LOCUS       NM_001400970            3018 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus MTOR associated protein, eak-7 homolog (Meak7),
            mRNA.
ACCESSION   NM_001400970 XM_039098201
VERSION     NM_001400970.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3018)
  AUTHORS   Cai,X., Yao,Y., Ren,F. and Zhang,S.
  TITLE     circTldc1 increases Tldc1 expression by targeting miR-485-5p to
            promote fibroblast-like synoviocytes proliferation in
            collagen-induced arthritis
  JOURNAL   Exp Cell Res 435 (1), 113928 (2024)
   PUBMED   38190869
  REMARK    GeneRIF: circTldc1 increases Tldc1 expression by targeting
            miR-485-5p to promote fibroblast-like synoviocytes proliferation in
            collagen-induced arthritis.
REFERENCE   2  (bases 1 to 3018)
  AUTHORS   Nguyen,J.T., Ray,C., Fox,A.L., Mendonca,D.B., Kim,J.K. and
            Krebsbach,P.H.
  TITLE     Mammalian EAK-7 activates alternative mTOR signaling to regulate
            cell proliferation and migration
  JOURNAL   Sci Adv 4 (5), eaao5838 (2018)
   PUBMED   29750193
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3018)
  AUTHORS   Finelli,M.J., Sanchez-Pulido,L., Liu,K.X., Davies,K.E. and
            Oliver,P.L.
  TITLE     The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif
            (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against
            Oxidative Stress
  JOURNAL   J Biol Chem 291 (6), 2751-2763 (2016)
   PUBMED   26668325
REFERENCE   4  (bases 1 to 3018)
  AUTHORS   Moriya,K., Nagatoshi,K., Noriyasu,Y., Okamura,T., Takamitsu,E.,
            Suzuki,T. and Utsumi,T.
  TITLE     Protein N-myristoylation plays a critical role in the endoplasmic
            reticulum morphological change induced by overexpression of protein
            Lunapark, an integral membrane protein of the endoplasmic reticulum
  JOURNAL   PLoS One 8 (11), e78235 (2013)
   PUBMED   24223779
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3018)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jan 31, 2022 this sequence version replaced XM_039098201.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.80298.1,
                                           SRR26643294.59649.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000019.1  64744538-64744592   c
            56-224              JAXUCZ010000019.1  64739408-64739576   c
            225-455             JAXUCZ010000019.1  64736486-64736716   c
            456-600             JAXUCZ010000019.1  64735673-64735817   c
            601-1029            JAXUCZ010000019.1  64732274-64732702   c
            1030-1148           JAXUCZ010000019.1  64727234-64727352   c
            1149-1328           JAXUCZ010000019.1  64725526-64725705   c
            1329-3018           JAXUCZ010000019.1  64722528-64724217   c
FEATURES             Location/Qualifiers
     source          1..3018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3018
                     /gene="Meak7"
                     /gene_synonym="RGD1308461; Tldc1"
                     /note="MTOR associated protein, eak-7 homolog"
                     /db_xref="GeneID:307901"
                     /db_xref="RGD:1308461"
     exon            1..55
                     /gene="Meak7"
                     /gene_synonym="RGD1308461; Tldc1"
                     /inference="alignment:Splign:2.1.0"
     exon            56..224
                     /gene="Meak7"
                     /gene_synonym="RGD1308461; Tldc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1445
                     /gene="Meak7"
                     /gene_synonym="RGD1308461; Tldc1"
                     /EC_number="3.1.4.11"
                     /note="TLD domain-containing protein 1;
                     TBC/LysM-associated domain containing 1"
                     /codon_start=1
                     /product="MTOR-associated protein MEAK7"
                     /protein_id="NP_001387899.1"
                     /db_xref="GeneID:307901"
                     /db_xref="RGD:1308461"
                     /translation="MGNAKSLSGQKMGSRFLPEEQAEVDKLFDALSSSDGGVATGTFS
                     LEALKSHVKEALPPAMVARLYNGMWRVKPTDRAHGSCRSVSREQFTVFLSHLLKGSCE
                     EKGLMVMKMISVAEGPTKTRDVQKFTEDLVASVVHVLTHRHELRGWTWRKSTVPHDSM
                     QAMVAQLLSEMKFQDGQKFLGPQCLDQVCDQAMIEEWVFHVPLVGVFLSVVIHRGLCL
                     LASSFDLSTLVPECHVDGGRPSESILDVLSVIYLSSHLAVEHRQCWRLLFSTQLHGQS
                     FSQLCSLITSQGPSLIVLEDRDGYVFGGFASCSWEVKPQFQGDNKCFLFSIAPRMATY
                     TPTGYNNHFMYLNYGQQTMPNGLGMGGQHHYFGLWVAADFGKGHSKAKPACTTYSSPQ
                     LSAQEDFQFEKMEVWGLGNLSEKDQGTNKKSILDSNPDARSLLEISGRTRHSEGLREV
                     PKDED"
     exon            225..455
