LOCUS       NM_001389282            5453 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus MDS1 and EVI1 complex locus (Mecom), mRNA.
ACCESSION   NM_001389282
VERSION     NM_001389282.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5453)
  AUTHORS   Hood,D., Moxon,R., Purnell,T., Richter,C., Williams,D., Azar,A.,
            Crompton,M., Wells,S., Fray,M., Brown,S.D. and Cheeseman,M.T.
  TITLE     A new model for non-typeable Haemophilus influenzae middle ear
            infection in the Junbo mutant mouse
  JOURNAL   Dis Model Mech 9 (1), 69-79 (2016)
   PUBMED   26611891
REFERENCE   2  (bases 1 to 5453)
  AUTHORS   An,Q., Wu,D., Ma,Y., Zhou,B. and Liu,Q.
  TITLE     Suppression of Evi1 promotes the osteogenic differentiation and
            inhibits the adipogenic differentiation of bone marrow-derived
            mesenchymal stem cells in vitro
  JOURNAL   Int J Mol Med 36 (6), 1615-1622 (2015)
   PUBMED   26497332
  REMARK    GeneRIF: Data suggest that the ectopic viral integration site1
            (Evi1) gene may be targeted as a therapeutic strategy for promoting
            bone formation.
REFERENCE   3  (bases 1 to 5453)
  AUTHORS   Harms,M.J., Ishibashi,J., Wang,W., Lim,H.W., Goyama,S., Sato,T.,
            Kurokawa,M., Won,K.J. and Seale,P.
  TITLE     Prdm16 is required for the maintenance of brown adipocyte identity
            and function in adult mice
  JOURNAL   Cell Metab 19 (4), 593-604 (2014)
   PUBMED   24703692
REFERENCE   4  (bases 1 to 5453)
  AUTHORS   Pinheiro,I., Margueron,R., Shukeir,N., Eisold,M., Fritzsch,C.,
            Richter,F.M., Mittler,G., Genoud,C., Goyama,S., Kurokawa,M.,
            Son,J., Reinberg,D., Lachner,M. and Jenuwein,T.
  TITLE     Prdm3 and Prdm16 are H3K9me1 methyltransferases required for
            mammalian heterochromatin integrity
  JOURNAL   Cell 150 (5), 948-960 (2012)
   PUBMED   22939622
REFERENCE   5  (bases 1 to 5453)
  AUTHORS   Boualia,S.K., Gaitan,Y., Murawski,I., Nadon,R., Gupta,I.R. and
            Bouchard,M.
  TITLE     Vesicoureteral reflux and other urinary tract malformations in mice
            compound heterozygous for Pax2 and Emx2
  JOURNAL   PLoS One 6 (6), e21529 (2011)
   PUBMED   21731775
REFERENCE   6  (bases 1 to 5453)
  AUTHORS   Chakraborty,S., Senyuk,V., Sitailo,S., Chi,Y. and Nucifora,G.
  TITLE     Interaction of EVI1 with cAMP-responsive element-binding
            protein-binding protein (CBP) and p300/CBP-associated factor
            (P/CAF) results in reversible acetylation of EVI1 and in
            co-localization in nuclear speckles
  JOURNAL   J Biol Chem 276 (48), 44936-44943 (2001)
   PUBMED   11568182
REFERENCE   7  (bases 1 to 5453)
  AUTHORS   Kurokawa,M., Mitani,K., Yamagata,T., Takahashi,T., Izutsu,K.,
            Ogawa,S., Moriguchi,T., Nishida,E., Yazaki,Y. and Hirai,H.
  TITLE     The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents
            stress-induced cell death
  JOURNAL   EMBO J 19 (12), 2958-2968 (2000)
   PUBMED   10856240
REFERENCE   8  (bases 1 to 5453)
  AUTHORS   Peeters,P., Wlodarska,I., Baens,M., Criel,A., Selleslag,D.,
            Hagemeijer,A., Van den Berghe,H. and Marynen,P.
