LOCUS       NM_001108099            2855 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus MDM2 proto-oncogene (Mdm2), mRNA.
ACCESSION   NM_001108099 XM_001080981 XM_235169
VERSION     NM_001108099.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2855)
  AUTHORS   Jiang,J., Feng,S., Li,Z., Luo,Y., Wang,Z., Li,M. and Wu,G.
  TITLE     The Expression of MDM2 Gene Promoted Chondrocyte Proliferation in
            Rats with Osteoarthritis via the Wnt/beta-Catenin Pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (6), 236-241 (2022)
   PUBMED   35818191
  REMARK    GeneRIF: The Expression of MDM2 Gene Promoted Chondrocyte
            Proliferation in Rats with Osteoarthritis via the Wnt/beta-Catenin
            Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2855)
  AUTHORS   Guo,Q., Xie,M., Guo,M., Yan,F., Li,L. and Liu,R.
  TITLE     ZEB2, interacting with MDM2, contributes to the dysfuntion of brain
            microvascular endothelial cells and brain injury after
            intracerebral hemorrhage
  JOURNAL   Cell Cycle 20 (17), 1692-1707 (2021)
   PUBMED   34334113
  REMARK    GeneRIF: ZEB2, interacting with MDM2, contributes to the dysfuntion
            of brain microvascular endothelial cells and brain injury after
            intracerebral hemorrhage.
REFERENCE   3  (bases 1 to 2855)
  AUTHORS   Wang,L., Chen,M., Fu,H., Ni,T. and Wei,G.
  TITLE     Tempo-spatial alternative polyadenylation analysis reveals that 3'
            UTR lengthening of Mdm2 regulates p53 expression and cellular
            senescence in aged rat testis
  JOURNAL   Biochem Biophys Res Commun 523 (4), 1046-1052 (2020)
   PUBMED   31973811
  REMARK    GeneRIF: Tempo-spatial alternative polyadenylation analysis reveals
            that 3' UTR lengthening of Mdm2 regulates p53 expression and
            cellular senescence in aged rat testis.
REFERENCE   4  (bases 1 to 2855)
  AUTHORS   Wang,Q.S., Zhou,J. and Li,X.
  TITLE     LncRNA UCA1 protects cardiomyocytes against hypoxia/reoxygenation
            induced apoptosis through inhibiting miR-143/MDM2/p53 axis
  JOURNAL   Genomics 112 (1), 574-580 (2020)
   PUBMED   30998966
  REMARK    GeneRIF: LncRNA UCA1 protects cardiomyocytes against
            hypoxia/reoxygenation induced apoptosis through inhibiting
            miR-143/MDM2/p53 axis.
REFERENCE   5  (bases 1 to 2855)
  AUTHORS   Aiken,J., Mandel,E.R., Riddell,M.C. and Birot,O.
  TITLE     Hyperglycaemia correlates with skeletal muscle capillary regression
            and is associated with alterations in the murine double
            minute-2/forkhead box O1/thrombospondin-1 pathway in type 1
            diabetic BioBreeding rats
  JOURNAL   Diab Vasc Dis Res 16 (1), 28-37 (2019)
   PUBMED   30360646
  REMARK    GeneRIF: Murine double minute-2-forkhead box O1-thrombospondin-1
            pathway plays an important role in angio-regulation of the skeletal
            muscle in the pathophysiological context of type 1 diabetes.
REFERENCE   6  (bases 1 to 2855)
  AUTHORS   Honda,R., Tanaka,H. and Yasuda,H.
  TITLE     Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
  JOURNAL   FEBS Lett 420 (1), 25-27 (1997)
   PUBMED   9450543
REFERENCE   7  (bases 1 to 2855)
  AUTHORS   Thut,C.J., Goodrich,J.A. and Tjian,R.
  TITLE     Repression of p53-mediated transcription by MDM2: a dual mechanism
  JOURNAL   Genes Dev 11 (15), 1974-1986 (1997)
   PUBMED   9271120
REFERENCE   8  (bases 1 to 2855)
  AUTHORS   Haupt,Y., Maya,R., Kazaz,A. and Oren,M.
