LOCUS       NM_001108325            3243 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus mediator complex subunit 15 (Med15), mRNA.
ACCESSION   NM_001108325 XM_001065699 XM_341015
VERSION     NM_001108325.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3243)
  AUTHORS   Poss ZC, Ebmeier CC and Taatjes DJ.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   2  (bases 1 to 3243)
  AUTHORS   Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL,
            Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J
            and Young RA.
  TITLE     Mediator and cohesin connect gene expression and chromatin
            architecture
  JOURNAL   Nature 467 (7314), 430-435 (2010)
   PUBMED   20720539
  REMARK    Erratum:[Nature. 2011 Apr 14;472(7342):247]
REFERENCE   3  (bases 1 to 3243)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 3243)
  AUTHORS   De Luca A, Conti E, Grifone N, Amati F, Spalletta G, Caltagirone C,
            Bonaviri G, Pasini A, Gennarelli M, Stefano B, Berti L, Mittler G,
            Meisterernst M, Dallapiccola B and Novelli G.
  TITLE     Association study between CAG trinucleotide repeats in the PCQAP
            gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 116B (1), 32-35 (2003)
   PUBMED   12497610
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473999.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341015.3, XM_001065699.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3243
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..3243
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /note="mediator complex subunit 15"
                     /db_xref="GeneID:360743"
                     /db_xref="RGD:1307560"
     CDS             1..2373
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /note="positive cofactor 2, multiprotein complex,
                     glutamine/Q-rich-associated protein"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 15"
                     /protein_id="NP_001101795.1"
                     /db_xref="GeneID:360743"
                     /db_xref="RGD:1307560"
                     /translation="MDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESH
                     VFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPTPGAAGIGMP
                     PRGPGQSLGGMGGLGAMGQPLPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVAL
                     QQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQLQQQQ
                     QQQHLIKLHHQSQQQQMQQQQQLQRMAQLQLQQQQQQQQQQQALQAQPPMQQPPMQQP
                     QPPPSQALPQQLSQMHHPQHHQPPPQAQQSPVAQNQPPQLQPQSQNQPLVSQAQALSG
                     PMLYAAQQPLKFVRPPMVVQQPQVQPQVQQVQPQVQPQAAVQTAQSAQMVAPGVQMIA
                     EALAQGGMHVRARFPPTSTMSAGPSSSISLGGQPTAQVSQSSLTMLSSPSPGQQVQTP
                     QSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSP
                     GPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLS
                     KMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLL
                     DAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIVSPVVCSRKRRFEEDERQSIPNVLQG
                     EVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPMWVD
                     RQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA"
     exon            1..68
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            69..156
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            157..208
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            209..238
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            239..451
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            452..702
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            703..1038
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1167
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1287
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1415
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1543
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1678
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1742
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1809
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1970
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2137
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2236