  TITLE     Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in
            myeloproliferative disorders
  JOURNAL   Cancer Res 57 (4), 564-569 (1997)
   PUBMED   9044825
REFERENCE   9  (bases 1 to 5453)
  AUTHORS   Perkins,A.S. and Kim,J.H.
  TITLE     Zinc fingers 1-7 of EVI1 fail to bind to the GATA motif by itself
            but require the core site GACAAGATA for binding
  JOURNAL   J Biol Chem 271 (2), 1104-1110 (1996)
   PUBMED   8557637
REFERENCE   10 (bases 1 to 5453)
  AUTHORS   Matsugi,T., Morishita,K. and Ihle,J.N.
  TITLE     Identification, nuclear localization, and DNA-binding activity of
            the zinc finger protein encoded by the Evi-1 myeloid transforming
            gene
  JOURNAL   Mol Cell Biol 10 (3), 1259-1264 (1990)
   PUBMED   2106070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 24, 2022 this sequence version replaced NM_001389282.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760386,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               JAXUCZ010000002.1  114837893-114838212
            321-667             JAXUCZ010000002.1  115118845-115119191
            668-802             JAXUCZ010000002.1  115334348-115334482
            803-905             JAXUCZ010000002.1  115346592-115346694
            906-1122            JAXUCZ010000002.1  115350664-115350880
            1123-1270           JAXUCZ010000002.1  115357000-115357147
            1271-1427           JAXUCZ010000002.1  115358515-115358671
            1428-2784           JAXUCZ010000002.1  115363097-115364453
            2785-2872           JAXUCZ010000002.1  115366880-115366967
            2873-2899           JAXUCZ010000002.1  115371530-115371556
            2900-3066           JAXUCZ010000002.1  115377434-115377600
            3067-3144           JAXUCZ010000002.1  115378655-115378732
            3145-3314           JAXUCZ010000002.1  115380958-115381127
            3315-3459           JAXUCZ010000002.1  115383007-115383151
            3460-3696           JAXUCZ010000002.1  115386569-115386805
            3697-3877           JAXUCZ010000002.1  115387635-115387815
            3878-5453           JAXUCZ010000002.1  115391477-115393052
FEATURES             Location/Qualifiers
     source          1..5453
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..5453
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /note="MDS1 and EVI1 complex locus"
                     /db_xref="GeneID:294924"
                     /db_xref="RGD:1310997"
     exon            1..320
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..4012
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /EC_number="2.1.1.354"
                     /note="MDS1 and EVI1 complex locus protein EVI1;
                     myelodysplasia syndrome 1 homolog; ecotropic viral
                     integration site 1; MDS1 and EVI1 complex locus protein
                     MDS1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase MECOM"
                     /protein_id="NP_001376211.1"
                     /db_xref="GeneID:294924"
                     /db_xref="RGD:1310997"
                     /translation="MRSKGRARKLATSNECAYGNYPEIPLEEMPDAEDADGIANAPSL
