LOCUS       NM_001106801            4181 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus mediator complex subunit 17 (Med17), mRNA.
ACCESSION   NM_001106801 XM_001074512 XM_217086
VERSION     NM_001106801.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4181)
  AUTHORS   Poss ZC, Ebmeier CC and Taatjes DJ.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   2  (bases 1 to 4181)
  AUTHORS   Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL,
            Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J
            and Young RA.
  TITLE     Mediator and cohesin connect gene expression and chromatin
            architecture
  JOURNAL   Nature 467 (7314), 430-435 (2010)
   PUBMED   20720539
  REMARK    Erratum:[Nature. 2011 Apr 14;472(7342):247]
REFERENCE   3  (bases 1 to 4181)
  AUTHORS   Krebs AR, Demmers J, Karmodiya K, Chang NC, Chang AC and Tora L.
  TITLE     ATAC and Mediator coactivators form a stable complex and regulate a
            set of non-coding RNA genes
  JOURNAL   EMBO Rep 11 (7), 541-547 (2010)
   PUBMED   20508642
REFERENCE   4  (bases 1 to 4181)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 4181)
  AUTHORS   Malik S, Guermah M, Yuan CX, Wu W, Yamamura S and Roeder RG.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. PMID:
            36255214]
REFERENCE   6  (bases 1 to 4181)
  AUTHORS   Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM and
            Roeder RG.
  TITLE     Transcription coactivator TRAP220 is required for PPAR gamma
            2-stimulated adipogenesis
  JOURNAL   Nature 417 (6888), 563-567 (2002)
   PUBMED   12037571
REFERENCE   7  (bases 1 to 4181)
  AUTHORS   Kang YK, Guermah M, Yuan CX and Roeder RG.
  TITLE     The TRAP/Mediator coactivator complex interacts directly with
            estrogen receptors alpha and beta through the TRAP220 subunit and
            directly enhances estrogen receptor function in vitro
  JOURNAL   Proc Natl Acad Sci U S A 99 (5), 2642-2647 (2002)
   PUBMED   11867769
REFERENCE   8  (bases 1 to 4181)
  AUTHORS   Naar AM, Beaurang PA, Zhou S, Abraham S, Solomon W and Tjian R.
  TITLE     Composite co-activator ARC mediates chromatin-directed
            transcriptional activation
  JOURNAL   Nature 398 (6730), 828-832 (1999)
   PUBMED   10235267
REFERENCE   9  (bases 1 to 4181)
  AUTHORS   Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang
            X, Qin J and Roeder RG.
  TITLE     Identity between TRAP and SMCC complexes indicates novel pathways
            for the function of nuclear receptors and diverse mammalian
            activators
  JOURNAL   Mol Cell 3 (3), 361-370 (1999)
   PUBMED   10198638
REFERENCE   10 (bases 1 to 4181)
  AUTHORS   Ryu S, Zhou S, Ladurner AG and Tjian R.
  TITLE     The transcriptional cofactor complex CRSP is required for activity
            of the enhancer-binding protein Sp1
  JOURNAL   Nature 397 (6718), 446-450 (1999)
   PUBMED   9989412
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473993.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217086.4, XM_001074512.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4181
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..4181
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /note="mediator complex subunit 17"
                     /db_xref="GeneID:300367"
                     /db_xref="RGD:1311120"
     exon            1..378
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2084
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /note="cofactor required for Sp1 transcriptional
                     activation, subunit 6"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 17"
