LOCUS       NM_001107741            2592 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mediator complex subunit 19 (Med19), mRNA.
ACCESSION   NM_001107741 XM_001069345 XM_230275
VERSION     NM_001107741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2592)
  AUTHORS   Wang,H., Zhao,H., Chen,Z., Cai,X., Wang,X., Zhou,P., Tang,Y.,
            Ying,T., Zhang,X., Shen,Y., Wang,B., Zhu,W., Zhu,J., Wang,X. and
            Li,S.
  TITLE     Hypoxic Bone Mesenchymal Stem Cell-Derived Exosomes Direct Schwann
            Cells Proliferation, Migration, and Paracrine to Accelerate Facial
            Nerve Regeneration via circRNA_Nkd2/miR-214-3p/MED19 Axis
  JOURNAL   Int J Nanomedicine 19, 1409-1429 (2024)
   PUBMED   38371458
  REMARK    GeneRIF: Hypoxic Bone Mesenchymal Stem Cell-Derived Exosomes Direct
            Schwann Cells Proliferation, Migration, and Paracrine to Accelerate
            Facial Nerve Regeneration via circRNA_Nkd2/miR-214-3p/MED19 Axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2592)
  AUTHORS   Poss,Z.C., Ebmeier,C.C. and Taatjes,D.J.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   3  (bases 1 to 2592)
  AUTHORS   Tomomori-Sato,C., Sato,S., Parmely,T.J., Banks,C.A., Sorokina,I.,
            Florens,L., Zybailov,B., Washburn,M.P., Brower,C.S., Conaway,R.C.
            and Conaway,J.W.
  TITLE     A mammalian mediator subunit that shares properties with
            Saccharomyces cerevisiae mediator subunit Cse2
  JOURNAL   J Biol Chem 279 (7), 5846-5851 (2004)
   PUBMED   14638676
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_230275.4, XM_001069345.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2592
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2592
                     /gene="Med19"
                     /gene_synonym="RGD1311926"
                     /note="mediator complex subunit 19"
                     /db_xref="GeneID:311165"
                     /db_xref="RGD:1311926"
     exon            1..261
                     /gene="Med19"
                     /gene_synonym="RGD1311926"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..779
                     /gene="Med19"
                     /gene_synonym="RGD1311926"
                     /note="mediator of RNA polymerase II transcription,
                     subunit 19 homolog"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 19"
                     /protein_id="NP_001101211.1"
                     /db_xref="GeneID:311165"
                     /db_xref="RGD:1311926"
                     /translation="MENFTALFGAQTDPPPPPSALGFGPGKPPPPPPPPPGGGPGTAP
                     PSTATSAPVGADKSTAGSGPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVK
                     EKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPITGTMLSGFRLHTGPLP
                     EQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEK
                     KKKKNRHSPDHPGMGSSQASSSSSLR"
     exon            262..518
                     /gene="Med19"
                     /gene_synonym="RGD1311926"
                     /inference="alignment:Splign:2.1.0"
     exon            519..615
                     /gene="Med19"
                     /gene_synonym="RGD1311926"
                     /inference="alignment:Splign:2.1.0"
     exon            616..710
                     /gene="Med19"
                     /gene_synonym="RGD1311926"
                     /inference="alignment:Splign:2.1.0"