                     HIQEPCSPATSSESFTPKEGSPYKAPIYIPDDIPIPDEFELRESTMPGAGLGIWTKRK
                     IEIGEKFGPYMGEQRSDLKDSSYGWEILDEFCNVKFCIDASQPDVGSWLKYIRFAGCY
                     DQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEEDPHEPMAPDIHEERQHRCEDCD
                     QLFESKAELADHQKFPCSTPHSAFSMVEEDLQQNLESESDLREIHGNQDCKECDRVFP
                     DLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKQVFTD
                     PSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQF
                     SNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLP
                     GTPAMDKTSMVNMGHANPGLVDYFGTNRHPAGLTFPTAPGFSLSFPGLFPSGLYHRPP
                     LIPASSPVKGLSSTEQSNKCQSPLLTHPQILPATQDILKALSKHPPVGDNKPVELLPE
                     RSSEERPLEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDLESDKEKCKENGKMFK
                     DKVSPLQNLASINNKKEYSNHSVFSASVEEQTAVSGAVNDSIKAIASIAEKYFGSTGL
                     VGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQSPSEVKKLQKG
                     SSESPFDLTTKRKDEKPLTSGSSKLPATPATSQDQPLDLSMGSRSRASGTKLTEPRKN
                     HVFGEKKGSNMETRPSSDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSP
                     GFLFHPQFPLPDQRTWMSAIENMAEKLESFSGLKPEASELLQSVPSMFSFRAPPNTLP
                     ENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHV
                     RNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESAGAILDD
                     KEDAYFTEIRNFIGNSNHGSQSPRNMEERMNGSHFKDEKALATSQNSDLLDDEEVEDE
                     VLLDEEDEDNDIPGKPRKELGVTNLDEEIPEDDYEEAGALEMSCKVSPVRYKEEDYKS
                     GLSALDHIRHFTDSLKMREMEENQYTDAELSFGSSHVPEELKQPLHRKSKSQAYAMML
                     SLSDKDALHPTSHGSSNVWHSMARAAAESSAIQSISHV"
     exon            321..667
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..802
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..905
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1122
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1270
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1427
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..2784
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2872
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2899
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..3066
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3144
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3314
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3459
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3696
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3877
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
     exon            3878..5453
                     /gene="Mecom"
                     /gene_synonym="Evi1; Mds1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgagatgt tggaggggcg tctaacgcgc atgtgcgaag gtgtccaaac tgacaatgct
       61 agagatagcg agtgtggatt gagagaaaga gagagaggga gggagagaga gagtgaaaga
      121 ccgagtgtgt gtgtgcgtgt gtgagacgag agagagagag agagagagag agagagagag
      181 agagaggagg agggaggggg agagagagac caaaagaagg aaaagatcca agaaaaaaaa
      241 aaaaacctaa ccacccagca gcggctgcag aactgggcac agcatgagat ccaaaggcag
      301 ggcaaggaaa ctggccacaa gtaatgagtg tgcttatggc aactaccctg aaataccctt
