LOCUS       NM_001399397            6304 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus myocyte enhancer factor 2C (Mef2c), transcript
            variant 1, mRNA.
ACCESSION   NM_001399397 XM_006231731
VERSION     NM_001399397.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6304)
  AUTHORS   Zhang,R., Sui,L., Hong,X., Yang,M. and Li,W.
  TITLE     MiR-448 promotes vascular smooth muscle cell proliferation and
            migration in through directly targeting MEF2C
  JOURNAL   Environ Sci Pollut Res Int 24 (28), 22294-22300 (2017)
   PUBMED   28799067
REFERENCE   2  (bases 1 to 6304)
  AUTHORS   Desjardins,C.A. and Naya,F.J.
  TITLE     Antagonistic regulation of cell-cycle and differentiation gene
            programs in neonatal cardiomyocytes by homologous MEF2
            transcription factors
  JOURNAL   J Biol Chem 292 (25), 10613-10629 (2017)
   PUBMED   28473466
  REMARK    GeneRIF: MEF2A and MEF2D were absolutely required for cardiomyocyte
            survival, whereas MEF2C, despite its major role in cardiac
            morphogenesis and direct reprogramming, was dispensable for this
            process.
REFERENCE   3  (bases 1 to 6304)
  AUTHORS   Cardoso,A.C., Pereira,A.H.M., Ambrosio,A.L.B., Consonni,S.R., Rocha
            de Oliveira,R., Bajgelman,M.C., Dias,S.M.G. and Franchini,K.G.
  TITLE     FAK Forms a Complex with MEF2 to Couple Biomechanical Signaling to
            Transcription in Cardiomyocytes
  JOURNAL   Structure 24 (8), 1301-1310 (2016)
   PUBMED   27427476
  REMARK    GeneRIF: In cardiomyocytes exposed to biomechanical stimulation,
            FAK accumulates in the nucleus, binds to and upregulates the
            transcriptional activity of MEF2c through an interaction with the
            FAK focal adhesion targeting (FAT) domain.
REFERENCE   4  (bases 1 to 6304)
  AUTHORS   Xu,Z., Han,Y., Liu,J., Jiang,F., Hu,H., Wang,Y., Liu,Q., Gong,Y.
            and Li,X.
  TITLE     MiR-135b-5p and MiR-499a-3p Promote Cell Proliferation and
            Migration in Atherosclerosis by Directly Targeting MEF2C
  JOURNAL   Sci Rep 5, 12276 (2015)
   PUBMED   26184978
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6304)
  AUTHORS   Paulin,R., Sutendra,G., Gurtu,V., Dromparis,P., Haromy,A.,
            Provencher,S., Bonnet,S. and Michelakis,E.D.
  TITLE     A miR-208-Mef2 axis drives the decompensation of right ventricular
            function in pulmonary hypertension
  JOURNAL   Circ Res 116 (1), 56-69 (2015)
   PUBMED   25287062
  REMARK    GeneRIF: Mef2c expression was sharply increased in compensating
            phase of right ventricular heart failure but lost in decompensation
            phase.
REFERENCE   6  (bases 1 to 6304)
  AUTHORS   Sato,H., Tsukada,T., Nagayoshi,M., Ikawa,Y., Aizawa,S. and
            Kato,M.V.
  TITLE     Repression of p53-dependent sequence-specific transactivation by
            MEF2c
  JOURNAL   Biochem Biophys Res Commun 214 (2), 468-474 (1995)
   PUBMED   7677753
REFERENCE   7  (bases 1 to 6304)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   8  (bases 1 to 6304)
  AUTHORS   Dechesne,C.A., Wei,Q., Eldridge,J., Gannoun-Zaki,L., Millasseau,P.,
            Bougueleret,L., Caterina,D. and Paterson,B.M.
