LOCUS       NM_031634               3223 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus MEFV innate immunity regulator, pyrin (Mefv),
            mRNA.
ACCESSION   NM_031634
VERSION     NM_031634.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3223)
  AUTHORS   Kimura,T., Jain,A., Choi,S.W., Mandell,M.A., Schroder,K.,
            Johansen,T. and Deretic,V.
  TITLE     TRIM-mediated precision autophagy targets cytoplasmic regulators of
            innate immunity
  JOURNAL   J Cell Biol 210 (6), 973-989 (2015)
   PUBMED   26347139
REFERENCE   2  (bases 1 to 3223)
  AUTHORS   Celik,S., Tangi,F. and Oktenli,C.
  TITLE     Increased frequency of Mediterranean fever gene variants in
            multiple myeloma
  JOURNAL   Oncol Lett 8 (4), 1735-1738 (2014)
   PUBMED   25202401
REFERENCE   3  (bases 1 to 3223)
  AUTHORS   Salah,S., Rizk,S., Lotfy,H.M., El Houchi,S., Marzouk,H. and
            Farag,Y.
  TITLE     MEFV gene mutations in Egyptian children with Henoch-Schonlein
            purpura
  JOURNAL   Pediatr Rheumatol Online J 12, 41 (2014)
   PUBMED   25232290
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3223)
  AUTHORS   Vajjhala,P.R., Kaiser,S., Smith,S.J., Ong,Q.R., Soh,S.L.,
            Stacey,K.J. and Hill,J.M.
  TITLE     Identification of multifaceted binding modes for pyrin and ASC
            pyrin domains gives insights into pyrin inflammasome assembly
  JOURNAL   J Biol Chem 289 (34), 23504-23519 (2014)
   PUBMED   25006247
REFERENCE   5  (bases 1 to 3223)
  AUTHORS   Mohammadnejad,L. and Farajnia,S.
  TITLE     Mediterranean Fever gene analysis in the azeri turk population with
            familial mediterranean Fever: evidence for new mutations associated
            with disease
  JOURNAL   Cell J 15 (2), 152-159 (2013)
   PUBMED   23862117
REFERENCE   6  (bases 1 to 3223)
  AUTHORS   Lachmann,H.J., Sengul,B., Yavuzsen,T.U., Booth,D.R., Booth,S.E.,
            Bybee,A., Gallimore,J.R., Soyturk,M., Akar,S., Tunca,M. and
            Hawkins,P.N.
  TITLE     Clinical and subclinical inflammation in patients with familial
            Mediterranean fever and in heterozygous carriers of MEFV mutations
  JOURNAL   Rheumatology (Oxford) 45 (6), 746-750 (2006)
   PUBMED   16403826
REFERENCE   7  (bases 1 to 3223)
  AUTHORS   Brik,R., Gershoni-Baruch,R., Shinawi,M., Barak,L. and Bentur,L.
  TITLE     Pulmonary manifestations and function tests in children genetically
            diagnosed with FMF
  JOURNAL   Pediatr Pulmonol 35 (6), 452-455 (2003)
   PUBMED   12746942
REFERENCE   8  (bases 1 to 3223)
  AUTHORS   Mansfield,E., Chae,J.J., Komarow,H.D., Brotz,T.M., Frucht,D.M.,
            Aksentijevich,I. and Kastner,D.L.
  TITLE     The familial Mediterranean fever protein, pyrin, associates with
            microtubules and colocalizes with actin filaments
  JOURNAL   Blood 98 (3), 851-859 (2001)
   PUBMED   11468188
REFERENCE   9  (bases 1 to 3223)
  AUTHORS   Papin,S., Duquesnoy,P., Cazeneuve,C., Pantel,J., Coppey-Moisan,M.,
            Dargemont,C. and Amselem,S.
  TITLE     Alternative splicing at the MEFV locus involved in familial
            Mediterranean fever regulates translocation of the
            marenostrin/pyrin protein to the nucleus
  JOURNAL   Hum Mol Genet 9 (20), 3001-3009 (2000)
   PUBMED   11115844
REFERENCE   10 (bases 1 to 3223)
  AUTHORS   Chae,J.J., Centola,M., Aksentijevich,I., Dutra,A., Tran,M.,
            Wood,G., Nagaraju,K., Kingma,D.W., Liu,P.P. and Kastner,D.L.