      361 ggaagaaatg ccagatgccg aagatgcaga tgggatagcc aatgctccct cccttcacat
      421 ccaagagcca tgctctcctg cgacatccag tgagtcattt actcctaagg agggctcgcc
      481 ctacaaagcc cccatctaca tccccgatga catccccatt cctgatgaat tcgagcttcg
      541 agagtcaact atgcctggag caggacttgg aatatggacc aaaaggaaga ttgaaatagg
      601 agaaaagttt gggccataca tgggagagca gagatcagac ctgaaagatt ccagctatgg
      661 atgggagatc ttagatgagt tttgcaatgt gaagttctgc atagatgcca gtcaaccaga
      721 tgtaggaagc tggctcaagt acatccgatt cgctggctgc tacgatcagc acaaccttgt
      781 tgcatgccag ataaacgatc agatattcta cagagtagtc gcagacattg cgcctgggga
      841 ggaactcctg ctgttcatga agagtgaaga ggacccacat gagcccatgg cgcctgacat
      901 ccatgaagaa cggcagcacc gctgtgagga ctgtgaccag ctctttgaat ccaaggctga
      961 gctggctgat caccagaagt tcccatgcag cacacctcac tcggccttct ccatggtgga
     1021 ggaggacttg cagcaaaacc tggagagtga gagtgatctc cgagagatcc atggcaacca
     1081 ggactgtaag gaatgtgacc gagttttccc cgatctacaa agcttggaga agcacatgtt
     1141 gtcacacact gaggagaggg aatacaagtg tgatcagtgc cccaaggcat ttaactggaa
     1201 gtccaattta attcgccacc agatgtcaca tgacagtgga aagcactatg agtgtgaaaa
     1261 ctgtgccaag caggttttca cggaccctag caaccttcag cgacacattc gatctcagca
     1321 tgttggtgcc cgggctcatg cttgcccgga gtgtggtaaa acatttgcca cttcgtcagg
     1381 cctcaaacaa cacaagcaca tccacagcag tgtgaagccc tttatctgtg aggtctgcca
     1441 taaatcctat actcagtttt caaacctttg tcgtcataag cgcatgcatg ctgattgcag
     1501 aacccaaatc aagtgcaaag actgtggaca aatgttcagc actacgtctt ccttaaataa
     1561 acacaggagg ttttgtgagg gcaagaacca ttttgcggca ggtggatttt ttggccaagg
     1621 catttcactt cctggaaccc cagctatgga taaaacgtcc atggttaata tgggccacgc
     1681 caacccgggc ctggttgact attttggcac caataggcat cctgctggtc ttacctttcc
     1741 aacagctccg ggattttcct tgagctttcc tggtctgttt ccttcgggct tgtaccacag
     1801 gcctcctttg atacccgcta gctctcctgt taaaggacta tcaagtaccg aacagtcaaa
     1861 caaatgtcaa agtcccctct tgacacatcc tcagatactg ccagccaccc aggatatttt
     1921 gaaggcacta tctaaacacc cacctgtagg ggacaataag ccagtggaac tgctgcccga
     1981 gaggtcctct gaagagaggc cccttgagaa aatcagtgac cagtcagaga gtagtgacct
     2041 tgatgatgtc agtacgccaa gtggcagtga tctggaaaca acctcgggct ctgatctgga
     2101 aagtgacctt gaaagtgata aagagaaatg taaagaaaat ggtaaaatgt tcaaagacaa
     2161 agtaagccct ctgcagaatc tggcttcaat aaataataag aaagaataca gcaatcattc
     2221 cgttttctca gcatctgtag aggagcagac cgcggtgtca ggagctgtga atgattctat
     2281 aaaggctatt gcgtctattg ctgaaaaata ctttggttcc acaggactgg tggggctgca
     2341 agacaaaaaa gtcggagcgt taccttaccc ttccatgttt cccctcccgt tttttccagc
     2401 attctctcaa tcaatgtacc catttcctga tagagacttg aggtcgttac ctttgaaaat
     2461 ggagccccaa tcaccaagtg aagtaaagaa actgcagaag ggaagctctg agtccccttt
     2521 tgacctcacc actaagagaa aggacgagaa gcccttgact tcaggctcct caaagcttcc
     2581 agcaacaccc gccacaagcc aagaccagcc cctggatcta agtatgggca gtaggagtag
     2641 agccagtggg acaaagttga ctgagcctcg aaaaaaccat gtgtttgggg aaaagaaagg
     2701 aagcaacatg gaaacaaggc catcttcaga tggctccttg cagcatgcca gacccactcc
     2761 cttcttcatg gatcccattt atagagtaga gaaaagaaag ctcactgatc cgcttgaagc
     2821 tttgaaagaa aaatacttga gaccttctcc aggattcttg tttcacccac aattcccact
     2881 acctgaccag agaacatgga tgtcggctat cgagaacatg gcggaaaaac tagaaagctt
