LOCUS       NM_001413214             834 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus midkine (Mdk), transcript variant 2, mRNA.
ACCESSION   NM_001413214
VERSION     NM_001413214.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 834)
  AUTHORS   Fu,C., Zhang,Y., Xi,W.J., Xu,K., Meng,F., Ma,T., Li,W., Wu,L. and
            Chen,Z.
  TITLE     Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization
            in liver cirrhosis and hepatocellular carcinoma rat model via the
            MK/integrin signaling pathway
  JOURNAL   J Ethnopharmacol 308, 116191 (2023)
   PUBMED   36731809
  REMARK    GeneRIF: Dahuang Zhechong pill attenuates hepatic sinusoidal
            capillarization in liver cirrhosis and hepatocellular carcinoma rat
            model via the MK/integrin signaling pathway.
REFERENCE   2  (bases 1 to 834)
  AUTHORS   Zhang,J., Wei,X., Zhang,W., Wang,F. and Li,Q.
  TITLE     MiR-326 targets MDK to regulate the progression of cardiac
            hypertrophy through blocking JAK/STAT and MAPK signaling pathways
  JOURNAL   Eur J Pharmacol 872, 172941 (2020)
   PUBMED   31972179
  REMARK    GeneRIF: MiR-326 targets MDK to regulate the progression of cardiac
            hypertrophy through blocking JAK/STAT and MAPK signaling pathways.
REFERENCE   3  (bases 1 to 834)
  AUTHORS   Lautz,T., Lasch,M., Borgolte,J., Troidl,K., Pagel,J.I.,
            Caballero-Martinez,A., Kleinert,E.C., Walzog,B. and Deindl,E.
  TITLE     Midkine Controls Arteriogenesis by Regulating the Bioavailability
            of Vascular Endothelial Growth Factor A and the Expression of
            Nitric Oxide Synthase 1 and 3
  JOURNAL   EBioMedicine 27, 237-246 (2018)
   PUBMED   29233575
REFERENCE   4  (bases 1 to 834)
  AUTHORS   Maliza,R., Fujiwara,K., Azuma,M., Kikuchi,M. and Yashiro,T.
  TITLE     Effect of retinoic acid on midkine gene expression in rat anterior
            pituitary cells
  JOURNAL   Endocr J 64 (6), 633-638 (2017)
   PUBMED   28392548
  REMARK    GeneRIF: Data suggest that retinoic acid up-regulates Mdk gene
            expression via Rar signaling in neurons of anterior pituitary which
            also express Raldh1. (Mdk = midkine; Rar = retinoic acid receptor;
            Raldh1= retinaldehyde dehydrogenase 1)
REFERENCE   5  (bases 1 to 834)
  AUTHORS   Masuda,T., Maeda,K., Sato,W., Kosugi,T., Sato,Y., Kojima,H.,
            Kato,N., Ishimoto,T., Tsuboi,N., Uchimura,K., Yuzawa,Y.,
            Maruyama,S. and Kadomatsu,K.
  TITLE     Growth Factor Midkine Promotes T-Cell Activation through Nuclear
            Factor of Activated T Cells Signaling and Th1 Cell Differentiation
            in Lupus Nephritis
  JOURNAL   Am J Pathol 187 (4), 740-751 (2017)
   PUBMED   28183532
REFERENCE   6  (bases 1 to 834)
  AUTHORS   Nakamura,E., Kadomatsu,K., Yuasa,S., Muramatsu,H., Mamiya,T.,
            Nabeshima,T., Fan,Q.W., Ishiguro,K., Igakura,T., Matsubara,S.,
            Kaname,T., Horiba,M., Saito,H. and Muramatsu,T.
  TITLE     Disruption of the midkine gene (Mdk) resulted in altered expression
            of a calcium binding protein in the hippocampus of infant mice and
            their abnormal behaviour
  JOURNAL   Genes Cells 3 (12), 811-822 (1998)
   PUBMED   10096022
REFERENCE   7  (bases 1 to 834)
  AUTHORS   Liu,X., Mashour,G.A., Webster,H.F. and Kurtz,A.
  TITLE     Basic FGF and FGF receptor 1 are expressed in microglia during
            experimental autoimmune encephalomyelitis: temporally distinct
            expression of midkine and pleiotrophin
  JOURNAL   Glia 24 (4), 390-397 (1998)
   PUBMED   9814819
REFERENCE   8  (bases 1 to 834)
  AUTHORS   Obama,H., Biro,S., Tashiro,T., Tsutsui,J., Ozawa,M., Yoshida,H.,
            Tanaka,H. and Muramatsu,T.
