LOCUS       NM_001017459            3159 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus Mdm1 nuclear protein (Mdm1), mRNA.
ACCESSION   NM_001017459 XM_235172
VERSION     NM_001017459.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3159)
  AUTHORS   Van de Mark,D., Kong,D., Loncarek,J. and Stearns,T.
  TITLE     MDM1 is a microtubule-binding protein that negatively regulates
            centriole duplication
  JOURNAL   Mol Biol Cell 26 (21), 3788-3802 (2015)
   PUBMED   26337392
REFERENCE   2  (bases 1 to 3159)
  AUTHORS   Hoh,R.A., Stowe,T.R., Turk,E. and Stearns,T.
  TITLE     Transcriptional program of ciliated epithelial cells reveals new
            cilium and centrosome components and links to human disease
  JOURNAL   PLoS One 7 (12), e52166 (2012)
   PUBMED   23300604
REFERENCE   3  (bases 1 to 3159)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   4  (bases 1 to 3159)
  AUTHORS   Chang,B., Mandal,M.N., Chavali,V.R., Hawes,N.L., Khan,N.W.,
            Hurd,R.E., Smith,R.S., Davisson,M.L., Kopplin,L., Klein,B.E.,
            Klein,R., Iyengar,S.K., Heckenlively,J.R. and Ayyagari,R.
  TITLE     Age-related retinal degeneration (arrd2) in a novel mouse model due
            to a nonsense mutation in the Mdm1 gene
  JOURNAL   Hum Mol Genet 17 (24), 3929-3941 (2008)
   PUBMED   18805803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB544747.1, CV126474.1 and BC087101.1.
            
            On Oct 1, 2011 this sequence version replaced NM_001017459.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               CB544747.1         1-107
            108-765             CV126474.1         1-658
            766-3159            BC087101.1         732-3125
FEATURES             Location/Qualifiers
     source          1..3159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3159
                     /gene="Mdm1"
                     /note="Mdm1 nuclear protein"
                     /db_xref="GeneID:314859"
                     /db_xref="RGD:1561092"
     exon            1..141
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2283
                     /gene="Mdm1"
                     /note="transformed mouse 3T3 cell double minute 1; Mdm1
                     nuclear protein homolog"
                     /codon_start=1
                     /product="nuclear protein MDM1"
                     /protein_id="NP_001017459.2"
                     /db_xref="GeneID:314859"
                     /db_xref="RGD:1561092"
                     /translation="MPVRFKGLSEYQRNFLWKKSYLSESYNPSVGQKYTWAGLRSDQL
                     GITKEPSFISKRRVPYYDPQISKYLEWNGTVRENDALAPPEPQIIRTPKPQEAEQRED
                     ANHETVLPQEASRVPKRTRSHSADSRAEGASDGVEKHQDVTKNHSLVNADVELRPSTK
                     PLPESIEPRLDRHLRKKAGLAVVPLNNALRNSEYQRQFVWKTCKETAPVCAANQVFRN
                     KSQVIPQFQGNTFIHESEYKRNFKGLTPVKEPKLREYLKGNSSFEILSPEKKADEPLD
                     LEVDMASEDSDQPIKKPAPWRHQRLGKVNSEYRAKFLSPAQYLYKAGAWTRVKESLSH
                     QGSLNAMWYAEVKELREKAESYRKRVQGTHFSRDHLNQIMSDSNCCWDVSSVASSEGT
                     ISSNIQALDLAGDLTSHRTLQKHPPTKLEEKKVALAEQPLENTIRSLELPEAPTMARR
                     KLAWDAAEGTQKEDTQEEPSGEEDGREARGKDKQVCAGELQKVDMQTSKADGPTEGSE
                     TSSVSSGKGGRLPTPRLRELGIQRTHHDLTTPAVGGAVLVSPAKAKPSALEQRRRPSS
                     QDGLETLKKGITKKGKHRPLSLLTSPTAGMKTVDPLPLRQDCDANVLRVAEGTLPVLK
                     NLDHQTNTPGQPSPCTLPYCHPSSRIQGRLRDPEFQHNIGKPRMNNTQLLPHGAFNDE
                     DADRLSEISARSAVSSLQAFQTLARAQKRKENFWGKP"
     exon            142..256
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     exon            257..630
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..765
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     exon            766..933
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1028
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1128
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1158
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1334
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1640
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1750
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1860
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2110