  TITLE     Isolation, genomic organization, and expression analysis of the
            mouse and rat homologs of MEFV, the gene for familial mediterranean
            fever
  JOURNAL   Mamm Genome 11 (6), 428-435 (2000)
   PUBMED   10818206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 24, 2020 this sequence version replaced NM_031634.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF143410.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               JAXUCZ010000010.1  12293782-12294120
            340-1188            JAXUCZ010000010.1  12295495-12296343
            1189-1529           JAXUCZ010000010.1  12297618-12297958
            1530-1625           JAXUCZ010000010.1  12298295-12298390
            1626-1844           JAXUCZ010000010.1  12299200-12299418
            1845-1867           JAXUCZ010000010.1  12299817-12299839
            1868-1983           JAXUCZ010000010.1  12301453-12301568
            1984-2276           JAXUCZ010000010.1  12301740-12302032
            2277-3223           JAXUCZ010000010.1  12302387-12303333
FEATURES             Location/Qualifiers
     source          1..3223
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..3223
                     /gene="Mefv"
                     /gene_synonym="pyrin"
                     /note="MEFV innate immunity regulator, pyrin"
                     /db_xref="GeneID:58923"
                     /db_xref="RGD:61889"
     exon            1..339
                     /gene="Mefv"
                     /gene_synonym="pyrin"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2312
                     /gene="Mefv"
                     /gene_synonym="pyrin"
                     /note="marenostrin; Mediterranean fever; MEFV, pyrin
                     innate immunity regulator; MEFV innate immuity regulator,
                     pyrin"
                     /codon_start=1
                     /product="pyrin"
                     /protein_id="NP_113822.2"
                     /db_xref="GeneID:58923"
                     /db_xref="RGD:61889"
                     /translation="MANTRVDHLLNTLEELLPYELEKFKFKLHTTSLEKGHSRIPLSL
                     VKMARPIKLTRLLLTYYGEEYAVRLTLQILRATNQRQLAEELHKATGPEHLTEENGVG
                     GSVQSSAENKDKGVKGSDVPGEDEAQQNDDESDILPPIQAEVGKGPQKKSLAKRKDQR
                     GPESLDSQTKPGARSAAPLYRRTLVTQSPGDKENRAGAQLRRNASSAGRLQGLYSNVP
                     GRREIKKAEVYLPSGKKRPRSLEITTYSKEGEPPNSEALPTQEETRNGSLIRTRTATL
                     NGRTTGTLEKGVGIPEHSMMLDEETSRNMSSKISLTREKRCTASWTENGNGGPETPET
                     LGETVSSILCDSCSPKVLLSLGEKLAQTPEDPASLGQAASKGRSRDKVACPLCHTQGE
                     LPAKACVQSSCSCSVAPGDPKASGRHSICFQCQSSRAGKSCEAQSPQFLPQCPRHMKQ
                     VQLLFCEDHREPICLICRLSQEHQGHRVRPIEEAALQYKEQIRKQLERLREMRGYVEE
                     HKLPADKKAEDFLKQTETQKQRISCPLEKLFQFLEQQEQLFVTWLQELVQTIGKVRET
                     YYTQVSLLDKLIGELEAKQDQPEWELMQDIGATLHRAETMTASELLGIPPGVKEKLHL
                     LYQKSKSAEKNMQRFSEMLGSEMAFSASDVATREGCRPSTTKAQALIPTVHLKCDGAH
                     TQDFDVILCAELEAGGSEPQDYLHPSSAQDTPELHEIHSQNNKRKFKSFLKWKPSFSR
                     TDRCLRTCW"
     exon            340..1188
                     /gene="Mefv"
                     /gene_synonym="pyrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1529
                     /gene="Mefv"
                     /gene_synonym="pyrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1625
                     /gene="Mefv"
                     /gene_synonym="pyrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1844
                     /gene="Mefv"
                     /gene_synonym="pyrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1867
                     /gene="Mefv"
                     /gene_synonym="pyrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1983
                     /gene="Mefv"
                     /gene_synonym="pyrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2276
                     /gene="Mefv"
                     /gene_synonym="pyrin"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..3223
                     /gene="Mefv"
