LOCUS       NM_001106565            1252 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus mediator complex subunit 27 (Med27), mRNA.
ACCESSION   NM_001106565 XM_001076126 XM_216025
VERSION     NM_001106565.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1252)
  AUTHORS   Poss ZC, Ebmeier CC and Taatjes DJ.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   2  (bases 1 to 1252)
  AUTHORS   Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL,
            Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J
            and Young RA.
  TITLE     Mediator and cohesin connect gene expression and chromatin
            architecture
  JOURNAL   Nature 467 (7314), 430-435 (2010)
   PUBMED   20720539
  REMARK    Erratum:[Nature. 2011 Apr 14;472(7342):247]
REFERENCE   3  (bases 1 to 1252)
  AUTHORS   Krebs AR, Demmers J, Karmodiya K, Chang NC, Chang AC and Tora L.
  TITLE     ATAC and Mediator coactivators form a stable complex and regulate a
            set of non-coding RNA genes
  JOURNAL   EMBO Rep 11 (7), 541-547 (2010)
   PUBMED   20508642
REFERENCE   4  (bases 1 to 1252)
  AUTHORS   Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R,
            Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW
            and Conaway RC.
  TITLE     Mammalian mediator subunit mMED8 is an Elongin BC-interacting
            protein that can assemble with Cul2 and Rbx1 to reconstitute a
            ubiquitin ligase
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10353-10358 (2002)
   PUBMED   12149480
REFERENCE   5  (bases 1 to 1252)
  AUTHORS   Malik S, Gu W, Wu W, Qin J and Roeder RG.
  TITLE     The USA-derived transcriptional coactivator PC2 is a submodule of
            TRAP/SMCC and acts synergistically with other PCs
  JOURNAL   Mol Cell 5 (4), 753-760 (2000)
   PUBMED   10882111
REFERENCE   6  (bases 1 to 1252)
  AUTHORS   Ryu S, Zhou S, Ladurner AG and Tjian R.
  TITLE     The transcriptional cofactor complex CRSP is required for activity
            of the enhancer-binding protein Sp1
  JOURNAL   Nature 397 (6718), 446-450 (1999)
   PUBMED   9989412
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474001.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001076126.1, XM_216025.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167032.1, EV772276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1252
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..1252
                     /gene="Med27"
                     /gene_synonym="RGD1564993"
                     /note="mediator complex subunit 27"
                     /db_xref="GeneID:296612"
                     /db_xref="RGD:1564993"
     exon            1..250
                     /gene="Med27"
                     /gene_synonym="RGD1564993"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..983
                     /gene="Med27"
                     /gene_synonym="RGD1564993"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 27"
                     /protein_id="NP_001100035.1"
                     /db_xref="GeneID:296612"
                     /db_xref="RGD:1564993"
                     /translation="MADVLSVGVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKET
                     LEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTP
                     LYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQ
                     YVDDVISRIDRMFPEMSIHLSRPNGTSAVLLVTLGKVLKVIVVMRSLFIDRTIVKGYN
                     ESVYTEDGKLDIWSKSSYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKL
                     FQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ"
     exon            251..395
                     /gene="Med27"
                     /gene_synonym="RGD1564993"
                     /inference="alignment:Splign:2.1.0"
     exon            396..526
                     /gene="Med27"
                     /gene_synonym="RGD1564993"
                     /inference="alignment:Splign:2.1.0"
     exon            527..620
                     /gene="Med27"
                     /gene_synonym="RGD1564993"
                     /inference="alignment:Splign:2.1.0"
     exon            621..728
                     /gene="Med27"
                     /gene_synonym="RGD1564993"
                     /inference="alignment:Splign:2.1.0"
     exon            729..770
                     /gene="Med27"
                     /gene_synonym="RGD1564993"
                     /inference="alignment:Splign:2.1.0"
     exon            771..848
                     /gene="Med27"
                     /gene_synonym="RGD1564993"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1252
                     /gene="Med27"
                     /gene_synonym="RGD1564993"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgttcagg ctgcgagctc tggaaagccg gctgaggcgg ctgcaacatg gcggatgtgc
       61 tgagcgttgg ggtgaacctg gaggcctttt cgcaggccat tagtgccatc caggcgctgc
      121 gttctagcgt gagcagggtg ttcgactgcc ttaaggatgg catgcgcaac aaagagacgc
      181 tagagggccg cgagaaggcc ttcatcgcgc acttccagga caacttgcat tccgtcaacc
      241 gggacctcaa cgaactggaa cgtttgagca acctggtagg caagccgtct gagaaccacc
      301 ctctccataa cagtgggctg ctaagcctgg atcctgtgca ggacaaaact ccactctaca
      361 gccagcttct tcaagcatac aaatggtcca acaagctgca gtaccatgca ggtctagcgt
      421 ctggccttct gaatcaacag tccttgaagc gctctgcaaa tcagatgggt gtgtctgcta
      481 agcggagacc taaggcccag cccaccactc tggttctacc gcctcaatat gtggatgacg
      541 tgatcagccg cattgacaga atgtttccag aaatgtccat tcacttatcg agacccaatg
      601 ggacttcagc agtgcttctg gtgaccctgg ggaaggtgtt gaaagtgatc gtggtcatga
      661 ggagcctgtt catcgaccgc acgatcgtga aggggtacaa cgaaagcgtc tacacagagg
      721 acggaaagct agacatatgg tccaaatcca gctatcaggt attccagaag gtgacagacc
      781 atgccaccac tgccctgctt cactatcagt taccccagat gccagacgtt gtggtcaggt
      841 ccttcatgac ctggttgaga agctacatta agctgttcca ggccccgtgc cagcgctgtg
      901 ggaagtttct acaagatggc ctgcccccaa catggagaga cttccgaact ctggaagctt
      961 tccatgacac ctgccggcag tgaccccagc cccgccactg ggcagcgcca gcacctttcc
     1021 agaccagcct gacccattca ccacgtaggt gtttgtcgct gatctccctg gcagaactgt
     1081 cacccccatt ggtgcagcat gggagggtgg tctgcccctt ccctgtgtgc tggcccctgg
     1141 gtcttgcttc catgagctgt tactggaatg agccctttct tcttatgttg gctatgcttg
     1201 gttggttttt gtaacttatt tttgtaaaca ataaagcttt tgtacgctgg tc
//