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..3243
                     /gene="Med15"
                     /gene_synonym="Pcqap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggacgttt cggggcagga gaccgactgg cgtagcgccg cctttcggca gaagctggtc
       61 agccaaattg aggatgccat gaggaaagct ggtgtggccc acagtaaatc tagcaaggat
      121 atggagagtc atgtgttcct gaaggccaag acccgggatg aatatctttc ccttgtggcc
      181 cgactcatta tccatttccg agatattcat aacaagaaat cccaagcttc tgtcagtgac
      241 cccatgaatg cactgcagag ccttactggt ggacccaccc caggagcagc tgggattggc
      301 atgcctcctc ggggcccagg acagtccctg ggtgggatgg gtggccttgg tgcgatggga
      361 caaccactgc ccctctccgg gcagccaccc cctggaacct ctggaatggc ccctcatggc
      421 atggctgtgg tgtctacagc aactccacag actcagctgc agctccagca agtggcattg
      481 cagcagcagc aacagcaaca acagcagcag ttccagcaac agcaggcagc attgcagcag
      541 cagcaacagc agcagcagca acagcagcag caacagcagt tccaggcaca acagaatgcc
      601 atgcagcagc agttccaagc agtagtgcag cagcagcaac tacagcagca gcagcagcaa
      661 cagcacctga ttaagttgca tcaccaaagc cagcaacaac agatgcaaca gcagcagcaa
      721 ctgcagagga tggcacagtt gcagctgcag caacagcaac aacagcagca acagcagcag
      781 gctttgcagg cccagccacc aatgcaacag ccaccaatgc agcagccaca gcctcctcct
      841 tctcaggccc taccccagca gctgtcacag atgcatcatc cacagcatca ccagccacca
      901 cctcaggctc agcagtcccc cgttgctcag aaccaaccac cacaactcca accacagtca
      961 cagaaccagc ctttggtgtc acaagcacaa gccctgtctg gaccaatgct ctatgctgcc
     1021 caacagccac tgaaatttgt ccgtcctccg atggtggtcc agcagccgca ggtgcagccc
     1081 caggtgcagc aggtgcagcc ccaggtgcag ccacaggcag cagtgcagac agcacagtct
     1141 gcccagatgg tagctcccgg cgttcagatg attgctgaag ccttggccca aggcgggatg
     1201 cacgtaagag cccggttccc gcccacctcc accatgtctg ctggcccgtc aagctccatc
     1261 tctttgggcg gacagcccac ggcacaggtc agccaaagca gcctcaccat gctgtcctca
     1321 ccgtcaccag gccagcaggt gcagacccca cagtcgatgc cccctccccc acagccatcc
     1381 ccacaacctg gctcacagcc caactctaat gtcagctccg gccctgcccc atcccccagc
     1441 agcttcctgc ctagcccctc accacagcct tcccagagcc cagtgacagc acgcacccca
     1501 cagaacttca gcgtcccttc ccccggacct ttaaacaccc ctgtgaaccc cagctctgtc
     1561 atgagccccg ctggctccag tcaggctgag gagcagcagt acctggacaa gctgaagcaa
     1621 ctgtccaagt acatcgagcc cttgcgccgt atgatcaaca agatcgacaa gaacgaagac
     1681 aggaaaaagg acttaagtaa gatgaagagc ttgctggaca tcctcactga cccctctaag
     1741 cggtgtcccc tgaagaccct gcaaaagtgt gagattgccc tggagaagct caagaatgac
     1801 atggcagtgc ccacaccccc accaccccca gttcttccaa ccaaacagca ggacctgtgc
     1861 caaccactcc tagatgcagt cctggccaac atccgttcac ctgtcttcaa ccattccctg
     1921 tatcgcacat tcgtgccagc catgatggcc atccatggtc cgcctatcgt gtccccagtg
     1981 gtgtgctccc ggaagcgcag gtttgaggag gatgagcggc agagcatacc caatgtgctg
     2041 caaggtgagg tggcaaggct ggatcccaag ttcctggtga acttggaccc ttctcactgc
     2101 agcaacaacg gtactgtcca cctgatctgc aagctggatg acaaggacct ccctagtgtg
     2161 ccaccactgg agctcagtgt acctgctgac taccctgccc agagcccgat gtgggtcgac
     2221 cgtcagtggc aatatgatgc caaccccttc ctgcagtcag tgcaccggtg catgacctcc
     2281 aggctgctgc agctccctga caagcactca gtcacagccc tgctcaacac ctgggcccag
     2341 agcatccacc aggcctgcct ctcagctgcc tagcaaactt gaacttcagg acggccagca
     2401 gcccttctgg ctgagggtct cataccacct accaaacgtc actaggtgtt ggcttcttag
     2461 agggccgggg ctaggttacc tttcctgctt ttaccttctg ccttggagac ctgcccgctc
     2521 tccccatctt gtgcagtatt gaccaggcag ctgtggagct ggctgcatga ggctgggggt
     2581 gttcccacaa ggttttccat tgtcgttttc ccccagaggt cagtccccac acttctacag
     2641 cctttctggg cttccatgtc cactcagcag catgagaact cagggtccca tcaaagcatc
     2701 tctgtgttac aacccattgt gctcatatct ggagaatgtg gaggacacag gaaaccctca
     2761 ccatacatac ggttctccag tcacactggg gttcaggctg tgccgcctaa ggcatgcgga
     2821 cacggtgcag gactcagtct gaattcaggg cacagatttc agtctggaag aaaggccagt
     2881 aaggaatcag caggttctct gccgccaaaa cttccacttt gtgggcctcc tcccagtcat
     2941 gggaggagag cagccagctg gggcagaggc tgcccctgac attgctgcac cagtgttggg
     3001 ccacgagctg tcagtgctgt gagacacagg cggctagcca gaaactgtca ttgggaccca
     3061 ccagcctcag cctcatactt actctctgta ccgccaccaa gagtgtgggt ttccttcaga
     3121 acgcaccaga tggcacttgc cacaccgagc agcaatgggt agcactctgg tggaaagaaa
     3181 ttcccccttt tatatgtgca ctactctgtc atatgattct tataataaat ttattattcc
     3241 tgt
//
