LOCUS       NM_001415793            3789 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus mediator complex subunit 25 (Med25), transcript
            variant 1, mRNA.
ACCESSION   NM_001415793 XM_006229008
VERSION     NM_001415793.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3789)
  AUTHORS   Poss,Z.C., Ebmeier,C.C. and Taatjes,D.J.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   2  (bases 1 to 3789)
  AUTHORS   Nakamura,Y., Yamamoto,K., He,X., Otsuki,B., Kim,Y., Murao,H.,
            Soeda,T., Tsumaki,N., Deng,J.M., Zhang,Z., Behringer,R.R.,
            Crombrugghe,Bd., Postlethwait,J.H., Warman,M.L., Nakamura,T. and
            Akiyama,H.
  TITLE     Wwp2 is essential for palatogenesis mediated by the interaction
            between Sox9 and mediator subunit 25
  JOURNAL   Nat Commun 2, 251 (2011)
   PUBMED   21427722
REFERENCE   3  (bases 1 to 3789)
  AUTHORS   Leal,A., Huehne,K., Bauer,F., Sticht,H., Berger,P., Suter,U.,
            Morera,B., Del Valle,G., Lupski,J.R., Ekici,A., Pasutto,F.,
            Endele,S., Barrantes,R., Berghoff,C., Berghoff,M., Neundorfer,B.,
            Heuss,D., Dorn,T., Young,P., Santolin,L., Uhlmann,T.,
            Meisterernst,M., Sereda,M.W., Sereda,M., Stassart,R.M., Meyer zu
            Horste,G., Nave,K.A., Reis,A. and Rautenstrauss,B.
  TITLE     Identification of the variant Ala335Val of MED25 as responsible for
            CMT2B2: molecular data, functional studies of the SH3 recognition
            motif and correlation between wild-type MED25 and PMP22 RNA levels
            in CMT1A animal models
  JOURNAL   Neurogenetics 10 (4), 275-287 (2009)
   PUBMED   19290556
  REMARK    GeneRIF: Data show that Med25 is coordinately expressed with Pmp22
            gene dosage and expression in transgenic mice and rats, and suggest
            a potential role of this protein in the molecular etiology of
            Charcot-Marie-Tooth disease.
            Erratum:[Neurogenetics. 2009 Oct;10(4):375-376. doi:
            10.1007/s10048-009-0213-1. Sereda, Michael [corrected to Sereda,
            Michael Werner]; Stassart, Ruth Martha [added]. PMID: 25488817]
REFERENCE   4  (bases 1 to 3789)
  AUTHORS   Lee,H.K., Park,U.H., Kim,E.J. and Um,S.J.
  TITLE     MED25 is distinct from TRAP220/MED1 in cooperating with CBP for
            retinoid receptor activation
  JOURNAL   EMBO J 26 (15), 3545-3557 (2007)
   PUBMED   17641689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 30, 2022 this sequence version replaced XM_006229008.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.1590.1,
                                           SRR26643287.1107.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               JAXUCZ010000001.1  104511876-104512069 c
            195-240             JAXUCZ010000001.1  104511752-104511797 c
            241-365             JAXUCZ010000001.1  104511438-104511562 c
            366-464             JAXUCZ010000001.1  104505716-104505814 c
            465-585             JAXUCZ010000001.1  104505319-104505439 c
            586-748             JAXUCZ010000001.1  104504894-104505056 c
            749-879             JAXUCZ010000001.1  104504639-104504769 c
            880-967             JAXUCZ010000001.1  104504329-104504416 c
            968-1161            JAXUCZ010000001.1  104504059-104504252 c
            1162-1290           JAXUCZ010000001.1  104503599-104503727 c
            1291-1376           JAXUCZ010000001.1  104502944-104503029 c
            1377-1434           JAXUCZ010000001.1  104502813-104502870 c
            1435-1542           JAXUCZ010000001.1  104502602-104502709 c
            1543-1731           JAXUCZ010000001.1  104500710-104500898 c
            1732-1803           JAXUCZ010000001.1  104500368-104500439 c
            1804-2022           JAXUCZ010000001.1  104500052-104500270 c
            2023-2200           JAXUCZ010000001.1  104499728-104499905 c
            2201-3789           JAXUCZ010000001.1  104496447-104498035 c
