LOCUS       NM_001012026            1923 bp    mRNA    linear   ROD 22-JUL-2024
DEFINITION  Rattus norvegicus MDM4 regulator of p53 (Mdm4), mRNA.
ACCESSION   NM_001012026 XM_222632
VERSION     NM_001012026.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1923)
  AUTHORS   Katsel,P., Tan,W., Fam,P., Purohit,D.P. and Haroutunian,V.
  TITLE     Cell cycle checkpoint abnormalities during dementia: A plausible
            association with the loss of protection against oxidative stress in
            Alzheimer's disease [corrected]
  JOURNAL   PLoS One 8 (7), e68361 (2013)
   PUBMED   23861893
  REMARK    Erratum:[PLoS One. 2013;8(7).
            doi:10.1371/annotation/59ecb64c-1f53-4d8a-903c-2f835e78bd13]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1923)
  AUTHORS   Li,Q. and Lozano,G.
  TITLE     Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy
  JOURNAL   Clin Cancer Res 19 (1), 34-41 (2013)
   PUBMED   23262034
  REMARK    Review article
REFERENCE   3  (bases 1 to 1923)
  AUTHORS   Zhang,Q., He,X., Chen,L., Zhang,C., Gao,X., Yang,Z. and Liu,G.
  TITLE     Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in
            cardiac endocardial cushion morphogenesis during heart development
  JOURNAL   J Pathol 228 (3), 416-428 (2012)
   PUBMED   22821713
REFERENCE   4  (bases 1 to 1923)
  AUTHORS   Chen,B., Longtine,M.S., Sadovsky,Y. and Nelson,D.M.
  TITLE     Hypoxia downregulates p53 but induces apoptosis and enhances
            expression of BAD in cultures of human syncytiotrophoblasts
  JOURNAL   Am J Physiol Cell Physiol 299 (5), C968-C976 (2010)
   PUBMED   20810912
REFERENCE   5  (bases 1 to 1923)
  AUTHORS   Allende-Vega,N., Sparks,A., Lane,D.P. and Saville,M.K.
  TITLE     MdmX is a substrate for the deubiquitinating enzyme USP2a
  JOURNAL   Oncogene 29 (3), 432-441 (2010)
   PUBMED   19838211
REFERENCE   6  (bases 1 to 1923)
  AUTHORS   Mancini,F., Gentiletti,F., D'Angelo,M., Giglio,S., Nanni,S.,
            D'Angelo,C., Farsetti,A., Citro,G., Sacchi,A., Pontecorvi,A. and
            Moretti,F.
  TITLE     MDM4 (MDMX) overexpression enhances stabilization of stress-induced
            p53 and promotes apoptosis
  JOURNAL   J Biol Chem 279 (9), 8169-8180 (2004)
   PUBMED   14660608
REFERENCE   7  (bases 1 to 1923)
  AUTHORS   Steinman,H.A., Sluss,H.K., Sands,A.T., Pihan,G. and Jones,S.N.
  TITLE     Absence of p21 partially rescues Mdm4 loss and uncovers an
            antiproliferative effect of Mdm4 on cell growth
  JOURNAL   Oncogene 23 (1), 303-306 (2004)
   PUBMED   14712235
REFERENCE   8  (bases 1 to 1923)
  AUTHORS   Migliorini,D., Lazzerini Denchi,E., Danovi,D., Jochemsen,A.,
            Capillo,M., Gobbi,A., Helin,K., Pelicci,P.G. and Marine,J.C.
  TITLE     Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell
            death during early embryonic mouse development
  JOURNAL   Mol Cell Biol 22 (15), 5527-5538 (2002)
   PUBMED   12101245
REFERENCE   9  (bases 1 to 1923)
  AUTHORS   Sharp,D.A., Kratowicz,S.A., Sank,M.J. and George,D.L.
  TITLE     Stabilization of the MDM2 oncoprotein by interaction with the
            structurally related MDMX protein
  JOURNAL   J Biol Chem 274 (53), 38189-38196 (1999)
   PUBMED   10608892
REFERENCE   10 (bases 1 to 1923)
  AUTHORS   Shvarts,A., Bazuine,M., Dekker,P., Ramos,Y.F., Steegenga,W.T.,
            Merckx,G., van Ham,R.C., van der Houven van Oordt,W., van der
            Eb,A.J. and Jochemsen,A.G.
  TITLE     Isolation and identification of the human homolog of a new
            p53-binding protein, Mdmx
  JOURNAL   Genomics 43 (1), 34-42 (1997)
   PUBMED   9226370
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083647.1.
