LOCUS       NM_001107217            2089 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus mediator complex subunit 28 (Med28), mRNA.
ACCESSION   NM_001107217 XM_001059017 XM_223463
VERSION     NM_001107217.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2089)
  AUTHORS   Poss,Z.C., Ebmeier,C.C. and Taatjes,D.J.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   2  (bases 1 to 2089)
  AUTHORS   Kagey,M.H., Newman,J.J., Bilodeau,S., Zhan,Y., Orlando,D.A., van
            Berkum,N.L., Ebmeier,C.C., Goossens,J., Rahl,P.B., Levine,S.S.,
            Taatjes,D.J., Dekker,J. and Young,R.A.
  TITLE     Mediator and cohesin connect gene expression and chromatin
            architecture
  JOURNAL   Nature 467 (7314), 430-435 (2010)
   PUBMED   20720539
  REMARK    Erratum:[Nature. 2011 Apr 14;472(7342):247]
REFERENCE   3  (bases 1 to 2089)
  AUTHORS   Krebs,A.R., Demmers,J., Karmodiya,K., Chang,N.C., Chang,A.C. and
            Tora,L.
  TITLE     ATAC and Mediator coactivators form a stable complex and regulate a
            set of non-coding RNA genes
  JOURNAL   EMBO Rep 11 (7), 541-547 (2010)
   PUBMED   20508642
REFERENCE   4  (bases 1 to 2089)
  AUTHORS   Beyer,K.S., Beauchamp,R.L., Lee,M.F., Gusella,J.F., Naar,A.M. and
            Ramesh,V.
  TITLE     Mediator subunit MED28 (Magicin) is a repressor of smooth muscle
            cell differentiation
  JOURNAL   J Biol Chem 282 (44), 32152-32157 (2007)
   PUBMED   17848560
REFERENCE   5  (bases 1 to 2089)
  AUTHORS   Wiederhold,T., Lee,M.F., James,M., Neujahr,R., Smith,N., Murthy,A.,
            Hartwig,J., Gusella,J.F. and Ramesh,V.
  TITLE     Magicin, a novel cytoskeletal protein associates with the NF2 tumor
            suppressor merlin and Grb2
  JOURNAL   Oncogene 23 (54), 8815-8825 (2004)
   PUBMED   15467741
REFERENCE   6  (bases 1 to 2089)
  AUTHORS   Brower,C.S., Sato,S., Tomomori-Sato,C., Kamura,T., Pause,A.,
            Stearman,R., Klausner,R.D., Malik,S., Lane,W.S., Sorokina,I.,
            Roeder,R.G., Conaway,J.W. and Conaway,R.C.
  TITLE     Mammalian mediator subunit mMED8 is an Elongin BC-interacting
            protein that can assemble with Cul2 and Rbx1 to reconstitute a
            ubiquitin ligase
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10353-10358 (2002)
   PUBMED   12149480
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473963.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001059017.1, XM_223463.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218099.1, FQ211206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2089
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q11"
     gene            1..2089
                     /gene="Med28"
                     /gene_synonym="Eg1; FKSG20; RGD1305875"
                     /note="mediator complex subunit 28"
                     /db_xref="GeneID:305391"
                     /db_xref="RGD:1305875"
     exon            1..201
                     /gene="Med28"
                     /gene_synonym="Eg1; FKSG20; RGD1305875"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..579
                     /gene="Med28"
                     /gene_synonym="Eg1; FKSG20; RGD1305875"
                     /note="endothelial-derived; mediator of RNA polymerase II
                     transcription, subunit 28 homolog"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 28"
                     /protein_id="NP_001100687.1"
                     /db_xref="GeneID:305391"
