LOCUS       NM_001286183            1172 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus mediator complex subunit 7 (Med7), mRNA.
ACCESSION   NM_001286183 XM_003750805 XM_003752319
VERSION     NM_001286183.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1172)
  AUTHORS   Poss,Z.C., Ebmeier,C.C. and Taatjes,D.J.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   2  (bases 1 to 1172)
  AUTHORS   Kagey,M.H., Newman,J.J., Bilodeau,S., Zhan,Y., Orlando,D.A., van
            Berkum,N.L., Ebmeier,C.C., Goossens,J., Rahl,P.B., Levine,S.S.,
            Taatjes,D.J., Dekker,J. and Young,R.A.
  TITLE     Mediator and cohesin connect gene expression and chromatin
            architecture
  JOURNAL   Nature 467 (7314), 430-435 (2010)
   PUBMED   20720539
  REMARK    Erratum:[Nature. 2011 Apr 14;472(7342):247]
REFERENCE   3  (bases 1 to 1172)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   4  (bases 1 to 1172)
  AUTHORS   Malik,S., Guermah,M., Yuan,C.X., Wu,W., Yamamura,S. and Roeder,R.G.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. PMID:
            36255214]
REFERENCE   5  (bases 1 to 1172)
  AUTHORS   Brower,C.S., Sato,S., Tomomori-Sato,C., Kamura,T., Pause,A.,
            Stearman,R., Klausner,R.D., Malik,S., Lane,W.S., Sorokina,I.,
            Roeder,R.G., Conaway,J.W. and Conaway,R.C.
  TITLE     Mammalian mediator subunit mMED8 is an Elongin BC-interacting
            protein that can assemble with Cul2 and Rbx1 to reconstitute a
            ubiquitin ligase
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10353-10358 (2002)
   PUBMED   12149480
REFERENCE   6  (bases 1 to 1172)
  AUTHORS   Ryu,S., Zhou,S., Ladurner,A.G. and Tjian,R.
  TITLE     The transcriptional cofactor complex CRSP is required for activity
            of the enhancer-binding protein Sp1
  JOURNAL   Nature 397 (6718), 446-450 (1999)
   PUBMED   9989412
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Oct 31, 2013 this sequence version replaced
            XM_003750805.1, XM_003752319.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228105.1, FQ231187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000010.1  31355037-31355082
            47-215              JAXUCZ010000010.1  31357681-31357849
            216-1172            JAXUCZ010000010.1  31358236-31359192
FEATURES             Location/Qualifiers
     source          1..1172
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..1172
                     /gene="Med7"
                     /gene_synonym="Crsp9"
                     /note="mediator complex subunit 7"
                     /db_xref="GeneID:100911235"
                     /db_xref="RGD:6494481"
     exon            1..46
                     /gene="Med7"
                     /gene_synonym="Crsp9"
                     /inference="alignment:Splign:2.1.0"
     exon            47..215
                     /gene="Med7"
                     /gene_synonym="Crsp9"
                     /inference="alignment:Splign:2.1.0"
     exon            216..1172
                     /gene="Med7"
                     /gene_synonym="Crsp9"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..934
                     /gene="Med7"
                     /gene_synonym="Crsp9"
                     /note="mediator of RNA polymerase II transcription subunit
                     7-like; cofactor required for Sp1 transcriptional
                     activation, subunit 9"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 7"
                     /protein_id="NP_001273112.1"
                     /db_xref="GeneID:100911235"
                     /db_xref="RGD:6494481"
                     /translation="MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMM
                     FGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGS
                     IKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERV
                     IEMIQNCLASLPDDLPHSEAGMRVKTEPMDTDDNSNCTGQNEQQRESSGHRRDQIIEK
                     DAALCVLIDEMNERP"
ORIGIN      
        1 ccgctgcgct gaggaaaaag tcgctacggg aaaagctaga gctgaggatt acctgtctcc
       61 ctagggtgaa attagcacac ctgttgtctt tgctggccaa caagttctca atttttatac
      121 ttcccatcag gaagcttgaa gataatatgg tctgaaccca caacgaactt gtactgaaca
      181 ttgtacttgt gttgatcagg ctgctctggt cttaggttct tgattgtcca caatgggtga
      241 accacagcaa gtgagtgcac ttcccccacc tccaatgcag tacatcaagg aatatacaga
      301 tgaaaacatt caggaaggct tggctcccaa gcctccccct ccaatcaaag acagttacat
      361 gatgtttggc aaccagttcc aatgcgatga tcttatcatt cgccctttag aaagtcaggg
      421 cattgaacga cttcatccta tgcaatttga tcataagaaa gaactgagaa aactcaatat
      481 gtctatactg attaatttct tagacctttt agacatctta ataaggagtc ctgggagtat
      541 caaacgagaa gaaaagctag aagatcttaa gctgcttttt gtacatgtgc atcatcttat
      601 aaatgaatat cgaccccacc aagcaagaga gactttgaga gtcatgatgg aggtccagaa
      661 acgccagcgc cttgaaacag ctgagaggtt tcagaaacat ctggaacgag taattgaaat
      721 gattcaaaac tgcttggctt ctttgcctga tgatttacct cactcagaag cagggatgag
      781 agttaaaacg gagccgatgg atactgatga taacagcaat tgtactgggc agaatgaaca
      841 gcaaagagaa agttcaggtc acagaaggga ccagattata gaaaaagatg ctgccttatg
      901 tgtgttaatt gatgaaatga atgaaaggcc atgaagagta ttcctttttt ccttttagtg
      961 atagcatcat gtattagttt ttgttctctc agacagtctt aagagggata actaaagata
     1021 gagactgttt tcagttgaaa tgctgtaggt ggtaatttaa cactaaatag gctggcaagt
     1081 atatctgagt aactgccata aaaaagccga atgtttgcta ttgtttggga tagtcctatt
     1141 ttttggagtt ggaataaaaa cttgaagtaa ta
//
