LOCUS       NM_001415766            7985 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus mediator complex subunit 1 (Med1), mRNA.
ACCESSION   NM_001415766 XM_006247398
VERSION     NM_001415766.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7985)
  AUTHORS   Zhang,Y., Fu,Y., Zhang,C., Jia,L., Yao,N., Lin,Y., Dong,Y.,
            Fatima,N., Alam,N., Wang,R., Wang,W., Bai,L., Zhao,S. and Liu,E.
  TITLE     MED1 Deficiency in Macrophages Accelerates Intimal Hyperplasia via
            ROS Generation and Inflammation
  JOURNAL   Oxid Med Cell Longev 2021, 3010577 (2021)
   PUBMED   34853629
  REMARK    GeneRIF: MED1 Deficiency in Macrophages Accelerates Intimal
            Hyperplasia via ROS Generation and Inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7985)
  AUTHORS   Lo,K.A., Huang,S., Walet,A.C.E., Zhang,Z.C., Leow,M.K., Liu,M. and
            Sun,L.
  TITLE     Adipocyte Long-Noncoding RNA Transcriptome Analysis of Obese Mice
            Identified Lnc-Leptin, Which Regulates Leptin
  JOURNAL   Diabetes 67 (6), 1045-1056 (2018)
   PUBMED   29519872
REFERENCE   3  (bases 1 to 7985)
  AUTHORS   Jia,Y., Chang,H.C., Schipma,M.J., Liu,J., Shete,V., Liu,N.,
            Sato,T., Thorp,E.B., Barger,P.M., Zhu,Y.J., Viswakarma,N.,
            Kanwar,Y.S., Ardehali,H., Thimmapaya,B. and Reddy,J.K.
  TITLE     Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator
            Complex Causes Lethal Dilated Cardiomyopathy in Mice
  JOURNAL   PLoS One 11 (8), e0160755 (2016)
   PUBMED   27548259
  REMARK    Erratum:[PLoS One. 2016 Sep 30;11(9):e0164316. PMID: 27690354]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7985)
  AUTHORS   Mizuta,S., Minami,T., Fujita,H., Kaminaga,C., Matsui,K., Ishino,R.,
            Fujita,A., Oda,K., Kawai,A., Hasegawa,N., Urahama,N., Roeder,R.G.
            and Ito,M.
  TITLE     CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a
            novel pathway for GATA1 function
  JOURNAL   Genes Cells 19 (1), 28-51 (2014)
   PUBMED   24245781
  REMARK    Erratum:[Genes Cells. 2023 Jan;28(1):78. PMID: 36647803]
REFERENCE   5  (bases 1 to 7985)
  AUTHORS   Poss,Z.C., Ebmeier,C.C. and Taatjes,D.J.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   6  (bases 1 to 7985)
  AUTHORS   Naar,A.M., Beaurang,P.A., Zhou,S., Abraham,S., Solomon,W. and
            Tjian,R.
  TITLE     Composite co-activator ARC mediates chromatin-directed
            transcriptional activation
  JOURNAL   Nature 398 (6730), 828-832 (1999)
   PUBMED   10235267
REFERENCE   7  (bases 1 to 7985)
  AUTHORS   Treuter,E., Johansson,L., Thomsen,J.S., Warnmark,A., Leers,J.,
            Pelto-Huikko,M., Sjoberg,M., Wright,A.P., Spyrou,G. and
            Gustafsson,J.A.
  TITLE     Competition between thyroid hormone receptor-associated protein
            (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for
            binding to nuclear receptors. Implications for the recruitment of
            TRAP and p160 coactivator complexes
  JOURNAL   J Biol Chem 274 (10), 6667-6677 (1999)
   PUBMED   10037764
REFERENCE   8  (bases 1 to 7985)
  AUTHORS   Ito,M., Yuan,C.X., Malik,S., Gu,W., Fondell,J.D., Yamamura,S.,
            Fu,Z.Y., Zhang,X., Qin,J. and Roeder,R.G.