  TITLE     Mdm2 promotes the rapid degradation of p53
  JOURNAL   Nature 387 (6630), 296-299 (1997)
   PUBMED   9153395
REFERENCE   9  (bases 1 to 2855)
  AUTHORS   Finlay,C.A.
  TITLE     The mdm-2 oncogene can overcome wild-type p53 suppression of
            transformed cell growth
  JOURNAL   Mol Cell Biol 13 (1), 301-306 (1993)
   PUBMED   8417333
REFERENCE   10 (bases 1 to 2855)
  AUTHORS   Oliner,J.D., Kinzler,K.W., Meltzer,P.S., George,D.L. and
            Vogelstein,B.
  TITLE     Amplification of a gene encoding a p53-associated protein in human
            sarcomas
  JOURNAL   Nature 358 (6381), 80-83 (1992)
   PUBMED   1614537
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001080981.1, XM_235169.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2855
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2855
                     /gene="Mdm2"
                     /note="MDM2 proto-oncogene"
                     /db_xref="GeneID:314856"
                     /db_xref="RGD:1305332"
     exon            1..170
                     /gene="Mdm2"
                     /inference="alignment:Splign:2.1.0"
     exon            171..243
                     /gene="Mdm2"
                     /inference="alignment:Splign:2.1.0"
     exon            244..328
                     /gene="Mdm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1624
                     /gene="Mdm2"
                     /EC_number="2.3.2.27"
                     /note="double minute 2; MDM2 proto-oncogene, E3 ubiquitin
                     protein ligase; Mdm2 p53 binding protein homolog; p53 E3
                     ubiquitin protein ligase; MDM2 oncogene, E3 ubiquitin
                     protein ligase; transformed mouse 3T3 cell double minute
                     2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Mdm2"
                     /protein_id="NP_001101569.1"
                     /db_xref="GeneID:314856"
                     /db_xref="RGD:1305332"
                     /translation="MCNTNMSVSTEGAAGTSQIPASEQETLIIFYIGQYIMTKRLYDE
                     KQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVVVSQQDSGTSPSESRCQPE
                     GGSDLKDPVQASQEEKPSSSDVVSRPSTSSRRRAISETEENTDELPGERQRKRHRALS
                     FDESLGLCVLREICCERSSSSEATDTPSHQDLDDGVSDHSADCLDQDSVSDQFSVEFE
                     VESLDSEDYSLSDEGHELSDEDDEVYRVTVYQAGESDADSFEGDPEISLADYWKCTSC
                     NEMNPPLPSHCNRCWTLRENWLPDDKGKDKVEISEKAKLESSDQAEEGLDVPDGKKVT
                     EDDAKESSAEDSEEKVAQMLLSQESDDYSQPSTSSSIVYSSQESGKELKEDTQDKEES
                     MESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQ
                     MIVLTYFN"
     exon            329..462
                     /gene="Mdm2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..512
                     /gene="Mdm2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..571
                     /gene="Mdm2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..668
                     /gene="Mdm2"
                     /inference="alignment:Splign:2.1.0"
     exon            669..817
                     /gene="Mdm2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..973
                     /gene="Mdm2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1051
                     /gene="Mdm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..2855
                     /gene="Mdm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctttgtta acggggcctc cgaagccggg gtagcctagg agcggccgcg ttctacgtca