FEATURES             Location/Qualifiers
     source          1..3789
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3789
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /note="mediator complex subunit 25"
                     /db_xref="GeneID:292889"
                     /db_xref="RGD:1305137"
     exon            1..194
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..2466
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mediator of RNA polymerase II transcription, subunit 25
                     homolog; mediator of RNA polymerase II transcription
                     subunit 25"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 25 isoform 1"
                     /protein_id="NP_001402722.1"
                     /db_xref="GeneID:292889"
                     /db_xref="RGD:1305137"
                     /translation="MVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAI
                     EYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIK
                     FMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTT
                     YSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPADVSQDPR
                     HMVLVRGLVLPVGGSSAPGPLQPKQAVPLPPAPTSAATLSAAPQQTLPPVPPQYQVPG
                     NLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQAPAPPLAPGPPG
                     APKPPPASQPSLVSTVAPGPGLAAPAQPGAPSMAGTVTPGGVSGPSPAQLGGPALGGQ
                     QSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM
                     QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEV
                     RVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPG
                     LGPILEDQARPPQNLLQLRAPQPQPQGAVGASAATGQPQPQGTTQAPTGAPQGPPGAA
                     PGPPPSGPILRPQNPGANPQLRSLLLNPAPPQTGVPPPQASLHHLQPPGAPALLPPHQ
                     SLGQPQLGPQLLHPPPTQSWPTQLPQRAPLPVAKRKREGEGRVFREKWERDYFFVEVK
                     SMPTCLICKKNVSVLKEYNLKRHYESQHSRSYGQYTAQSRDTLLQELKRALRASEALE
                     SQE"
     exon            195..240
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            241..365
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            366..464
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            465..585
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            586..748
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            749..879
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            880..967
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1161
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1290
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1376
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1434
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1542
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1731
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1803
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2022
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2200
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..3789
                     /gene="Med25"
                     /gene_synonym="RGD1305137"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcgtcccg ggacggcgac ggcctctgcg gcgctggcgg cggcggcggc ggcgcggggc
       61 atggtccccg gatccgaagg cccggcccgg gccgggggcc tggtcgctga tgtggtgttt
      121 gtgatcgagg ggacggcaaa cctggggccg tacttcgagg gactccgcaa gcactacctg
      181 ctgcccgcca tagagtactt caacggagga ccacccgcag agacggactt tgggggagac
      241 tatggcggaa cccagtacag ccttgtggtg ttcaacacag tagactgcgc tccagagtcc
      301 tatgtacaat gccatgctcc taccagcagt gcctatgagt ttgtcacctg gctcgatggc
      361 atcaagttca tgggtggtgg tggcgagagc tgcagtctca ttgctgaagg tctgagcact
      421 gctctgcagc tgtttgatga cttcaagaag atgcgtgaac agatcggcca gacccaccga
      481 gtctgtctcc tcatctgcaa ctccccccca tacctactgc ctgccgtgga gagcaccaca
      541 tactcaggct gtacgacgga gagcctggtg cagaagatag gagagcgtgg tatccacttc
      601 tccatcgttt ctccaagaaa gctgccagca cttaggcttc tgtttgagaa ggcggctcct
