LOCUS       NM_001024256            1352 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus mediator complex subunit 4 (Med4), mRNA.
ACCESSION   NM_001024256 XM_224355
VERSION     NM_001024256.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1352)
  AUTHORS   Poss,Z.C., Ebmeier,C.C. and Taatjes,D.J.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   2  (bases 1 to 1352)
  AUTHORS   Krebs,A.R., Demmers,J., Karmodiya,K., Chang,N.C., Chang,A.C. and
            Tora,L.
  TITLE     ATAC and Mediator coactivators form a stable complex and regulate a
            set of non-coding RNA genes
  JOURNAL   EMBO Rep 11 (7), 541-547 (2010)
   PUBMED   20508642
REFERENCE   3  (bases 1 to 1352)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 1352)
  AUTHORS   Lando,M., Holden,M., Bergersen,L.C., Svendsrud,D.H., Stokke,T.,
            Sundfor,K., Glad,I.K., Kristensen,G.B. and Lyng,H.
  TITLE     Gene dosage, expression, and ontology analysis identifies driver
            genes in the carcinogenesis and chemoradioresistance of cervical
            cancer
  JOURNAL   PLoS Genet 5 (11), e1000719 (2009)
   PUBMED   19911042
REFERENCE   5  (bases 1 to 1352)
  AUTHORS   Malik,S., Guermah,M., Yuan,C.X., Wu,W., Yamamura,S. and Roeder,R.G.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. doi:
            10.1128/mcb.00359-22.. PMID: 36255214]
REFERENCE   6  (bases 1 to 1352)
  AUTHORS   Wang,Q., Sharma,D., Ren,Y. and Fondell,J.D.
  TITLE     A coregulatory role for the TRAP-mediator complex in androgen
            receptor-mediated gene expression
  JOURNAL   J Biol Chem 277 (45), 42852-42858 (2002)
   PUBMED   12218053
REFERENCE   7  (bases 1 to 1352)
  AUTHORS   Kang,Y.K., Guermah,M., Yuan,C.X. and Roeder,R.G.
  TITLE     The TRAP/Mediator coactivator complex interacts directly with
            estrogen receptors alpha and beta through the TRAP220 subunit and
            directly enhances estrogen receptor function in vitro
  JOURNAL   Proc Natl Acad Sci U S A 99 (5), 2642-2647 (2002)
   PUBMED   11867769
REFERENCE   8  (bases 1 to 1352)
  AUTHORS   Malik,S., Gu,W., Wu,W., Qin,J. and Roeder,R.G.
  TITLE     The USA-derived transcriptional coactivator PC2 is a submodule of
            TRAP/SMCC and acts synergistically with other PCs
  JOURNAL   Mol Cell 5 (4), 753-760 (2000)
   PUBMED   10882111
REFERENCE   9  (bases 1 to 1352)
  AUTHORS   Naar,A.M., Beaurang,P.A., Zhou,S., Abraham,S., Solomon,W. and
            Tjian,R.
  TITLE     Composite co-activator ARC mediates chromatin-directed
            transcriptional activation
  JOURNAL   Nature 398 (6730), 828-832 (1999)
   PUBMED   10235267
REFERENCE   10 (bases 1 to 1352)
  AUTHORS   Ito,M., Yuan,C.X., Malik,S., Gu,W., Fondell,J.D., Yamamura,S.,
            Fu,Z.Y., Zhang,X., Qin,J. and Roeder,R.G.
  TITLE     Identity between TRAP and SMCC complexes indicates novel pathways
            for the function of nuclear receptors and diverse mammalian
            activators
  JOURNAL   Mol Cell 3 (3), 361-370 (1999)
   PUBMED   10198638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC093402.1.
