LOCUS       NM_001014035            3216 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus myocyte enhancer factor 2a (Mef2a), mRNA.
ACCESSION   NM_001014035 XM_226648
VERSION     NM_001014035.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3216)
  AUTHORS   Carrillo,E.D., Hernandez,D.I., Clara,M.V., Lezama,I., Garcia,M.C.
            and Sanchez,J.A.
  TITLE     Exercise increases MEF2A abundance in rat cardiac muscle by
            downregulating microRNA-223-5p
  JOURNAL   Sci Rep 13 (1), 14481 (2023)
   PUBMED   37660209
  REMARK    GeneRIF: Exercise increases MEF2A abundance in rat cardiac muscle
            by downregulating microRNA-223-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3216)
  AUTHORS   He,T., Huang,J., Chen,L., Han,G., Stanmore,D., Krebs-Haupenthal,J.,
            Avkiran,M., Hagenmuller,M. and Backs,J.
  TITLE     Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5
  JOURNAL   J Mol Cell Cardiol 145, 88-98 (2020)
   PUBMED   32485181
  REMARK    GeneRIF: Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5.
REFERENCE   3  (bases 1 to 3216)
  AUTHORS   Meyer,M., Berger,I., Winter,J. and Jurek,B.
  TITLE     Oxytocin alters the morphology of hypothalamic neurons via the
            transcription factor myocyte enhancer factor 2A (MEF-2A)
  JOURNAL   Mol Cell Endocrinol 477, 156-162 (2018)
   PUBMED   29928931
  REMARK    GeneRIF: the present study reveals a previously unknown OTR-coupled
            MAPK-MEF-2A pathway, which is responsible for oxytocin-induced
            neurite retraction of hypothalamic neurons.
REFERENCE   4  (bases 1 to 3216)
  AUTHORS   Wu,R., Wang,J., Yao,J., Dong,Z., Liu,Y. and Liu,M.
  TITLE     MEF2A regulates Calpain 3 expression in L6 myoblasts
  JOURNAL   Gene 668, 204-210 (2018)
   PUBMED   29783071
  REMARK    GeneRIF: MEF2A is a transcriptional regulator for Capn3 gene
            expression.
REFERENCE   5  (bases 1 to 3216)
  AUTHORS   Zhu,B., Carmichael,R.E., Solabre Valois,L., Wilkinson,K.A. and
            Henley,J.M.
  TITLE     The transcription factor MEF2A plays a key role in the
            differentiation/maturation of rat neural stem cells into neurons
  JOURNAL   Biochem Biophys Res Commun 500 (3), 645-649 (2018)
   PUBMED   29678571
  REMARK    GeneRIF: MEF2A participates in neuronal differentiation/maturation
            from neural stem cells.
REFERENCE   6  (bases 1 to 3216)
  AUTHORS   Katoh,Y., Molkentin,J.D., Dave,V., Olson,E.N. and Periasamy,M.
  TITLE     MEF2B is a component of a smooth muscle-specific complex that binds
            an A/T-rich element important for smooth muscle myosin heavy chain
            gene expression
  JOURNAL   J Biol Chem 273 (3), 1511-1518 (1998)
   PUBMED   9430690
REFERENCE   7  (bases 1 to 3216)
  AUTHORS   Lin,X., Shah,S. and Bulleit,R.F.
  TITLE     The expression of MEF2 genes is implicated in CNS neuronal
            differentiation
  JOURNAL   Brain Res Mol Brain Res 42 (2), 307-316 (1996)
   PUBMED   9013788
REFERENCE   8  (bases 1 to 3216)
  AUTHORS   Black,B.L., Ligon,K.L., Zhang,Y. and Olson,E.N.
  TITLE     Cooperative transcriptional activation by the neurogenic basic
            helix-loop-helix protein MASH1 and members of the myocyte enhancer
            factor-2 (MEF2) family
  JOURNAL   J Biol Chem 271 (43), 26659-26663 (1996)
   PUBMED   8900141
REFERENCE   9  (bases 1 to 3216)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   10 (bases 1 to 3216)
  AUTHORS   Komuro,I., Schalling,M., Jahn,L., Bodmer,R., Jenkins,N.A.,
            Copeland,N.G. and Izumo,S.