      661 cctgccctac tggagccatt gcagccccca gcagacgtca gccaggaccc caggcacatg
      721 gtacttgtgc gtgggctcgt gctgcctgtt ggcggcagct cagccccagg ccctctgcag
      781 cccaagcaag ccgttcccct gccaccagct ccaacttcag ctgccacgct ctcagcagcc
      841 ccccagcaga ccctgccccc ggtcccacca cagtaccagg tccctgggaa cctaagtgct
      901 gctcaggtgg ctgcgcagaa tgctgtggag gctgccaaga accagaaggc cgggctgggc
      961 ccacgcttct cacccatcaa ccctctccag caagctgctt caggagtggg gccccccttc
     1021 agccaggccc cggcaccccc attagctcct gggccccctg gagctcccaa gccacctcct
     1081 gcctcacagc ctagcctagt ctccactgtg gcccctggac caggcctggc agccccggct
     1141 cagcctgggg ctccgtctat ggcaggcact gtgaccccag gtggggtcag tggtccttca
     1201 ccagcccagc tggggggtcc tgcacttggt gggcaacagt cagtatccaa caagctccta
     1261 gcctggagtg gcgtccttga gtggcaggag aaacccaagc ctgcatccgt ggatgccaac
     1321 accaagctga caaggtctct gccttgtcag gtctatgtga accatggaga aaacctgaag
     1381 actgagcaat ggccccagaa actgatcatg cagctcatcc ctcagcaact gctgaccacc
     1441 ctgggcccgc tgttccggaa ctcgagaatg gtccagttcc acttcaccaa caaggacctg
     1501 gagtccctca aaggcctcta ccgcatcatg ggcaatggct ttgccggctg cgtgcacttc
     1561 ccacatacag ccccgtgcga ggtgcgcgtg ctcatgctcc tgtactcgtc taagaagaag
     1621 atcttcatgg gcctcatccc ctacgaccag agtggcttcg tcaatggcat ccgccaggtc
     1681 atcaccaacc ataagcaggt ccagcagcag aagctagagc agcagcgtgg gatgggggca
     1741 cagcaggcac ctccaggcct gggccccatt ctggaggacc aagcgaggcc cccgcagaat
     1801 ctattacagc tccgtgcacc acagcctcag cctcagggtg ctgtgggagc ttctgcggct
     1861 acagggcagc cccagcccca aggtactacc caggccccaa caggggcacc ccaaggtcct
     1921 cctggagcag cccctggccc acctccttct ggacccatcc ttcgacccca gaaccctgga
     1981 gccaaccccc agctgcggag ccttctcctt aatccagcac cgccccagac tggggtaccc
     2041 ccaccccagg cctccctaca ccacctccag cctccagggg cccctgcatt gctgccgcca
     2101 catcagagcc tggggcagcc gcagctaggg ccgcaactcc tgcaccctcc acctacccag
     2161 tcttggccca cacagctacc ccagagggcg ccactgccag tggccaaacg aaagagagaa
     2221 ggagagggcc gcgtgtttcg agaaaaatgg gagcgagact atttctttgt ggaagtgaag
     2281 agcatgccta cgtgcttaat atgcaaaaaa aacgtgtcag tgctgaaaga gtacaacctg
     2341 aagcgccact atgagtccca gcacagcagg agctacggtc agtacacagc gcagagccgc
     2401 gacacactcc tgcaggaact caagagggcc ctccgagcca gcgaggcttt ggagagccag
     2461 gaatagccat gcagtgcagt ggagaaaaga actgtcatca aggctgtcct gtgagtctga
     2521 caagcttttg caggctgaag cacacaggag tcagaggcct tacggatcca gttgcctgaa
     2581 ccacagcagt ggccttttga tggctgcaca gaaactctga gcacatggtt agctttattt
     2641 atttgtggtg gtggtgatct ccatgcaacc gaggtagtct gtgaggtggc gccaagccag
     2701 cccctgactt tgaagtggct tgctcttgtg catgcagaca tcagattcat aagcacagct
     2761 acagtcccct catggtggtc gggctgtccg ttgtggggct gtcccatacc tccgtcccac
     2821 tcatggtggt cgggctgtcc atcgtggggc tgtcccatac ctccatccca agtggcactg
     2881 tttgccagga cccagctcag atcctagtct cagtaaccag gaattgagat gctcaaagaa
     2941 acaccatgac gccttgactc gcattcctgt acttgaactg agccagttgc ctgagaccag
     3001 gacatgcagg gaatctgaac tggcctgttc agttcacttc agagtgtgcc gagccgagcc
     3061 ctggttccct ggagggaacc tggttagaca cgtttggttg aagttcccac ccttgtgaac
     3121 actgactctg tctcagaagg acattcacga acagctcctg aatgtatgac tggggtgtga
     3181 tcctggcaga tggatgcctt ttcgagcaat agtgggactg cctatccttg ctgcagctgg
     3241 tttctggaaa tgagaggcgg ccaggaccag ttacccacac tgtgagaccc aagaccaagt
     3301 tccccgaggg ccatattcta cttgaacttg agctaacact ggctagctcg ccttacgatg
     3361 atgtgaatgc agaccccagt ccgagttgca gtgcaacagg gtgcatgcag ttctgcaaga
     3421 tggcgaggat cctttacctc tgtccagcag tatcctgagt gtttggctgc ccacacttgt
     3481 gacagtcact gttttccgtt actaaatcaa aaaactccgt tttaaggatt aaggttgaaa
     3541 tttcacctgc ccatctctct gtcccaacca atgccagcac tgacacctgg gtgtagaagg
     3601 gcaggtgtca accttccact caaaaggcac aagagaatta caagagagaa attttaataa
     3661 ctaaatattt ctatttttca atttgtattt tttcaatttt gaatttaaag tatgaactct
     3721 agtatcatac gtgtttgtgt tgtattccgt gcgttcacca tagctcagta aagatccaat
     3781 ttgattatc
//
