LOCUS       NM_022673               1711 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus methyl CpG binding protein 2 (Mecp2), mRNA.
ACCESSION   NM_022673
VERSION     NM_022673.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1711)
  AUTHORS   Zuo,C., Fan,P., Yang,Y. and Hu,C.
  TITLE     MiR-488-3p facilitates wound healing through CYP1B1-mediated
            Wnt/beta-catenin signaling pathway by targeting MeCP2
  JOURNAL   J Diabetes Investig 15 (2), 145-158 (2024)
   PUBMED   37961023
  REMARK    GeneRIF: MiR-488-3p facilitates wound healing through
            CYP1B1-mediated Wnt/beta-catenin signaling pathway by targeting
            MeCP2.
REFERENCE   2  (bases 1 to 1711)
  AUTHORS   Xu,M., Qi,S., Calhoun,V., Dai,J., Yu,B., Zhang,K., Pei,M., Li,C.,
            Wei,Y., Jiang,R., Zhi,D., Huang,Z., Qiu,Z., Liang,Z. and Sui,J.
  TITLE     Aberrant brain functional and structural developments in MECP2
            duplication rats
  JOURNAL   Neurobiol Dis 173, 105838 (2022)
   PUBMED   35985556
  REMARK    GeneRIF: Aberrant brain functional and structural developments in
            MECP2 duplication rats.
REFERENCE   3  (bases 1 to 1711)
  AUTHORS   Choi,M., Ko,S.Y., Seo,J.Y., Kim,D.G., Lee,H., Chung,H. and Son,H.
  TITLE     Autistic-like social deficits in hippocampal MeCP2 knockdown rat
            models are rescued by ketamine
  JOURNAL   BMB Rep 55 (5), 238-243 (2022)
   PUBMED   35410641
  REMARK    GeneRIF: Autistic-like social deficits in hippocampal MeCP2
            knockdown rat models are rescued by ketamine.
REFERENCE   4  (bases 1 to 1711)
  AUTHORS   Mao,X. and Yin,Z.
  TITLE     Inhibition of miR-205 promotes proliferation, migration and
            fibrosis of tenocytes through targeting MECP2: Implications for
            rotator cuff injury
  JOURNAL   Adv Clin Exp Med 31 (4), 437-443 (2022)
   PUBMED   35166074
  REMARK    GeneRIF: Inhibition of miR-205 promotes proliferation, migration
            and fibrosis of tenocytes through targeting MECP2: Implications for
            rotator cuff injury.
REFERENCE   5  (bases 1 to 1711)
  AUTHORS   Li,J., Kells,P.A., Osgood,A.C., Gautam,S.H. and Shew,W.L.
  TITLE     Collapse of complexity of brain and body activity due to excessive
            inhibition and MeCP2 disruption
  JOURNAL   Proc Natl Acad Sci U S A 118 (43) (2021)
   PUBMED   34686597
  REMARK    GeneRIF: Collapse of complexity of brain and body activity due to
            excessive inhibition and MeCP2 disruption.
REFERENCE   6  (bases 1 to 1711)
  AUTHORS   Rountree,M.R., Bachman,K.E. and Baylin,S.B.
  TITLE     DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex
            at replication foci
  JOURNAL   Nat Genet 25 (3), 269-277 (2000)
   PUBMED   10888872
REFERENCE   7  (bases 1 to 1711)
  AUTHORS   Coy,J.F., Sedlacek,Z., Bachner,D., Delius,H. and Poustka,A.
  TITLE     A complex pattern of evolutionary conservation and alternative
            polyadenylation within the long 3'-untranslated region of the
            methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory
            role in gene expression
  JOURNAL   Hum Mol Genet 8 (7), 1253-1262 (1999)
   PUBMED   10369871
REFERENCE   8  (bases 1 to 1711)
  AUTHORS   Nan,X., Campoy,F.J. and Bird,A.
  TITLE     MeCP2 is a transcriptional repressor with abundant binding sites in
            genomic chromatin
  JOURNAL   Cell 88 (4), 471-481 (1997)
   PUBMED   9038338
REFERENCE   9  (bases 1 to 1711)
  AUTHORS   Tate,P., Skarnes,W. and Bird,A.
  TITLE     The methyl-CpG binding protein MeCP2 is essential for embryonic
            development in the mouse
  JOURNAL   Nat Genet 12 (2), 205-208 (1996)
   PUBMED   8563762
REFERENCE   10 (bases 1 to 1711)
  AUTHORS   Lewis,J.D., Meehan,R.R., Henzel,W.J., Maurer-Fogy,I., Jeppesen,P.,
            Klein,F. and Bird,A.
  TITLE     Purification, sequence, and cellular localization of a novel
            chromosomal protein that binds to methylated DNA
  JOURNAL   Cell 69 (6), 905-914 (1992)
   PUBMED   1606614
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ897369.1.
            
            [WARNING] On Jul 18, 2024 this sequence was replaced by
            NM_022673.3.