                     /protein_id="NP_001100271.1"
                     /db_xref="GeneID:300367"
                     /db_xref="RGD:1311120"
                     /translation="MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLA
                     QRIDFSQGSGSEEEEAAGPDGDAPDWAGAGADQDDEEGLVKFQPSLWPWDSVRNNLRS
                     ALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQSPQTLQLISKKKSLAGAAQILLK
                     GAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHG
                     TFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFK
                     RPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPF
                     PSLQLSISLCHSSDDKKSQKCAPEKPGQEGHLYVLEHNLHLLIREFHKQTLSSIVMPH
                     PASAPFGHKRMRLSGPQAFDKNEINSIQSTEGLLEKIIKQAKHIFLRSRTAATIDSLA
                     SRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQVRVVHRDGR
                     VITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASA
                     ITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWSHLRGPFKEVQ
                     WNKMEGRNFVYKMELLMSALSPCLL"
     exon            379..545
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /inference="alignment:Splign:2.1.0"
     exon            546..765
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /inference="alignment:Splign:2.1.0"
     exon            766..902
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /inference="alignment:Splign:2.1.0"
     exon            903..987
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1140
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1271
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1456
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1594
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1712
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1872
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..4181
                     /gene="Med17"
                     /gene_synonym="Crsp6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgtgggac agcggtgggt ggttggcttc cgccgggtcc gccgcgtcgg gctttcggag
       61 agattggtgt ccagccttcc gtgtccgtgc tcgtttctga gtctctggca agtcacccgc
      121 aggctgccgc caggatgtcg ggcgtgcgag ctgtgcgcat cagcatcgag tcggcctgcg
      181 agaagcaggt gcaggaggtg ggccttgatg gcaccgagac gtacctgcag ccgctgtcta
      241 tgtcgcagaa cctggcgcgt ctggcgcagc gcatcgactt cagccagggc tccggctccg
      301 aggaggagga ggcggcgggg cctgacggcg acgcgccgga ctgggcgggc gcgggggccg
      361 accaggacga cgaagagggg ttggtaaaat tccaaccttc tctgtggcct tgggactctg
      421 tgaggaacaa tttgcgaagt gcccttacag agatgtgtgt tctctatgat gtcctcagta
      481 ttgtcaggga caaaaagttc atgactctgg accccgtctc tcaggatgcg cttcctccca
      541 aacagagccc acagacgctg cagctgatct ctaagaagaa gtcccttgct ggagcagctc
      601 agatcctatt gaagggggcg gaaagactga ccaagtcggt gactgagaac caggaaaaca
      661 agcttcagcg agacttcaat tctgagctct tgagactacg gcaacactgg aaactgagga
      721 aggtgggaga caagatcctg ggtgacctaa gctacagaag tgcaggctct ctttttcccc
      781 accatggtac ctttgaagtg ataaagaata cagacattga cttggataaa aagataccag
      841 aagattactg tcctctagat gtccagattc ctagtgactt agaggggtct gcatatatca
      901 aggtttctat tcagaaacag gctccagaca ttggtgatct tggtacagtt aaccttttta
      961 agagaccttt gcccaaatcc aagccaggtt ccccacactg gcagacaaaa ttagaagcag
     1021 cacaaaatgt tcttctttgt aaggaaattt ttgcacagct ctctcgggaa gccgttcaga
     1081 ttaagtctca gatccctcac attgtggtga aaaaccagat catctctcag ccctttccaa
     1141 gcttgcagtt gtctatttct ctgtgccact cctcagatga taagaagtcc cagaaatgtg
     1201 ccccagagaa gcctggtcag gagggtcacc tctacgtcct ggagcacaac ttgcacctgc
     1261 tgatcagaga gtttcataaa cagaccttga gctccatcgt gatgccacac ccagcgagtg
