LOCUS       NM_001106742            1086 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mediator complex subunit 6 (Med6), mRNA.
ACCESSION   NM_001106742 XM_001055672 XM_216759
VERSION     NM_001106742.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1086)
  AUTHORS   Poss,Z.C., Ebmeier,C.C. and Taatjes,D.J.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   2  (bases 1 to 1086)
  AUTHORS   Kagey,M.H., Newman,J.J., Bilodeau,S., Zhan,Y., Orlando,D.A., van
            Berkum,N.L., Ebmeier,C.C., Goossens,J., Rahl,P.B., Levine,S.S.,
            Taatjes,D.J., Dekker,J. and Young,R.A.
  TITLE     Mediator and cohesin connect gene expression and chromatin
            architecture
  JOURNAL   Nature 467 (7314), 430-435 (2010)
   PUBMED   20720539
  REMARK    Erratum:[Nature. 2011 Apr 14;472(7342):247]
REFERENCE   3  (bases 1 to 1086)
  AUTHORS   Krebs,A.R., Demmers,J., Karmodiya,K., Chang,N.C., Chang,A.C. and
            Tora,L.
  TITLE     ATAC and Mediator coactivators form a stable complex and regulate a
            set of non-coding RNA genes
  JOURNAL   EMBO Rep 11 (7), 541-547 (2010)
   PUBMED   20508642
REFERENCE   4  (bases 1 to 1086)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1086)
  AUTHORS   Tatarakis,A., Margaritis,T., Martinez-Jimenez,C.P., Kouskouti,A.,
            Mohan,W.S. 2nd, Haroniti,A., Kafetzopoulos,D., Tora,L. and
            Talianidis,I.
  TITLE     Dominant and redundant functions of TFIID involved in the
            regulation of hepatic genes
  JOURNAL   Mol Cell 31 (4), 531-543 (2008)
   PUBMED   18722179
REFERENCE   6  (bases 1 to 1086)
  AUTHORS   Lee,H.K., Park,U.H., Kim,E.J. and Um,S.J.
  TITLE     MED25 is distinct from TRAP220/MED1 in cooperating with CBP for
            retinoid receptor activation
  JOURNAL   EMBO J 26 (15), 3545-3557 (2007)
   PUBMED   17641689
REFERENCE   7  (bases 1 to 1086)
  AUTHORS   Malik,S., Guermah,M., Yuan,C.X., Wu,W., Yamamura,S. and Roeder,R.G.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. PMID:
            36255214]
REFERENCE   8  (bases 1 to 1086)
  AUTHORS   Tomomori-Sato,C., Sato,S., Parmely,T.J., Banks,C.A., Sorokina,I.,
            Florens,L., Zybailov,B., Washburn,M.P., Brower,C.S., Conaway,R.C.
            and Conaway,J.W.
  TITLE     A mammalian mediator subunit that shares properties with
            Saccharomyces cerevisiae mediator subunit Cse2
  JOURNAL   J Biol Chem 279 (7), 5846-5851 (2004)
   PUBMED   14638676
REFERENCE   9  (bases 1 to 1086)
  AUTHORS   Brower,C.S., Sato,S., Tomomori-Sato,C., Kamura,T., Pause,A.,
            Stearman,R., Klausner,R.D., Malik,S., Lane,W.S., Sorokina,I.,
            Roeder,R.G., Conaway,J.W. and Conaway,R.C.
  TITLE     Mammalian mediator subunit mMED8 is an Elongin BC-interacting
            protein that can assemble with Cul2 and Rbx1 to reconstitute a
            ubiquitin ligase
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10353-10358 (2002)
   PUBMED   12149480
REFERENCE   10 (bases 1 to 1086)
  AUTHORS   Ge,K., Guermah,M., Yuan,C.X., Ito,M., Wallberg,A.E.,
            Spiegelman,B.M. and Roeder,R.G.
  TITLE     Transcription coactivator TRAP220 is required for PPAR gamma
            2-stimulated adipogenesis
  JOURNAL   Nature 417 (6888), 563-567 (2002)
   PUBMED   12037571
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473982.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216759.4, XM_001055672.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158786.1, EV780174.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132270,
                                           SAMEA5756307 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1086
                     /gene="Med6"
                     /note="mediator complex subunit 6"
                     /db_xref="GeneID:299180"
                     /db_xref="RGD:1310296"
     exon            1..95
                     /gene="Med6"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..814
                     /gene="Med6"
                     /note="mediator of RNA polymerase II transcription,
                     subunit 6 homolog"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 6"
                     /protein_id="NP_001100212.1"
                     /db_xref="GeneID:299180"
                     /db_xref="RGD:1310296"
                     /translation="MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRT
                     CNNEVVKMQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIA
                     GVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVKP
                     KAKRKEEPSSIFQRQRVDALLIDLRQKFPPRFVQQKSGEKPVPVDQAKKEAEPLPETV
                     KSEEKESAKSAQQTVSTKGPPEKRMRLQ"
     exon            96..255
                     /gene="Med6"
                     /inference="alignment:Splign:2.1.0"
     exon            256..347
                     /gene="Med6"
                     /inference="alignment:Splign:2.1.0"
     exon            348..430
                     /gene="Med6"
                     /inference="alignment:Splign:2.1.0"
     exon            431..539
                     /gene="Med6"
                     /inference="alignment:Splign:2.1.0"
     exon            540..655
                     /gene="Med6"
                     /inference="alignment:Splign:2.1.0"
     exon            656..683
                     /gene="Med6"
                     /inference="alignment:Splign:2.1.0"
     exon            684..1086
                     /gene="Med6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcagcttc cgtcgcagta ctcattacct ttactgtgcg ccggaagtag gttcttagag
       61 cgcttttgga attatggcgg cggtggatat ccgagataat ctgctgggaa tctcttgggt
      121 tgacagttct tggatcccca ttttgaacag tggtagtgtc ctggattact tttcagaaag
      181 aagcaatcct ttttatgaca ggacgtgtaa taatgaagtg gttaaaatgc agaggctgac
      241 attagagcac ttgaatcaga tggttggaat cgaatacatc cttttacatg ctcaagagcc
      301 cattcttttc atcattcgaa agcaacagcg gcagtccccc gctcaagtta ttccactggc
      361 tgattactat atcatcgctg gagtcatcta tcaggcgcca gacttgggat cagttataaa
      421 ctccagagtg cttaccgcag tgcatggcat tcagtcagct tttgatgaag ctatgtcata
      481 ctgtcgatat catccttcca aagggtattg gtggcacttt aaagatcatg aagagcaaga
      541 taaagtcaaa cctaaagcca aaaggaaaga agaaccaagc tctattttcc agagacaacg
      601 tgtggatgct ttactcatag acctcagaca gaaatttcca cccagatttg ttcagcaaaa
      661 gtctggagag aagcctgtcc cagtggacca ggcaaagaaa gaggcagagc ccctgccaga
      721 aactgtaaag tccgaggaga aggagagcgc aaagagcgct cagcagactg taagcactaa
      781 aggtccccct gagaagcgaa tgagacttca gtgagtgttg gacaagaaag aagccggcaa
      841 gccccttgtc agtcagtata cctcagcccc gtgggaggct ctagagcctg gaaacactat
      901 cacagccctc tcgtttgtac ggaatgcact tgttctttac aaaggacatt ctcctaccat
      961 gctttctatg tgaatatttc ttaagtatct tttgtaatct ttccactgct ggacttgggc
     1021 agtgcaccta actcacagat atgccagtat atatctttaa aacaataaag ttatttgtat
     1081 atatta
//