       61 ggagccgctg tcgcttcgct cgacctcccg agcgaaatgg tctctcaagt cccggccacc
      121 gggcctccgc gctccccatg aagggtcgga ggccgcgcgg ggagtagcag cggtctgcag
      181 gcgagcggag acggacacac cggggacctc tccgaccacc gtgcttctgc tgcgcgcctc
      241 caggccaatg tgcaatacca acatgtctgt gtctaccgag ggtgctgcag gcacctcaca
      301 gattccagcg tcggaacaag agactctgat tatattttat attggacagt atattatgac
      361 taaaagatta tatgatgaga agcagcagca cattgtgtat tgctcaaatg atctcctagg
      421 agatgtgttc ggagtcccaa gtttctctgt gaaggagcac aggaaaatat atgcaatgat
      481 ctacagaaac ttagtggttg taagtcaaca agactctgga acatcgccga gtgagagcag
      541 atgtcagcct gaaggtggga gtgacctgaa ggaccccgtg caagcatcac aagaagagaa
      601 accttcatct tctgatgtag tttctagacc atctacctca tctagaagga gagcaattag
      661 tgaaacagaa gagaacacag atgaactacc tggggaacga cagaggaagc gccacagagc
      721 cctgtccttt gatgagagcc tgggtctgtg tgtgctcagg gagatatgct gtgaaagaag
      781 cagcagcagc gaggccacag acaccccctc acatcaggat cttgatgatg gcgtaagtga
      841 ccattctgct gattgcctgg atcaggattc agtttctgat caattcagtg tagaatttga
      901 agttgagtct cttgactcag aagattacag cctgagtgat gaagggcatg agctctcaga
      961 tgaggatgat gaggtctatc gggtcacagt ctatcaggca ggagaaagcg atgcagactc
     1021 ttttgaggga gatcctgaaa tttccttagc tgactattgg aaatgcacct cgtgcaatga
     1081 aatgaatcct ccccttccat cacactgcaa cagatgttgg acccttcgtg agaactggct
     1141 tccagacgat aaggggaaag ataaagtgga aatttctgaa aaagccaaac tggaaagctc
     1201 agatcaggca gaagaaggct tagatgtgcc tgatggcaaa aaagtgacag aggatgatgc
     1261 taaggagtca tctgctgagg atagcgagga aaaagtggcc cagatgctcc tgtcacagga
     1321 gagtgacgac tattcccagc cgtcgacttc cagtagcatt gtttacagca gccaagaaag
     1381 tggcaaagag ttgaaggagg acacacaaga caaagaggaa agtatggaat ccagcttctc
     1441 tctgaacgcc atcgagccat gtgtgatttg ccaggggcgg cctaaaaatg gttgcattgt
     1501 tcacggcaaa accggacacc tgatgtcatg tttcacgtgt gcaaagaagc taaagaagag
     1561 gaataagccc tgccccgtgt gcagacagcc gatccaaatg attgtgctca cgtacttcaa
     1621 ctagacggcg ggcagacgca gacctttaca cttctaatgt atgaccccca aattagacaa
     1681 catgggtatt attttcatac attaaagccg gagcattgtc ttagtctaca taaagttcat
     1741 ttgtaattta tcctcgagag taagaatagt aactgttttc ttccttttag gaaaatttca
     1801 gttgattatt ttatatttgt gttttaacgt aatttgcatt agctcttttc attttcctta
     1861 cgttttaagt aatctccact tggaaggact tttgaaagta tactttatac agtgagaagt
     1921 cctctccatc tctgtctctt ggagataatg ataggctatc gaattgtgct tgatttcctt
     1981 ttttttcctt gttaatattt aatttattta gtatctttca tgtaaagagt taaagactat
     2041 gtgaaggatt gagtgtatat ttaagttatt gaaattctga acctccttag ttctcttaag
     2101 tgggggttgt gggctgcaga gaagagtcag ccggtaaagg cgcccactgt gtatgcctaa
     2161 tgacacacat ttgatccttg caacgcccag aaagagagaa ccagttccac aaagtagttc
     2221 tcggatctcc aaatggattc atatacacac tttttttttt ttttaaggtc tgagttgcat
     2281 ctggtgatac ataagtgaaa acacacacct tgttttccag ctttttgtca tatggggtgt
     2341 ggcacgagtg ttgcagtctg tcccaggttg aaaaagtctg tggcccttcg aagcaccttc
     2401 atggcccgct ccatggttcc tgatggctgt tgaagtttca ggcctgtact tagtctaggt
     2461 tagaaaccag tccattcaga aagactaaat cagagcatgg atgaagtgga tcctccaacc
     2521 gtgtagatga gtctcttgat tcataataag aatcttccat tttaattgaa gggtcatgcc
     2581 taagtgtaga aaacaagttc cctaactgta tggagtaacc aaaggatagt tctgtattga
     2641 agttgactta aagtatcaaa gatcactccc cacatgattt agcagttaag tcggaggcag
     2701 cgcctcagcc tgggcatcct aactctggac tttgattccc catttacaat gtaatactga
     2761 ggttatatcc tagtattact agttcttaaa tgtttattta ggtgtggtag acatacatta
     2821 tttatttgca aataaatggt ttattgaatt gtttc
//