  TITLE     Gtx: a novel murine homeobox-containing gene, expressed
            specifically in glial cells of the brain and germ cells of testis,
            has a transcriptional repressor activity in vitro for a
            serum-inducible promoter
  JOURNAL   EMBO J 12 (4), 1387-1401 (1993)
   PUBMED   8096811
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001014035.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2165447.1,
                                           SRR26643295.2507.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN09345329,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000001.1  130392055-130392162 c
            109-161             JAXUCZ010000001.1  130365401-130365453 c
            162-355             JAXUCZ010000001.1  130337632-130337825 c
            356-559             JAXUCZ010000001.1  130317243-130317446 c
            560-697             JAXUCZ010000001.1  130292969-130293106 c
            698-917             JAXUCZ010000001.1  130290825-130291044 c
            918-977             JAXUCZ010000001.1  130289823-130289882 c
            978-1165            JAXUCZ010000001.1  130277028-130277215 c
            1166-1292           JAXUCZ010000001.1  130267560-130267686 c
            1293-1419           JAXUCZ010000001.1  130263566-130263692 c
            1420-3216           JAXUCZ010000001.1  130260332-130262128 c
FEATURES             Location/Qualifiers
     source          1..3216
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3216
                     /gene="Mef2a"
                     /note="myocyte enhancer factor 2a"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
     exon            1..108
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            109..161
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            162..355
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..1789
                     /gene="Mef2a"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2A"
                     /protein_id="NP_001014057.1"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPD
                     TSYVLTPHTEEKYKKINEEFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPNALSYTNPG
                     SSLVSPSLAASSTLAESSMLSPPPATLHRNVSPGAPQRPPSTGSAGGMLSTTDLTVPN
                     GAGNSPVGNGFVNSRASPNLIGNTGANSVGKVMPTKSPPPPGGGSVGMNSRKPDLRVV
                     IPPSSKGMMPPLNAQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSL
                     TSADLSALQGFTSPGMLSLGQASAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNI
                     NIKSEPISPPRDRMTPSGFQQQQQQQPQQQPPPQPPQPQPQPRQEMGRSPVDSLSSSS
                     SSYDGSDREDPRGDFHSPIVLGRPPNAEDRESPSVKRMRMDTWVT"
     exon            356..559
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            560..697
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            698..917
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            918..977
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1165
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1292
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1419
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..3216
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcgagtc ccgggctgaa ggaggcggct ccgggcggcg cggagtgctg tggcgggccg
       61 ggccggggct gcggcgtatg cgcgcccgcc ggctgtagcg gagactcgga attgcatctt
      121 gtggaaaagg aacaaagaag aactttctgc aaggataaaa tatttttaag acaatttcag
      181 cggcagcctt ggactggaag gttaaataat aggaactgtg tacgatgcat taggatattg
      241 aagaaaatta gcttctgaat taattatttg gaatataagg aagaaaaggt gacttttgaa
      301 aatggggcga aagaaaatac aaattacacg cataatggat gagaggaacc gacaggtgac