  TITLE     E-box- and MEF-2-independent muscle-specific expression, positive
            autoregulation, and cross-activation of the chicken MyoD (CMD1)
            promoter reveal an indirect regulatory pathway
  JOURNAL   Mol Cell Biol 14 (8), 5474-5486 (1994)
   PUBMED   8035824
REFERENCE   9  (bases 1 to 6304)
  AUTHORS   Martin,J.F., Schwarz,J.J. and Olson,E.N.
  TITLE     Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the
            MEF-2 family of transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 90 (11), 5282-5286 (1993)
   PUBMED   8506376
REFERENCE   10 (bases 1 to 6304)
  AUTHORS   McDermott,J.C., Cardoso,M.C., Yu,Y.T., Andres,V., Leifer,D.,
            Krainc,D., Lipton,S.A. and Nadal-Ginard,B.
  TITLE     hMEF2C gene encodes skeletal muscle- and brain-specific
            transcription factors
  JOURNAL   Mol Cell Biol 13 (4), 2564-2577 (1993)
   PUBMED   8455629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000065.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001399397.2.
            
            On Jan 7, 2022 this sequence version replaced XM_006231731.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JACYVU010000065.1  6498696-6498957
            263-455             JACYVU010000065.1  6549462-6549654
            456-659             JACYVU010000065.1  6566325-6566528
            660-803             JACYVU010000065.1  6599687-6599830
            804-990             JACYVU010000065.1  6607244-6607430
            991-1038            JACYVU010000065.1  6609621-6609668
            1039-1211           JACYVU010000065.1  6627347-6627519
            1212-1235           JACYVU010000065.1  6629075-6629098
            1236-1365           JACYVU010000065.1  6629978-6630107
            1366-1501           JACYVU010000065.1  6630665-6630800
            1502-6304           JACYVU010000065.1  6636533-6641335
FEATURES             Location/Qualifiers
     source          1..6304
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q11"
     gene            1..6304
                     /gene="Mef2c"
                     /gene_synonym="RGD1563119"
                     /note="myocyte enhancer factor 2C"
                     /db_xref="GeneID:499497"
                     /db_xref="RGD:1563119"
     exon            1..262
                     /gene="Mef2c"
                     /gene_synonym="RGD1563119"
                     /inference="alignment:Splign:2.1.0"
     exon            263..455
                     /gene="Mef2c"
                     /gene_synonym="RGD1563119"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..1823
                     /gene="Mef2c"
                     /gene_synonym="RGD1563119"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myocyte-specific enhancer factor 2C"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2C isoform 1"
                     /protein_id="NP_001386326.1"
                     /db_xref="GeneID:499497"
                     /db_xref="RGD:1563119"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPD
                     ADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNP
                     VSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGN
                     PRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDL
                     LLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLS
                     GFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKS
                     EPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLT
                     RPSPDERESPSVKRMRLSEGWAT"
     exon            456..659
                     /gene="Mef2c"
                     /gene_synonym="RGD1563119"
                     /inference="alignment:Splign:2.1.0"
     exon            660..803
                     /gene="Mef2c"
                     /gene_synonym="RGD1563119"
                     /inference="alignment:Splign:2.1.0"
     exon            804..990
                     /gene="Mef2c"
                     /gene_synonym="RGD1563119"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1038
                     /gene="Mef2c"
                     /gene_synonym="RGD1563119"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1211
                     /gene="Mef2c"
                     /gene_synonym="RGD1563119"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1235
                     /gene="Mef2c"
                     /gene_synonym="RGD1563119"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1365
                     /gene="Mef2c"
                     /gene_synonym="RGD1563119"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1501
                     /gene="Mef2c"
                     /gene_synonym="RGD1563119"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..6304
                     /gene="Mef2c"
                     /gene_synonym="RGD1563119"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacttcgtc tccagctctc agctcactcg cctcgcagtc acagacactt gagcacacgc
       61 gtacacccag acatcttcgg gctgctattg gattgacttt gaaggttctg tgtgggtcgc
      121 cgtgcctgca gctttgaatc aggtggagaa gtacttcaag gctggacgaa gtaaagatta
      181 ttgttatttt tttttctttc tcttcctctc ttttaagaaa ggaaaatatt ccaaggacta
      241 atctggtcgg gtcttccttc atgaacgaat gcggggaact gggaactgag ctgtgcacgt
      301 gctgaagaag gaaactcgtt tgaaggaaac aggaaagaga aagaaaagga aggaaaaaat
      361 acataatttc agggacgaga gagagaagaa acacggggac tatggggaga aaaaagattc
      421 agatcacgag gattatggat gaacgtaaca gacaggtgac ttttacaaag aggaaattcg
      481 gactgatgaa gaaggcttat gagttgagcg tgctgtgcga ctgtgagatt gccctgatca
      541 tcttcaacag caccaacaag ctgttccagt acgccagcac cgacatggac aaggtgctgc
      601 tcaagtacac cgagtacaac gagccgcacg agagccggac aaactcggac attgtggaga
      661 cattgagaaa gaagggcctt aatggttgtg acagccccga tcccgatgca gacgattcag
      721 taggtcacag ccctgagtct gaggacaagt acaggaaaat taacgaagat attgatctaa
      781 tgatcagcag gcaaagattg tgtgctgttc cacctcccaa ctttgagatg ccagttacca
      841 tcccagtgtc cagtcataac agtttggtat acagcaaccc tgtcagctca ctgggaaacc
      901 ctaatcttct gccactggcc cacccttctc tgcagaggaa tagtatgtct cctggtgtga
      961 cacatagacc tccaagtgca ggtaacacag gtggtctgat gggtggagac ctcacatccg
     1021 gtgcaggcac cagtgcaggg aatggatacg gcaacccccg gaactcacca ggcctgctgg
     1081 tctcacctgg taacctgaac aagaatatac aagccaaatc tcctccccct atgaatctag
     1141 gaatgaataa tcgtaagcca gatctccgcg tcctcatccc ccctggcagc aagaacacaa
