LOCUS       NM_001106768            2942 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus mediator complex subunit 16 (Med16), mRNA.
ACCESSION   NM_001106768 XM_001073685 XM_001073722 XM_216837
VERSION     NM_001106768.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2942)
  AUTHORS   Poss ZC, Ebmeier CC and Taatjes DJ.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   2  (bases 1 to 2942)
  AUTHORS   Krebs AR, Demmers J, Karmodiya K, Chang NC, Chang AC and Tora L.
  TITLE     ATAC and Mediator coactivators form a stable complex and regulate a
            set of non-coding RNA genes
  JOURNAL   EMBO Rep 11 (7), 541-547 (2010)
   PUBMED   20508642
REFERENCE   3  (bases 1 to 2942)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2942)
  AUTHORS   Malik S, Guermah M, Yuan CX, Wu W, Yamamura S and Roeder RG.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. PMID:
            36255214]
REFERENCE   5  (bases 1 to 2942)
  AUTHORS   Wang Q, Sharma D, Ren Y and Fondell JD.
  TITLE     A coregulatory role for the TRAP-mediator complex in androgen
            receptor-mediated gene expression
  JOURNAL   J Biol Chem 277 (45), 42852-42858 (2002)
   PUBMED   12218053
REFERENCE   6  (bases 1 to 2942)
  AUTHORS   Ito M, Okano HJ, Darnell RB and Roeder RG.
  TITLE     The TRAP100 component of the TRAP/Mediator complex is essential in
            broad transcriptional events and development
  JOURNAL   EMBO J 21 (13), 3464-3475 (2002)
   PUBMED   12093747
REFERENCE   7  (bases 1 to 2942)
  AUTHORS   Kang YK, Guermah M, Yuan CX and Roeder RG.
  TITLE     The TRAP/Mediator coactivator complex interacts directly with
            estrogen receptors alpha and beta through the TRAP220 subunit and
            directly enhances estrogen receptor function in vitro
  JOURNAL   Proc Natl Acad Sci U S A 99 (5), 2642-2647 (2002)
   PUBMED   11867769
REFERENCE   8  (bases 1 to 2942)
  AUTHORS   Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang
            X, Qin J and Roeder RG.
  TITLE     Identity between TRAP and SMCC complexes indicates novel pathways
            for the function of nuclear receptors and diverse mammalian
            activators
  JOURNAL   Mol Cell 3 (3), 361-370 (1999)
   PUBMED   10198638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474029.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216837.4, XM_001073722.1, XM_001073685.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2942
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2942
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /note="mediator complex subunit 16"
                     /db_xref="GeneID:299607"
                     /db_xref="RGD:1308001"
     exon            1..107
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..2627
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /note="thyroid hormone receptor associated protein 5"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 16"
                     /protein_id="NP_001100238.1"
                     /db_xref="GeneID:299607"
                     /db_xref="RGD:1308001"
                     /translation="MAAPDPGRWGECGPRPPGRLGARGGQEPGTVLGAVGMMDLAYVC
                     EWEKWAKSTYCPSLPLACAWSCRNLIAFTTDLRNDDQDLTHMIHILDTEHPWEVHSVS
                     SGHSEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSQVEGDPIVALS
                     WLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLL
                     KPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVAAADGSSASPVKFYKVCVSVVSE
                     KCRIDTEILPSLFMRCTTDPNRKDRFPAITHLKFLARDMSEQVLLCASSQTSSLVECW
                     SLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTD
                     LKVASDTQFYPGLGLALAFQDGSVHMVHRLSLQTMAVFYSSAPRSLDEPALKRPRTTG
                     PAVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSLGHALEPKLALQHLLFLLEYCMVT
                     GYDWWDILLHVQPGMVQSLVERLHEEYTRQKPALQQVLSTRILAMKASLCKLSPCTVA
                     RVCDYHTKLFLMAITSTLKSLLRPHFLNTPDKSPGDRLAEICAKITDVDIDKVMINLK
                     TEEFVLDMNTLQALQQLLQWVGDFVLYLLVSLPNQGSALRPGHSFLRDGASLGMLREL
                     MVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEGLVDE
                     CCLLPSQLLVPSLDWLPASDGLVSRLQPKQPLRLRFGRAPTLPSSTSILQLDGLTRAP
                     GQPKIDHLRRLHLGAYPTEECKACTRCGCVTMLKSPNKTTAVKQWEQRWIKNCLCGGL
                     WRRVPLSCS"
     exon            108..273
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     exon            274..381
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     exon            382..551
