LOCUS       NP_001094127            1145 aa            linear   ROD 30-MAR-2024
DEFINITION  multiple epidermal growth factor-like domains protein 10 precursor
            [Rattus norvegicus].
ACCESSION   NP_001094127 XP_001059780 XP_238019
VERSION     NP_001094127.1
DBSOURCE    REFSEQ: accession NM_001100657.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1145)
  AUTHORS   Saha,M., Mitsuhashi,S., Jones,M.D., Manko,K., Reddy,H.M.,
            Bruels,C.C., Cho,K.A., Pacak,C.A., Draper,I. and Kang,P.B.
  TITLE     Consequences of MEGF10 deficiency on myoblast function and Notch1
            interactions
  JOURNAL   Hum Mol Genet 26 (15), 2984-3000 (2017)
   PUBMED   28498977
REFERENCE   2  (residues 1 to 1145)
  AUTHORS   Iram,T., Ramirez-Ortiz,Z., Byrne,M.H., Coleman,U.A., Kingery,N.D.,
            Means,T.K., Frenkel,D. and El Khoury,J.
  TITLE     Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic
            Cells by Astrocytes
  JOURNAL   J Neurosci 36 (19), 5185-5192 (2016)
   PUBMED   27170117
REFERENCE   3  (residues 1 to 1145)
  AUTHORS   Kay,J.N., Chu,M.W. and Sanes,J.R.
  TITLE     MEGF10 and MEGF11 mediate homotypic interactions required for
            mosaic spacing of retinal neurons
  JOURNAL   Nature 483 (7390), 465-469 (2012)
   PUBMED   22407321
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1145)
  AUTHORS   Logan,C.V., Lucke,B., Pottinger,C., Abdelhamed,Z.A., Parry,D.A.,
            Szymanska,K., Diggle,C.P., van Riesen,A., Morgan,J.E., Markham,G.,
            Ellis,I., Manzur,A.Y., Markham,A.F., Shires,M., Helliwell,T.,
            Scoto,M., Hubner,C., Bonthron,D.T., Taylor,G.R., Sheridan,E.,
            Muntoni,F., Carr,I.M., Schuelke,M. and Johnson,C.A.
  TITLE     Mutations in MEGF10, a regulator of satellite cell myogenesis,
            cause early onset myopathy, areflexia, respiratory distress and
            dysphagia (EMARDD)
  JOURNAL   Nat Genet 43 (12), 1189-1192 (2011)
   PUBMED   22101682
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1145)
  AUTHORS   Wu,H.H., Bellmunt,E., Scheib,J.L., Venegas,V., Burkert,C.,
            Reichardt,L.F., Zhou,Z., Farinas,I. and Carter,B.D.
  TITLE     Glial precursors clear sensory neuron corpses during development
            via Jedi-1, an engulfment receptor
  JOURNAL   Nat Neurosci 12 (12), 1534-1541 (2009)
   PUBMED   19915564
REFERENCE   6  (residues 1 to 1145)
  AUTHORS   Holterman,C.E., Le Grand,F., Kuang,S., Seale,P. and Rudnicki,M.A.
  TITLE     Megf10 regulates the progression of the satellite cell myogenic
            program
  JOURNAL   J Cell Biol 179 (5), 911-922 (2007)
   PUBMED   18056409
REFERENCE   7  (residues 1 to 1145)
  AUTHORS   Suzuki,E. and Nakayama,M.
  TITLE     MEGF10 is a mammalian ortholog of CED-1 that interacts with
            clathrin assembly protein complex 2 medium chain and induces large
            vacuole formation
  JOURNAL   Exp Cell Res 313 (17), 3729-3742 (2007)
   PUBMED   17643423
REFERENCE   8  (residues 1 to 1145)
  AUTHORS   Hamon,Y., Trompier,D., Ma,Z., Venegas,V., Pophillat,M.,
            Mignotte,V., Zhou,Z. and Chimini,G.