     exon            711..2592
                     /gene="Med19"
                     /gene_synonym="RGD1311926"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaattaac gccagatccc gggtaaccaa gagcggcgag tgctatggag aacttcacag
       61 ccctgttcgg agctcaaact gaccccccac cgccaccaag cgcactaggg ttcgggcctg
      121 gaaagcctcc gccgccaccc cctcctcctc cgggaggtgg tccaggcacg gctccacctt
      181 cgaccgcgac ctcggccccc gtgggagcgg ataagtccac ggctggaagc ggtcccttct
      241 accttatgcg ggaattgcca ggcagcacag agctgacggg cagcaccaat ttaatcacac
      301 actacaacct ggaacaggcc tataataagt tctgtgggaa gaaagtgaag gagaagctaa
      361 gtaacttcct gcctgacctc cctgggatga ttgatcttcc tggctcccat gacaacagca
      421 gcctccgctc cctcattgag aaacctccta ttcttggtgg ctcttttaat ccgatcacag
      481 ggaccatgct gtctggtttc cgcctccata ctggcccgtt gccagagcag tgtcgtctga
      541 tgcatattca gcctcccaag aagaagaata agcataagca caaacagagc cgtacccagg
      601 atcctgttcc cccagaaaca ccatctgatt cagatcacaa gaagaagaaa aagaaaaaag
      661 aggaggatcc tgaacgaaaa aggaagaaaa aagaaaagaa gaagaagaag aaccgacata
      721 gtccagacca cccgggtatg ggcagctctc aagccagcag cagcagcagc ctccgctaat
      781 aggactactg gactttgcca aggatgactt tcctgtgata ctgaacctgc tgataaaaac
      841 tgtcttctgg gcacttggac cctgttgtgg ggtcatccag cggctggaca ggggccagcc
      901 cctgctgtgc atgtgactaa tacactttag agaagggcca tgctttttat ggtttagacc
      961 aattggtgtt tccatggacg tcctttttta caagaagctg tttttctttt ttttccccct
     1021 ctcctttatg caatttgatt ccaggacttc ggttttttgt tttgctttta aagtgcgttt
     1081 aacagactag catagctgcc ttttaagaga caagtgccat tctatttgaa tcaaagttta
     1141 ggacaaggga ctaagataag atgcaagaga ttctggatct tgccatcaca tgatttcttc
     1201 tttagcaggc tagaaaatca aaatgagact agagaacatg gtgtgaaagc aagtttgcta
     1261 gtattttccc accatagaca caaaattact ttgctgatta tgctcagagc aaagtgcctg
     1321 gatgatcttc atcttccatc aggaaagctg gcccaaataa ggtttatacc tgtgtttata
     1381 taccacagtg aactggtgat ccacagccac cagtatattt cagcaggaaa gaccaactag
     1441 tatttgtctc atcgtgctcc taccgttctc tggtgcctgt cccctaagac gtatgtatac
     1501 taggcaagtt tatcttttcc tttccctccc tttttttccc tacatgcttt ttaaatgaac
     1561 ctctcacaag aagtttaata ttggatttgg ttgttttgaa aaagtttagg ggtttttttt
     1621 tttttttttt tttttttttt ttttttttga gacatcacac tatgcaaccc tggattgcta
     1681 tgacggctag gctggctgga gacccatctg cagttcccac caagttctgg gatcaaaggc
     1741 atgcaccacc atgcttcgct gtttttactt tctaaagagg aaattaagga ggagtaacac
     1801 aagaaatttc aacaaaccag atgcttttgt tatgaaaagc caggtttttc tcacccagcc
     1861 aggcatttaa tttgatagcc agaataaaaa caggaccaga gaatgaggtt ttccttttga
     1921 ctccataaga ccattctgcc ttaaccagac aaaacacaag tcagggggaa ctggttagat
     1981 caggatttat tttattcttt gttggtttaa aatggctaat cagaataaaa aaattaaagg
     2041 gtctctgtat agaggctgga gtcttccctg tttaaggtta gaacccagct acccctctac
     2101 ccagcaccat attgaggtgg gctaaggggt aaaccccaag ggacaatcgg aggggcctag
     2161 gcctgccact ccttctctct atcccatttt tggcatatga tgaaaaatat tgcttttttg
     2221 gattcttctc tcctggcctt ggattttaag attttcctgt aaattctagg gaagcattga
     2281 aggggctcac cacaatccct gtcttccaag aatggagggc agggctgcct ggtgtttctt
     2341 aaatttggcc aagctctctt cctgatctcc caccaccatc atggaactgt gacccctttc
     2401 ctggggaaat tagatgtgaa ggagtttaaa aactctccaa gttcttttat ctgacagaat
     2461 cccagatgta cccaggtttc tttcctaatc actgagcacc agcaggtgct acttcttcag
     2521 tcggtaactg ggacaaaaga gggaaccatg gagaaaagga agactttaat gtctctcttt
     2581 tcctgctggt ct
//