     1321 ctccttttgg gcacaagaga atgagactct caggtcctca agcttttgat aagaatgaaa
     1381 ttaattcaat acagtccaca gaaggactcc tagaaaaaat aattaaacaa gcaaagcata
     1441 tttttctaag gagcagaact gctgcgacca ttgacagctt ggcaagtcgc attgaggacc
     1501 cccagatcca ggcccactgg tcgaacatca acgatgtgta tgagtctagt gtaaaagttt
     1561 taatcacatc gcagggttat gaacagatct gcaagtccat ccagctgcag ctgaacattg
     1621 gcgttgagca ggtccgtgtc gtgcacagag atgggcgggt gatcacgctg tctcaccagg
     1681 aacaggaact acaggacttc cttctgtctc agatgtccca gcaccaggtg catgcggttc
     1741 agcagcttgc caaggtcatg ggctggcagg tcctcagctt cagcaatcac gtgggactcg
     1801 ggcccataga gagtattggc aatgcctccg ccatcacagt ggcctcgcca agtggtgact
     1861 atgctatttc agttcgtaac ggacccgaga gtggcagcaa gatcatggtt cagtttcccc
     1921 gtaaccagtg caaagacctt ccgaaaagtg atgttttaca agatagcaag tggagccatc
     1981 tccgaggacc gttcaaggag gttcagtgga acaagatgga gggccgaaac ttcgtttata
     2041 aaatggagct gcttatgtct gccctgagtc cctgtctcct gtgattttct ccagaacaag
     2101 ttgcagaaat tctgacctgc gtgtttgcag atcagttata agcacaaggg agcgatggcc
     2161 tccgtatgag tactgagcac agactcgtgc actggcgctc tagcctttcg cgggagtcct
     2221 gtttaaaagt gacatgttta ccctgcgttt gaattctctc acgttataag tgacgagtac
     2281 tttggaatgg aaaaatgtat gtacagtttt agtatgcagt atggggagat gtaaaatagt
     2341 acatttttat acagctcacc tgaaaatatt actaacttaa gggcttgaat ttgctttttt
     2401 ttaaattaca tctttaatgt taacataaac tttgtgttta aaaatctcca agtattttgt
     2461 gaatttctca taacctatat gagctgcgtc tcaaatcagc cactcctgct gtttctttaa
     2521 aaatcactga agaccgtctt acagcacaga ttcactgacc acaccaggcc ctgtccctga
     2581 agttcaccga gatcactcac aggagtagtc ttccctagca cctggggctc tcggggtgtg
     2641 gggacatgaa gtgcctttgt agccatcttc ttcctcacct gggtcaacat gaatgaacag
     2701 ggtaagaact tcctcaaaaa gcagtggaaa ccaaaaaatg taccatgata gtctgttttc
     2761 cctgttagtg ctcactgttt ctggctgtgt agaaacttcc acagagccgc atctcgcttg
     2821 aattttgaca agctgaggta aatataaagg agatgcacca agtgtgatgg ctcatgccgg
     2881 tgattggagg actagggagt tgaagacagg aagacaaaga gttcaagttc agcctgatct
     2941 gcatgagttc caggccatct ggggctacgt agggcgagcc ttgtctcaaa gtttaaagat
     3001 ttatttattt tatgtatata gtacacaata atctttagac acaccagaag gtagagcatc
     3061 agatcccatg acagatggct gtgagccacc atttggttgc tgggaattga actgaggacc
     3121 ttgggaagag cagccagtgc tcttaaccac tgcgccatct ctccagtcct ctaagtttaa
     3181 aagaaaagaa agggggtttt agtaaacaaa ctgtattcat actatgggtt atgttttcca
     3241 aggaggaaga gtgaaattta atagggagag atgtgaagtg agagaatgca tcaggaaaag
     3301 cagacaggcc atgggtacag tggcatccgt gggctgccat gtcgcctagc gggaaaatgc
     3361 ctagtatgct ccaggattac agagaagagg ggcgggtgca ttcggttgtc agagtgtgta
     3421 ctgtaatgta gagacctgtt tatgtgtgtg tccagaaaga tactgtgccc tctgagaagt
     3481 aaggttgagg agagagaact ttcagtgtat tgggttcctg tgtatctttt gacttttcaa
     3541 gaagcatttt ttatttttgc aattagagat tcttgaaagg taagagaaat gaggactcca
     3601 gctgtccttg aggattggca gctgagatgg tggtcacatg cagaagcaca cacgtggaca
     3661 gtccatccct cttctgagtg aaacttgatg tagctgtggt aacaatagtt tctcagttaa
     3721 ctctagaggt gtttgatatc aggaaacagc ataataagcc gatctgatcc atgaatctgg
     3781 agggaagagc ctttactacc ctggtatcac tcaaggcaac tgcgactgag acaggtgcct
     3841 gaaggtcact tcaggctttg agtgtaattg gcccccatag acccatagag agtggcacca
     3901 ttaggaggtg tggccttgct ggaggaagtg agtcactgtg ggggtgggcc ttgaggtctc
     3961 atatgctcat ggtacaccca gtgtggtaca gtttctcctt gctgcctgca gatcaagaag
     4021 tagaactgta aactccacgt ccaacatgtc tgcccatacg ctgccatgtt atccgccatg
     4081 atgatactgg actaaacctc tgaaagtgta agccagcccc actcagtgtt ttacttcgtg
     4141 ggagttgcct tggtcctgct gtttcttcac agcaatagaa c
//