      361 ttttacaaag cgaaagttcg gattgatgaa gaaagcctat gaactcagtg tgctctgtga
      421 ctgtgagata gcactcatca tcttcaacag ctctaacaag ttgtttcagt acgccagcac
      481 tgacatggac aaagtccttc tcaagtacac cgagtacaac gagcctcatg aaagcaggac
      541 gaactcggat attgtggagg ctctgaacaa gaaggaacac agaggctgcg acagcccaga
      601 ccctgatact tcatatgtgc taactccaca tacagaagaa aaatataaaa aaattaatga
      661 ggaatttgat aatatgatgc ggaatcataa aatcgcacct ggcttgccgc ctcagaactt
      721 ctcaatgtct gtcacagtcc ctgtgaccag ccctaatgct ttgtcgtaca ctaacccagg
      781 gagttcactc gtgtcaccgt ctttggcagc cagctcaaca ttagcagagt ccagcatgct
      841 gtctccaccc ccagccacgc tacatagaaa tgtgtctcca ggagctccgc agagaccacc
      901 aagcactggc agtgcaggtg ggatgttgag cactacagac ctcacggtac caaatggagc
      961 tggaaatagt cctgtgggga atggatttgt aaactcaagg gcctctccaa atttgattgg
     1021 aaatactggt gcgaatagtg taggcaaagt catgcctaca aagtcccccc cgccaccagg
     1081 tgggggcagt gttggaatga acagtcggaa accagatcta cgggttgtca ttcccccttc
     1141 aagcaagggc atgatgcccc cacttaatgc ccaaaggata agtagttctc aagccacaca
     1201 acctcttgcc acgcccgtgg tgtctgtgac aactccaagc ttgcctccgc agggactagt
     1261 gtactcggcc atgccgacag cctacaacac tgattactca ttgaccagcg ctgacctgtc
     1321 cgccctgcaa ggctttactt cccctggaat gctgtctctg gggcaggctt cagcctggca
     1381 gcagcaccat ctaggacaag cggccctcag ctctctagtg gctggagggc agttatctca
     1441 gggttcaaat ttgtccatta acaccaacca gaacatcaac attaagtcag agccaatttc
     1501 acctccccgt gatagaatga ccccatcagg cttccagcag cagcagcagc agcagccaca
     1561 gcagcaacca ccgccacaac ctccacagcc ccagccccaa ccccggcagg aaatggggcg
     1621 ctcccctgtg gacagtctga gcagctctag cagctcctac gatggcagtg accgggagga
     1681 tccacggggc gacttccatt ctccaattgt gcttggccga cctccaaatg ctgaggacag
     1741 agaaagcccc tctgtaaaac gcatgaggat ggacacatgg gtgacctaag gcttcctggt
     1801 tcatgtctgt tctttgtgtt actgcagtga actgccctac atatcttaaa ttggtgaata
     1861 aggacatgag ttcaatatat ttatatgtac atgcatacat atatatccct ttacatatat
     1921 atgtatgtcg gtgtgagtgt gtgtatgtgt gggtgtgtgt tgcatacaca gaatcaggca
     1981 cttactgcga ctccttgtag gtatgcagat gtgtgcacac ggcacacaga gcaccttgta
     2041 gagacagacc agcctggcac ttccttggac tacttgtctc ctaagataaa gtttttgcag
     2101 agaaacgtgt acccatatat aattcttcca cattagcctg cagaaaccta ggggccccta
     2161 tttgttttat ttacctgtgc ggtgactgta gttacttcaa aaaaaaaaaa aattgctttg
     2221 tagaacagag cagtagaaaa gcaggaacca agaaagcaat actgtacata aagtcattta
     2281 tattaataac ccaacctggc atgggtctat tgcagagggg tgcatgggca agggctgtct
     2341 atattaaaca gacacagtaa acaaagagcc ccacacataa ctgttttgca cgtgcaaaaa
     2401 aatgtattgg gtcaaagaag tgatttttag ctattaaaaa gagagaatag aaaacacgca
     2461 tgaaatattc agaaatacta gcctagaaat atagagcatt aacaaaataa aattaatata
     2521 ttaagttata attggaatat gtcagaagtt tcttttacat tcatatcttt aaaaattaaa
     2581 gaaactgatt ttaggtcatg tatattttat atgaaagaaa acacccttaa tgaattgatg
     2641 actatatata aaattatatc cactactttt gaacacattc tgctgaatta tttatataag
     2701 ccaaagctgt atgttgtaac tttttttttt aaagaatagc tttatcttgt tttaactttt
     2761 tagttttatt ttaagaggga agaaaaaaac aaaaatatct tgcaagcaga accttggaaa
     2821 aaaaaaagcc atgaacatta ttattctata tgtaaattaa aagtcgagcc aaactctttg
     2881 tgtatatagc atcttaaata tattaccacc tttgatgtaa gtacctatgt attgtatggt
     2941 caccagatta aaaagtatat ttttgtggat tgccaccaat ttggggggaa aggcgaagtc
     3001 cttaagtaga gtattcactg tttaatattt actattttgt taaatatact gtactttgga
     3061 ttttaattat tagcccagtt tttcagagga ttgtgtaaag gggtttcccc tcactggtgg
     3121 tgaatgtgtg atgttctgtt gtaatctttg tgctgtatgg ggtgagcatc attatatatt
     3181 ttatatgtgt acataaatag caaagtggca aaaaaa
//
