LOCUS       NM_030860               2165 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus myocyte enhancer factor 2D (Mef2d), mRNA.
ACCESSION   NM_030860 XM_001069089 XM_001069142
VERSION     NM_030860.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2165)
  AUTHORS   Cao,J., Guo,B., Li,S., Zhang,X., Zhang,X., Zhang,G., Sun,Y.,
            Wang,Y., Song,X. and Zhang,Z.
  TITLE     Neuroprotection against 1-Methyl-4-phenylpyridinium-induced
            cytotoxicity by naturally occurring polydatin through activation of
            transcription factor MEF2D
  JOURNAL   Neuroreport 32 (12), 1065-1072 (2021)
   PUBMED   34232128
  REMARK    GeneRIF: Neuroprotection against
            1-Methyl-4-phenylpyridinium-induced cytotoxicity by naturally
            occurring polydatin through activation of transcription factor
            MEF2D.
REFERENCE   2  (bases 1 to 2165)
  AUTHORS   Li,J., Aponte Paris,S., Thakur,H., Kapiloff,M.S. and
            Dodge-Kafka,K.L.
  TITLE     Muscle A-kinase-anchoring protein-beta-bound calcineurin toggles
            active and repressive transcriptional complexes of myocyte enhancer
            factor 2D
  JOURNAL   J Biol Chem 294 (7), 2543-2554 (2019)
   PUBMED   30523159
  REMARK    GeneRIF: these results highlight the importance of mAKAPbeta
            signalosomes for regulating MEF2D activity in striated muscle,
            affirming mAKAPbeta as a nodal regulator in the myocyte
            intracellular signaling network.
REFERENCE   3  (bases 1 to 2165)
  AUTHORS   Guo,B., Hu,S., Zheng,C., Wang,H., Luo,F., Li,H., Cui,W., Yang,X.,
            Cui,G., Mak,S., Choi,T.C., Ma,E.D., Wang,Y., Lee,S.M.Y., Zhang,Z.
            and Han,Y.
  TITLE     Substantial protection against MPTP-associated Parkinson's
            neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via
            activation of MEF2D and inhibition of MAO-B
  JOURNAL   Neuropharmacology 126, 12-24 (2017)
   PUBMED   28807675
  REMARK    GeneRIF: Study suggests that SU4312 provides therapeutic benefits
            in cellular and animal models of Parkinson's disease, possibly
            through multiple mechanisms including enhancement of myocyte
            enhancer factor 2D through the activation of PI3-K/Akt pathway.
REFERENCE   4  (bases 1 to 2165)
  AUTHORS   Li,K., Pan,J., Wang,J., Liu,F. and Wang,L.
  TITLE     MiR-665 regulates VSMCs proliferation via targeting FGF9 and MEF2D
            and modulating activities of Wnt/beta-catenin signaling
  JOURNAL   Am J Transl Res 9 (10), 4402-4414 (2017)
   PUBMED   29118903
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2165)
  AUTHORS   Desjardins,C.A. and Naya,F.J.
  TITLE     Antagonistic regulation of cell-cycle and differentiation gene
            programs in neonatal cardiomyocytes by homologous MEF2
            transcription factors
  JOURNAL   J Biol Chem 292 (25), 10613-10629 (2017)
   PUBMED   28473466
  REMARK    GeneRIF: MEF2A and MEF2D were absolutely required for cardiomyocyte
            survival, whereas MEF2C, despite its major role in cardiac
            morphogenesis and direct reprogramming, was dispensable for this
            process.
REFERENCE   6  (bases 1 to 2165)
  AUTHORS   Yang,C.C., Ornatsky,O.I., McDermott,J.C., Cruz,T.F. and Prody,C.A.
  TITLE     Interaction of myocyte enhancer factor 2 (MEF2) with a
            mitogen-activated protein kinase, ERK5/BMK1
  JOURNAL   Nucleic Acids Res 26 (20), 4771-4777 (1998)
   PUBMED   9753748
REFERENCE   7  (bases 1 to 2165)
  AUTHORS   Di Lisi,R., Millino,C., Calabria,E., Altruda,F., Schiaffino,S. and
            Ausoni,S.
  TITLE     Combinatorial cis-acting elements control tissue-specific
            activation of the cardiac troponin I gene in vitro and in vivo
  JOURNAL   J Biol Chem 273 (39), 25371-25380 (1998)
   PUBMED   9738004
REFERENCE   8  (bases 1 to 2165)
  AUTHORS   Black,B.L., Ligon,K.L., Zhang,Y. and Olson,E.N.
  TITLE     Cooperative transcriptional activation by the neurogenic basic
            helix-loop-helix protein MASH1 and members of the myocyte enhancer
            factor-2 (MEF2) family
  JOURNAL   J Biol Chem 271 (43), 26659-26663 (1996)
   PUBMED   8900141
REFERENCE   9  (bases 1 to 2165)
  AUTHORS   Hata,Y. and Sudhof,T.C.
  TITLE     A novel ubiquitous form of Munc-18 interacts with multiple
            syntaxins. Use of the yeast two-hybrid system to study interactions
            between proteins involved in membrane traffic
  JOURNAL   J Biol Chem 270 (22), 13022-13028 (1995)
   PUBMED   7768895
REFERENCE   10 (bases 1 to 2165)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081790.1.
