LOCUS       NM_001414735            6825 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus mediator complex subunit 12 (Med12), transcript
            variant 1, mRNA.
ACCESSION   NM_001414735 XM_006257104
VERSION     NM_001414735.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6825)
  AUTHORS   Makinen,N., Aavikko,M., Heikkinen,T., Taipale,M., Taipale,J.,
            Koivisto-Korander,R., Butzow,R. and Vahteristo,P.
  TITLE     Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent
            Mutations in TP53, ATRX, and MED12
  JOURNAL   PLoS Genet 12 (2), e1005850 (2016)
   PUBMED   26891131
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6825)
  AUTHORS   Lesca,G., Moizard,M.P., Bussy,G., Boggio,D., Hu,H., Haas,S.A.,
            Ropers,H.H., Kalscheuer,V.M., Des Portes,V., Labalme,A.,
            Sanlaville,D., Edery,P., Raynaud,M. and Lespinasse,J.
  TITLE     Clinical and neurocognitive characterization of a family with a
            novel MED12 gene frameshift mutation
  JOURNAL   Am J Med Genet A 161A (12), 3063-3071 (2013)
   PUBMED   24039113
REFERENCE   3  (bases 1 to 6825)
  AUTHORS   Poss,Z.C., Ebmeier,C.C. and Taatjes,D.J.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   4  (bases 1 to 6825)
  AUTHORS   Vogl,M.R., Reiprich,S., Kuspert,M., Kosian,T., Schrewe,H.,
            Nave,K.A. and Wegner,M.
  TITLE     Sox10 cooperates with the mediator subunit 12 during terminal
            differentiation of myelinating glia
  JOURNAL   J Neurosci 33 (15), 6679-6690 (2013)
   PUBMED   23575864
REFERENCE   5  (bases 1 to 6825)
  AUTHORS   Vulto-van Silfhout,A.T., de Vries,B.B., van Bon,B.W., Hoischen,A.,
            Ruiterkamp-Versteeg,M., Gilissen,C., Gao,F., van Zwam,M.,
            Harteveld,C.L., van Essen,A.J., Hamel,B.C., Kleefstra,T.,
            Willemsen,M.A., Yntema,H.G., van Bokhoven,H., Brunner,H.G.,
            Boyer,T.G. and de Brouwer,A.P.
  TITLE     Mutations in MED12 cause X-linked Ohdo syndrome
  JOURNAL   Am J Hum Genet 92 (3), 401-406 (2013)
   PUBMED   23395478
REFERENCE   6  (bases 1 to 6825)
  AUTHORS   Ge,K., Guermah,M., Yuan,C.X., Ito,M., Wallberg,A.E.,
            Spiegelman,B.M. and Roeder,R.G.
  TITLE     Transcription coactivator TRAP220 is required for PPAR gamma
            2-stimulated adipogenesis
  JOURNAL   Nature 417 (6888), 563-567 (2002)
   PUBMED   12037571
REFERENCE   7  (bases 1 to 6825)
  AUTHORS   Kang,Y.K., Guermah,M., Yuan,C.X. and Roeder,R.G.
  TITLE     The TRAP/Mediator coactivator complex interacts directly with
            estrogen receptors alpha and beta through the TRAP220 subunit and
            directly enhances estrogen receptor function in vitro
  JOURNAL   Proc Natl Acad Sci U S A 99 (5), 2642-2647 (2002)
   PUBMED   11867769
REFERENCE   8  (bases 1 to 6825)
  AUTHORS   Tchernev,V.T., Mansfield,T.A., Giot,L., Kumar,A.M., Nandabalan,K.,
            Li,Y., Mishra,V.S., Detter,J.C., Rothberg,J.M., Wallace,M.R.,
            Southwick,F.S. and Kingsmore,S.F.
