LOCUS       NM_001106097             860 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus mediator complex subunit 10 (Med10), mRNA.
ACCESSION   NM_001106097 XM_001062474 XM_214417
VERSION     NM_001106097.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 860)
  AUTHORS   Poss ZC, Ebmeier CC and Taatjes DJ.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   2  (bases 1 to 860)
  AUTHORS   Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL,
            Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J
            and Young RA.
  TITLE     Mediator and cohesin connect gene expression and chromatin
            architecture
  JOURNAL   Nature 467 (7314), 430-435 (2010)
   PUBMED   20720539
  REMARK    Erratum:[Nature. 2011 Apr 14;472(7342):247]
REFERENCE   3  (bases 1 to 860)
  AUTHORS   Malik S, Guermah M, Yuan CX, Wu W, Yamamura S and Roeder RG.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. PMID:
            36255214]
REFERENCE   4  (bases 1 to 860)
  AUTHORS   Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R,
            Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW
            and Conaway RC.
  TITLE     Mammalian mediator subunit mMED8 is an Elongin BC-interacting
            protein that can assemble with Cul2 and Rbx1 to reconstitute a
            ubiquitin ligase
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10353-10358 (2002)
   PUBMED   12149480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB582092.1 and AA819805.1.
            
            On Dec 24, 2009 this sequence version replaced NM_001106097.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB582092.1, CB581501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-602               CB582092.1         1-602
            603-860             AA819805.1         1-258               c
FEATURES             Location/Qualifiers
     source          1..860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..860
                     /gene="Med10"
                     /gene_synonym="RGD1310128"
                     /note="mediator complex subunit 10"
                     /db_xref="GeneID:290939"
                     /db_xref="RGD:1310128"
     exon            1..166
                     /gene="Med10"
                     /gene_synonym="RGD1310128"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..452
                     /gene="Med10"
                     /gene_synonym="RGD1310128"
                     /note="mediator of RNA polymerase II transcription,
                     subunit 10 homolog (NUT2, S. cerevisiae)"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 10"
                     /protein_id="NP_001099567.2"
                     /db_xref="GeneID:290939"
                     /db_xref="RGD:1310128"
                     /translation="MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLSQKLNFI
                     VTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTM
                     KKFKSLLIQELSKVFPEDMAKYRSIRGEDHPPS"
     exon            167..250
                     /gene="Med10"
                     /gene_synonym="RGD1310128"
                     /inference="alignment:Splign:2.1.0"
     exon            251..353
                     /gene="Med10"
                     /gene_synonym="RGD1310128"
                     /inference="alignment:Splign:2.1.0"
     exon            354..844
                     /gene="Med10"
                     /gene_synonym="RGD1310128"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgagtcgct gggagctgtg gctaagaggc gggtggggct ggcgatggcg gagaagtttg
       61 accatctaga ggagcacctg gagaagttcg tggagaacat tcggcagctc ggcatcatcg
      121 tcagcgactt ccaacccagc agccaggcgg ggctgagcca gaagctgaac ttcattgtta
      181 cgggcttaca ggacatagat aaatgcagac agcagctaca tgatatcacg gtgcctctgg
      241 aagtttttga atacattgat caaggtcgaa atccccagct ctacaccaaa gaatgcctgg
      301 agagggctct tgctaaaaac gaacaagtca aggggaagat cgacacaatg aagaaattta
      361 aaagcctact gattcaggaa ctttctaaag tgtttccaga agacatggcc aagtatcgga
      421 gcattcgggg ggaggatcac ccgccttcct aatgtgcgaa gaccccacat ccttctgata
      481 actggactga cccagtgaga gctgtgcctg ccaatgctgc cttccagcca cgggactggc
      541 cttgccccac ctcccgctcc catcctttga gctgtgggac tcggggctgg aggagccgag
      601 ctgtgcccca ctgtccctgc agctctcagg cccttgggga ccaggcagga agacagcctt
      661 gctgaatgtg acatgggctt gggattctac tggacatttt cttttcatgt actctgttct
      721 gttacactgt ccataagagg aaacttggtt ctatatttta cattttcaga tgttgtgcat
      781 aagaaaataa ctgttttcat gggtttcaac tcgatataat aaagcctaaa gtttacactg
      841 ctcaaaaaaa aaaaaaaaaa
//