            
            On Feb 11, 2005 this sequence version replaced XM_222632.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083647.1, SRR8487231.156184.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1923
                     /gene="Mdm4"
                     /note="MDM4 regulator of p53"
                     /db_xref="GeneID:304798"
                     /db_xref="RGD:1309306"
     exon            1..79
                     /gene="Mdm4"
                     /inference="alignment:Splign:2.1.0"
     exon            80..190
                     /gene="Mdm4"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1585
                     /gene="Mdm4"
                     /note="double minute 4 homolog; protein Mdmx; double
                     minute 4 protein; p53-binding protein Mdm4; mdm2-like
                     p53-binding protein; transformed mouse 3T3 cell double
                     minute 4; Mdm4 p53 binding protein homolog; MDM4, p53
                     regulator"
                     /codon_start=1
                     /product="protein Mdm4"
                     /protein_id="NP_001012026.1"
                     /db_xref="GeneID:304798"
                     /db_xref="RGD:1309306"
                     /translation="MTSHSTSAQCSASDSACRISSEQINQQVRPKLQLLKILQAAGAQ
                     GEVFTMKEVMHYLGQYIMVKQLYDQQEQHLVYCGGDLLGDLLGCQSFSVKDPSPLYDM
                     LRKNLVTSASVNTDAAQTLALAQDHTMDIPSQDRLKHGATECSNPRKRTEEDDTHTLP
                     TSRRKCRDSRADEDLIEHLSQDETSRLDLDFEEWDVAGLPWWFLGNLRNNYIPRSNGS
                     TDLQTNQDIGTAIVSDTTDDLWFLNETVSEQLGVGVKVEAANCEQPSEVGRTRDKKMV
                     EGGKDDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDC
                     SKLTHSLSTSNITAIPEKKDNEGIDVPDCRRTISAPVVRPKDGYLKEEKPRFDPCNSV
                     EFLDLAHGSESQEIISSTREQTDIFSEQKTETESMEDFQNVLKPCSLCEKRPRDGNII
                     HGKTSHLTTCFHCARRLKKSGASCPACKKEIQLVIKVFIA"
     exon            191..268
                     /gene="Mdm4"
                     /inference="alignment:Splign:2.1.0"
     exon            269..402
                     /gene="Mdm4"
                     /inference="alignment:Splign:2.1.0"
     exon            403..458
                     /gene="Mdm4"
                     /inference="alignment:Splign:2.1.0"
     exon            459..526
                     /gene="Mdm4"
                     /inference="alignment:Splign:2.1.0"
     exon            527..626
                     /gene="Mdm4"
                     /inference="alignment:Splign:2.1.0"
     exon            627..787
                     /gene="Mdm4"
                     /inference="alignment:Splign:2.1.0"
     exon            788..934
                     /gene="Mdm4"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1015
                     /gene="Mdm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1898
                     /gene="Mdm4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtgcagg ccttaggacc ttcaactgcc acccctcccc cagctaggag gggggagcga
       61 ctcatggagc ggccgtaagt tgctaactga gtttggaatc ttcactgcca aaatgacatc
      121 acattccacc tctgcccagt gttcagcatc tgacagtgct tgcagaattt cttcggaaca
      181 aatcaatcag caggtacgac caaaactgca gcttctcaag attttgcaag cagcaggtgc
      241 tcagggggaa gttttcacca tgaaagaggt aatgcactat ctaggccagt atataatggt
      301 gaagcagctc tatgatcaac aggagcaaca tctggtgtac tgtggtggag accttttggg
      361 agatctactt ggatgtcaga gcttttctgt gaaagatcca agccctctgt atgacatgct
      421 aagaaagaac cttgttacgt cagcctctgt taacacagat gctgctcaga ctctcgctct
      481 cgcacaggat cacactatgg atattccaag tcaagaccga ctgaagcacg gtgcaacaga
      541 gtgctccaac cccagaaaaa gaactgaaga agatgatact cacacactgc ctacctcacg
      601 acgtaaatgc agagattcca gagcagatga agacttgata gaacatttat ctcaagatga
      661 gacatctagg cttgatcttg attttgagga gtgggatgtt gctggcctgc cttggtggtt
      721 tctagggaat ttgagaaaca actatatacc tagaagtaat ggctcaactg atttacagac
      781 aaatcaggat ataggtactg ccattgtttc agacactacg gacgatttgt ggtttttaaa
      841 tgagaccgtg tcagagcaat taggtgttgg agtaaaagtt gaagctgcta actgtgagca
      901 accaagtgaa gtagggagaa caagagacaa gaagatggtt gaagggggaa aagatgatga
      961 ccttgaggac tccaagtcct taagtgatga tactgatgtg gaagtcactt ctgaggatga
     1021 gtggcagtgt acggaatgca agaagtttaa ttctccaagc aagaggtact gttttcgttg
     1081 ctgggccttg aggaaggatt ggtattcgga ttgctctaaa ttaactcatt ctctctctac
     1141 atctaatatc actgccatac ctgaaaagaa ggacaatgaa ggaatcgatg tccccgattg
     1201 tcggagaacc atttccgctc ctgtggttag gcctaaagat ggatatttaa aggaggaaaa
     1261 gcccaggttt gacccttgca actcagtgga atttttggat ttggcccatg gttctgaaag
     1321 ccaagagatc atctcaagca caagagaaca aacagatatt ttctctgagc agaagacaga
     1381 aacagaaagt atggaagatt tccagaatgt cttgaagccc tgtagcttat gtgaaaaaag
     1441 gcctcgggat gggaacatta ttcatgggaa gacgagccat ctgactacat gtttccactg
     1501 tgccaggaga ctgaagaagt ctggggcttc atgtcctgct tgtaagaaag agattcagtt
     1561 ggttattaag gtttttatag catagttgag tcagttgcag agaaatacta ggagtaccag
     1621 gtcatttatc aaaagtcagt attcttagag gaaggggcag aagattacca attttgatgc
     1681 cagtctgggc catataatga gacctcggtc ttaaaaggat cagtattgag catcttttat
     1741 aaatgtgacc catcatatat atttatttat ataagcatat atggaatttt agatcagttt
     1801 tgagggtttc attgatgaga agatacataa ataactttgt tttccttccg aattgtaaac
     1861 ccgagaggca ataataccaa tacaaacata acaatgcaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaa
//