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2170
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..3107
                     /gene="Mdm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtgcgtcg tcggggacgc ccggtccagt atcttgctag ggaaccagtg ttgtcgcccc
       61 gccccctcgg ggcttttagt cccgttaact gtcggccggg ctggttccgc agggcagggc
      121 gacatgccgg tgcgcttcaa ggggctgagt gaataccaga gaaacttcct gtggaaaaag
      181 tcctatttgt cagagtccta taatccctca gtggggcaaa agtacacatg ggcaggactt
      241 agatcggacc agttggggat cacgaaagaa ccgagtttta tttcaaaaag aagagtccct
      301 tactatgacc ctcagatttc aaaatacctg gagtggaatg gaactgtccg agagaatgat
      361 gctcttgccc caccagaacc ccagattatc cgaaccccaa aaccacaaga agcagagcaa
      421 agagaagatg ctaaccacga aacagttctc ccacaagagg cttccagggt ccccaagaga
      481 actcgatctc attctgcaga ctccagagct gaaggggctt cagacggtgt ggaaaagcac
      541 caggatgtca caaaaaacca ttcactagtt aatgcagacg tggagctgag accttccacc
      601 aaacctcttc ctgagagtat agaacccagg ttggacaggc atcttcgcaa gaaagctgga
      661 ttggccgttg tccccttgaa taatgccttg agaaattctg aataccagag gcagtttgtt
      721 tggaagacct gtaaagaaac tgctccagtg tgtgcagcca atcaggtttt ccgtaataaa
      781 agccaagtta ttccacagtt ccaaggcaat acattcatcc acgaaagtga atataagcga
      841 aatttcaagg gtttaactcc agtgaaggaa ccgaagttga gagagtattt gaaaggaaac
      901 agcagttttg agatattgtc tccagagaag aaggcagacg agcctttaga cttagaagta
      961 gacatggcgt cggaagactc agaccagcct ataaagaagc ctgctccttg gagacatcaa
     1021 aggcttggaa aggtgaattc tgaatataga gcaaaatttc tgagcccagc ccagtattta
     1081 tataaggctg gagcttggac gcgtgtgaag gagagcttgt cgcaccaggg ttctctaaat
     1141 gccatgtggt atgcagaggt taaggagctc cgggaaaagg ctgagtccta tcggaagcga
     1201 gttcagggga cgcatttttc tcgggaccat ctgaatcaga ttatgtctga cagcaactgc
     1261 tgttgggatg tctcctcagt cgcaagctcg gaaggcacca ttagtagcaa catccaagcc
     1321 ctggatcttg ctggagatct tacaagccac aggaccctcc agaaacaccc tcctaccaaa
     1381 ctggaagaga aaaaagttgc attggcagaa cagcccctgg aaaataccat caggagcctg
     1441 gagctgccag aggctcccac catggccagg aggaagttgg cttgggatgc tgcggagggc
     1501 acacagaagg aagataccca ggaggagccc agtggggagg aggacgggag agaggccaga
     1561 ggaaaggaca agcaggtctg tgcaggagag ctacagaaag tggacatgca gacatctaag
     1621 gcagacggac cgacagaagg gtcagaaacg tcttccgttt cctcagggaa gggaggcaga
     1681 cttccgacac caagactgag agagctcggt atccagcgga ctcaccatga tctcacaact
     1741 ccagctgttg gtggagcggt cttagtgtct ccagctaaag cgaagccgtc agccctggag
     1801 caaaggagga gaccatcctc ccaagatggc ttggagactc tgaagaaagg cattactaag
     1861 aaaggaaaac accgtcctct ctctctcctg acttctccta ctgccggcat gaaaacagtt
     1921 gatcccctgc ctttgcgaca agattgtgac gccaatgtgc tcagagttgc tgagggtact
     1981 cttcctgttt tgaaaaattt ggaccatcag accaacactc ctggacagcc ttctccatgt
     2041 accctgcctt actgtcatcc ttccagcagg atccaggggc gtcttcgaga ccctgaattt
     2101 cagcataaca taggaaaacc aaggatgaac aacacgcagt tacttccaca tggcgccttt
     2161 aatgacgaag atgcagacag actgtctgag atctccgctc gctctgcggt ttccagcctc
     2221 caggctttcc agactttagc ccgagctcag aaaagaaagg agaatttctg gggcaaaccg
     2281 taaacctgct catctgacct agagaaaagt gggcctcatc tttccttgct tgttgtgtaa
     2341 agatctctgg agggtgtgga ttttcttcca acgcttctga ctcagataat ttgagttctc
     2401 agtggctcgt cttacccaga aaactgtaat gtagcggtgt ccaagtttaa gtctttgaga
     2461 agtcctttgc acttgtctga ggacaaaggc gtagattgtg tagttcttca tactctgtct
     2521 tctgcagcag gtgtcggggt tgctgtgaga cgtgtgaagg tcatctgtct ggagaatatt
     2581 ctaaagggat aaatgaactc aaaattaagg tcttccaact taatcccctc tcagattggt
     2641 tttaggcatt ttaatagctg taggtgtcat gaaaggaatc tgccactttt tattagcacc
     2701 ttctgtatac acaggtgcag tgttaagatg attggacttt gaaaatctgg ctgtacatat
     2761 tttcttattt atgtaacaaa atttgctgag agaatatgta tatttttgat ctttttatgc
     2821 attttatttg tataattggc atacatttga ataatgtcta gattttgaga aattatttgt
     2881 gtaatggaga attgaaactt tgtagactga aaagtaaatg cacttggctt cctcagagtt
     2941 atcatgtgga gtaaatacct tgtagaagcg ttctgttagg actggttaat cagaaatcat
     3001 tctaccattg cagctgctaa atgcagtgaa accgagtcta cagtatttgg ggtttttttg
     3061 cacaaataca aggttttaaa aagattcatt aaaaaattta acaccaaaaa aaaaaaaaaa
     3121 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