  TITLE     Identity between TRAP and SMCC complexes indicates novel pathways
            for the function of nuclear receptors and diverse mammalian
            activators
  JOURNAL   Mol Cell 3 (3), 361-370 (1999)
   PUBMED   10198638
REFERENCE   9  (bases 1 to 7985)
  AUTHORS   Yuan,C.X., Ito,M., Fondell,J.D., Fu,Z.Y. and Roeder,R.G.
  TITLE     The TRAP220 component of a thyroid hormone receptor- associated
            protein (TRAP) coactivator complex interacts directly with nuclear
            receptors in a ligand-dependent fashion
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 7939-7944 (1998)
   PUBMED   9653119
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14584]
REFERENCE   10 (bases 1 to 7985)
  AUTHORS   Zhu,Y., Qi,C., Jain,S., Rao,M.S. and Reddy,J.K.
  TITLE     Isolation and characterization of PBP, a protein that interacts
            with peroxisome proliferator-activated receptor
  JOURNAL   J Biol Chem 272 (41), 25500-25506 (1997)
   PUBMED   9325263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 29, 2022 this sequence version replaced XM_006247398.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.45351.1,
                                           SRR26643292.43065.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               JAXUCZ010000010.1  83685321-83685545   c
            226-332             JAXUCZ010000010.1  83681468-83681574   c
            333-411             JAXUCZ010000010.1  83675401-83675479   c
            412-466             JAXUCZ010000010.1  83671927-83671981   c
            467-599             JAXUCZ010000010.1  83671692-83671824   c
            600-628             JAXUCZ010000010.1  83670718-83670746   c
            629-700             JAXUCZ010000010.1  83664361-83664432   c
            701-775             JAXUCZ010000010.1  83662864-83662938   c
            776-849             JAXUCZ010000010.1  83662157-83662230   c
            850-939             JAXUCZ010000010.1  83658746-83658835   c
            940-1051            JAXUCZ010000010.1  83657778-83657889   c
            1052-1176           JAXUCZ010000010.1  83656936-83657060   c
            1177-1295           JAXUCZ010000010.1  83656345-83656463   c
            1296-1497           JAXUCZ010000010.1  83653925-83654126   c
            1498-1593           JAXUCZ010000010.1  83650696-83650791   c
            1594-1699           JAXUCZ010000010.1  83650487-83650592   c
            1700-7985           JAXUCZ010000010.1  83641851-83648136   c
FEATURES             Location/Qualifiers
     source          1..7985
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..7985
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /note="mediator complex subunit 1"
                     /db_xref="GeneID:497991"
                     /db_xref="RGD:1559552"
     exon            1..225
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..4949
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 1"
                     /protein_id="NP_001402695.1"
                     /db_xref="GeneID:497991"
                     /db_xref="RGD:1559552"
                     /translation="MKAQGETEESEKLSKMSSLLDRLHAKFNQSRPWSETIKLVRQVM
                     EKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECY
                     ITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNL
                     YNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNATPLDKILHGSVGYLTPRSGGH
                     LMNMKYYASPSDLLHDTTASPITLHEKNVPRSLGMNASVTIEGTSAMYKLPIAPLIMG
                     SHPADNKWTPSFSAVTSANSVDLPACFFLKFPQPIPVSKAFVQKLQNCTGIPLFETPP
                     TYLPLYELITQFELSKDPDPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGQSLQGTL
                     VSKITFQHPGRVPLILNMIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRF
                     SVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTM
                     RAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNT
                     FPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTP
                     PHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCS
                     GSNKTKKNKSSRVPPDKPKHQTEDDFQRELFSMDVDSQNPMFDVSMTADALDTPHITP
                     APSQCSTPPTTYPQPVSHPQPSIQRMGRLSSSDSIGPDVTDILSDIAEEASKLPSTSD
                     DCPPIGTPVRDSSSSGHSQSALFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTN
                     HFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGMPMLGGD
                     NGESKLKGSSQADTVDFSILSVAGKALGAADLLEHHSGSQSPLLTTGELGKEKTQKRV
                     KEGNGMGASSGSGPGSDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSNRPF
                     TPPTSTGGSKSPGSSGRCQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYSSSGSV
                     SSSGSKSHHSHSSSSSSLSSASTSGKMKSSKSEGSSSAKLSGSMYSSQGSSGSSQSKN
                     SSQTGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSISKPNISPSHSRPPGGSD
                     KLASPMKPVPGTPPSSKAKSPISSGSGSSHVSGTSSSSGMKSSSGSGSSGSLSQKTPP
                     ASNSCTPSSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGP
                     GGEDPIDSQMGASTNSSNHPMSSKHNMSGGEFQSKREKSDKDKSKVSTSGGSVDSSKK
                     TSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGDSGGEGLRPQIASSKNYGSPL
                     ISGSTPKHERGSPSHSKSPAYTPQNVDSESESGSSIAERSYQNSPSSDDGVRPLPEYS
                     TEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPENWSKSPISSDQTSSMTNNPI
                     LSADRPSRLSPDFMIGEEDDDLMDVALIGN"
     exon            226..332
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            333..411
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            412..466
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            467..599
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            600..628
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            629..700
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            701..775
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            776..849
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            850..939
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1051
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1176
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1295
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1497
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1593
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1699
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..7985
                     /gene="Med1"
                     /gene_synonym="RGD1559552"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagttccgtt ggggaagatg gcggcggccg cgagcaccct tctcttcttg ccgccgggga