  TITLE     The Chediak-Higashi protein interacts with SNARE complex and signal
            transduction proteins
  JOURNAL   Mol Med 8 (1), 56-64 (2002)
   PUBMED   11984006
REFERENCE   9  (bases 1 to 6825)
  AUTHORS   Naar,A.M., Beaurang,P.A., Zhou,S., Abraham,S., Solomon,W. and
            Tjian,R.
  TITLE     Composite co-activator ARC mediates chromatin-directed
            transcriptional activation
  JOURNAL   Nature 398 (6730), 828-832 (1999)
   PUBMED   10235267
REFERENCE   10 (bases 1 to 6825)
  AUTHORS   Ito,M., Yuan,C.X., Malik,S., Gu,W., Fondell,J.D., Yamamura,S.,
            Fu,Z.Y., Zhang,X., Qin,J. and Roeder,R.G.
  TITLE     Identity between TRAP and SMCC complexes indicates novel pathways
            for the function of nuclear receptors and diverse mammalian
            activators
  JOURNAL   Mol Cell 3 (3), 361-370 (1999)
   PUBMED   10198638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Dec 9, 2022 this sequence version replaced XM_006257104.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.56101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               JAXUCZ010000021.1  70444810-70444929
            121-225             JAXUCZ010000021.1  70445442-70445546
            226-417             JAXUCZ010000021.1  70445748-70445939
            418-577             JAXUCZ010000021.1  70446062-70446221
            578-759             JAXUCZ010000021.1  70446675-70446856
            760-870             JAXUCZ010000021.1  70447017-70447127
            871-1125            JAXUCZ010000021.1  70447239-70447493
            1126-1272           JAXUCZ010000021.1  70447998-70448144
            1273-1372           JAXUCZ010000021.1  70448435-70448534
            1373-1509           JAXUCZ010000021.1  70448647-70448783
            1510-1641           JAXUCZ010000021.1  70449009-70449140
            1642-1768           JAXUCZ010000021.1  70449865-70449991
            1769-1998           JAXUCZ010000021.1  70450604-70450833
            1999-2079           JAXUCZ010000021.1  70451207-70451287
            2080-2250           JAXUCZ010000021.1  70451406-70451576
            2251-2395           JAXUCZ010000021.1  70451780-70451924
            2396-2446           JAXUCZ010000021.1  70452092-70452142
            2447-2565           JAXUCZ010000021.1  70452439-70452557
            2566-2709           JAXUCZ010000021.1  70452738-70452881
            2710-2873           JAXUCZ010000021.1  70453321-70453484
            2874-3005           JAXUCZ010000021.1  70453728-70453859
            3006-3233           JAXUCZ010000021.1  70454205-70454432
            3234-3378           JAXUCZ010000021.1  70454606-70454750
            3379-3499           JAXUCZ010000021.1  70454867-70454987
            3500-3601           JAXUCZ010000021.1  70455426-70455527
            3602-3715           JAXUCZ010000021.1  70455623-70455736
            3716-3891           JAXUCZ010000021.1  70455994-70456169
            3892-4071           JAXUCZ010000021.1  70456335-70456514
            4072-4143           JAXUCZ010000021.1  70457520-70457591
            4144-4277           JAXUCZ010000021.1  70458016-70458149
            4278-4439           JAXUCZ010000021.1  70458315-70458476
            4440-4551           JAXUCZ010000021.1  70459172-70459283
            4552-4641           JAXUCZ010000021.1  70459446-70459535
            4642-4751           JAXUCZ010000021.1  70460279-70460388
            4752-4887           JAXUCZ010000021.1  70460600-70460735
            4888-5049           JAXUCZ010000021.1  70461441-70461602
            5050-5427           JAXUCZ010000021.1  70462850-70463227
            5428-5578           JAXUCZ010000021.1  70463448-70463598
            5579-5784           JAXUCZ010000021.1  70463741-70463946
            5785-5862           JAXUCZ010000021.1  70464108-70464185
            5863-6080           JAXUCZ010000021.1  70464273-70464490
            6081-6324           JAXUCZ010000021.1  70466142-70466385