                     /gene="Meak7"
                     /gene_synonym="RGD1308461; Tldc1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..600
                     /gene="Meak7"
                     /gene_synonym="RGD1308461; Tldc1"
                     /inference="alignment:Splign:2.1.0"
     exon            601..1029
                     /gene="Meak7"
                     /gene_synonym="RGD1308461; Tldc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1148
                     /gene="Meak7"
                     /gene_synonym="RGD1308461; Tldc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1328
                     /gene="Meak7"
                     /gene_synonym="RGD1308461; Tldc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..3018
                     /gene="Meak7"
                     /gene_synonym="RGD1308461; Tldc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccttgctg ccttttacgt accggaagga gctcggtccc tgtaggccca ggctgagagt
       61 tccggaaagc aggcaagatg gggaatgcca agagcctgtc gggccagaag atgggctcaa
      121 ggttcttgcc cgaggagcag gctgaggtgg ataagctgtt tgatgccctg tcatctagtg
      181 atggtggtgt ggcaacgggg acattctctc tggaggcgct gaagagccat gtcaaggagg
      241 ctcttccccc agccatggtc gccagactct acaacggcat gtggagggtg aagccgaccg
      301 acagggcaca cgggagctgc aggagtgttt ccagggaaca gttcacagta ttcctgtccc
      361 acctgttgaa agggagctgt gaggagaagg gccttatggt tatgaaaatg atctcagttg
      421 cagagggtcc tacgaagacc agagatgtcc agaagttcac agaggacctg gtggcctctg
      481 tggtacacgt gctgacccac cggcatgagc ttcgaggctg gacctggagg aaatccacag
      541 tgccccacga tagtatgcag gccatggtcg cccagctgct ctcagagatg aagtttcaag
      601 acgggcagaa gtttctgggc cctcagtgcc tggaccaggt gtgcgaccaa gccatgatcg
      661 aggagtgggt gttccatgtc cctctcgtgg gcgtgtttct gagcgtggtc atccacaggg
      721 gcctgtgcct cctggcctca tcctttgacc tctccacgct ggtccccgag tgccacgtgg
      781 acggagggag gccgtctgag agcatcctgg atgtgctgtc cgtcatctac ctcagctccc
      841 acctggcagt ggaacaccgg cagtgctggc gcctgctgtt ctccacgcag ctccacggac
      901 agagcttctc ccagctctgc agcctcatca cgagccaggg gcccagcctg atcgtccttg
      961 aggacaggga tggctacgtc ttcggtggct ttgcctcctg ctcctgggaa gtcaagcctc
     1021 agttccaagg ggacaacaag tgcttcctgt tctccattgc ccccagaatg gccacgtaca
     1081 cgcccaccgg ctacaacaac cacttcatgt acttgaatta cgggcagcag accatgccca
     1141 acggactggg catgggtggg cagcaccatt actttgggct ttgggtggct gctgattttg
     1201 ggaaaggaca cagcaaggcc aagccggcgt gtaccaccta cagcagccca cagctgtctg
     1261 cccaggagga cttccagttt gagaagatgg aggtgtgggg acttggcaac ctctcagaga
     1321 aagatcaggg cacgaacaag aagagcatcc tggactcaaa tcctgacgcc cggagcctgt
     1381 tggagatcag tggacggact cggcacagcg agggacttcg ggaagtcccc aaggatgagg
     1441 actgaaggtc ctggacagtt tcccggggca ggggcaggga ctcccccagg gatgcagggc
     1501 agactcctca ctgctgggtg agcagagaga actcttctta ccctctgtcc tcactcctgc
     1561 ttagccttaa cacagccata tggttacacc caggtcatca tggacataat caaaacacag
     1621 ctatgcgaag aaatgcccct ctgaagccat aactgatggg tgttgcctcc caggggccct
     1681 gagtgcaggt tagaaccttg gccttaaacg tttgtcttct gccttttgtc catggcatcc
     1741 aaagacaaag aggctggaaa tcttccgggg ctggaggtct gcagttgggg ggcacattct
     1801 tgccttgtga gggggcacca tgcctggcct ttgctctgag gtccctgtaa gtgccctgat
     1861 ggcccgtcat gagcggaaag acaggagtgc ttagatgagc atcttggtac tctgtgagaa
     1921 tacccccaca cacccccagc atggaatttg tgggtttgta gctgaagatc tgagggaaat
     1981 gtctctgggg caggtcctca gagtgggcta gccatggggt cccatctagc tttctcaaca
     2041 cttttaaagt gaatctaatg aacaagtggg gaaacccact atttacccag agaccaaacc
     2101 tttactgtgc tgctaaccca gatatgggat ctgggacctt tgaggggact tgaagcctgt
     2161 gtgcttgcct aatgtgtgca taagagccac ccatcccaga tgtcagtggt gggtgatgtc
     2221 cagccctggc tgggagtatc agcctctagg agccttctct gaggtcacag cccagggttt
     2281 ctcatgagga ggatgggcca taggacagca taggctcact tcagacagat aggagatgac
     2341 tcaggtggcc aggctgccca tcacaccggg cgcccagctc cacccaccga gaggagcttg
     2401 tgggcccctg agacttctac gtcttgttca tcttttgttg caaacttcaa cctctatgga
     2461 tctgacacag tttcactttt gcatacacag tttgcctcaa tcaaaagcca cagtaaagtc
     2521 gactatgcac gcatttttcc cgttctgtat ttttgcccag gaagctcctg gaattttcca
     2581 gataacaacc ttgagcatga cggaaagtct gaggcaagac tttcccacga aagtaccact
     2641 tctgtgcacg gagggattgg tgcgcggtgc tgacgaggcc tgggccactt tggttttctt
     2701 ggcaagaaga ccgttgtcag tggtatgtgg gatagagaga gaaaacacta gaatctccag
     2761 agaacccctg tgtaatttca cagaattggg tcaccgtgct atggagtgtt ttttgttttg
     2821 cccccccccc atcccccagg agacagggtt tctttgtgta gccctggctc tcctccaaca
     2881 agccagcctc caactcagag atgcacttgc ccctgcctcc caagtgcagg gattaaaggt
     2941 gtgcacgacc actgcctggg aagtgggaag tgtttttctg tttgttttaa ataaaaatgc
     3001 agtcatgtct ttcattgg
//