       61 cttcagactg aaccttcccc ggaagagtgg gggccgctgg tgcgctgctt ccccggagtc
      121 caggctaact tggttcccct cttagtggtg gggaaaggct ccctggcttg tggcggaccc
      181 aagacctcac cgctgtcagg atgaaggctc agggggaaac cgaggagtca gagaagctga
      241 gtaagatgag ttctctcttg gaccggctcc atgcaaaatt taaccaaagt agaccttgga
      301 gtgagaccat taagcttgtg cgtcaagtca tggagaagag ggtcgtaatg agttctggag
      361 gacatcagca tttggtcagc tgtttggaga cattacagaa ggctctcaaa gtaacatctt
      421 tgccagcaat gactgatcgt ttggaatcca tagccagaca gaatggactg ggctctcatc
      481 tcagtgccag tggcactgaa tgttacatca cgtcagatat gttctatgtg gaagtgcagt
      541 tagaccctgc aggacagctt tgtgatgtaa aagtggctca ccatggggag aatcctgtga
      601 gctgtccaga gcttgtgcag cagttaaggg aaaagaattt tgatgagttt tctaagcatc
      661 ttaagggtct tgttaatctg tataaccttc caggagacaa caaactgaag actaagatgt
      721 atctggctct ccagtcctta gaacaggacc tttctaaaat ggcaattatg tactggaagg
      781 caactaatgc tactcccttg gataagattc ttcacggaag tgttggctat ctcactccac
      841 ggagcggggg tcatttaatg aacatgaaat actatgcctc tccgtctgac ctgctgcatg
      901 atacaactgc ctctcctatc actttgcatg aaaagaatgt tcctcggtct ttgggaatga
      961 atgcctcagt gacaattgaa ggaacctctg ctatgtacaa actcccaatt gccccattaa
     1021 ttatggggtc acacccagct gacaacaaat ggaccccttc tttctctgca gtcactagtg
     1081 ccaacagtgt tgatcttcct gcgtgtttct tcttgaaatt tccccagcca atcccagtat
     1141 ctaaagcatt tgttcagaaa ctgcaaaatt gcacgggaat cccgttgttt gagactccgc
     1201 ctacttacct gcccctctat gaactcatca ctcagtttga gctgtcaaag gatcctgacc
     1261 ctttaccttt gaatcacaac atgcgatttt acgctgctct tccaggtcag cagcactgct
     1321 attttctcaa taaagatgct cctcttcctg atggccaaag cctgcaggga acactggtca
     1381 gcaaaatcac cttccagcac cctggccgag ttcctcttat cttgaatatg atcagacacc
     1441 aagtggccta taacacccta attggaagct gtgttaaaag aactatttta aaagaagatt
     1501 ctcctgggct cctccaattt gaagtgtgtc ctctttcaga atctcgattc agtgtatctt
     1561 ttcagcaccc tgtgaatgac tcccttgtgt gtgtggtgat ggacgtgcaa gactcaacac
     1621 atgtgagctg taaactctac aaggggctat cagatgcact gatctgtaca gacgacttca
     1681 ttgccaaagt tgttcaaaga tgtatgtcca tccctgtgac gatgagggct attcggagga
     1741 aggctgaaac catacaggct gacacgccag cactgtccct cattgcagag acagtcgaag
     1801 acatggtgaa aaagaacctg cccccggcta gcagcccagg gtatggcatg accacaggca
     1861 gcaacccaat gagcggtacc accacaccaa ccaacacctt tccggggggt cccattacca
     1921 ccttgtttaa tatgagcatg agcatcaaag atcggcatga gtcggtgggc catggggagg
     1981 acttcagcaa ggtgtctcag aacccaattc ttaccagttt gttgcaaatc acagggaacg
     2041 gggggtctac cattggctcg agtccgaccc ctcctcatca cacgccgcca cctgtctctt
     2101 cgatggccgg caacaccaag aaccacccga tgctcatgaa ccttcttaaa gataaccctg
     2161 cccaagattt ctcaaccctt tatggaagca gccctttaga aaggcagaac tcctcttccg
     2221 gatcaccccg gatggaaatg tgctcgggga gcaacaagac caagaaaaat aagtcatcaa
     2281 gagtaccacc ggacaaaccc aagcaccaga ccgaagatga ttttcagagg gagctctttt
     2341 caatggatgt cgactcacag aaccctatgt tcgatgtcag catgacagct gacgcgctgg
     2401 atacacctca tatcactcca gctccaagcc agtgtagtac gcccccaaca acgtacccac
     2461 agccagtgtc tcacccccag cccagtattc aaaggatggg ccgactgtcc agttcagaca
     2521 gcattggccc agatgtaact gatattcttt cagacattgc agaagaagct tcaaagcttc
     2581 ccagcactag tgatgattgc ccacccattg gtaccccagt tcgagattcc tcgagttctg
     2641 ggcattctca gagtgccctc tttgactctg atgtctttca gactaataac aatgaaaatc