            6325-6468           JAXUCZ010000021.1  70466888-70467031
            6469-6550           JAXUCZ010000021.1  70467223-70467304
            6551-6825           JAXUCZ010000021.1  70467503-70467777
FEATURES             Location/Qualifiers
     source          1..6825
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..6825
                     /gene="Med12"
                     /note="mediator complex subunit 12"
                     /db_xref="GeneID:679693"
                     /db_xref="RGD:1585896"
     exon            1..120
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..6594
                     /gene="Med12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mediator of RNA polymerase II transcription subunit 12"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 12 isoform 1"
                     /protein_id="NP_001401664.1"
                     /db_xref="GeneID:679693"
                     /db_xref="RGD:1585896"
                     /translation="MAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQG
                     FNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNF
                     WLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLI
                     KMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGVCGS
                     AIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKL
                     LLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVNSHSSHVISAQSTSSLPTTPA
                     PQPPTSNTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTG
                     SPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATA
                     GFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLL
                     CEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPI
                     FQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGD
                     LAFGTPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEK
                     PDFSLFSPTMPCEGKGSPSPEKPDVEKDVKPPPKEKIEGTLGILYDQPRHVQYATHFP
                     IPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIV
                     PLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQ
                     ITSFALGMSYHLPLVQHVQFVFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSD
                     LVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCI
                     LAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENP
                     AAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKS
                     LSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLED
                     LIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSC
                     DRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGR
                     RQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQR
                     LMQLICYPHRLLDSEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNS
                     LLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKAKPVLSSLERSGVWLVAPLIAKL
                     PTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQD
                     EQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRST
                     QQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEEN
                     KRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAG
                     FDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLL
                     LYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGTAPPSTEER
                     KKKSTKGKKRSQPATKSEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMG
                     LYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTTVMGLEPSSYKTSVY
                     RQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQSSQGYTSYVSHVGL
                     QQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLT
                     STQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQ
                     QQQQQQQQQQQQQYHIRQQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQPQQQQPHQ
                     QQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
                     "
     exon            121..225
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            226..417
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            418..577
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            578..759
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            760..870
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1125
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1272
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1372
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1509
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1641
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1768
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1998
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2079
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2250
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2395
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2446
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2565
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2709
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2873
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3005
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3233
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3378
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3499
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3601
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            3602..3715
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3891
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            3892..4071
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4143
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            4144..4277
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            4278..4439
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            4440..4551
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            4552..4641
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            4642..4751
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            4752..4887
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            4888..5049
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            5050..5427
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            5428..5578
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            5579..5784
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            5785..5862
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            5863..6080
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            6081..6324
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            6325..6468
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            6469..6550
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
     exon            6551..6825
                     /gene="Med12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcggtacg ggctgggcaa gatggcggct ttcgggatct tgagctatga acaccgaccc
       61 ctgaagcggc tgcggctggg gcctcccgat gtgtaccctc aagatcccaa acagaaggag
      121 gatgaactga cggctttgaa tgtaaaacaa ggtttcaata accagcctgc tgtctctggg
      181 gatgaacatg gcagtgccaa gaacgtcaac ttcaatcctg ccaagatcag ttccaacttc
      241 agcagcatca tcgcagagaa gttaaggtgt aatactctct ctgacactgg tcgaaggaag
      301 tccctaatga accagaagga caacttctgg ctggtgactg caagatctca gagtgctatt
      361 aacacctggt tcactgacct agctggcacc aaaccactca cacacctagc caaaaaggtc
      421 cccattttca gtaagaagga agaagtattt gggtacttgg ccaaatacac agtgcctgtg
      481 atgcgggctg cttggctcat taagatgacc tgcgcctact atgcagcaat gtctgagact
      541 aaggttaaga agaaaaacac cgctgacccc ttcactgaat ggactcaaat catcacaaag