  TITLE     Cooperation between engulfment receptors: the case of ABCA1 and
            MEGF10
  JOURNAL   PLoS One 1 (1), e120 (2006)
   PUBMED   17205124
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 1145)
  AUTHORS   Asakura,K., Pogulis,R.J., Pease,L.R. and Rodriguez,M.
  TITLE     A monoclonal autoantibody which promotes central nervous system
            remyelination is highly polyreactive to multiple known and novel
            antigens
  JOURNAL   J Neuroimmunol 65 (1), 11-19 (1996)
   PUBMED   8642059
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XP_001059780.1, XP_238019.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.74108.1,
                                           SRR26360176.2055538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1145
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     Protein         1..1145
                     /product="multiple epidermal growth factor-like domains
                     protein 10 precursor"
                     /note="multiple epidermal growth factor-like domains
                     protein 10"
                     /calculated_mol_wt=120215
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2610
     Region          31..100
                     /region_name="EMI"
                     /note="EMI domain; pfam07546"
                     /db_xref="CDD:462204"
     Region          281..318
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domai;
                     smart00180"
                     /db_xref="CDD:214543"
     Site            order(281,283,289,296,298,307)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          542..587
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     CDS             1..1145
                     /gene="Megf10"
                     /coded_by="NM_001100657.1:18..3455"
                     /db_xref="GeneID:291445"
                     /db_xref="RGD:735084"
ORIGIN      
        1 maissssclg licsllchwl raasslnled pnvcshwesy svtvqesyph pfdqiyytsc
       61 tdilnwfkct rhrvsyrtay rhgektmyrr ksqccpgfye srdvcvphca dkcvhgrcia
      121 pntcqcepgw ggtncssacd gdhwgphcss rcqcknralc npitgachca agyrgwrced
      181 rceqgtygnd chqrcqcqng atcdhitgec rcspgytgaf cedlcppgkh gpqceqrcpc
      241 qnggvchhvt gecscpsgwm gtvcgqpcpe grfgkncsqe cqchnggacd aatgqchcsp
      301 gytgercqde cpvgtygvrc aetcrcvngg kcyhvsgtcl ceagfsgefc earlcpegly
      361 gikcdkrcpc hldnthschp msgecgckpg wsglycnetc spgfygeacq qicscqngad
      421 cdsvsgrcac apgfkgtdcs tpcplgrygi ncssrcgckn davcspvdgs cickagwhgv
      481 dcsiscpsgt wgfgcnltcq clnggacntl dgtctcapgw rgekcefpcq dgtyglncae
      541 rcdcshadgc hpttghcrcl pgwsgvhcds vcaegrwgpn cslpcyckng ascspddgic
      601 ecapgfrgtt cqricspgfy ghrcsqtcpq cvhssgpchh itglcdclpg ftgalcnevc
      661 psgrfgknca gvctctnngt cnpidrscqc ypgwigsdcs qpcppahwgp ncihtcnchn
      721 gafcsaydge ckctpgwtgl yctqrcplgf ygkdcalvcq cqngadcdhi sgqctcrtgf
      781 mgrhceqkcp agtygygcrq icdclnnstc dhitgtcycs pgwkgarcdq agviivgnln
      841 slsrtstalp adsyqigaia givvlllvvl fllalfviyr hkqkrkessm pavtytpamr
      901 vinadytiae tlphsnggna nshyftnpsy htlsqcaasp hvnnrdrmti aksknnqlfv
      961 nlknvnpgkr galvdctgtl padwkqggyl nelgafgldr symgkslkdl gknseynsst
     1021 cslsssenpy atikdppall pkssecgyve mksparrdsp yaeinnstsa nrnvyevept
     1081 vsvvqgvfsn nghvtqdpyd lpknshipch ydllpvrdss sspkredggg sssstttsns
     1141 snsse
//