     2701 catacactga cccggctgac cttattgcag atgctgctgg gagccccagt agtgattctc
     2761 ctaccaatca ttttttccct gatggagtag atttcaatcc tgatttgttg aacagccaaa
     2821 gccaaagtgg ttttggagag gagtattttg atgaaagtag tcagagtggg gataatgatg
     2881 atttcaaagg atttgcatct caggcactaa atactttggg gatgccaatg ctcggaggtg
     2941 acaatgggga gtcgaaattg aagggcagca gccaagctga cacagttgac ttcagtattc
     3001 tgtcagtagc tggtaaggct ttgggtgcag cagaccttct ggagcaccac agtggtagtc
     3061 agagtcctct gctgaccact ggagaattag ggaaagaaaa aactcaaaag agggtgaagg
     3121 aaggcaacgg tatgggcgct agcagtgggt caggcccggg gtcagacagc aagccaggca
     3181 agcgcagccg cacaccttcc aatgatggga agagcaaaga taagcctcca aagcgaaaga
     3241 aggcagacac ggagggaaaa tccccatctc acagttctaa tagacctttc accccaccca
     3301 ccagtacagg tgggtccaaa tcccctggca gttcaggacg atgtcagacg ccccctggtg
     3361 tcgccacacc gcccattccc aagatcacca ttcagattcc taaaggaaca gtgatggtgg
     3421 gcaagccttc ctcgcacagt cagtactcta gcagtggttc tgtgtcttcc tctggcagca
     3481 aaagccacca cagtcattct tcctcctcct cttccttatc ttctgcttcc acctcaggca
     3541 agatgaaaag cagtaaatca gaaggctcct caagtgccaa gctcagtggc agtatgtatt
     3601 ctagccaagg gtcttctgga tccagccagt ccaaaaattc atctcagact ggggggaagc
     3661 caggctcctc tcccattacc aaacatggac tgagtagtgg gtctagcagc accaagatga
     3721 aacctcaagg caagccatcc tcacttatga atccttctat aagtaaacca aacatatccc
     3781 cttcccattc aaggcctcct ggaggctcag ataagcttgc ctctccaatg aagcctgttc
     3841 ccgggacccc cccatcctct aaagccaagt cccctatcag ttcaggttct ggtagctctc
     3901 atgtgtcagg aactagttca agctctggta tgaagtcttc ttcagggtca ggatcctcag
     3961 gctcattgtc tcaaaaaact cccccagcat ctaattcttg tacaccatct tcctcctcat
     4021 tttcctcaag tggttcttcc atgtcatcct ctcagaatca acatgggagt tccaaaggga
     4081 aatctcccag taggaataag aagccttctt tgacagctgt catagataaa ttgaagcatg
     4141 gggtggttac cagtgggcct gggggtgagg atccaataga cagtcagatg ggtgcaagca
     4201 caaattcctc taaccatccc atgtcctcca aacataacat gtcaggagga gaattccaga
     4261 gcaaacgtga gaaaagcgat aaagacaaat caaaggtttc tacttctgga ggatcagttg
     4321 attcctctaa gaagacttca gagtcaaaaa atgtggggag cacgggtgtg gcaaaaatta
     4381 ttatcagcaa gcacgatgga ggctccccga gcatcaaagc caaagtgact ctacagaaac
     4441 ctggagatag tggtggagaa gggctcaggc cacagatcgc ctcttcaaaa aactatggct
     4501 ctccattgat cagtggttct actccaaagc atgaacgggg ttctcccagc cacagtaagt
     4561 cgccagcata tacacctcag aatgtggaca gtgaaagtga gtcaggctcc tccatagcag
     4621 agagatccta ccagaacagc cccagctcag atgatggtgt ccggccactc ccagaataca
     4681 gcacagagaa gcataagaag cacaaaaagg aaaagaaaaa agtaaaagat aaagatagag
     4741 accgggacag agacaaagac agagacaaga aaaaatctca cagcatcaag ccagagaatt
     4801 ggtctaaatc ccccatttct tcagatcaga cttcatctat gacaaataac cctatcttat
     4861 ctgcagacag gccttccagg ctcagccctg actttatgat tggggaggaa gatgatgatc
     4921 ttatggatgt ggctctgatt ggcaattaac cttactttct aaacagacat gtccagaggc
     4981 gaaattaacg atacatgtaa accaacatga ggggtgagtc agacaggccg atctgtgctt
     5041 gagaatccta caggcatggc gtctgcatca ggctgggtgc atttatacac atatctaaac
     5101 cctgctagga aaccatgccg ctggttgctc atgaacaagt cctatctctt tgccagaaag
     5161 caatgaataa aatacttgct taagaaaggg agagggggtg gtgggaaagg gtgtagagag
     5221 ggaggggtgg gaaacttttg tgggaaatat tcatatatat ttttctccct tttccatttt
     5281 caggacatgc tttaaagtca ttttagtgca tgtatttgaa gggctgggca gaaaatgaaa
