LOCUS       NP_001402901             604 aa            linear   ROD 22-SEP-2024
DEFINITION  NADP-dependent malic enzyme, mitochondrial [Rattus norvegicus].
ACCESSION   NP_001402901 XP_038938303
VERSION     NP_001402901.1
DBSOURCE    REFSEQ: accession NM_001415972.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 604)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 604)
  AUTHORS   Hasan,N.M., Longacre,M.J., Stoker,S.W., Kendrick,M.A. and
            MacDonald,M.J.
  TITLE     Mitochondrial malic enzyme 3 is important for insulin secretion in
            pancreatic beta-cells
  JOURNAL   Mol Endocrinol 29 (3), 396-410 (2015)
   PUBMED   25594249
  REMARK    GeneRIF: The data suggest that ME3, far more than ME1 or ME2, is
            necessary for insulin release.
REFERENCE   3  (residues 1 to 604)
  AUTHORS   Loeber,G., Maurer-Fogy,I. and Schwendenwein,R.
  TITLE     Purification, cDNA cloning and heterologous expression of the human
            mitochondrial NADP(+)-dependent malic enzyme
  JOURNAL   Biochem J 304 (Pt 3) (Pt 3), 687-692 (1994)
   PUBMED   7818469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 6, 2023 this sequence version replaced XP_038938303.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.2192.1,
                                           SRR26643296.2018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     Protein         1..604
                     /product="NADP-dependent malic enzyme, mitochondrial"
                     /EC_number="1.1.1.40"
                     /note="mitochondrial malic enzyme 3; malic enzyme 3,
                     NADP(+)-dependent, mitochondrial"
                     /calculated_mol_wt=67021
     Region          9..587
                     /region_name="PLN03129"
                     /note="NADP-dependent malic enzyme; Provisional"
                     /db_xref="CDD:215594"
     CDS             1..604
                     /gene="Me3"
                     /coded_by="NM_001415972.1:157..1971"
                     /db_xref="GeneID:361602"
                     /db_xref="RGD:1311070"
ORIGIN      
        1 mgaalgtgar ltslprlacg slrrqalsap aqgchsksgp prpvplkkrg ydvtrnphln
       61 kgmaftleer lqlgihglip pcflsqdvql lrimryyenq qsdldkyiil mtlqdrnekl
      121 fyrvltsdve kfmpivytpt vglacqhygl tfrrprglfi tihdkghiat mlnswpedni
      181 kavvvtdger ilglgdlgcy gmgipvgkla lytacggvnp qqclpvlldv gtnneellrd
      241 plyiglkhqr vrgkeyddll defmqavtdk fgincliqfe dfananafrl lnkyrnkycm
      301 fnddiqgtas vavagilaal ritknrlsnh vfvfqgagea amgiahllvm alekegipkt
      361 eavrkiwmvd skglivkgrs hlnhekemfa qehpevnsle evvrlvkpta iigvaaiaga
      421 fteqilrdma sfherpiifa lsnptskaec taekcyqvte grgifasgsp fksvtledgr
      481 tfipgqgnna yvfpgvalgi iaggirhvpd eiflltaeqi aqevseqhls qgrlypplst
      541 irdvslriav kvldyaykhn lasyypepkd keafiksliy tpdydsfsld tytwpkeams
      601 vqkv
//
