LOCUS       NM_001115037            1536 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus mediator complex subunit 18 (Med18), mRNA.
ACCESSION   NM_001115037 XM_001065061 XM_001065118
VERSION     NM_001115037.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1536)
  AUTHORS   Poss ZC, Ebmeier CC and Taatjes DJ.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   2  (bases 1 to 1536)
  AUTHORS   Krebs AR, Demmers J, Karmodiya K, Chang NC, Chang AC and Tora L.
  TITLE     ATAC and Mediator coactivators form a stable complex and regulate a
            set of non-coding RNA genes
  JOURNAL   EMBO Rep 11 (7), 541-547 (2010)
   PUBMED   20508642
REFERENCE   3  (bases 1 to 1536)
  AUTHORS   Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens
            L, Zybailov B, Washburn MP, Brower CS, Conaway RC and Conaway JW.
  TITLE     A mammalian mediator subunit that shares properties with
            Saccharomyces cerevisiae mediator subunit Cse2
  JOURNAL   J Biol Chem 279 (7), 5846-5851 (2004)
   PUBMED   14638676
REFERENCE   4  (bases 1 to 1536)
  AUTHORS   Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R,
            Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW
            and Conaway RC.
  TITLE     Mammalian mediator subunit mMED8 is an Elongin BC-interacting
            protein that can assemble with Cul2 and Rbx1 to reconstitute a
            ubiquitin ligase
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10353-10358 (2002)
   PUBMED   12149480
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Mar 2, 2008 this sequence version replaced
            XM_001065118.1, XM_001065061.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158672.1, EV770813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1536
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1536
                     /gene="Med18"
                     /note="mediator complex subunit 18"
                     /db_xref="GeneID:682988"
                     /db_xref="RGD:1592757"
     exon            1..150
                     /gene="Med18"
                     /inference="alignment:Splign:2.1.0"
     exon            151..294
                     /gene="Med18"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..848
                     /gene="Med18"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 18"
                     /protein_id="NP_001108509.1"
                     /db_xref="GeneID:682988"
                     /db_xref="RGD:1592757"
                     /translation="MEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCD
                     NMEPETFLDHEMVFLLKGQQASPFVLRARRSMDRAGAPWHLRYLGQPEMGDKNRHALV
                     RNCVDIATSENLTDFLMEMGFRMDHEFVAKGHLFRKGIMKIVVYKIFRILVPGNTDST
                     EALSLSYLVELSVVAPAGQDMVSDDMRNFAEQLKPLVHLEKIDPKRLM"
     exon            295..1536
                     /gene="Med18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttcctacc ggaagtgctg aagggaatgt ttggcggttt ctctggatct gtgcaggagg
       61 gatttggggg tgcggattgc gggtgtgcac gcgtggattt aagtccagct ttgcatggat
      121 ctgtagcgcg aacggagacg tgttgctagt gtgtatcccg tgcttccccg gttggaagat
      181 ctgtttgcag ttctgtcgtc ttgaacctaa ttagaggcat catggaggca cctccagtca
      241 ccatgatgcc agtcactggg ggcaccatta acatgatgga gtacctcctg caggggagtg
      301 ttttagacca cagtttggaa agtctgatcc atcgcctccg tggtttgtgt gacaacatgg
      361 agcctgagac ttttctcgat cacgagatgg tcttcctgct taagggccag caggccagcc
      421 cgttcgtcct aagggcccgg cgctccatgg atagggcagg ggcgccctgg catctgcgtt
      481 acctgggaca gcccgaaatg ggagacaaga accgccatgc cctggtgcgc aactgcgtgg
      541 acatcgccac gtctgagaac ctcacggact tcctgatgga aatgggcttc cgcatggacc
      601 atgagttcgt cgccaaagga cacctgttcc ggaagggcat catgaagatt gtggtgtaca
      661 agattttccg aatcctggtc ccagggaaca cagacagcac tgaggccctg tcgctctctt
      721 atcttgtgga attaagtgtt gtcgcaccag ctgggcagga catggtctct gatgacatga
      781 ggaactttgc agagcagctc aaacctctgg ttcacctaga aaaaatagac cctaaaaggc
      841 tgatgtgagg aagaaagtct gtcggccttt gagacctgtc ctcacgtggg aggtgagaga
      901 tcccacaagt accctaggta ctgatgccag ccaggccact tccttctgga agatggatgg
      961 tgagaatttg gttcctttga actgtttcct tcacctggta attccttcct tccttccttc
     1021 ctcccttcct tccttccttc cttccttcct tccttccttt tttccttcct ttctttcctt
     1081 tctttgttgt ctgtctgtct tcctttcttt tttcaacagg gttttaccat gtagccctgg
     1141 ctcccctgga actcactaca taaactagct agcctggaac tcagaggtcc ctgtcctgtc
     1201 cgcctaggtg cctgtgttaa gggtccttat tgaacccgac tgttcatctt cttgacagtc
     1261 ttttccaatg aaagacccag tataatatgg agaattgttc aagtcttccc tccacccaaa
     1321 aagagggaac tggaatacat tagcttttta gagggaaaag tcaaaaaaca actgataatt
     1381 gtttttcttt tgttttttaa gaaaagtatt ttctcattcc tttatttatt tgttgttttc
     1441 ttcatatttt ttaattgtgt tgttttgcca ttactattca aggttcataa tggtggtgtg
     1501 agctggcatt gtggggcaat aaagactgaa aagaca
//