            
            On Sep 24, 2006 this sequence version replaced NM_022673.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ897369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1711
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..1711
                     /gene="Mecp2"
                     /gene_synonym="MECP2_e1"
                     /note="methyl CpG binding protein 2"
                     /db_xref="GeneID:29386"
                     /db_xref="RGD:3075"
     exon            1..119
                     /gene="Mecp2"
                     /gene_synonym="MECP2_e1"
                     /inference="alignment:Splign:2.1.0"
     exon            120..243
                     /gene="Mecp2"
                     /gene_synonym="MECP2_e1"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1696
                     /gene="Mecp2"
                     /gene_synonym="MECP2_e1"
                     /note="meCP-2 protein"
                     /codon_start=1
                     /product="methyl-CpG-binding protein 2"
                     /protein_id="NP_073164.2"
                     /db_xref="GeneID:29386"
                     /db_xref="RGD:3075"
                     /translation="MVAGMLGLREEKSEDQDLQGLKEKPLKFKKVKKDKKEDKEGKHE
                     PLQPSAHHSAEPAEAGKAETSESSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPE
                     GWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVT
                     GRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSGTGRPKAAASEGVQVKRVLEKSPG
                     KLLVKMPFQASPGGKGEGGGATTSAQVMVIKRPGRKRKAEADPQAIPKKRGRKPGSVV
                     AAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGK
                     GLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHAESPKAPMPLLPPPPPPEPQ
                     SSEDPISPPEPQDLSSSICKEEKMPRAGSLESDGCPKEPAKTQPMVAAAATTTTTTTT
                     TVAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS"
     exon            244..594
                     /gene="Mecp2"
                     /gene_synonym="MECP2_e1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..1711
                     /gene="Mecp2"
                     /gene_synonym="MECP2_e1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccggaaaa tggccgccgc cgctgccgcc gctgccgccg ccgccgccgc cgctgccgcc
       61 gccgccgccg ccgccgccgc cgcgccgagc ggaggaggag gaggcgagga ggagagactg
      121 ctccataaaa atacagactc accagttcct gctttgatgt gacatgtgac tccccagaat
      181 acaccttgct tctgtagacc agctccaaca ggattccatg gtagctggga tgttagggct
      241 cagggaggaa aagtcagaag accaggatct ccagggcctc aaagagaaac ccctgaagtt
      301 taagaaggtg aagaaagaca agaaggaaga caaagagggc aaacatgaac cactacagcc
      361 ttcagcccac cattctgcag agccagcaga ggcaggcaaa gcagagacat cagaaagctc
      421 aggctctgcc ccagcagtac cagaagcctc tgcttctccc aaacagcgac gttccatcat
      481 tcgtgaccgg ggacctatgt atgatgaccc caccttgcct gaaggttgga cgcgaaagct
      541 taaacagagg aagtctggtc gctctgctgg aaagtatgat gtatatttga tcaatcccca
      601 gggaaaagcc tttcgctcta aagtagaatt gattgcatat tttgaaaagg tgggagacac
      661 ctccttggac cctaatgatt ttgacttcac tgtaactggg agagggagcc cttccaggag
      721 agaacagaaa ccacctaaga agcccaaatc tcccaaagct ccaggaactg gcaggggtcg
      781 gggacgcccg aaagggagcg gcactgggag accaaaggca gcagcatcag aaggtgttca
      841 agtgaaaagg gtcctggaga agagccctgg gaaacttctc gtcaagatgc ctttccaagc
      901 atcacctggg ggtaagggtg agggaggtgg ggctaccaca tctgcgcagg tcatggtgat
      961 caaacgccct ggcagaaagc gaaaagctga agctgacccc caggccattc ctaagaaacg
     1021 gggtagaaag cctgggagtg tggtggcagc tgctgctgca gaggccaaaa agaaagctgt
     1081 gaaggaatct tctatacggt ctgtgcagga gactgtgctc cccatcaaga agcgcaagac
     1141 ccgggaaacc gtcagcattg aggtcaagga ggtggtgaag cccctgctgg tgtctacact
     1201 tggtgagaag agtggaaagg gactgaagac atgcaagagc cctgggcgta aaagcaagga
     1261 gagcagcccc aaggggcgca gcagcagtgc ctcctcacca cctaagaagg agcaccatca
     1321 tcaccaccat cacgcagagt ccccaaaggc ccccatgcca ttgcttccac ctccaccccc
     1381 acctgagcct cagagctctg aggaccccat cagcccccct gagcctcagg acttgagcag
     1441 cagcatctgc aaagaggaga agatgccccg agcaggctca ctggaaagcg atggctgccc
     1501 caaggagcca gctaagactc agcccatggt tgctgccgcc gccaccacca ccaccaccac
     1561 caccaccaca gttgcagaaa agtacaaaca ccgaggggag ggagagcgca aagacattgt
     1621 ttcatcctcc atgccgaggc caaacagaga ggagcctgtg gacagccgga cgcccgtgac
     1681 cgagagagtt agctgacttt acatagagcg g
//