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     exon            552..983
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1089
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1245
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1454
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1661
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1872
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2006
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2199
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2416
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2500
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2942
                     /gene="Med16"
                     /gene_synonym="Thrap5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgttcgaggg ggccggcgcg ggccgagaaa tggcggcgcc ggatcccggg cgttggggcg
       61 agtgtggacc gcggccgccc ggtcggctgg gcgcccgggg cggacaggag ccagggacgg
      121 tgctgggtgc ggtgggtatg atggacctag cctatgtgtg cgaatgggag aagtgggcca
      181 agagcacgta ctgcccgtcg ctgcccctgg cctgcgcctg gtcctgcagg aacctcattg
      241 ccttcaccac agacctacgc aatgatgacc aggacctcac acacatgatt catatccttg
      301 acacagaaca tccctgggaa gtgcactctg tcagctctgg ccacagtgag gccatcacct
      361 gcctggaatg ggaccagtca gggtcccggc tcctgtctgc cgatgctgac gggcagatca
      421 aatgttggag catggctgac cacctggcca acagctggga gagctccgtg ggcagccagg
      481 tggaagggga ccccatcgtg gctctgtcct ggctgcataa cggggtgaaa ctggcactgc
      541 acgtagagaa gtctggtgcc tccagcttcg gagaaaagtt ctcccgggtg aaattctccc
      601 cgtctctcac gctgtttggt ggcaagccaa tggagggttg gattgcggtg acagtcagcg
      661 gcctggtcac tgtgtccctc ctgaagccca gtgggcaggt gctgacgtcc acggagagcc
      721 tgtgccggct gcgtggccga gtggcactgg ccgacatcgc cttcacaggc ggtgggaaca
      781 tcgttgtggc cgctgcggac ggcagcagtg catcgcccgt gaagttctac aaggtgtgcg
      841 tgagcgtggt gagcgagaag tgccgcatcg acacggagat cctgccctcg ctgtttatgc
      901 gctgcaccac cgaccccaac cgcaaggacc ggttccccgc catcacacac ctcaagttcc
      961 tggcgagaga catgtctgag caggtgctcc tgtgtgcatc cagccagacc agcagcctag
     1021 tggagtgctg gtcccttcgg aaagagggcc ttcctgtgaa caacatcttc cagcagatct
     1081 cgcctgtggt tggtgacaaa cagcccatga tcctcaagtg gcggatcctg tcagccacca
     1141 atgacctgga ccgtgtatca gctgtggcac tgccgaaact gcccatctca ctcaccaaca
     1201 ctgacctcaa ggtggccagt gacacccagt tctatccagg ccttggcttg gcgctggcct
     1261 tccaggacgg cagcgtgcac atggtgcatc ggctatccct tcagaccatg gctgtattct
     1321 acagctcggc cccacgctct ctggatgagc ctgccctgaa gcgcccacgc accacaggcc
     1381 ccgctgtaca cttcaaggcc atgcagctgt cctggacttc gctggccctg gtgggcatcg
     1441 ataaccacgg gaagctcagc atgctgcgca tctctccgtc cctgggccac gcgctggagc
     1501 ccaagctggc cctgcagcat ctgctgttcc tgctggagta ctgcatggtg actggctacg
     1561 actggtggga catcctgctc cacgtgcagc caggcatggt gcagagcctg gtggagcggc
     1621 tgcacgagga gtacacacgc cagaagcctg ccctgcaaca ggtcctctcc acccggatct
     1681 tagccatgaa ggcctcgctg tgcaagctgt caccctgcac cgtggctcgt gtgtgtgact
     1741 accacaccaa gctgttcctc atggctatca cgtccaccct caagtcgctg ctgcgcccac
     1801 acttcctcaa cacccctgac aagagccctg gagaccgcct ggccgagatc tgtgccaaga
     1861 tcaccgatgt tgacatcgac aaagtcatga tcaacctgaa gacagaagag tttgttctag
     1921 acatgaacac tttgcaggcg ctgcagcagt tgctacaatg ggtgggagac ttcgtgctct
     1981 acctcctggt cagcctgccc aaccagggct ccgcactgag gccgggccac agcttcctcc
     2041 gggatggtgc ctcactgggt atgctgcggg aattgatggt tgtcatccga atatggggcc
     2101 tactgaagcc cagttgcctg cccgtctata cagccacctc agacacccag gacagcatgt
     2161 ccctgctctt ccggctgctc accaagctgt ggatttgctg ccgtgacgaa ggcccagcca
     2221 gtgagcccga tgagggcttg gtggacgaat gctgcctgct gcccagccag ctgctggtcc
     2281 ccagcctgga ctggcttcct gccagtgacg gcctggtcag tcgcctgcag cccaaacagc
     2341 ccttgcgcct gcgcttcggc agggcaccca ccctgcccag cagcacctcc atcctgcagc
     2401 tggacggcct caccagggcc cctgggcagc ccaagatcga ccaccttcgg aggctacacc
     2461 tgggtgccta ccccacggag gagtgcaaag cctgcaccag gtgtggctgt gtcaccatgc
     2521 tgaagtcacc caacaagaca actgctgtga aacagtggga acagcggtgg atcaagaatt
     2581 gcctgtgtgg tgggctgtgg cggagagtgc ctctcagctg ttcctgagcc acagcccgcc
     2641 agtctgcgta tgtacagcca ctctctgaac agatgcaggg gactgtctgt gatgaaacat
     2701 tgacatcctc actggggcac tggcaccggc agcagcctgg gtctgcccct tctcggggcg
     2761 tgtgcgtctc cagtcccatg gttttatcca gcccagcttg aaggagctgg gctgctctgt
     2821 gttcatcctt taaaacacca cagcccatat gcccctgtcc tgattggggt atctgcctca
     2881 gtttcccttt gggacctatg ggaggggaag actagcccaa taaagttctc ttgtacccca
     2941 gg
//