     1201 tgccatcagt gtctgaggat gtggacttgc tgttgaatca aaggataaat aactcccagt
     1261 cggcccagtc attggctacc ccagtggttt ctgtagcaac tcctacttta ccaggacaag
     1321 gaatgggagg atatccgtca gccatttcaa caacatatgg taccgaatac tctctgagca
     1381 gcgcagatct gtcatctctg tctggcttca atactgccag tgcgctccac ctcggctccg
     1441 tcactggctg gcagcagcag cacctacata acatgccgcc atctgccctc agtcagttgg
     1501 gagcttgcac tagcactcat ttatctcaga gttcaaatct ctccctgcct tctactcaaa
     1561 gcctcaacat caagtcagaa cctgtttctc ctcctagaga ccgtaccacc accccatcga
     1621 gatacccaca acacacgcgc cacgaggcgg ggagatctcc tgttgacagc ctgagcagct
     1681 gtagcagttc ctacgatggg agcgaccggg aggatcaccg gaacgaattc cactccccca
     1741 ttggactcac cagaccttcg ccggacgaaa gggaaagtcc ctcagtcaag cgcatgcggc
     1801 tctctgaagg atgggcaaca tgatcacatt attacttaat agtttttttt tcttgcagtg
     1861 tgtgtgtgtg ctatacctta atggggaagg ggggtcgata tgcattatat gtgccgtgtg
     1921 tggaaaaaaa agtcaggtac tctgttttgt aaaagtactt ttaaattgcc tcagtgatac
     1981 agtataaaga taaacagaaa tgctgagata cgcttagcac ttgagttgta caacagaaca
     2041 cttgtacaaa atagatttta aggctaactt cttttcactg ttgtgaccct ttgcaaaatg
     2101 tatgttacaa tagatagtgt catgttgcag gttcaacgtt atttacatgt aaatagacaa
     2161 aaggaaacat ttgccaaaag cggcagatct ttactgaaag agagagcagc tgttatgcaa
     2221 catatagaaa aatgtataga cgttcggaca gacccggcaa ggggtggcca ctggttaatg
     2281 ttaggaacat gccggtcacc taacatctga gcacgctcac aaacctgcag gcatatatca
     2341 ttggcgtatg gcactcatgc aaaaggatca gaaaccattc aaagaggacc atacccactt
     2401 taaaagaaaa ggaaaaaaaa gtgtggtgtt tgagagctaa cgtatttaat taaataaata
     2461 aatctgggtc tgcatctctt attaaataaa aatataaaaa tatgtacatt acattttgct
     2521 tattttcata taaaaggtaa gaaagagttt gcaaagcatt tgtggctttt tgtagtttac
     2581 ttaagccaaa atgtgttttt cccctcaata gcttcgctac tattttaaac agtcctgtaa
     2641 accccaccaa ggactttttg tatagaaagc actaccctaa gccatgagga actccatgct
     2701 ttgctaacca acataactgt tttctctttg tagaagtttt gtttttgaaa tgtgtatttc
     2761 taattatata aaatattaag aatcttttaa aaatctgtga aattaacatg cttgtgtata
     2821 gctttctaat atatataata ttatggtaat ggcagaagtt ttgttttctt aatagcggga
     2881 ggggggtata tctgtgcagt tgcacatttg agtaactatt ttctttctga tttcttttac
     2941 tctgcataca ttttataagt ttgaggtcag ctgtcaaaag gataagctgt ggggttagaa
     3001 catactacat tgtaacatcc tgaattgttt ttaaaacgtc agcaaactat cgggtcaact
     3061 gacatccatt gtatatactg attggtttct ttccaactat ttgttttgtt ttgttgtttt
     3121 cttttttctt ttcattttat caaaagcagg gcccctttca gatctctcca tttcaccaca
     3181 tatcttggaa tctgtaagtt cgtatgctaa cttgcccata ttctaaattc acatagttca
     3241 ttttcagcct tgaatttgat gtttcttaga aatatgccca gagtaagaag ctgtgttgga
     3301 gcataagtcc tgcaagccgg ggccctagga acaaccaatg tgctttactt gatggctaag
     3361 ttacagagtt cctgagaaca atgtgaaaag actgggtgct ggagaggaag gaaacagtta
     3421 aaggatagtt acttggtgtc ccccttcatg attttaactg acccataaca atattgattg
     3481 tcagcagtat aggactgttg aacagctggt gtgtcagtac ccccaatgtc acttctgcat
     3541 aaagcatgta tgtcacctat tttttcttca ataaagagat tcaacagcca tttcaagaaa
     3601 tcccatttaa aaaaaaaaaa accactttct ctatgtcccg tttttcgatt ttcaagataa
     3661 tttaactctt gtctaatatt catgtgtaag ggattaattt tcagacccct taaaaaaaag
     3721 agtgccataa agagtcaata tatagtgtag aagtgatact tcaggctagg aatgaccccc