     5341 aagcaataca ttccttgatg cgttcgcatg aaggttgttc acctttggga ggtgaccagt
     5401 ggaagcatgg gcaaggaagg gacttggcag ttctggacac ttaaagcaat gtttggtgtc
     5461 tgtttcttag gagtgattgg gggagggaaa attattttag ctatttattt gtaatatttt
     5521 aatccttgat gtttgttttt atgcaatgtt tgttcctaaa tctatgaagg ttatggttca
     5581 gaacagtagg caggcagcaa ggattgtctg gtgggggaag cttgcggctc gtgttgatgc
     5641 tgcagcacca agcccacaga gctaatcaca gcctgtcttt ggagttaaat agaaaaacca
     5701 aaactattat ctttggaggt ttttcacagg gttcagacac cataggaata ttaggagtga
     5761 gttacctccc tatgcagata aaagatttat cttctttaat taaaaaggaa gggtggcttt
     5821 tgggggtata catatatttt cagaatctat accctattgt ataaaaacca gtatagaatt
     5881 attagttctc ctagttccac aatgtgccaa acgtctacat cccagcattt tgtttgcagg
     5941 agagctgatg ccattcctaa gagctggact ctttgtttct cttcaacacc aggaggagga
     6001 gttcagacgt aaatcactcc actgtatgct ccccagataa acagttttta aaaaaaaaat
     6061 gcagccatag ttcacttaaa acaatttcaa gctcacttga agtgattagg gcctggaatg
     6121 ctaagtgagc atgaagataa cccttgctac cgtgtagcac acaattggac ctttttggag
     6181 aaacaggtct gagtctggat tctgagggac atcaaggaag accttctcat aagtacagga
     6241 acgcaggaga ccgttttgag tgcaacagaa gtttctcagt atttggaggg tcctctcaaa
     6301 aatccgcggc cttactttga tttcgccacc tgcactgtgc cattcctgat gattctgttc
     6361 aggatctgtg tcagcggggc ggggcatgat ccccagcaca actcttctgg attacaaaac
     6421 gaaaaaaaaa aaaaaaagcc aggtgattga tgtttgtgtg tgttataagt ggagtgactt
     6481 catcagatat ggacgcttct acatccaaca ctctgcaggc tggagtcagc atagactgga
     6541 aaatctactg tggttcctga ctcttccttt ttctttcttt attttttgac attcttcctt
     6601 ttctggttct caacaactct gccatttctg tgtcccaagg caataaacag gaaacaaaat
     6661 attggaaagt ggagcaagaa aagttatctg ttcccctatc ggagcctggt gtcttgggtg
     6721 acagtaccaa ggacacgggc agggtgtagt ggagtgcttt ctctgtggtg ctgctgacac
     6781 agtagccgtg cggtgtctta gataaagcca ggttggattt ctcagaaatt tgccacctgg
     6841 ttctgaatcc tatcctctta gtttctgcag gaaagttaaa gtcatatggg ggtttcattt
     6901 tgttctgggt ggggacaatc tcatggggaa atgtactgca tagtataagg ggctaaggcc
     6961 cgccaagcag agtcaacaaa taccaaaatg agtaaactgg gaagcttttc tctctttctg
     7021 tcttcatccc agatcaaaga atcccgagtt aggatctgga tgaaggataa gcccctgaat
     7081 tgctgatggg cacaccccac acaatgaccc agcatctgaa cttgcttaac agggagccgg
     7141 ggctaaactg cttcaccctg cctgggaacc agggagcact gcatttctcc acagggtgga
     7201 ggagaagagg cagagtaaac caagcctggg acacctccct cccatccagg tgtactcatt
     7261 ctcctgtttg aaaagacggc aaggatatga agtcaacttc tacctatgtg ctgctgctgg
     7321 actttaatgt attgttagtt tgacctgatt cttctgtctt tgggcttcat gttaagggtc
     7381 tttggacaaa atctgctctg atgtacaaga atatttcatt gtatcttaaa acaagtgttt
     7441 ccgaggtgag gaaggggacc taatgtaatt gccaaagcca gcttgaggtt gataactctt
     7501 gaattggatt ttccttttgt caggtggagg cctgacaatc tgtaacagca atatatcatg
     7561 aattttcagc agagccagtg agtcacacac agtgtcctca ttggtcacag cagatgtcag
     7621 tatagaaaac aaacaatccc tgggtaatct tgtgttctat tttaccttta gccctgtcct
     7681 ccaattattt gtttggagtt aagttttgag ggacaggaag tattatggta gaaactaggt
     7741 tgggaaaatg ttcaactata gggttgagat ttaaaatttg agtttaaaaa tgtacatcag
     7801 gagcagtgag aagagtgttt tcttaaaggc atttctaatt tgattttctg tgtgtatggc
     7861 tgttctgtaa atattttttt ttcatttttt tgaaagtgga caaaatctgt gggattttcc
     7921 cccaaaagaa cacaaaaata aaactgtttc tttacataca aataaatttc tttgataaaa
     7981 agaaa
//