                     /db_xref="RGD:1305875"
                     /translation="MAASLGGMFAGQPPGPPPPPPGLPGQASLLQAAPGAPRPSNSTL
                     VDELESSFEACFASLVSQDYVNGTDQEEIRTGVDQCIQKFLDIARQTECFFLQKRLQL
                     SVQKPDQVIKEDVSELRSELQRKDALVQKHLTKLRHWQQVLEDINVQHKKPADMPQGS
                     LAYLEQASANIPAPLKQT"
     exon            202..268
                     /gene="Med28"
                     /gene_synonym="Eg1; FKSG20; RGD1305875"
                     /inference="alignment:Splign:2.1.0"
     exon            269..381
                     /gene="Med28"
                     /gene_synonym="Eg1; FKSG20; RGD1305875"
                     /inference="alignment:Splign:2.1.0"
     exon            382..2089
                     /gene="Med28"
                     /gene_synonym="Eg1; FKSG20; RGD1305875"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtacgcga gcccggtggc gtttccgccc gccattacag acatggcggc gtccctggga
       61 gggatgttcg ccggccagcc tccaggacct cctccgccac cgcccgggct cccaggccag
      121 gcgtcgcttc tacaagcagc ccctggggct ccgagaccat ctaacagcac tttggtggac
      181 gagttggaat catcattcga ggcttgcttt gcttcccttg tgagtcagga ttatgtcaat
      241 gggactgatc aggaagaaat tcgaactggt gttgatcagt gtatccagaa gtttttggac
      301 attgcaagac agacagaatg ctttttctta caaaaaaggt tgcaattgtc tgtccagaaa
      361 ccagatcaag ttatcaaaga ggatgtctca gaactaagga gtgaattgca gcggaaagat
      421 gctctggtcc agaagcactt gacaaaactg agacattggc agcaggtgct ggaagacatc
      481 aatgtgcagc acaagaagcc agccgacatg cctcagggct ccttggccta ccttgagcag
      541 gcatctgcca acatacctgc acctctgaag cagacctaag gactctggcc tgtggtgcag
      601 ccttgcaggc ttgccagaca cctttcctta caaacctggc atattggaag gactctactg
      661 gacaatgagt tgttatttgt ttatgtccct attttataag gtagggtttc agtatgaagc
      721 ccagacagcc cttgaaccta tgatcccctg cctcaagctc ctcgggtact ctaaattcct
      781 gaatacttta taaaatgcct gaatctttga taaagtagtg tgtgtttttg ttgttgttgt
      841 ttttgttttt tttttaatct ttagcactat ttaatcttta gactgttaga gccatcacac
      901 acattcttaa ttggcctttg ccatttattt tgacaacatt ttgtggcttt atctctcttt
      961 tttcttaagc tataaatttg gtgaaaaacc tgaaggaaac agtgtttaat agtttgagaa
     1021 gccagaggat acagtttggt tatcagcctt agtaacaacc agaggtagtg tagacagata
     1081 tgtcagtgtg ctgtgctgtg ccaaagctca actgcctcac aaggatgctt cagggcggca
     1141 cagggagagc atgtttcaca tggctcagaa gttaagatgc tgctaatgta ggattacagg
     1201 aggatcttac cttcatgctg gagtctgtct gggctgctac attttctgag tccttgttca
     1261 ctctgccttg agggcacaca taacaggaat atggcagctg agtgctcttg ggcggtgctg
     1321 ccatggtcag tgtaaggaat ggagtcacag ggaaggctcc ggtgaggtgt gaggccaaag
     1381 gcctgcttgg attgtctctg tctctgagtt ttgctttttt gtttgtttta ttacccccaa
     1441 agccaagcac ctcactttac ccaaaacaaa tactccatac ctcttgaata gtcagtgcat
     1501 ctcctgcttg gttttgccca atttggtttc tggagccttg aagcccaggt cccaagcgtt
     1561 aacaccctct cactgcgttc caggtctggg cacagccatt tggtctctga aacttcagac
     1621 tgcgccttcg ctgcatccca gggcacagtg ttctgtttcg tttttaattt tgttggcttt
     1681 cttaggttct attatgcttt atgaattgtg actatgttag ttagttgctc cattgtacac
     1741 ctttagaatt aggaatttcc atgattatgc aggatcttag tcttttcata cgtgtccttg
     1801 attgtatgat atttagtggc tggaccaatt agaaccagcg tgagaccatc aagtccccat
     1861 aattagaata cataaacagt gttgaaaaat ttagactggc atggtagcat gcttgtaatc
     1921 agctacatag caggtttgaa gctgttgtag gccgcatacg agctgctctc ctccgccaaa
     1981 caaaacaaaa aacctaaaac ccacacattt tctgaagcac tgacagctca gccagttttg
     2041 gatttcttgg ctaaaaccta aataaactgg ttacattttg gctggtttt
//