            
            On or before Jun 25, 2006 this sequence version replaced
            XM_001069142.1, XM_001069089.1, NM_030860.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2165
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2165
                     /gene="Mef2d"
                     /note="myocyte enhancer factor 2D"
                     /db_xref="GeneID:81518"
                     /db_xref="RGD:621489"
     exon            1..324
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            325..508
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..1978
                     /gene="Mef2d"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2D"
                     /protein_id="NP_110487.2"
                     /db_xref="GeneID:81518"
                     /db_xref="RGD:621489"
                     /translation="MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNHSNKLFQYASTDMDKVLLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPD
                     GEDSLEQSPLLEDKYRRASEELDGLFRRYGSSVPAPNFAMPVTVPVSNQSSMQFSNPS
                     SSLVTPSLVTSSLTDPRLLSPQQPALQRNSVSPGLPQRPASAGAMLGGDLNSANGACP
                     SPVGNGYVSARASPGLLPVANGNGLNKVIPAKSPPPPTHNTQLGAPSRKPDLRVITSQ
                     GGKGLMHHLNNAQRLGVSQSTHSLTTPVVSVATPSLLSQGLPFSSMPTAYNTDYQLPS
                     AELSSLPAFSSPAGLALGNVTAWQQPQQPQQPQPPQPPQSQPQPPQPQPQQPPQQQPH
                     LVPVSLSNLIPGSPLPHVGAALTVTTHPHISIKSEPVSPSRERSPAPPPPAVFPAARP
                     EPGEGLSSPAGGSYETGDRDDGRGDFGPTLGLLRPAPEPEAEGSAVKRMRLDTWTLK"
     exon            509..712
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            713..850
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1061
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1118
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1309
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1439
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1659
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1966
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2138
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttctatct cgcaagctag gctgcgctgt gcctacgtcg gcctcgagtc tggggctgga
       61 ggagttgcct ttggagcccg aaaggaggaa ggaagcaaaa tatcaacaac cgtcgaggcg
      121 gcttgggcgc tcggctgcgt ccccgccgcc cgccgccgcc gcccccgcgc gcaccagggg
      181 gtcccggccc tgtggcgccg cccaggccgc gtggacgcgg cgccttcgct gttccccgtc
      241 cgagctgcgg cttcgcgcag ccgaggattc cgcggaccgg gccgaagctc ccggcgccgt
      301 gacaccccgt tcccccacgg gctggaggct gtgcataggt gttctgcaga ccatgaactg
      361 agcactagtc ccagacattc atgagcacag tgtgaggctc ctgatcacca cccagcagcc
      421 ccttcctctc tggcactaag gacccctgga gaagatgggg aggaaaaaga ttcagatcca
      481 gcgaatcact gatgaacgga accgccaggt gacattcacc aagcggaagt ttgggctgat
      541 gaagaaggcc tacgaactga gtgtgctgtg cgactgtgag atcgcgctca tcatcttcaa
      601 ccactccaac aagctgtttc agtacgccag caccgacatg gacaaggtgc tgctcaagta
      661 cacggagtac aacgagccgc atgagagccg caccaatgct gacatcattg agaccctgag
      721 gaagaagggt ttcaacggct gtgacagccc agagccggat ggggaggact cactggagca
      781 gagccccctg ctggaggaca agtaccggcg ggccagtgag gaactggatg ggctcttcag
      841 gcgctatggg tcatctgttc cggcccccaa ttttgccatg cctgtcacag tgcccgtgtc
      901 caatcagagc tccatgcagt tcagcaatcc aagtagctct ctggtcactc cttccctggt
      961 gacatcatcc cttacggacc cacggctcct gtccccccag cagccagcac tacagagaaa
     1021 cagtgtttct ccgggcctgc cccagcggcc tgctagtgca ggagccatgc tgggtggaga
     1081 cctcaacagt gctaatggag cctgccccag ccccgttggg aatggctacg tcagtgcccg
     1141 ggcttccccc ggcctcctcc ctgtggccaa tggcaacggc ctaaacaagg tcatccctgc
     1201 caagtctcca cccccaccca cccacaacac ccagcttgga gcccccagcc gcaagcctga
     1261 tctgcgggtc atcacttccc agggaggcaa agggttaatg catcatttga acaatgccca
     1321 gcgccttggg gtctcccagt ctacccactc gctcaccacc ccagtggttt ccgtggcaac
     1381 accaagttta ctcagccagg gcctcccctt ctcctccatg cccactgcct acaacacaga
     1441 ttaccagctg cccagtgcag agctttcctc cttaccagcc ttcagctcac ctgcagggct
     1501 ggcactaggc aacgtcaccg cctggcagca gccccagcag ccccagcagc cacaaccacc
     1561 acaaccgcca cagtcacagc cacagccacc acagccacag ccacagcagc cacctcagca
     1621 acagccccac ttggtccctg tttctctcag caacctcatc cctggcagcc ccttgcccca
     1681 tgtgggtgct gctctcactg tcactaccca cccccacatc agcatcaagt cagaaccagt
     1741 gtccccaagt cgtgaacgca gccctgcacc tcctccacca gctgtgttcc cagctgcccg
     1801 ccctgagcct ggcgaaggtc tcagcagccc agctggagga tcctatgaga ccggggaccg
     1861 ggatgatgga cggggggact ttgggcccac actaggcctg ctgcgcccag ccccagagcc
     1921 tgaggctgag ggctcagctg tgaagaggat gcggctggat acttggacat taaagtgatg
     1981 gttcccactc ccatctctca gcctccctga tgaagagttg acaatctcac cgcccacccc
     2041 tccctgtcct gggctcctcc cgctcgaccc cacttccttt cttctgctcc atgtcctgtt
     2101 gatggttaca tttgtgtata attatattat tatttttaaa aaaaaaaaaa aaaaaaaaaa
     2161 aaaaa
//