                     /gene_synonym="pyrin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaagtctt cattttctgt cagaagccac gtagctggct gtagtccttc ctggcctgca
       61 tcatggccaa tacccgtgtt gaccatctgc taaacaccct ggaggagctg ctgccctatg
      121 aactagagaa attcaagttt aagttgcaca ccaccagcct ggagaagggc cactctagga
      181 tccccctgag cctcgtgaag atggccaggc caataaagct gaccagactc ctgctaacct
      241 actatgggga agaatatgct gtaaggctga ccctgcagat cctgcgggcc accaaccagc
      301 gccaactagc agaggagctt cacaaggcca caggcccaga acatttgact gaagaaaatg
      361 gagttggcgg ttctgtgcag tcttctgcag agaataagga caagggtgtg aagggatcag
      421 atgtccctgg agaggatgag gcacagcaga acgatgatga atcagacatc ctgccaccca
      481 tccaggcaga agtggggaag gggccccaga agaaatcact ggccaaaagg aaggatcaga
      541 ggggccctga gagcctggac tcacagacca agccaggggc caggagtgca gcaccactct
      601 ataggagaac cctggtgacc cagtccccag gggacaagga gaacagagcg ggtgctcagc
      661 tccgcaggaa tgccagctct gcagggaggc tgcaaggact ctacagcaat gtcccaggga
      721 ggagagagat caagaaggct gaagtgtatt tgccttcagg aaagaagcga cccaggagtc
      781 ttgaaattac cacttactca aaagaaggag aacccccaaa ttcagaagct cttccgactc
      841 aagaggaaac aagaaatggc agtctcattc gtacgagaac agccaccctg aatggaagga
      901 ctacggggac tctggaaaag ggtgtaggga ttccagaaca ttccatgatg ctggatgaag
      961 aaacatccag aaacatgtct tccaaaatat cgttgactag ggagaagaga tgcactgcgt
     1021 catggacaga aaatggaaac gggggtccag aaaccccaga gaccttggga gagacagtca
     1081 gcagcatact ctgtgactcc tgcagtccaa aagtgctgct gtcattaggt gaaaaactgg
     1141 cccagactcc agaagaccca gcatctttag gacaggcagc ttctaaagga aggtcacggg
     1201 acaaggttgc atgccctctt tgccacaccc aaggagaact gcctgctaag gcctgtgtgc
     1261 aaagttcctg tagctgctcg gttgctcctg gggaccccaa ggcctcaggc agacactcca
     1321 tatgcttcca gtgccaaagc tcgcgtgcag gaaagagctg tgaagcccag agcccccagt
     1381 tcctaccaca gtgcccacgt cacatgaagc aggtgcagct gctcttctgt gaggaccaca
     1441 gggagcccat ctgcctcatc tgcaggctga gccaggagca tcaaggacat cgagtgcgcc
     1501 ccatagagga ggctgcacta cagtacaagg agcagatccg gaagcagttg gagcgcctgc
     1561 gggagatgag gggatatgtg gaggagcaca agcttccggc agacaagaaa gcagaggact
     1621 tcctgaaaca aacagaaact cagaaacaga ggatatcatg tccgcttgag aagctattcc
     1681 aattcctgga gcagcaagag caactctttg tgacctggct gcaggagcta gtccagacca
     1741 tcggcaaggt ccgagagaca tactacaccc aggtttccct actggataag ctgattggag
     1801 aactagaggc caagcaagac cagccagagt gggagctcat gcaggacatt ggagccacct
     1861 tgcacagggc tgagacgatg actgcctctg agctgttggg cattcctcca ggcgttaaag
     1921 aaaaactgca cctgctctac cagaaatcaa agtccgccga gaagaatatg cagcgtttct
     1981 cagaaatgct gggctccgaa atggcattca gcgcttcaga tgtagcaaca cgggaagggt
     2041 gcaggcctag cacaaccaag gcccaggcct tgatccccac cgttcaccta aagtgtgatg
     2101 gtgcacacac acaggatttc gatgtaatac tttgcgcaga gctggaagct ggaggatcag
     2161 aacctcaaga ttaccttcat ccgtcgtcag ctcaagacac acctgagcta cacgagatcc
     2221 attctcagaa caacaaaaga aaatttaaat ctttcctgaa gtggaaacct tccttctcca
     2281 gaaccgacag gtgcttaaga acatgctggt aaatgcctaa atcaaggcaa gtactggctt
     2341 tggtacaccg ggtccctgta tgttcctgtc ccctaccgca atctcagtaa actccctctt
     2401 ccttagattg ggagcgcctt gggagaagcc cacacatccc catcccagct aggtcttctt
     2461 cttcctgcag ttgtcgtgac tgggacctag cagctgttca ccccagcctc atcttctgtg
     2521 gtgatacgaa gagtgcacgg acctgctgcc tgacactctc cagaggttct aaagttacat
     2581 caccatgctg gggactactc ctgtcttgga ctccagcggc tgtcactggg aggtggagta
     2641 tggagacaag acagttcaga gtcccaggaa cttgcaacgc tctggcgagc aggaagggga
     2701 ctataactca gtggagaatg gctcctggtg gtaataatag caacgcaaca ggaaggcaca
     2761 tttctccagc ctgtgaatga gggtggcccc aagcaggcgg gcagctttct agactacaca
     2821 gctaggagca acatgacatg tacctggcct ctggcttctc ccctccagtt cctgtcaacc
     2881 tgcctttaac cctggggaca tgaagaacaa catagctctt tggaccctca gtcctgccag
     2941 tgaccagata cttcaccgag cgcccaacac tgtgccaaca ttctggctta tgcctcacat
     3001 tcatgcactc ggaagtcatt aaaaaggtgt cagctggtgc aaggaatgga atgaatagga
     3061 agataataaa ctgagaggct gaggcaggat ggtacccgtg agtttgagtc taactggatg
     3121 gattcgggtt actctgactg gggtccagcc gtcaaaaaga aaaaacaata ttgtacttgt
     3181 attatttagt actattattg ctgtaataaa atattctgac aaa
//