            
            On May 27, 2005 this sequence version replaced XM_224355.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093402.1, EV763024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1352
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..1352
                     /gene="Med4"
                     /gene_synonym="Vdrip"
                     /note="mediator complex subunit 4"
                     /db_xref="GeneID:306030"
                     /db_xref="RGD:1306671"
     exon            1..137
                     /gene="Med4"
                     /gene_synonym="Vdrip"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..825
                     /gene="Med4"
                     /gene_synonym="Vdrip"
                     /note="mediator of RNA polymerase II transcription,
                     subunit 4 homolog; vitamin D receptor interacting protein"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 4"
                     /protein_id="NP_001019427.1"
                     /db_xref="GeneID:306030"
                     /db_xref="RGD:1306671"
                     /translation="MAASSSGEKEKERMGGVSGMTGLGSTRERLLSALEDLEVLSREL
                     IEMLAISRNQKLLQLEEENQVLELLIHRDGDFQELMKLALNQGKVHHEMQALEKEVEK
                     RDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNA
                     VCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTSGVNGHLPGDALAAGRLPDVLAP
                     QYPWQSNDMSVNMLPPNHSTDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD"
     exon            138..204
                     /gene="Med4"
                     /gene_synonym="Vdrip"
                     /inference="alignment:Splign:2.1.0"
     exon            205..375
                     /gene="Med4"
                     /gene_synonym="Vdrip"
                     /inference="alignment:Splign:2.1.0"
     exon            376..433
                     /gene="Med4"
                     /gene_synonym="Vdrip"
                     /inference="alignment:Splign:2.1.0"
     exon            434..520
                     /gene="Med4"
                     /gene_synonym="Vdrip"
                     /inference="alignment:Splign:2.1.0"
     exon            521..652
                     /gene="Med4"
                     /gene_synonym="Vdrip"
                     /inference="alignment:Splign:2.1.0"
     exon            653..1323
                     /gene="Med4"
                     /gene_synonym="Vdrip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagtggga cgatggcggc ttcttcaagt ggtgagaagg aaaaggagcg gatgggaggc
       61 gtttcaggaa tgacaggcct tggcagtacg cgagagcggc ttctgtctgc gctggaagat
      121 ctggaggtct tgtcgaggga acttatagaa atgcttgcaa tttcaagaaa tcagaagctg
      181 ttacagctgg aagaggaaaa tcaggtcttg gagttgctaa ttcaccgaga tggggacttt
      241 caagaactaa tgaaattagc acttaatcag ggaaaagtcc accatgaaat gcaagcttta
      301 gagaaagaag tagagaagag agacagtgat attcagcagc tgcagaaaca gctgaaggag
      361 gcagagcaaa tcctggcaac agctgtttac caggcaaagg agaaactcaa gtcaatagag
      421 aaagcaagaa aaggcgctat ctcctctgaa gaaatcatta agtacgcaca caggatcagt
      481 gccagcaatg ctgtatgtgc tccactgact tgggttccag gagaccctcg acggccatac
      541 ccaactgatt tagagatgag aagtggattg ctgggtcaga tgaacaatcc ttctaccagt
      601 ggtgtgaatg gtcacctccc gggagatgcc cttgcagcag gtagactgcc agatgtcctt
      661 gctccacagt acccatggca gtcaaatgac atgtctgtga acatgctgcc gccaaatcat
      721 agcactgact ttctgttgga gcctcccggg cacaacaaag aaaatgaaga tgacgttgag
      781 gttatgtcaa cagattcctc aagcagcagc agtgactctg actgagaaag gggtggcatg
      841 cagactccac tgccacagag ttctgtcaag tgggaaatgg aaagcacaga cctctaagga
      901 gcccaggaaa gtcagtggtc tttcttcctg tagccagaac tgctggttct catctgttac
      961 acacgtgttt gagggtttgt cacaattact gttgtgcttg gtttgtacat agcagctatg
     1021 ggatgagact gaaggagaac tgcacaactc atggagagta cttaccaagg gcactgagcc
     1081 aggctcctgc cttagtccca gcgcctggga ggctgaagga ttgctgggag tgtcgggccg
     1141 ccttgagcta tgtaataaac tgagccatca gggtagcaga acaagaacag aggcatggag
     1201 ctctgtgata tttcaaaaag tgctcacttg aaagtgaagt tgtctgctgt tacagtgaca
     1261 actgtcaata tttatatgtg gtaaatactg taatttgtgt aaataaactt ggttttgttt
     1321 gtaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
