LOCUS       NM_017209               1302 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus mitochondrial trans-2-enoyl-CoA reductase (Mecr),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_017209
VERSION     NM_017209.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1302)
  AUTHORS   Heimer,G., Keratar,J.M., Riley,L.G., Balasubramaniam,S., Eyal,E.,
            Pietikainen,L.P., Hiltunen,J.K., Marek-Yagel,D., Hamada,J.,
            Gregory,A., Rogers,C., Hogarth,P., Nance,M.A., Shalva,N., Veber,A.,
            Tzadok,M., Nissenkorn,A., Tonduti,D., Renaldo,F., Kraoua,I.,
            Panteghini,C., Valletta,L., Garavaglia,B., Cowley,M.J.,
            Gayevskiy,V., Roscioli,T., Silberstein,J.M., Hoffmann,C.,
            Raas-Rothschild,A., Tiranti,V., Anikster,Y., Christodoulou,J.,
            Kastaniotis,A.J., Ben-Zeev,B. and Hayflick,S.J.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a
            Mitochondrial Fatty Acid Synthesis Disorder
  JOURNAL   Am J Hum Genet 99 (6), 1229-1244 (2016)
   PUBMED   27817865
REFERENCE   2  (bases 1 to 1302)
  AUTHORS   Miinalainen,I.J., Chen,Z.J., Torkko,J.M., Pirila,P.L.,
            Sormunen,R.T., Bergmann,U., Qin,Y.M. and Hiltunen,J.K.
  TITLE     Characterization of 2-enoyl thioester reductase from mammals. An
            ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid
            synthesis type II
  JOURNAL   J Biol Chem 278 (22), 20154-20161 (2003)
   PUBMED   12654921
REFERENCE   3  (bases 1 to 1302)
  AUTHORS   Masuda,N., Yasumo,H., Furusawa,T., Tsukamoto,T., Sadano,H. and
            Osumi,T.
  TITLE     Nuclear receptor binding factor-1 (NRBF-1), a protein interacting
            with a wide spectrum of nuclear hormone receptors
  JOURNAL   Gene 221 (2), 225-233 (1998)
   PUBMED   9795230
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB015724.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB015724.1, FQ210707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1302
                     /gene="Mecr"
                     /gene_synonym="Nrbf1"
                     /note="mitochondrial trans-2-enoyl-CoA reductase"
                     /db_xref="GeneID:29470"
                     /db_xref="RGD:3208"
     exon            1..195
                     /gene="Mecr"
                     /gene_synonym="Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1141
                     /gene="Mecr"
                     /gene_synonym="Nrbf1"
                     /EC_number="1.3.1.104"
                     /note="trans-2-enoyl-CoA reductase, mitochondrial; NRBF-1;
                     nuclear receptor-binding factor 1; 2-enoyl thioester
                     reductase; enoyl-[acyl-carrier-protein] reductase,
                     mitochondrial"
                     /codon_start=1
                     /product="enoyl-[acyl-carrier-protein] reductase,
                     mitochondrial precursor"
                     /protein_id="NP_058905.1"
                     /db_xref="GeneID:29470"
                     /db_xref="RGD:3208"
                     /translation="MLVSRRLTGARARAPLLASLLEAWCRQGRTTSSYSAFSEPSHVR
                     ALVYGNHGDPAKVIQLKNLELTAVEGSDVHVKMLAAPINPSDINMIQGNYGLLPKLPA
                     VGGNEGVGQVIAVGSSVSGLKPGDWVIPANAGLGTWRTEAVFSEEALIGVPKDIPLQS
                     AATLGVNPCTAYRMLVDFEQLQPGDSVIQNASNSGVGQAVIQIASALGLKTINVIRDR
                     PDIKKLTDRLKDLGADYVLTEEELRMPETKNIFKDLPLPRLALNCVGGKSSTELLRHL
                     APGGTMVTYGGMAKQPVTASVSMLIFKDLKLRGFWLSQWKKNHSPDEFKELILILCNL
                     IRQGQLTAPAWSGIPLQDYQQALEASMKPFVSLKQILTM"
     exon            196..293
                     /gene="Mecr"
                     /gene_synonym="Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..425
                     /gene="Mecr"
                     /gene_synonym="Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..569
                     /gene="Mecr"
                     /gene_synonym="Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..672
                     /gene="Mecr"
                     /gene_synonym="Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..775
                     /gene="Mecr"
                     /gene_synonym="Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..849
                     /gene="Mecr"
                     /gene_synonym="Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..910
                     /gene="Mecr"
                     /gene_synonym="Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..983
                     /gene="Mecr"
                     /gene_synonym="Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1302
                     /gene="Mecr"
                     /gene_synonym="Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1302
                     /gene="Mecr"
                     /gene_synonym="Nrbf1"
ORIGIN      
        1 tgtcagtgct ggaagcggca tgttggtcag ccggcgactg acaggggcgc gagcccgggc
       61 acctctgctt gcgagtctcc tcgaggcttg gtgccgccag ggcaggacca cctcctccta
      121 ctccgctttc tcggagccgt cgcatgtgcg ggcgctggtc tatggcaacc acggggatcc
      181 agccaaggtc atccaactga agaacctgga gctcactgct gtggaaggat ctgacgtcca
      241 tgtgaagatg ctggcagccc ctatcaatcc atctgacata aatatgatcc aagggaacta
      301 tggcctcctt cccaagctgc ctgctgttgg agggaatgaa ggtgttggac aggtgatagc
      361 agtgggcagc agtgtgtctg gattgaagcc aggagattgg gtgatcccag caaatgctgg
      421 tttgggaacc tggcggactg aggcggtgtt cagtgaggaa gcgctgattg gagtccctaa
      481 ggacatccct ctccagagtg ctgccaccct aggtgtcaac ccctgcacag cctacaggat
      541 gttggtggac tttgaacagc tacaaccagg ggactctgtc atccagaatg cgtccaacag
      601 tggagtaggg caagcagtca ttcagatcgc ctcagccctt ggcctaaaga ccatcaacgt
      661 gatccgagac agacctgaca tcaagaagct aactgacaga ctgaaggatc taggagctga
      721 ttatgtcctc acagaggagg agctaaggat gcccgagacc aaaaacatct tcaaggacct
      781 gccgctgccc cgactggctc tcaactgtgt cggtgggaag agttccacag agctgctccg
      841 gcacctagcg cccggaggaa ccatggtgac ctatggagga atggccaagc agcctgtaac
      901 agcctctgtg agtatgctca tttttaagga cctcaaactt cgtggctttt ggttgtccca
      961 gtggaagaag aaccatagtc cagatgagtt caaggagctg attctcattc tctgcaacct
     1021 catccgccaa ggccagctca cagcccctgc ctggtccggg attccactgc aggactacca
     1081 gcaggctttg gaagcctcca tgaagccttt tgtgtctttg aagcagattc tcactatgtg
     1141 attactccag aggaccagga ggaaagcagg agaggcaggc cagcaagatt ggctggctgc
     1201 tggccctcca tgaggactcc agactgcctc accctcactg cctcttccta ccaggagggt
     1261 gggaggccaa ccccagggtc cctaataaac cctggacttc cc
//