     3781 ttctcttgga atgtgaagat ctgtctattc atcctgtcgt caatactgac atacagaaca
     3841 aagaatgcac tagtatcagt cacatgtagg tcatgtgtag gacgtgctta tccagttttt
     3901 tcccttttac ctgcataatt gctacatgtt tctcactgta aaaggctgcc gctgggtggc
     3961 agaagctgaa agaccttatt aacgaggcta tatttttctt accttgatct gcaatccaga
     4021 attagaccac aatgcacctt cggttgtatc cgtataggat gcctgcctgc cttgtagtaa
     4081 tgttttatat attaaaaaca aaataaagac atcaaccatt tcatatatat tccactacta
     4141 aaggtatcca tgaaacatga agactagtgt ttatgcagaa gcgaaacagg aaatcatcct
     4201 tacaaacacg attttacctg cacacccgtt tgcacggtca catgtacacg caaacaagca
     4261 ggtaaagtga aagagcacac ccgacattgt tcccgttctg gacgtgatcc catcccgaga
     4321 atccatgttt ataacttgcc gtgtgttaaa tatgcaagca tgatcacaaa tgtcccttgt
     4381 catttcaaaa tgcacttgtt catcaccatc aatggaatct taccagtggg tagggaaagg
     4441 gtcatataaa aatacgaaga aatagccata ttaaatttct acctgccatt tgcctcagca
     4501 aacaaagcga gcgtacgttt ctaaggctaa agatagagcg agctcgtgtg ccagcagaag
     4561 cctcctctat ttatagcagt tctgacaata gttttttttt tttttttttt ttttacaaac
     4621 tcaagaagaa cagattcact tgaaaagtgg atgccagtca cctggttccc accgctgcct
     4681 tcaaagcagc agcagatagc aaagggatac tctaagatct gtaaaggtga tttaacgaga
     4741 agcacaattt ttattgtgac cagtcatgtt ccagaaacag tcactgtcta cctttgccct
     4801 tgccttttct gtaacttggc cacctactgt atttgcaaat ctagtgtaga ttttgatcac
     4861 acgaacttct ttggatccag aagtctgggg cagagcgctg ggggattata attttgcatt
     4921 acctggccga gagtagcatt ttagccaaca gtcatcattg caagtaggag ggagcgtagg
     4981 tggcatttta catggctgca agtgttgtca taccggatcc tactttaaaa cagtttcggt
     5041 agcagtaagc tgagaaatac tggtgacggt gttgcagcct gtgcaagcca cacagcccgt
     5101 gtggtgtaca catcgcgcgc aagcaagcca ttcagtctgt ggattgtgca cattggcatg
     5161 tggaggctgt tgaattcaac cttttttaaa attgtggttt ttagtaaaaa acgcttattt
     5221 tttcccgaag gtggaattta atgttttgta atgatgaata tgaaaatgcc tgtcatcttt
     5281 agatcattta aaggttaact aatgtgagaa tttcaaaaca aatttcaata cacttttgaa
     5341 aagcatgtct gccctctcac acttctatgt atttgatttt ggatacactc accctttttg
     5401 agatagcatt ttgctccctt aatccccctt gttttgattt ttgatttttg ttttgttttg
     5461 ggtttctttt ttttccccct tcagagagta aaagctttgt atttctttct ttaaaaaaat
     5521 tgtttaaaag aagccacttg aacctccagt aaaggctgtt gcctaagcag ggcatacttc
     5581 gtctgttctt gtctgtgcca tctgctatgg tgtcgtcagt tacatggcgt taatttcctg
     5641 ccactacaga tcttttgaag attgcttaaa tgctggtgtc tgttagaatc cttcagactt
     5701 acagatgtaa ttaaaggctt ttcttactat gttttaacca aagatgtgga gcaatccaag
     5761 ccacattatc ttctgcatta aatttgtcca tcttggttat tcataatcgg gtattgcatt
     5821 ttgccttccc tgttcatacc tcaaattgat tgatacctca atttaattca gagaggttgg
     5881 ctaagcggtg gattctggct gtggtttgaa tgcgtcagta ttagagtatg cagacaaggg
     5941 tcaccgtagg catagagctt ggattgcttc agatggtttg ccgtaccgtt ttttcttctt
     6001 tttccttttc tggggacttg tttccattca atgacaataa ttaaaatagc ttgtaaatga
     6061 gggcatacaa gcatttgcaa caagtattcc aatagaggct cacagcggca taagctggac
     6121 tttgtcgcca ctggatgaca agatggcata cctaagctaa ccgcacgcgt gtatctcaag
     6181 ggacttaaat tcagctgtct gtagtgaatt caagtgggaa atgttcaaaa gtttctcctg
     6241 ctggaaataa ggtataattt gtattttgca gacaattcag taaagttact ggctttctta
     6301 gtga
//
