtgtca gaatggagcg acctgtgacc acatcactgg ggaatgtcgt tgttcacctg
      661 gatacactgg agccttctgt gaggatctgt gtcctcctgg caaacatggc ccacagtgtg
      721 agcagagatg tccctgccaa aatggaggcg tgtgccatca tgtcactgga gagtgctcct
      781 gcccttctgg ctggatgggc acagtgtgtg gtcagccctg ccccgagggt cgctttggaa
      841 agaactgttc ccaagaatgt cagtgccaca atggaggagc gtgtgatgct gccacaggcc
      901 aatgtcactg cagcccagga tacacagggg aacggtgtca ggatgaatgt cctgttggaa
      961 cctatggagt tcgctgtgct gagacctgca ggtgtgttaa tggagggaag tgttaccatg
     1021 tgagcggcac atgcctatgc gaagcaggtt tttcaggtga attttgcgag gctcgtctgt
     1081 gccctgaggg gctttacggc atcaaatgtg acaagcggtg cccctgccac ctggacaata
     1141 ctcatagctg tcatcccatg tctggagagt gtggctgcaa gccgggttgg tctggactgt
     1201 actgtaatga aacatgctct cctggattct acggggaagc ttgccaacag atctgcagct
     1261 gccaaaacgg ggctgactgt gacagtgtga gtggaaggtg tgcctgtgct ccaggattca
     1321 aaggaactga ctgctctact ccgtgtcctc tgggacgcta tgggataaat tgttcttctc
     1381 gctgtggctg taaaaacgat gctgtctgtt ctcctgtgga tggatcgtgc atctgtaagg
     1441 caggctggca cggggtggac tgttccatca gctgccccag tggcacatgg ggctttggct
     1501 gtaatctaac ctgtcagtgc ctcaatggcg gtgcctgcaa cacactggac ggcacctgca
     1561 cctgtgcgcc gggatggcga ggggagaaat gtgaatttcc ctgccaggat ggcacatatg
     1621 ggctgaactg tgctgagcgc tgtgactgca gccatgcaga cggatgtcac cccactaccg
     1681 gccattgccg atgcctccct ggatggtcag gtgtgcactg tgacagtgtg tgtgctgagg
     1741 gacgctgggg tcctaactgc tcgctgccct gctactgtaa aaatggggct tcgtgttctc
     1801 ccgatgatgg catctgtgaa tgcgcacccg gattccgagg caccacttgc cagagaatct
     1861 gctccccggg cttttatgga caccgctgta gccagacatg cccacagtgt gtgcacagca
     1921 gtggaccatg ccaccacatc acaggcctgt gtgactgctt gcctggcttc actggcgccc
     1981 tgtgcaatga agtgtgtccc agtggcagat ttgggaagaa ctgtgcaggt gtttgtacct
     2041 gcaccaacaa cggcacctgt aaccccatcg accggtcctg tcagtgctac ccaggctgga
     2101 ttggcagtga ctgctcccag ccctgtccac cagcccactg gggtccgaac tgcatccata
     2161 catgcaactg ccacaatgga gccttttgca gcgcctatga tggggaatgc aaatgcactc
     2221 ctggctggac ggggctctac tgcactcaga gatgccctct gggcttctat ggcaaggact
     2281 gtgcactggt atgccaatgt caaaacggag ctgactgcga ccacatctcg gggcagtgta
     2341 cctgccgcac gggattcatg ggacggcact gtgaacagaa atgccctgcg ggaacatacg
     2401 gctatggctg tcgccagatc tgcgactgtc tgaacaactc cacctgtgac cacatcaccg
     2461 gcacgtgtta ctgtagccca gggtggaaag gagcacgatg tgaccaagct ggggtcatca
     2521 tcgtgggcaa tctgaacagc ttaagcagga ccagcaccgc ccttcctgct gactcctatc
     2581 agattggggc catcgcgggc atcgtggtcc ttctgcttgt tgtgctcttc ctgctggcgc
     2641 tgttcgttat ctacagacac aagcagaaga ggaaggaatc gagcatgccg gccgtgacct
     2701 acacccctgc catgagggtt atcaatgcag actataccat tgcagaaacc ctgcctcaca
     2761 gcaatggcgg aaatgccaac agccactact tcaccaatcc cagttatcac acacttagcc
     2821 agtgtgccgc gtcccctcat gtgaacaaca gggacaggat gaccattgca aagtcaaaaa
     2881 acaatcaact gtttgtgaat cttaaaaatg tgaatccagg gaagagaggc gctttggtgg
     2941 actgcactgg gacgttgcca gctgactgga agcaaggagg ctacctcaat gaacttggtg
     3001 cttttgggct ggacagaagc tacatgggaa agtccttaaa agatctgggg aagaattctg
     3061 agtacaattc aagtacttgt tccctaagca gctcggagaa cccatatgcc accattaaag
     3121 accctcctgc gctcttgcct aaaagctccg agtgtggcta cgtggagatg aagtcgccag
     3181 cgcgaagaga ctccccatat gcagagatca ataactcaac ttcagccaac aggaatgtct
     3241 atgaagtcga acctacagtc agtgtggtgc aaggagtatt cagcaacaat ggtcatgtca
     3301 cccaagaccc atatgacctt ccaaagaaca gtcacatccc ttgccattat gacctgctgc
     3361 cagtaaggga cagttcatcc tccccaaaga gagaggatgg tggtggcagc agcagcagca
     3421 ccaccaccag caacagcagc aacagcagcg aatgacatca aaggactact gggtgaccat
     3481 tggtactctt ttcaagcctt cagttcatct ccagttggca ctgcagatga ctgtgaatta
     3541 ctctaataag cagttgttgg acatgtacca gaaagctcca agctgaggct aacacccatc
     3601 gaggtgtgtt gtgatcacag ggcttagaag gagagagctt catgatttct ccttgctgtt
     3661 aggttaggaa tggcaccaat gacttgtttt aagatgttgg ctgataaggt gaacttcatg
     3721 ggacctttaa gagacagaga ctggaggaga cattgtattg tcacctggaa aactaaagtc
     3781 tatttgttgt ctgtaacatc acagagccac tcctaggatc gtgcaggtca ccacatgttt
     3841 atctaagaaa agtgaaaact gccaaacaca taggagacaa ggaatattct cctgagtcct
     3901 ccttgcataa tggttttttt tttccatttg gactcaagat cagaagcatt ctgtcaggtg
     3961 gtaggattgg atagcaatga gagcaaatcg aaacataaaa cctttgtttg tttttaggat
     4021 gagaaatgtt caattagaat tattttagac atag
//