      601 tacttatggg agcagctaca gaagatggct gaatactatc ggccagggcc tgcaggaagt
      661 ggagtctgtg gttctgctat aggacctttg ccccatgatg tagagatggc aatcaggcag
      721 tgggactaca atgagaagct cgccctcttc atgtttcagg atggaatgct ggacagacat
      781 gagttcctga cttgggtgct tgagtgtttt gagaaaatac gccctggaga agatgaattg
      841 cttaaattgc tgcttcccct actgcttcga tactcagggg agttcgttca gtctgcctat
      901 ctgtcccgcc gccttgccta cttctgtacc cggagattgg ctctacagct ggatggtgtg
      961 aacagccact catctcacgt tatatcggct cagtcaacga gttctctgcc cactacccca
     1021 gcacctcaac ccccaactag caatacaccc tcgactccct ttagtgacct gcttatgtgc
     1081 cctcagcacc gtcccttggt ttttggcctc agctgtatcc ttcagaccat cctcctgtgt
     1141 tgccctagtg ccctagtttg gcactactca ttgactgata gccgaattaa gactggctca
     1201 ccacttgacc acctgcctat tgctccttcc aacttgccta tgccagaggg taacagtgcc
     1261 tttactcagc aggtccgtgc aaaattacga gagatcgaac aacagatcaa ggagcgtgga
     1321 caagcagttg aggttcgctg gtcctttgat aagtgccagg aagctactgc aggcttcacc
     1381 attggacggg tgcttcatac tttagaagtg ctggacagcc atagttttga gcgctctgac
     1441 tttagtaact ctcttgactc cctttgtaat cgaatctttg gactggggcc tagtaaggat
     1501 ggtcatgaga tctcctctga tgatgatgct gtggtgtcgt tattgtgtga atgggctgta
     1561 agctgtaagc gctccgggcg gcaccgtgct atggtagtag ccaaactcct ggagaagaga
     1621 caagcagaaa ttgaggctga gcgctgtgga gaatctgaag cagctgatga gaagggttcc
     1681 gtcgcctctg gttccctttc tgctcctagt gcacccattt tccaggatgt cctcctgcag
     1741 tttctggata cacaggctcc catgctgact gatccccgaa gtgagagtga gcgagtggaa
     1801 ttctttaact tggtactgct gttctgtgaa ctgatccgac atgatgtctt ctcccataat
     1861 atgtacacct gcactctcat ctctcgggga gaccttgcat ttggaacacc tggtcctcgg
     1921 cccccctctc cttttgatga tcctgcagat gatcccgagc gcaaggaggc tgaaggcagc
     1981 agcagcagca agctagagga tccagggctc tctgaatcta tggacatcga ccctagttcc
     2041 agtgtgcttt ttgaggacat ggaaaagcct gatttctcat tgttctcccc tactatgcct
     2101 tgtgagggga agggaagccc atcccctgag aagccagatg tcgaaaagga tgtgaaaccc
     2161 ccacccaaag agaagattga ggggacactt gggattctgt atgaccagcc acgacatgtg
     2221 cagtatgcca cacactttcc aatcccacag gaggagtcat gcagccatga gtgcaaccag
     2281 cggttggtcg tactgtttgg ggtggggaag cagcgagatg atgcccgcca tgccatcaag
     2341 aagattacca aggatatcct gaaggttctg aaccgcaagg ggacagcaga aactgaccag
     2401 cttgctccta ttgtgcctct gaatcctgga gacctgacat tcttaggtgg ggaagatggg
     2461 cagaagcgac gccgcaaccg gcctgaagcc ttccccactg ctgaagatat ttttgctaag
     2521 ttccagcacc tttctcatta tgaccaacat caggtcacgg ctcaggtctc ccggaatgtt
     2581 ctggagcaga ttacgagttt tgctcttggc atgtcatacc acttgcctct ggtgcagcat
     2641 gtgcagttcg tcttcgacct catggaatat tcactaagca tcagtggcct catcgacttt
     2701 gccattcagc tgctgaatga gctgagtgtg gttgaggcag agctccttct caaatcgtct
     2761 gatctggtgg gcagctatac taccagcctg tgcttatgca tcgtggctgt ccttcgacac
     2821 tatcatgcct gcctcatcct caatcaagac cagatggcgc aagtgtttga ggggctctgt
     2881 ggcgtggtga aacatggaat gaaccgttca gatggctcct ctgcagagcg ctgtatcctt
     2941 gcttatctct atgatctgta tacctcctgt agccatttaa agagcaaatt tggggagctc
     3001 ttcagtgact tttgctcaaa agtgaagaac accatctact gtaatgtgga gccatcagaa
     3061 tccaatatgc gctgggcacc ggagttcatg attgacactc tggagaaccc tgctgctcac
     3121 actttcacct acacggggct aggcaagagt cttagtgaga accctgccaa ccgctacagc
     3181 tttgtctgca atgctcttat gcacgtctgt gtgggccacc atgatcctga tagggtaaat
     3241 gacatcgcta tcctttgtgc agagctcacc ggctattgca agtcactgag tgcagagtgg
     3301 ttaggagtac ttaaggcctt gtgctgctcc tctaacaatg gcacttgtgg tttcaacgat
     3361 ctcctgtgca acgtagatgt cagtgacttg tctttccacg attccctggc tacttttgtt
     3421 gctatcctca tcgcccgtca gtgtttgctc ctagaagacc tgattcgctg tgcagccatc
     3481 ccttcgctcc tcaatgctgc ttgtagtgag caggattctg agccaggggc caggcttact
     3541 tgccgaattc tcctccacct gttcaagacg ccacaactca atccttgcca gtccgatgga
     3601 aacaaaccta ccgttggaat ccggtcctcc tgtgaccgcc acctgctggc tgcctcccag
     3661 aaccgcatcg tggatggagc tgtgtttgct gttctcaagg ctgtgtttgt actcggggat