  TITLE     Myocardial infarction induces expression of midkine, a
            heparin-binding growth factor with reparative activity
  JOURNAL   Anticancer Res 18 (1A), 145-152 (1998)
   PUBMED   9568069
REFERENCE   9  (bases 1 to 834)
  AUTHORS   Iwasaki,W., Nagata,K., Hatanaka,H., Inui,T., Kimura,T.,
            Muramatsu,T., Yoshida,K., Tasumi,M. and Inagaki,F.
  TITLE     Solution structure of midkine, a new heparin-binding growth factor
  JOURNAL   EMBO J 16 (23), 6936-6946 (1997)
   PUBMED   9384573
REFERENCE   10 (bases 1 to 834)
  AUTHORS   Karino,S., Minegishi,T., Ohyama,Y., Tano,M., Nakamura,K.,
            Miyamoto,K., Tanaka,S. and Ibuki,Y.
  TITLE     Regulation and localization of midkine in rat ovary
  JOURNAL   FEBS Lett 362 (2), 147-150 (1995)
   PUBMED   7720861
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV216351.1, SRR22399489.3422096.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000003.1  98358625-98358743   c
            120-196             JAXUCZ010000003.1  98358362-98358438   c
            197-355             JAXUCZ010000003.1  98358070-98358228   c
            356-517             JAXUCZ010000003.1  98357789-98357950   c
            518-834             JAXUCZ010000003.1  98356789-98357105   c
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..834
                     /gene="Mdk"
                     /note="midkine"
                     /db_xref="GeneID:81517"
                     /db_xref="RGD:69073"
     exon            1..119
                     /gene="Mdk"
                     /inference="alignment:Splign:2.1.0"
     exon            120..196
                     /gene="Mdk"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..543
                     /gene="Mdk"
                     /note="MK"
                     /codon_start=1
                     /product="midkine precursor"
                     /protein_id="NP_001400143.1"
                     /db_xref="GeneID:81517"
                     /db_xref="RGD:69073"
                     /translation="MQHRSFFLLALVALLAVTTAVAKKKDKVKKGSECSEWTWGPCTP
                     SSKDCGMGFREGTCGAQTQRIHCKVPCNWKKEFGADCKYKFESWGACDGSTGTKARQG
                     TLKKARYNAQCQETIRVTKPCTSKTKSKAKAKKGKGKD"
     exon            197..355
                     /gene="Mdk"
                     /inference="alignment:Splign:2.1.0"
     exon            356..517
                     /gene="Mdk"
                     /inference="alignment:Splign:2.1.0"
     exon            518..834
                     /gene="Mdk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttagcggga caggccgtag cgggagggaa cgaagcatcg agccggcccg tgagcgagtg
       61 agcgcacgca gtggctgtgg cccctgtccc tccaggctgc tgccaccaag ggggatgagg
      121 atgcagcacc gaagtttctt ccttctagcc cttgttgccc tcttggctgt cacgaccgcg
      181 gtggccaaaa agaaagacaa ggtgaagaag ggcagcgagt gttcggagtg gacctggggg
      241 ccctgcaccc ccagcagcaa ggactgcggc atgggtttcc gcgagggtac ctgtggggcc
      301 cagacccagc gcatccattg caaggtgccc tgcaactgga agaaggagtt tggagccgac
      361 tgcaaataca agtttgagag ctggggggcg tgtgatggga gcactggcac caaagcccgc
      421 caagggaccc tgaagaaggc tcggtacaat gcccagtgcc aggagaccat ccgcgtgacc
      481 aagccctgca cctccaagac caagtcaaag gccaaagcca agaaaggaaa aggaaaggac
      541 tgagtcagga ggccagagag tttctggcct gggacctgaa cggagccctc ctctcccaca
      601 ggcccaagat gtaacccacc agtgcctttt gtcttcctgt cagctttgtc aatcacaccc
      661 ttttactcct gccccctctt gctacaccta gtacccaaag tggggaggga caagggattc
      721 tgggaagtga gcctccccat aacccctttt gtttccccca ccctgatacc tgttatcgag
      781 aaatgaataa aatgaactca ctttttttcc aataaaagcc tcttttttaa tata
//