     2941 cagcggcctg aaaccagagg ccagcgagct cctgcagtca gtgccctcta tgttcagctt
     3001 ccgggctcct cccaacaccc tgccagagaa cctgctgcgg aagggaaagg aacgctatac
     3061 ctgcaggtac tgtggtaaga ttttcccaag gtctgcaaac ctaacacggc atttgagaac
     3121 ccacacagga gagcaacctt acagatgcaa atactgcgat agatcattca gtatttcctc
     3181 caacctgcag cgacacgtgc gcaacattca caacaaggag aagccattta agtgtcacct
     3241 atgtgacaga tgctttggtc aacaaaccaa tcttgacaga cacctgaaga aacacgagaa
     3301 cgggaacatg tctggtacag caacatcctc gcctcattcg gagctagaaa gcgcaggtgc
     3361 catcctggat gacaaagaag atgcttactt tacagagatc cgcaatttca tcgggaatag
     3421 caaccatggg agccagtctc ctcggaacat ggaggagagg atgaatggca gtcacttcaa
     3481 ggatgaaaag gctttggcga ccagccaaaa ttccgattta ttggatgacg aagaagtaga
     3541 ggatgaggtg ttgctggatg aggaggatga agacaatgat attcctggaa aacccagaaa
     3601 ggagctgggg gtaactaatt tagatgagga aatccctgag gatgactatg aggaagccgg
     3661 tgccctggag atgagttgta aggtgtcccc cgtgaggtat aaagaggaag actataaatc
     3721 tggcctttct gctctagatc acataaggca cttcacagat agcctcaaaa tgagggaaat
     3781 ggaagagaat caatacactg acgctgagct gtcctttggt tcttctcatg tgccagagga
     3841 gcttaaacag ccgttacaca gaaagtccaa atcacaggca tatgctatga tgttgtcact
     3901 gtctgacaag gatgccctcc atcccacctc ccacggttcc tccaacgtgt ggcacagcat
     3961 ggcaagagct gcagcggaat ccagtgccat ccagtccata agccatgtat gacattgtca
     4021 aggttgacca gagtgggacc aagtccaacg gcagcacgtc tctttcatac agaactattt
     4081 acaagactgc tgagcagaat gccttataac cctgaagggt cacgcattta aagtccggtg
     4141 accttaaact gaacgagtaa agaaagagag agagagaaag agaaaggaag ctatttattc
     4201 tcaatatttt gttttgcaca gccaaggcag ctgctgactt ctggaggatc aattcatcta
     4261 aaagtgattg gaggcgaaag aaaacctcac tggggaaggc acctttcgct ctcctgccgc
     4321 agggcatggg tgggtgagag gagcagttta gatggcagca ttgacatcaa cggacacttc
     4381 atagaaatca aactctacaa gatcacctga tctgatcggg aacagtggct tttaactacc
     4441 agatttaaat ttttttttcc tttttaaagc tttgtgtaat ttaacccttt gaagacggaa
     4501 gtagtcagaa gaaatgcaca atgattatag gaagtgatag caggagtttt tgtcaccccc
     4561 tccccaccct ttacctttgg ccttcttaag tacatcgttt aaaattaggg acaagaaggg
     4621 tatattgtaa actatggatt ctcatgctca gagaggtgtt aagtcggtga cgtgtcctgt
     4681 tcatcaccag taccgctgta ccactaatgc aatgtttgcc aaatccttgt aatgacatct
     4741 taattttaga caatcatgtc actgttttta atgtttcaat attttttgtg tgtgttgtgt
     4801 gtaccatgta tttatttgtt ggcaaactat ggtttgttga tcaaaaaaga gcactgttcc
     4861 tgtcagccac tattttatga tgtctgaggc ataccctctc tgaattccaa ggaccaaggt
     4921 gagccgtcct gtgtgtggga gtgcccaata gtgtttggct tttcttaaca ttccttcctt
     4981 ttggttgttg ttgttttgtt ttccttttta atgaactaaa tgcaattaga tgcaacttag
     5041 tttttgtaat actgagatcg attcgattgt ataaatgatt ctagtttctt tcacggaagc
     5101 atgatccttc tgattaagaa ctgaacccca tattttatgc tggttgtctg caagcttgtg
     5161 cgatgatgtt atgttcatgt taatcctatt tgtaaaatga agcattcctg accttatgtt
     5221 aaaaaaaaga gagagaagta aataacagac attattcagt tattttgtcc tttacggaga
     5281 aaccagattt cttttttttt ccattttgtt tgtaatctca tttggaaata attggcaagt
     5341 tgaggtactt tctcccaatg ctttgtacaa tataaactgt tatgcctttc agtgcgttac
     5401 tgtgggagga gcaactaaaa aaaaaaaata aagacttcca aaaaagacga aaa
//