     3721 gcggagctta aaggttcagg cttcactgtg ccgggaggaa cagaagaact tccagaagag
     3781 gagggaggag gtggtagtag cggtcggagg cagggtggcc gcaacatctc tgtggagaca
     3841 gcaagtctgg atgtctatgc caagtacgtg ctgcgaagca tctgccaaca ggaatgggta
     3901 ggagaacgtt gccttaagtc actgtgtgag gatagcaatg atctacaaga cccagtgttg
     3961 agtagtgccc aggcccagcg cctcatgcag ctcatctgct acccacatcg actgctggac
     4021 agcgaagatg gagaaaaccc ccagcggcag cgcattaagc ggattctcaa gaacttagac
     4081 caatggacca tgcgccagtc ctctttggag ctacagctga tgatcaagca gacccccaac
     4141 accgagatga actctctctt ggagaacatt gccaaggcca caattgaggt tttccaacag
     4201 tccgcagaga cgggatcatc ctctggcagt acagcaagca atatgcccag cagcagcaag
     4261 gccaaacctg tgctcagctc tctggagcgc tctggtgtat ggttggtggc tcctctcatt
     4321 gccaaactgc ccacttcagt tcagggccat gtattaaaag ctgctgggga ggaattggaa
     4381 aagggtcagc acctgggttc ttcttcccgg aaagaacgag atcgacaaaa acagaagagt
     4441 atgtccctgt tgagccagca gcctttctta tcactggtgc taacatgtct gaaaggacag
     4501 gatgaacaac gtgagggact ccttgcctcc ctccacagcc aggtgcacca gattgtgatt
     4561 aattggcgag aaaaccagta cttagatgat tgcaaaccaa agcagctaat gcatgaggca
     4621 ctcaaactgc ggctcaacct ggtcgggggc atgtttgaca ctgtgcagcg tagtacccaa
     4681 cagactacag agtgggccca gctcctcctg gagattatca tcagtggcac tgtggatatg
     4741 cagtctaaca atgaactctt cactactgtg ttggacatgc tgagcgtgct tatcaatgga
     4801 acgttggctg cagacatgtc cagtatctca caaggcagca tggaggaaaa caaacgtgca
     4861 tatatgaacc tggtgaagaa gcttcagaag gacttggggg agcgccaatc agacagtctg
     4921 gaaaaggttc accaactgtt gccactaccc aagcagaacc gagatgtcat aacctgtgag
     4981 ccacagggct cccttattga caccaagggc aacaagattg ctggcttcga ttccatcttc
     5041 aagaaggagg gtctacaagt ttccaccaaa caaaagatct ctccttggga gctttttgag
     5101 ggcctgaagc catcaacagc accactatca tgggcctggt ttggcacagt ccgagtggac
     5161 cgccgagtgg cacgagggga ggagcagcaa cgactgttgc tctaccatac ccacctgagg
     5221 cctcgaccca gagcctatta cctggagcca ctacctctgc ccccagaaga tgaggagcca
     5281 ccagcccctg ccctactaga gcctgagaaa aaggctcctg agccccccaa gactgacaaa
     5341 ccagggactg ctcctcccag cacagaggag cgcaagaaga aatctaccaa gggcaagaaa
     5401 cgcagtcagc cagccaccaa gagcgaggac tatggcatgg ggccaggtcg gagtggtccc
     5461 tatggtgtga cagtgcctcc agaccttcta caccatgcaa atccaggttc tatatcccac
     5521 cttagctaca ggcagagctc catgggcctg tacacccaaa accagccact gcctgctggt
     5581 ggccctcgtg tggacccata tcgccctgtg cgattaccaa tgcagaagct gccaactcga
     5641 ccaacttacc ccggtgtgct gcctacaact atgactactg tcatgggcct agaaccctct
     5701 tcttataaga cctctgtgta ccggcagcag caacccacag tgccccaggg acagcgcctt
     5761 cgccaacagc tccaggcaaa gatacagagt cagggaatgt tgggacagtc atctgtccat
     5821 cagatgactc ctagttcttc ctatggtttg cagagttccc agggctatac gtcctatgtc
     5881 tctcatgtgg gattgcagca acacacaggc cctgcaggta ccatggtgcc ccccagctac
     5941 tccagccagc cttatcagag cacccaccct tctaccaatc ctactcttgt agatcctacc
     6001 cgtcacctgc aacagcggcc cagtggctat gtgcatcagc aggccccaac ctatgggcat
     6061 ggactgactt ccactcaaag gttttcacac cagacactgc agcagacacc aatgatgggt
     6121 accatgactc cgttgagtgc ccagggtgtc caggcaggcg tccgttcaac ttccatcctg
     6181 cctgagcagc aacaacagca acaacagcag cagcagcaac agcagcagca acaacagcaa
     6241 cagcagcaac agcagcaaca gcaacaacag caacaacagc agtaccacat ccgacagcaa
     6301 caacagcaac agcagatcct aaggcaacag cagcaacagc agcagcagca gcaacaacag
     6361 cagcaacagc agcagcaaca acagcagcaa caaccacaac agcagcagcc acaccagcag
     6421 cagcagcagg cagcacctcc ccaacctcaa ccccagtccc agccccagtt ccagcgccag
     6481 gggcttcagc agacccagca gcagcaacag acagcagctt tggtccggca acttcaacaa
     6541 cagctctcta atacccagcc acagcccagt accaacatat ttggacgcta ctgagtcacc
     6601 tggaggaact gcttatacac tggatgtggc ccagcctttc tgcttaattc ccagtcccct
     6661 tcttgggcga gctccagtag tggttggggt ccttccctca ggctccattt ttaatgaatt
     6721 tttagtattt ttgttaatgt gaaacattga actgttgggt tttgtatatt atttatatag
     6781 agctccagag ctgctgcact caatacacag agcttctttg caaaa
//
